• Communications for Statistical Applications and Methods
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• 제25권5호
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• pp.501-512
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• 2018

We propose Sequential Patient Recruitment Monitoring (SPRM), a new monitoring procedure for patient recruitment in a clinical trial. Based on the sequential probability ratio test using improved stopping boundaries by Woodroofe, the method allows for continuous monitoring of the rate of enrollment. It gives an early warning when the recruitment is unlikely to achieve the target enrollment. The packet data approach combined with the Central Limit Theorem makes the method robust to the distribution of the recruitment entry pattern. A straightforward application of the counting process framework can be used to estimate the probability to achieve the target enrollment under the assumption that the current trend continues. The required extension of the recruitment period can also be derived for a given confidence level. SPRM is a new, continuous patient recruitment monitoring tool that provides an opportunity for corrective action in a timely manner. It is suitable for the modern, centralized data management environment and requires minimal effort to maintain. We illustrate this method using real data from two well-known, multicenter, phase III clinical trials.

• Structural Engineering and Mechanics
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• 제73권5호
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• pp.515-527
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• 2020

This paper presents a stress field approach for the shear capacity of stirrup-reinforced concrete beams that explicitly incorporates the contribution of principal tensile stresses in concrete. This formulation represents an extension of the variable strut inclination method adopted in the Eurocode 2. In this model, the stress fields in web concrete consist of principal compressive stresses inclined at an angle θ combined with principal tensile stresses oriented along a direction orthogonal to the former (the latter being typically neglected in other formulations). Three different failure mechanisms are identified, from which the strut inclination angle and the corresponding shear strength are determined through equilibrium principles and the static theorem of limit analysis, similar to the EC-2 approach. It is demonstrated that incorporating the contribution of principal tensile stresses of concrete slightly increases the ultimate inclination angle of the compression struts as well as the shear capacity of reinforced concrete beams. The proposed stress field approach improves the prediction of the shear strength in comparison with the Eurocode 2 model, in terms of both accuracy (mean) and precision (CoV), as demonstrated by a broad comparison with more than 200 published experimental results from the literature.

• Journal of applied mathematics & informatics
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• 제39권1_2호
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• pp.197-214
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• 2021

In this paper, we have studied dynamics of fractional order mathematical model of malaria transmission for two groups of human population say semi-immune and non-immune along with growing stages of mosquito vector. The present fractional order mathematical model is the extension of integer order mathematical model proposed by Ousmane Koutou et al. For this study, Atangana-Baleanu fractional order derivative in Caputo sense has been implemented. In the view of memory effect of fractional derivative, this model has been found more realistic than integer order model of malaria and helps to understand dynamical behaviour of malaria epidemic in depth. We have analysed the proposed model for two precisely defined set of parameters and initial value conditions. The uniqueness and existence of present model has been proved by Lipschitz conditions and fixed point theorem. Generalised Euler method is used to analyse numerical results. It is observed that this model is more dynamic as we have considered all classes of human population and mosquito vector to analyse the dynamics of malaria.

• 대한조선학회지
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• 제19권1호
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• pp.3-14
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• 1982

In this paper, the sway added mass of a rectangular cylinder in a restricted water is considered by applying Hamilton's principle as the frequency tends to zero. The present method is an extension of Isshiki's method proposed in 1978. In the present method, it is assumed that the fluid velocity distribution in each subdomain of the fluid can be represented by higher order polynomials while Isshiki assumed linear velocity distribution. The fluid flow is assumed as a rotational motion in the present analysis. However, the results obtained from the present method show good agreement with Bai's numerical results for the case of large clearances between a canal wall and a cylinder. From Kelvin's minimum energy theorem, we can see that the value of sway added mass obtained from the present method approaches the upper bound. The approximate formula obtained in the present study takes a simple form which consists of the dimensions of the canal and the cylinder. The present formulae are derived for the cases of a rectangular cylinder swaying at the center of a narrow or wide canal relative to a cylinder, at off-center location in a canal, and in the restricted water with a single wall. From the results of numerical calculation, it is concluded that the sway added mass in restricted waters is more affected by water depth than clearance between a wall and a cylinder.

• 전자공학회논문지SC
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• 제48권3호
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• pp.30-39
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• 2011

본 연구에서는 수정된 상태변수 의존 비선형 형을 바탕으로 부정합조건 불확실성과 정합조건 외란을 갖는 비선형 시스템의 제어를 위한 새로운 둔감한 비선형 연속 가변구조제어기의 체계적인 설계를 제안한다. 부정합조건 불확실과 정합조건 외란 비선형 시스템을 상태변수 의존 비선형 시스템 형으로 표현한 후 체계적인 둔감한 새로운 제어기 설계를 한다. 대상 시스템의 확장을 위하여 비선형 시스템 함수의 불확정성을 상태변수 의존 항과 비의존 항 두 부분으로 나눈다. 본 비선형 제어는 제어 결과 동특성을 선형으로하기 위하여 그리고 슬라이딩 모드 존재조건을 쉽게 만족시키기 위하여 변환된 선형 슬라이딩 면을 선정한다. 선정된 슬라이딩 면 위에 슬라이딩 존재조건과 폐루프 지수 안정성을 만족하는 제어입력을 제안한다. 정리를 통하여 증명한다. 본 제어의 실용성을 위하여 가변구조제어의 내재된 특성인 제어입력의 불연속성을 극적으로 개선한다. 설계 예와 시뮬레이션 연구를 통하여 제안된 제어기의 유용성을 입증한다.

• Journal of applied mathematics & informatics
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• 제30권1_2호
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• pp.161-171
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• 2012

We consider the fourth-order differential equation with one-dimensional $p$-Laplacian (${\phi}_p(x^{\prime\prime}(t)))^{\prime\prime}=f(t,x(t),x^{\prime}(t),x^{\prime\prime}(t)$) a.e. $t{\in}[0,1]$, subject to the boundary conditions $x^{\prime\prime}}(0)=0$, $({\phi}_p(x^{\prime\prime}(t)))^{\prime}{\mid}_{t=0}=0$, $x(0)={\sum}_{i=1}^n{\mu}_ix({\xi}_i)$, $x(t)=x(1-t)$, $t{\in}[0,1]$, where ${\phi}_p(s)={\mid}s{\mid}^{p-2}s$, $p$ > 1, 0 < ${\xi}_1$ < ${\xi}_2$ < ${\cdots}$ < ${\xi}_n$ < $\frac{1}{2}$, ${\mu}_i{\in}\mathbb{R}$, $i=1$, 2, ${\cdots}$, $n$, ${\sum}_{i=1}^n{\mu}_i=1$ and $f:[0,1]{\times}\mathbb{R}^3{\rightarrow}\mathbb{R}$ is a $L^1$-Carath$\acute{e}$odory function with $f(t,u,v,w)=f(1-t,u,-v,w)$ for $(t,u,v,w){\in}[0,1]{\times}\mathbb{R}^3$. We obtain the existence of at least one nonconstant symmetric solution by applying an extension of Mawhin's continuation theorem due to Ge. Furthermore, an example is given to illustrate the results.