• Communications for Statistical Applications and Methods
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• v.25 no.5
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• pp.501-512
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• 2018

We propose Sequential Patient Recruitment Monitoring (SPRM), a new monitoring procedure for patient recruitment in a clinical trial. Based on the sequential probability ratio test using improved stopping boundaries by Woodroofe, the method allows for continuous monitoring of the rate of enrollment. It gives an early warning when the recruitment is unlikely to achieve the target enrollment. The packet data approach combined with the Central Limit Theorem makes the method robust to the distribution of the recruitment entry pattern. A straightforward application of the counting process framework can be used to estimate the probability to achieve the target enrollment under the assumption that the current trend continues. The required extension of the recruitment period can also be derived for a given confidence level. SPRM is a new, continuous patient recruitment monitoring tool that provides an opportunity for corrective action in a timely manner. It is suitable for the modern, centralized data management environment and requires minimal effort to maintain. We illustrate this method using real data from two well-known, multicenter, phase III clinical trials.

• Structural Engineering and Mechanics
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• v.73 no.5
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• pp.515-527
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• 2020

This paper presents a stress field approach for the shear capacity of stirrup-reinforced concrete beams that explicitly incorporates the contribution of principal tensile stresses in concrete. This formulation represents an extension of the variable strut inclination method adopted in the Eurocode 2. In this model, the stress fields in web concrete consist of principal compressive stresses inclined at an angle θ combined with principal tensile stresses oriented along a direction orthogonal to the former (the latter being typically neglected in other formulations). Three different failure mechanisms are identified, from which the strut inclination angle and the corresponding shear strength are determined through equilibrium principles and the static theorem of limit analysis, similar to the EC-2 approach. It is demonstrated that incorporating the contribution of principal tensile stresses of concrete slightly increases the ultimate inclination angle of the compression struts as well as the shear capacity of reinforced concrete beams. The proposed stress field approach improves the prediction of the shear strength in comparison with the Eurocode 2 model, in terms of both accuracy (mean) and precision (CoV), as demonstrated by a broad comparison with more than 200 published experimental results from the literature.

• Journal of applied mathematics & informatics
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• v.39 no.1_2
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• pp.197-214
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• 2021

In this paper, we have studied dynamics of fractional order mathematical model of malaria transmission for two groups of human population say semi-immune and non-immune along with growing stages of mosquito vector. The present fractional order mathematical model is the extension of integer order mathematical model proposed by Ousmane Koutou et al. For this study, Atangana-Baleanu fractional order derivative in Caputo sense has been implemented. In the view of memory effect of fractional derivative, this model has been found more realistic than integer order model of malaria and helps to understand dynamical behaviour of malaria epidemic in depth. We have analysed the proposed model for two precisely defined set of parameters and initial value conditions. The uniqueness and existence of present model has been proved by Lipschitz conditions and fixed point theorem. Generalised Euler method is used to analyse numerical results. It is observed that this model is more dynamic as we have considered all classes of human population and mosquito vector to analyse the dynamics of malaria.

• Bulletin of the Society of Naval Architects of Korea
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• v.19 no.1
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• pp.3-14
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• 1982

In this paper, the sway added mass of a rectangular cylinder in a restricted water is considered by applying Hamilton's principle as the frequency tends to zero. The present method is an extension of Isshiki's method proposed in 1978. In the present method, it is assumed that the fluid velocity distribution in each subdomain of the fluid can be represented by higher order polynomials while Isshiki assumed linear velocity distribution. The fluid flow is assumed as a rotational motion in the present analysis. However, the results obtained from the present method show good agreement with Bai's numerical results for the case of large clearances between a canal wall and a cylinder. From Kelvin's minimum energy theorem, we can see that the value of sway added mass obtained from the present method approaches the upper bound. The approximate formula obtained in the present study takes a simple form which consists of the dimensions of the canal and the cylinder. The present formulae are derived for the cases of a rectangular cylinder swaying at the center of a narrow or wide canal relative to a cylinder, at off-center location in a canal, and in the restricted water with a single wall. From the results of numerical calculation, it is concluded that the sway added mass in restricted waters is more affected by water depth than clearance between a wall and a cylinder.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.48 no.3
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• pp.30-39
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• 2011

In this note, a systematic design of a new robust nonlinear continuous variable structure control system(VSCS) based on the modified state dependent nonlinear form is presented for the control of uncertain affine nonlinear systems with mismatched uncertainties and matched disturbance. After an affine uncertain nonlinear system is represented in the form of state dependent nonlinear system, a systematic design of a new robust nonlinear VSCS is presented. The uncertainty of the nonlinear system function is separated into the tow parts, i.e., state dependent term and state independent term for extension of target plants. To be linear in the closed loop resultant dynamics and in order to easily satisfy the existence condition of the sliding mode, the transformed linear sliding surface is applied. A corresponding control input is proposed to satisfy the closed loop exponential stability and the existence condition of the sliding mode on the linear transformed sliding surface, which will be investigated in Theorem 1. For practical application, the discontinuity of the control input as the inherent property of the VSS is improved dramatically. Through a design example and simulation studies, the usefulness of the proposed controller is verified.

• Journal of applied mathematics & informatics
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• v.30 no.1_2
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• pp.161-171
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• 2012

We consider the fourth-order differential equation with one-dimensional $p$-Laplacian (${\phi}_p(x^{\prime\prime}(t)))^{\prime\prime}=f(t,x(t),x^{\prime}(t),x^{\prime\prime}(t)$) a.e. $t{\in}[0,1]$, subject to the boundary conditions $x^{\prime\prime}}(0)=0$, $({\phi}_p(x^{\prime\prime}(t)))^{\prime}{\mid}_{t=0}=0$, $x(0)={\sum}_{i=1}^n{\mu}_ix({\xi}_i)$, $x(t)=x(1-t)$, $t{\in}[0,1]$, where ${\phi}_p(s)={\mid}s{\mid}^{p-2}s$, $p$ > 1, 0 < ${\xi}_1$ < ${\xi}_2$ < ${\cdots}$ < ${\xi}_n$ < $\frac{1}{2}$, ${\mu}_i{\in}\mathbb{R}$, $i=1$, 2, ${\cdots}$, $n$, ${\sum}_{i=1}^n{\mu}_i=1$ and $f:[0,1]{\times}\mathbb{R}^3{\rightarrow}\mathbb{R}$ is a $L^1$-Carath$\acute{e}$odory function with $f(t,u,v,w)=f(1-t,u,-v,w)$ for $(t,u,v,w){\in}[0,1]{\times}\mathbb{R}^3$. We obtain the existence of at least one nonconstant symmetric solution by applying an extension of Mawhin's continuation theorem due to Ge. Furthermore, an example is given to illustrate the results.