• Genomics & Informatics
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• 제8권1호
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• pp.34-40
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• 2010

Radiofrequency (RF) radiation might induce the transcription of a certain set of genes as other physical stresses like ionizing radiation and UV. To observe transcriptional changes upon RF radiation, we exposed WI-38, human lung fibroblast cell to 1763 MHz of mobile phone RF radiation at 60 W/kg of specific absorption rate (SAR) for 24h with or without heat control. There were no significant changes in cell numbers and morphology after exposure to RF radiation. Using quantitative RT-PCR, we checked the expression of three heat shock protein (HSP) (HSPA1A, HSPA6 and HSP105) and seven stress-related genes (TNFRSF11B, FGF2, TGFB2, ITGA2, BRIP1, EXO1, and MCM10) in RF only and RF/HS groups of RF-exposed cells. The expressions of three heat shock proteins and seven stress-related genes were selectively changed only in RF/HS groups. Based on the expression of ten genes, we could classify thermal and non-thermal effect of RF-exposure, which genes can be used as biomarkers for RF radiation exposure.

• 한국산업보건학회지
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• 제28권4호
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• pp.416-424
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• 2018

Objective: The objective of this study was to estimate the numbers of employees occupationally exposed to noise according to their industry and size. Methods: A Delphi panel consisting of 15 occupational health experts estimated the exposure prevalence of noise in workplace. Data on Industrial Accident Compensation Insurance provided from Occupational Safety and Health Research Institute were combined to produce the exposure population. Results: In Korea, 16.0% of employees, 2,539,890 out of 15,838,926, was estimated to exposed to noise occupationally. The rate was 32.7% and 10.3% in manufacturing sector and non-manufacturing sector, respectively. The highest rate, 52.5%, was found in manufacturing industries of wood and of products of wood and cork(except furniture) and of other transport equipment. Sorted by their size of business, the rate was higher as the number of employee was larger in manufacturing sector. Conclusions: Compared to the same rate estimated in the US, 17.2%, the result of this study seems to be in a resonable range.

• 한국재료학회지
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• 제33권3호
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• pp.87-94
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• 2023

Exposure to ultraviolet (UV) light is often associated with skin damage, sometimes very serious, and in recent times has received particular attention as a health risk. As a result, the proper use of sunscreen has long been recommended to protect against skin damage. The continued increase in the use of sunscreen may be linked to increased information about the risk of melanoma and non-melanoma skin cancer caused by prolonged exposure to ultraviolet rays. Natural and harmless materials that block and prevent UV light have emerged as essential household items in the field of skin beauty. New materials need to be considered and evaluated in relation to ultraviolet rays and their harmful effects. This study aims to explain the effect of UV exposure on human skin, the classification of sunscreens, the application of zeolite, nano clay, and LDH in sunscreen formulations, as well as the regulation of this service in various countries around the world.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.2783-2787
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• 2013

To assess the risk of cancer incidence after medical radiation exposure for coronary artery disease (CAD), a retrospective cohort study was conducted based on Taiwan's National Health Insurance Research Database (NHIRD). Patients with CAD were identified according to the International Classification of Diseases code, 9th Revision, Clinical Modification (ICD-9-CM), and their records of medical radiation procedures were collected from 1997 to 2010. A total of 18,697 subjects with radiation exposure from cardiac imaging or therapeutic procedures for CAD were enrolled, and 19,109 subjects receiving cardiac diagnostic procedures without radiation were adopted as the control group. The distributions of age and gender were similar between the two populations. Cancer risks were evaluated by age-adjusted incidence rate ratio (aIRR) and association with cumulative exposure were further evaluated with relative risks by Poisson regression analysis. A total of 954 and 885 subjects with various types of cancers in both cohorts after following up for over 10 years were found, with incidences of 409.8 and 388.0 per 100,000 person-years, respectively. The risk of breast cancer (aIRR=1.85, 95% confidence interval: 1.14-3.00) was significantly elevated in the exposed female subjects, but no significant cancer risk was found in the exposed males. In addition, cancer risks of the breast and lung were increased with the exposure level. The study suggests that radiation exposure from cardiac imaging or therapeutic procedures for CAD may be associated with the increased risk of breast and lung cancers in CAD patients.

• 한국산업보건학회지
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• 제31권2호
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• pp.147-155
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• 2021

Objective: The purpose of this study was to find ways for strengthening occupational health services through monitoring exposure to health hazards. Methods: About 70,000 workplaces that have conducted the work environment measurement(WEM) over the last three years(2017~2019) were classified according to the Korean Standard Industry Classification(KSIC), and the current status of WEM by industry was analyzed. The authors considered ways to monitor exposure to health hazards in order to strengthen occupational health services and protect workers' health. Results: Based on the KSIC, 934 of the 1,196 total sub-classified industries have conducted WEM in at least one workplace over the last three year(2017~2019). In the case of manufacturing, out of a total of 477 sub-classified industries, 474 have conducted WEM at more than one workplace. However, in some industries, WEM was not conducted or the implementation rate was low, so it was necessary to examine whether WEM should be expanded based on a detailed analysis of the WEM database. To this end, it is necessary to form an exposure monitoring committee in which various experts from different fields can participate. The committee needs to discuss the overall matters necessary for selecting industries that require detailed investigation or research, review the results, and prepare a final recommendation. Conclusion: In conclusion, the government needs to come up with a plan to strengthen occupational health services through surveys and research on the current status of WEM and work environment management models by industry.

• 한국가스학회지
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• 제21권1호
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• pp.6-17
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• 2017

본 연구는 3-methylpentane에 대한 흡입유해성을 평가하여 국제연합에서 정하는 화학물질의 분류 및 표지에 관한 세계조화시스템(Globally harmonized system, GHS)지침 및 고용노동부고시 제2013-37호에 따른 3-methylpentane의 화학물질 분류 표시 자료를 생산하기 위하여 OECD 화학물질 시험가이드라인 아급성흡입독성시험 TG 412(Subacute inhalation toxicity) 시험법에 따라 수행하였다. 본 연구를 위하여 6주령의 랫드(Rat)를 도입하여 1주간 순화시킨 후 암수 각각 대조군 5마리, 저농도군(284 ppm) 5마리, 중농도군(1,135 ppm) 5마리, 고농도군(4,540 ppm) 5마리 등으로 군을 구성하여 일일 6시간, 주 5일, 4주 동안 시험물질을 랫드에 전신으로 노출시켰다. 시험물질 노출을 종료하고 2주 후 시험동물을 희생하여 시험물질에 의한 시험동물의 영향을 평가하였다. 사료섭취량 변화, 체중 변화, 임상관찰, 혈액검사, 부검 소견, 장기무게 측정, 조직병리검사 등 모든 시험결과에서 시험물질에 의한 영향은 나타나지 않아 3-methylpentane의 무유해영향농도는 암수 모두 4,540 ppm이상으로 판단되어 세계조화시스템(GHS) 지침 및 고용노동부고시 제2013-37호(화학물질의 분류 표시 및 물질안전보건에 관한 기준)의 특정표적장기독성(반복노출) 구분 표시 물질에 해당하지 않은 물질로 판단되었다.

• 대한임상독성학회지
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• 제10권1호
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• pp.22-32
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• 2012

Purpose: The purpose of this study was to examine the occurrence of toxic exposure cases in Korean emergency centers using a toxic exposure surveillance system-based report form and to provide guidelines for the prevention and treatment of toxic exposures. Methods: We retrospectively reviewed the medical records of toxic exposure patients who had visited emergency centers from January 2009 to December 2009. Epidemiology data points for the toxic exposure cases included age, gender, type of exposure, number and kind of substances involved, reason and route of poison exposure, management of the patients in the emergency departments, and the clinical outcome. Results: A total of 3,501 patients from 12 emergency departments were enrolled in the study. 50.0% of the total exposure patients were male and 63.0% of the total cases were fatal. Acute intoxication occurred in 91.3% of the total patients and suicidal intent was the most common (43.3%) reason for exposure. The most common route of exposure was ingestion (75.9%). Of the total cases, pesticides were involved in 26.3%, sedatives/hypnotics/antipsychotics were involved in 22.0%, and bites and envenomations were involved in 15.7%. Conclusion: We provided a database of patients who were admitted to emergency departments after poisoning incidents. We recommend that toxicology professionals develop a classification scheme for toxicants which is adequate for Korean domestic circumstances and initiate a toxic surveillance system for all types of exposures. With support of a psychiatric surveillance system for suicidal patients and establishment of social mediation for pesticide poisoning, major reductions in poison exposures can be achieved.

• Toxicological Research
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• 제17권
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• pp.37-39
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• 2001

As the preliminary data collection for further chemical risk assessment. toxicants rating works is now rather extensively implemented in China. It consists of two parts, ie., rating of the hazard level of the exposed toxicant and that of the toxicant's profession. In the first part, the rating are based on six criteria, ie., acute toxicity, incidence of acute poisoning, prevalence of chronic poisoning, consequence of chronic poisoning, carcinogenecity and MAC level. Four hazardous levels are to be classified as extreme, high, medium, mild. In the second part. three determinants as weighted coefficients are taken into account, ie., toxicant's hazard level. exposure time and folds of MAC surpassing. Eventually, the index of classification C by which the work with toxic hazard can be classified is able to be calculated and assessed. Several comments were discussed and new recommendations were demonstrated.

• Nuclear Engineering and Technology
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• 제54권4호
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• pp.1167-1174
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• 2022

Cast austenitic stainless steels (CASSs) are widely used as structural materials in the nuclear industry. The main drawback of CASSs is the reduction in fracture toughness due to long-term exposure to operating environment. Even though ultrasonic non-destructive testing has been conducted in major nuclear components and pipes, the detection of cracks is difficult due to the scattering and attenuation of ultrasonic waves by the coarse grains and the inhomogeneity of CASS materials. In this study, the ultrasonic signals measured in thermally aged CASS were discriminated for the first time with the simple ultrasonic technique (UT) and machine learning (ML) models. Several different ML models, specifically the K-nearest neighbors (KNN), Support Vector Machine (SVM), and Multi-Layer Perceptron (MLP) models, were used to classify the ultrasonic signals as thermal aging condition of CASS specimens. We identified that the ML models can predict the category of ultrasonic signals effectively according to the aging condition.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2023년도 추계학술발표대회
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• pp.634-636
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• 2023

Surveillance systems play a pivotal role in ensuring the safety and security of various environments, including public spaces, critical infrastructure, and private properties. However, detecting abnormal human behavior in lowlight conditions is a critical yet challenging task due to the inherent limitations of visual data acquisition in such scenarios. This paper introduces a spatiotemporal framework designed to address the unique challenges posed by low-light environments, enhancing the accuracy and efficiency of human abnormality detection in surveillance camera systems. We proposed the pre-processing using lightweight exposure correction, patched frames pose estimation, and optical flow to extract the human behavior flow through t-seconds of frames. After that, we train the estimated-action-flow into autoencoder for abnormal behavior classification to get normal loss as metrics decision for normal/abnormal behavior.