• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.41-44
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• 2000

With the advent of DNA microarray and "chip" technologies, gene expression in an organism can be monitored on a genomic scale, allowing the transcription levels of many genes to be measured simultaneously. Functional interpretation of massive expression data and linking such data to DNA sequences have become the new challenges to bioinformatics. I will us yeast cell cycle expression data analysis as an example to demonstrate how special database and computational methods may be used for extracting functional information, I will also briefly describe a novel clustering algorithm which has been applied to the cell cycle data.

• Journal of Yeungnam Medical Science
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• 제28권2호
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• pp.153-164
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• 2011

Background: It has been reported that estrogen receptor beta ($ER{\beta}$) mRNA expression was down-regulated during carcinogenesis and was inversely related to estrogen receptor alpha ($ER{\alpha}$) expression in breast cancer. The association of $ER{\beta}$ mRNA expression to tamoxifen resistance has also been reported. In this study, the expression of $ER{\alpha}$ and $ER{\beta}$ via immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) was prompted, and an attempt was made to find out the relationship between $ER{\beta}$ expression and recurrence in the hormonal therapy group, and between $ER{\beta}$ expression and known prognostic factors. Methods: Tumor specimens were obtained at surgery from 67 female breast cancer patients during the period of September 1995 to December 2000. All the specimens were frozen in liquid nitrogen and kept at $-70^{\circ}C$ until they were used. The medical records were analyzed retrospectively. The expressions of ER were analyzed using IHC and RT-PCR methods. Results: The median follow-up was at 93.0 months (range: 14-157 months). The percentage of $ER{\alpha}+/ER{\beta}+$, $ER{\alpha}+/ER{\beta}-$, $ER{\alpha}-/ER{\beta}+$, and $ER{\alpha}-/ER{\beta}$ group were 35.9% 9.4%, 47.2%, and 7.5%, respectively, in 53 patients with hormonal therapy. $ER{\beta}$ was positive in 42 (82.3%) of 51 ER-positive patients. In the hormonal therapy group, the recurrence rates of each group was 15.8%, 0%, 40.0%, and 0%, respectively. In this group, the $ER{\beta}$ expression tended to recur, but there was no clinical significance (p=0.084). Conclusion: The $ER{\beta}$ expression may be a predictive marker of a poor response to endocrine therapy in breast cancer patients, although this needs to be confirmed in additional studies.

• 복식문화연구
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• 제11권5호
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• pp.711-720
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• 2003

The purposes of the study were to categorize eroticism expressed in modern fashion and to find out any significant difference in erotic expressions among designer brands and fashion seasons. The research methods was a documentary analysis. The documentary materials were 180 photographs randomly selected from fashion photographs of 3 major designer brand collections, from 1995 S/S to 2000 A/W. The data were analyzed by contents analysis, frequency, crosstabs. Results were as follows; 1) The existence of erotic expressions in modern fashion was found in 107 (59.4%) out of 180 fashion photographs and the eroticism was one of the major themes in the later 1990's fashion. 2) The erotic expression in the modern fashion were categorized into 5 categories exposure, adhesion, transparency, exposure+adhesion, and adhesion+transparency. The major erotic expression was exposure which was followed by adhesion and transparency. 3) The degree of erotic expression were separated into 3 levels-strong, medium, weak. The erotic levels in the modern fashion ranged between medium and weak; medium level 43%, weak 42% and strong 15%. 4) The erotic expression and the degree of erotic expression showed differences according to three designer brands. Chanel brand used less erotic expression than Christian Dior or Givenchy. Christian Dior brand showed the tendency of strongest erotic level while the Chanel brand showed the weakest level. 5) The erotic expression and the degree of erotic expression showed differences according to fashion seasons. Spring and summer seasons used more erotic expression than autumn and winter. In spring and summer seasons, exposure and transparency were methods used more frequently for erotic expressions, while adhesion was stronger themes in autumn and winter seasons.

• 복식
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• 제64권8호
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• pp.97-110
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• 2014

Animals, as a part of nature, have much influence on children's emotional development and are one of children's favorite subjects of design. This study analyzes the differences in animal expression methods and types of animals, in relation to gender and item based on a collection of children's clothing and accessories that use animal as their theme. The collection consists of 148 clothing and 75 accessories (total of 223 items), which were collected from on-line shopping sites for children's clothes. Analysis results showed the following observations. Animal expression was categorized into four methods: emblem, illustration, character, and pattern.(The most common method was character, followed by pattern, illustration, and emblem. In relation to gender and clothing item, animal expression methods varied widely:(character was the most popular for) boys' t-shirts and accessories, while girls' bottoms and dresses. As for (animal) types, Mammalia was the most common, followed by birds and insects. Dogs and puppies were popular both genders.(However, differences in preferences existed as) boys liked big and wild animals such as bears, tigers, and foxes, while girls liked small and cute animals such as rabbits, cats, owls, and butterflies. Based on these results, six types of animals (rabbits, elephants, large-beaked bird Toco Toucans, fish, penguins, and bees) were selected as themes for kids' vest designs and, among them, three designs were made.

• 한국실내디자인학회논문집
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• 제20권2호
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• pp.147-155
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• 2011

The purpose of this study is to grope for plan methods through analyzing preferences on expression methods of materials for visual differentiation in hosing space. The results are as follows : First, we could know that finish material is the important element to make differential design in housing space. It is a effective method to use the color and material of finish materials. Second, we could find they preferred woods in materials and Y color, N9.5, bright and light in colors through grasping preference about types in material elements. The preferred texture is soft and the preferred patterns are solid and geometry. Third, it is a good method to mix materials which give us different season feeling, and to mix colors which are different tones to lead the differential design by materials in housing space. In case texture and patterns, what we mix similar things is the effective method. Fourth, preference of the expression method is manifested differently depending on the selected elements. so when we plan the housing, we have to consider that. lastly, I think this study will be a basic data on a study to differentiate the design of the residential space.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2006년도 춘계학술발표대회 논문집
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• pp.131-134
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• 2006

This study aims to inspect changes of physical expression in surfaces of both building interior and exterior in contemporary architecture. Nowadays society has transformed into more complicated framework with the development of the new media and digital technology in 21 century. Surface's expressivity has been changed with design trend and material development. Although surface study has been mainly concentrated on properties of materials and structure characters, new technology and cultural acceptance enables it extend itself to a new area with various design methods, taking its place as an important contemporary architectural element. Interior surface design is expressed with several unique methods such as optical illusion, surface exposure and spacial depth and volume, and it created dynamic space within the surface itself. In case of exterior surface, whole space seems to be designed to be coordinated with structured optical illusion as well as symbolic expression. Surface's area is extends itself with the stream of the times. This study explored the nature of surfaces with categorizing and comparing them in a various views and methods.

• 제어로봇시스템학회논문지
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• 제11권10호
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• pp.830-836
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• 2005

Application of microarray technologies which monitor simultaneously the expression pattern of thousands of individual genes in different biological systems results in a tremendous increase of the amount of available gene expression data and have provided new insights into gene expression during drug development, within disease processes, and across species. There is a great need of data mining methods allowing straightforward interpretation, visualization and analysis of the relevant information contained in gene expression profiles. Specially, classifying biological samples into known classes or phenotypes is an important practical application for microarray gene expression profiles. Gene expression profiles obtained from tissue samples of patients thus allowcancer classification. In this research, molecular classification of microarray gene expression data is applied for multi-class cancer using computational biology such gene selection, principal component analysis and fuzzy clustering. The proposed method was applied to microarray data from leukemia patients; specifically, it was used to interpret the gene expression pattern and analyze the leukemia subtype whose expression profiles correlated with four cases of acute leukemia gene expression. A basic understanding of the microarray data analysis is also introduced.

• 대한본초학회지
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• 제29권3호
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• pp.43-50
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• 2014

Objectives : To investigate terminology of Herbal drug discrimination commonly used in China, and it was translated into Korean. It also has been modified to fit the circumstances of the Korean for easier understand for Korean student. Methods : First,Terminology for Identification of the Chinese Herbal Materia Medica (TICHMM) was classified by the appearance, cut surface, material, processing and storage of Herb. Chinese commentary of TICHMM was translated into Korean. Comparative Study was performed based on the Pharmacopoeia of Korea and China. Depending on the meaning of the word, TICHMM was modified to revised Korean expression or remain chinese expression or suggest new Korean expression Result : In the 28 TICHMM terms that describes the shape properties of herbal medicine, 5 was remained in Chinese expression, 22 was modified to revised Korean expression and 1 was suggested in new Korean expression. 8 terms that describes the Section properties of herbal medicine, 6 was modified to revised Korean expression and 2 was suggested in new Korean expression. 3 terms that describes the Material properties of herbal medicine, 1 was remained in Chinese expression, 2 was modified to revised Korean expression. 3 terms that describes the processing and storage properties of herbal medicine, 2 was modified to revised Korean expression and 1 was suggested in new Korean expression. Conclusion : By comparative Study of TICHMM, commonly used in China, it will contribute new guideline on the Visual Examination of Herbal Medicine for Korean student.

• 한국콘텐츠학회논문지
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• 제11권8호
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• pp.159-169
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• 2011

무대연기와 매체연기는 매체의 특성상 연기 표현 방법이 확연히 다르다. 그렇지만 연기 기초를 이루고 있는 연기자 내면의 진실이 변형되는 것은 결코 아니다. 연기자 내면의 연기는 무대연기와 매체연기에 공통적으로 적용 된다. 그럼에도 불구하고, 매체연기는 장르적 특성상 무대연기에 비해서 좀 더 섬세하고 자연스러운 연기를 요한다. 매체연기는 스크린을 통해서 무대연기보다 훨씬 더 디테일하고 확대 되어 보이기 때문이다. 이러한 매체연기의 표현특성을 어떻게 하면 무대연기의 표현방법과 차별화시킬 것인지를 연구하는 것이 본 연구의 목적이다. 본 연구를 통해서 매체연기를 학습하는 학생 또는 전문배우가 감정이나 행동을 표현하는데 있어서 매체의 특성을 반영한 리얼한 생활연기를 보여줄 수 있는 매체연기 표현 방법을 제시하고자 한다. 매체연기 훈련에서 제시하는 다양한 표현방법은 매체연기를 도전하는 배우가 내면의 진실을 프레임 안으로 자연스럽게 끌어들이는 훈련을 통해 성과를 낼 수 있을 것이라 기대한다. 또한 매체연기에서 요하는 섬세하고 디테일한 연기 스타일을 구축 할 수 있는 기회와 더불어 무대연기와는 차별화된 연기 스타일을 발견하게 될 것이다.

• 대한예방한의학회지
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• 제14권2호
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• pp.77-89
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• 2010

Objectives : This study was performed to evaluate the effect of CJ(Cuscuta japonica Chois) on osteoclast differentiation and gene expression. Methods : The osteoclastogenesis and gene expression were determined in RANKL(receptor activator of nuclear factor kappa B ligand)－stimulated RAW 264.7. The results were summarized as followes. Results : CJ decreased the number of TRAP positive cell in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of RANK(receptor activator of nuclear factor kappa B), $TNF{\alpha}$, and IL-6 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of iNOS and COX-2 in RANKL-stimulated RAW264.7 cell. CJ decreased the expression of Cathepsin K in RANKL-stimulated RAW264.7 cell. Conclusions : It is concluded that CJ might decrease the bone resorption resulted from decrease of osteoclast differentiation and it's related gene expression.