• Biomaterials Research
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• v.22 no.4
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• pp.235-248
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• 2018

Background: Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded. Main body: In this article, recent studies of injectable hydrogel systems applicable for therapeutic agent delivery, disease/cancer therapy, and tissue engineering have reviewed in terms of the various factors physically and chemically contributing to sol-gel transition via which gels have been formed. The various factors are as follows: several different non-covalent interactions resulting in physical crosslinking (the electrostatic interactions (e.g., the ionic and hydrogen bonds), hydrophobic interactions, ${\pi}$-interactions, and van der Waals forces), in-situ chemical reactions inducing chemical crosslinking (the Diels Alder click reactions, Michael reactions, Schiff base reactions, or enzyme-or photo-mediated reactions), and external stimuli (temperatures, pHs, lights, electric/magnetic fields, ultrasounds, or biomolecular species (e.g., enzyme)). Finally, their applications with accompanying therapeutic agents and notable properties used were reviewed as well. Conclusion: Injectable hydrogels, of which network morphology and properties could be tuned, have shown to control the load and release of therapeutic agents, consequently producing significant therapeutic efficacy. Accordingly, they are believed to be successful and promising biomaterials as scaffolds and carriers of therapeutic agents for disease and cancer therapy and tissue engineering.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.407-407
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• 2019

According to Asian Development Bank report Pakistan is among water scarce countries. Climate scenario on the basis IPCC fifth assessment report (AR5) revealed that annual mean temperature of Pakistan from year 2010-2019 was $17C^o$ which will rise up to $21C^o$ at the end of this century, similarly almost 10% decrease of annual rainfall is expected at the end of the century. It is a changing task in underdeveloped countries like Pakistan to meet the water demands of rapidly increasing population in a changing climate. While many studies have tackled scarcity and stream flow forecasting of the Upper Indus Basin (UIB) Pakistan, very few of them are related to socio-economic and climate change impact on sustainable water management of UIB. This study investigates the pattern of current and future surface water availability for various demand sites (e.g. domestic, agriculture and industrial) under different socio-economic and climate change scenarios in Upper Indus Basin (UIB) Pakistan for a period of 2010 to 2050. A state-of-the-art planning tool Water Evaluation and Planning (WEAP) is used to analyze the dynamics of current and future water demand. The stream flow data of five sub catchment (Astore, Gilgit, Hunza, Shigar and Shoyke) and entire UIB were calibrated and validated for the year of 2006 to 2011 using WEAP. The Nash Sutcliffe coefficient and coefficient of determination is achieved ranging from 0.63 to 0.92. The results indicate that unmet water demand is likely to increase severe threshold and the external driving forces e.g. socio-economic and climate change will create a gap between supply and demand of water.

• Wind and Structures
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• v.16 no.6
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• pp.579-601
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• 2013

Interference effects are of considerable concern for group hyperboloidal cooling towers, but evaluation methods and results are different from each other because of the insufficient understanding on the structure behavior. Therefore, the mechanical performance of hyperboloidal cooling tower shell under wind loads was illustrated according to some basic properties drawn from horizontal rings and cantilever beams. The hyperboloidal cooling tower shell can be regarded as the coupling of horizontal rings and meridian cantilever beams, and this perception is beneficial for understanding the mechanical performance under wind loads. Afterwards, the mean external latitude wind pressure distribution, CP(${\theta}$), was artificially adjusted to pursue the relationship between different CP(${\theta}$) and wind-induced responses. It was found that the maximum responses in hyperboloidal cooling tower shell are primarily dominated by the non-uniformity of CP(${\theta}$) but not the local pressure amplitude CP or overall resistance/drag coefficient CD. In all the internal forces, the maximum amplitude of meridian axial tension shows remarkable sensitivity to the variation of CP(${\theta}$) and it's also the controlling force in structure design, so it was selected as an indicator to evaluate the influence of CP(${\theta}$) on responses. Based on its sensitivity to different adjustment parameters of CP(${\theta}$), an comprehensive response influence factor, RIF, was deduced to assess the meridian axial tension for arbitrary CP(${\theta}$).

• Journal of Magnetics
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• v.16 no.1
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• pp.36-41
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• 2011

If gas is leaking out of gas pipelines, it could cause a huge explosion. Accordingly, it is important to ensure the integrity of gas pipelines. Traditionally, over the years, gas-operating companies have used the ILI system, which is based on axial magnetic flux leakage (MFL), to inspect the gas pipelines. Relatively, there is a low probability of detection (POD) for the axial defects with the axial MFL-based ILI. To prevent the buried pipeline from corrosion, it requires a protective coating. In addition to the potential damage to the coating by environmental factors and external forces, there could be defects on the damaged coating area. Thus, it is essential that nondestructive evaluation methods for detecting axial defects (axial cracks, axial groove) and damaged coating be developed. In this study, an electromagnetic acoustic transducer (EMAT) sensor was designed and fabricated for detecting axial defects and coating disbondment. In order to validate the performances of the developed EMAT sensor, experiments were performed with specimens from axial cracks, axial grooves, and coating disbondment. The experimental results showed that the developed EMAT sensor could detect not only the axial cracks (minimum 5% depth of wall thickness) and axial grooves (minimum 10% depth of wall thickness), but also the coating disbondment.

• Tribology and Lubricants
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• v.35 no.1
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• pp.59-64
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• 2019

When slipping occurs between two materials, the coefficients of friction must be considered because these values determine the overall efficiency of the machine or slip characteristics. Therefore, it is important to find the coefficient of friction between two materials. This paper focuses on obtaining the coefficient of friction between an aiming bolt and a retainer located in the headlamps of a vehicle. This bolt supports the headlamp, and if the bolt is loosened by external vibration, the angle of the light will change and block the vision of pedestrians or other drivers. In order to study these situations, the coefficient of friction between aiming bolts and retainers needs to be measured. In addition, the coefficient of friction of materials used in the headlamp should be obtained. To determine these two factors, a new device is designed for two cases: surface-surface contact and surface-line contact. To increase reliability of the results, the device is designed using an air-bearing stage which uses compressed air as lubricant to eliminate the friction of the stage itself. Experiments were carried out by applying various vertical forces, and the results show that the coefficient of friction can be measured consistently. The procedure for designing the device and the results are discussed.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.6
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• pp.24-30
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• 2018

Dental implants are currently widely used as artificial teeth due to their good chewing performance and long life cycle. A dental implant consists of an abutment as the upper part and a fixture as the lower part. When chewing forces are repeatedly applied to a dental implant, gap at the interface surface between the abutment and the fixture is often occurred, and results in some deteriorations such as loosening of fastening screw, dental retraction and fixture fracture. To cope with such problems, a sealing-type abutment having a number of grooves along the conical-surface circumference was previously developed, and shows better sealing performance than the conventional one. This study carries out optimization of the groove shape by genetic algorithm(GA) as well as structural analysis in consideration of external chewing force and pretension between the abutment and the fixture. The overall optimization system consists of two subsystems; the one is the genetic algorithm with MATLAB, and the other is the structural analysis with ANSYS. Two subsystems transmit and receive the relevant data with each other throughout the optimization processes. The optimization result is then compared with that of the conventional one with respect to the contact pressure and the maximum stress. The result shows that the optimized model gives better sealing performance than the conventional sealing abutment.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.3
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• pp.193-205
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• 2019

Looking at recent safety accidents in buildings, most of them due to lack of FM expertise, and this is due to human resources. In each all industry areas, some companies are competitive, representational, and leading in the market through long-term expertise and research in their respective fields. In the field of FM industry, some companies offer core-competencies in internal and external innovative building management through competition with others. However, old custom and old management form still exist in the FM field. However, an old custom and old management system still exist in the FM field; it forces cost-cutting and caused by carelessness in technical development competitiveness and safety measures. The government control by safety inspection and facility inspection through legislation of building management, but the management is still weak as a side of in the facility management section due to inspect sth as a mere formality and submit a paper report. These facts exist different kind of usage of the building have a three-party encounter between a building owner, user, and FM enterprises. In this research identify survey, especially building owner (manager)'s choice perception priority for optional factors to choose FM enterprises. Based on this, FM enterprises will be forced to seek a new dimension for better building management. In this light, the purpose of the research is to shape changes in the FM market culture safely and providing better service in building management and understanding building owner's insight through this research's information.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.39 no.2
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• pp.317-325
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• 2019

A suction caisson has been widely used for anchor and foundation of offshore structures due to its broad application, simple installation, and rapid construction. In design of suction caisson foundation, the bearing capacity and the stability of soil are mainly dealt with and analysis methods for them are presented in design codes related to the foundation. On the other hand, the method for structural safety analysis of the suction caisson is not generalized, in particular for load modeling of the caisson under suction. Consequently, there are difficulties in design of the caisson cross section. For this reason, this study analyzed the magnitude and distribution of pore water pressure on inner and outer surface of the caisson using theoretical and numerical seepage analyse, and an approach to reasonably estimate the load applied to the structural analysis of the caisson was presented. Furthermore, effects of penetration depth, anisotropy of permeability, and suction pressure on the pore water pressure were analyzed.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.55 no.1
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• pp.62-73
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• 2019

Recently, copper alloy netting has been proposed as a material for aquaculture facilities that can be set in harsh offshore environments. To design a cage made of copper alloy netting, it is necessary to calculate the flow of water through the netting and force of external sources on the netting. Therefore, this study measured and analyzed the current velocity reduction after passing through the netting and the hydrodynamic forces acting on the netting using copper alloy netting with nine solidity ratios. As a result of the reduction rate of the flow velocity through the netting, the flow reduction rate was increased as the solidity ratio of netting was increased. The flow reduction rate was also increased as the attack angle on the netting was decreased. In analyzing the resistance on the netting, we also discovered that resistance was increased with increase in the flow velocity and solidity ratio. An analysis of the hydrodynamic coefficient acting on the netting is shown that the drag coefficient tends to increase as the attack angle increases. We also analyzed the hydrodynamic coefficient according to the variation of the Reynolds number. When the drag coefficients acting on the netting were analyzed with the different Reynolds numbers, the Reynolds number increased from over 0.3 m/s to a relative constant. Finally, the copper alloy nettings had a smaller velocity reduction rate when comparing the flow velocity reduction rate between copper alloy nettings and nylon nettings.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.166-172
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• 2019

A case study was performed in order to develop well-designed of thin plate door impact beam. The conventional impact beam was consisted of steel-pipe welded two brackets on the both side, which causes low productivity and high cost. In order to overcome those disadvantage, it is necessary to develop a new type of door impact; thin plate impact beam. The thin plate impact beam was not needed a welding procedure, which can lead low cost and high productivity. In order to maximally resist from an external force, the cross-section design should be well designed. 6 different cross-section design were proposed based on engineer's experience. Three point bending test was simulated those 6 different impact beam and compared the reaction forces. Among them, one case was chosen and redesigned for detail design.