• Environmental Analysis Health and Toxicology
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• 제18권1호
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• pp.63-67
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• 2003

Benzoic acid is produced about 700 tons/year in Korea as of 1998 survey. Most is used as a stabilizer in the processes of synthesis of pharmaceuticals and dyes. It is also used for ingradient of paint, disinfections, and antifungals. Due to the antioxidant activity of benzoic acid, the chemical is also used as food preservatives. Although the chemical is widely used in Korea, exposure levels in air, water, soil or sediment have not been monitored or estimated so that risk evaluation of benzoic acid was not possible. In this study, distribution of the chemical among environmental media was estimated using EQC model based on the chemical-physical properties. In Level I and II of which the chemical are hypothesized in equilibrium and no transfer through the media, more than 93％ of benzoic acid are estimated to be distributed in water. However, in Level III of which non-equilibrium and intermedia transfer could be occurred, the chemical is estimated to distributed to soil, 64％ and water,35% as of total amount.

• Journal of Biosystems Engineering
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• 제36권1호
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• pp.1-8
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• 2011

Six models of operator seat supplied to local tractor manufacturers were tested in the laboratory in accordance with ISO 5007 and 78/764/EEC. No models out of the six met the allowable damping and transmissibility performance criteria of both ISO 5007 and 78/764/EEC. From the ISO criterion standpoint, one model failed in damping performance and 4 models in isolation performance. From the 78/764/EEC criterion standpoint, 4 models failed in damping performance and 4 models in isolation performance. However none of them failed in all of the criteria, either. Each model met the one acceptance criterion but failed in another. This indicated that operator seat must be improved to meet the current ISO 5007 or 78/764/EEC and the exposure limit value that will be enforced in EU tractor market from 2014 by EU Directive 2002/44 EC.

• 환경영향평가
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• 제14권5호
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• pp.291-303
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• 2005

Impact pathway analysis(IPA) is a bottom-up approach to estimates health and environmental risks from emissions of classical pollutants (eg. $PM_{10}$, $SO_2$, $NO_x$ and CO). The model starts from the emission rates of facility, calculates the yearly mean concentrations of pollutants at the ground level using atmospheric dispersion models. After this, proper epidemiological exposure-response functions are applied to determine the impact on the receptors. Finally the methodology can monetise the calculated physical impact on the basis of selected economic evaluation. The aim of this study is to evaluate an external cost of virtual point source in Suwon area using IPA. The results shows minor modification of local input data can make it possible to apply the model to Suwon area.

• Journal of Radiation Protection and Research
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• 제17권1호
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• pp.57-70
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• 1992

실내 라돈-222 자핵종의 농도에 피폭되므로서 유발될 수 있는 한국인의 초과 폐암위험을 방사선피폭의 확율론적 위험예측 모형을 이용하여 정량적으로 평가하였다. 1989년 기준 표준 생명표와 사망원인 통계연보 자료로부터 유도한 한국인의 폐암 사망률은 남, 여별로 각각 $22.4/10^5-$년 및 $9.5^/10^5-$년으로 추정 되었다. 이 폐암 사망율을 근거로 수학적으로 예상한 한 모든 사망원인하의 기저 폐암사망위험은 남, 여별로 각각 0.047(4.7%) 및 0.019(1.9%)로 1984년도 미국의 0.067(6.7%) 및 0.025(2.5%)보다 낮았다. 방사선 피폭의 확률론적 수정 상대위험 예측모형을 사용하여 예상한 한국인의 라돈자핵종 피폭당의 초과 폐암위험 계수는 남자 : 0.022/WLM, 여자 : 0.009/WLM 및 평균 : 0.017/WLM로 나타났으며 이로부터 추정한 한국인의 평균 수명중 라돈자핵종 피폭유발 초과 폐암의 사망빈도는 $230/10^6$인-WLM으로 최근 외국의 관련연구에서 보고한 $120{\sim}450/10^6-WLM$의 거의 중간치(median)정도에 해당하는 것으로 평가되었다.

• Toxicological Research
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• 제26권1호
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• pp.9-14
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• 2010

The evaluation of eye and skin irritation potential is essential to ensuring the safety of human in contact with a wide variety of substances. Despite this importance of irritation test, little is known with respect to the irritation potency of lomefloxacin, a fluoroquinolone antibiotic, which has been known to cause phototoxicity with an abnormal reaction of the skin. Thus, to investigate the tendency of lomefloxacin to cause eye and skin irritation, we carried out in vitro eye irritation test using Balb/c 3T3, and in vitro skin irritation test using $KeraSkin^{TM}$ human skin model system. 3T3 neutral red uptake assay has been proposed as a potential replacement alternative for the Draize Eye irritation test. In this study, the $IC_{50}$ value obtained for lomefloxacin was 375 ${\mu}g$. According to the classification model used for determining in vitro categories, lomefloxacin was classified as moderately irritant. For evaluation of skin irritation, engineered epidermal equivalents ($KeraSkin^{TM}$) were subjected to 10 and 25 mg of lomefloxacin for 15 minutes. Tissue damage was assessed by tissue viability evaluation, and by the release of a pro-inflammatory mediator, interleukin- 1${\alpha}$. Lomefloxacin increased the interleukin-1${\alpha}$ release after 15 minutes of exposure and 42 hours of post incubation, although no decrease in viability was observed. Therefore, lomefloxacin is considered to be moderately irritant to skin and eye.

• Toxicological Research
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• 제32권1호
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• pp.15-20
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• 2016

Physiologically based pharmacokinetic (PBPK) modeling can provide an effective way to utilize in vitro and in silico based information in modern risk assessment for children and other potentially sensitive populations. In this review, we describe the process of in vitro to in vivo extrapolation (IVIVE) to develop PBPK models for a chemical in different ages in order to predict the target tissue exposure at the age of concern in humans. We present our on-going studies on pyrethroids as a proof of concept to guide the readers through the IVIVE steps using the metabolism data collected either from age-specific liver donors or expressed enzymes in conjunction with enzyme ontogeny information to provide age-appropriate metabolism parameters in the PBPK model in the rat and human, respectively. The approach we present here is readily applicable to not just to other pyrethroids, but also to other environmental chemicals and drugs. Establishment of an in vitro and in silico-based evaluation strategy in conjunction with relevant exposure information in humans is of great importance in risk assessment for potentially vulnerable populations like early ages where the necessary information for decision making is limited.

• Computers and Concrete
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• 제24권6호
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• pp.541-553
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• 2019

Alkali-silica reaction (ASR) in concrete can induce degradation in its mechanical properties, leading to compromised serviceability and even loss in load capacity of concrete structures. Compared to other properties, ASR often affects the modulus of elasticity more significantly. Several empirical models have thus been established to estimate elastic modulus reduction based on the ASR expansion only for condition assessment and capacity evaluation of the distressed structures. However, it has been observed from experimental studies in the literature that for any given level of ASR expansion, there are significant variations on the measured modulus of elasticity. In fact, many other factors, such as cement content, reactive aggregate type, exposure condition, additional alkali and concrete strength, have been commonly known in contribution to changes of concrete elastic modulus due to ASR. In this study, an artificial intelligent model using artificial neural network (ANN) is proposed for the first time to provide an innovative approach for evaluation of the elastic modulus of ASR-affected concrete, which is able to take into account contribution of several influence factors. By intelligently fusing multiple information, the proposed ANN model can provide an accurate estimation of the modulus of elasticity, which shows a significant improvement from empirical based models used in current practice. The results also indicate that expansion due to ASR is not the only factor contributing to the stiffness change, and various factors have to be included during the evaluation.

• 한국구조물진단유지관리공학회 논문집
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• 제17권1호
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• pp.64-75
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• 2013

실내촉진실험과 동시에 현장폭로실험을 병행하였기 때문에 연차별 실험계획에 따라 최근 5년차의 현장실험체 분석을 수행하고 모델을 업그레이드하는 과정에서 모델 검증을 위해 준공된 지 30년 가량된 방조제의 배수갑문콘크리트의 염화물 침투프로파일을 분석하였다. Zhang의 연구결과에서 언급된 표면에 가까운 콘크리트내부 염화물 농도를 기본모델의 표면염화물농도 대신으로 적용하였다. 장기간 노출되는 실험체의 염화물 측정자료 분석에서 확산계수의 변화분석을 통하여 Maage의 제안식을 기본모델에 적용하였다. 이렇게 보완된 수정모델을 통하여 예측된 자료와 현장자료를 비교하고, 임계시점, 즉 보수시점을 도출함으로서 본 연구의 제안모델과 유지보수 시스템이 간만대 염화물 침투프로파일 추정과 적정보수 시점 및 비용 예측에 사용될 수 있음을 보였다.

• 소음진동
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• 제10권2호
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• pp.247-253
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• 2000

The evaluation of the ride quality had been performed by the subjective method before ISO2631(International Organization for Stadard 2631) and BS6841(British Standard 6841) was precented, but many research programs have been performed by the objective method after that. On this study, the ride quality was evaluated related with the objective method which considered the vibration which the human body feels on the driver's seat while driving on the road. In particular, we made the shock absorber nonlinear model and also selected the suitable shock absorber in the part of the vibration which the human body feels into the simulation. The shock absorber of suspension was dealt with 3 cases respectively with the front wheel and rear wheel. The vibration of the car driving on the road can be transferred to the wheel, the suspension, the vehicle body, the seat and the human body. The signal which was gained from the seat(hip) and the floor(foot) of the human body was changed to the vibration signal which the human body felt through using the frequency weighting function. And then the performance of the shock absorber was calculated through the statistic processing.

• 한국콘텐츠학회논문지
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• 제18권9호
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• pp.34-43
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• 2018

본 연구는 인물사진의 평가 요소들과 감상자들의 일반적인 선호도와의 관계를 통하여, 감상자 중심의 제품 개발 및 설계를 위한 이미지 측정 프로그램 모형을 개발하는 것을 목적으로 한다. 사전 연구에서 개발된 프로그램을 분석하여 개선을 필요로 하는 항목과 이미지 평가 시에 필수적으로 포함해야하는 사항을 신규 항목으로 추가하였다. 본 연구에서는 첫 번째 단계로 얼굴의 초점을 확인하였고, 객관적, 주관적 화질 평가 항목으로 나누어 인물사진을 평가하였다. 객관적 평가 항목에는 RSC 콘트라스트, 다이내믹 레인지를 선정하였고, 통계학적 분석방법으로 각 이미지의 수치를 평가할 수 있었다. 주관적 평가 항목에는 얼굴의 노출, 구도, 위치, 비율 그리고 아웃포커스를 선정하였다. 또한 새로운 얼굴 인식 알고리즘을 통하여 사람의 감정을 판단할 수 있어, 이미지 관련 제조사가 사람의 감정 콘텐츠로 인물사진을 분석할 수 있는 정보를 제시하였다. 본 연구에서 개발된 프로그램은 인물사진을 평가할 때 고려해야하는 평가 항목들을 정량적, 정성적으로 규합하였다. 이를 통하여, 일반인 사용자들의 필요에 보다 부합할 수 있는 제품을 만들기 위한 평가 모형을 개발하는데 필수적인 데이터로 활용가능하다.