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http://dx.doi.org/10.7842/kigas.2017.21.1.6

A Study on GHS Classification of 3-Methylpentane by Subacute Inhalation Toxicity  

Chung, Yong Hyun (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Han, Jeong Hee (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Shin, Seo Ho (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Publication Information
Journal of the Korean Institute of Gas / v.21, no.1, 2017 , pp. 6-17 More about this Journal
Abstract
Objectives : The purpose of this study was to obtain information regarding Globally Harmonized System(GHS) classification and health hazards that may result from a 4 weeks inhalation exposure of 3-Methylpentane in Sprague-Dawley rats. Methods : The testing method was conducted in accordance with OECD guidelines for the testing of chemicals No. 412(Subacute Inhalation Toxicity). The Rats were divided into 4 groups(5 male and 5 female rats in each group) and exposed to 0 ppm, 284 ppm, 1,135 ppm, 4,540 ppm 3-Methylpentane in each exposure chamber for 6 h/day, 5 days/week, for 4 weeks. After two weeks, the test animals were autopsied and carried out blood test and biochemical tests and histopathological examination. We used PRISTIMA (Toxicology data management system) to confirm the system and to have confidence of the raw data. Results : No death and particular clinical presentation including weight change and change of feed rate was observed. Relationship between dose, gender and response was also not significantly changed in hematologic examination, biochemical examination of blood and blood coagulation time. The histopathologic lesions caused by the test substance did not appear. Conclusions : NOAEL(No Observable Adverse Effect Level) of 3-Methylpentane is more than 4,540 ppm in male group and female group and the Ministry of Employment and Labor Guidance Announcement No. 2013-37(criteria for the classification marks and Safety of Chemicals) Specific target organ toxicity(repeated exposure) was determined with a substance that is not the separator material.
Keywords
3-Methylpentane; NOAEL; Subacute inhalation toxicity;
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