• Journal of Preventive Medicine and Public Health
• /
• 제47권1호
• /
• pp.1-6
• /
• 2014

A set of exposure factors that reflects the characteristics of individual behavior capable of influencing exposure is essential for risk and exposure assessment. In 2007, the Korean Exposure Factors Handbook was, therefore, issued, driven by the need to develop reliable exposure factors representing the Korean population. The purpose of this study was to overview the development process of the Korean Exposure Factors Handbook and major recommended exposure values for the Korean population to allow information exchanges and comparison of recommended values among nations. The researchers reviewed the domestic data that could be used in the development of exposure factors, confirmed a knowledge gap, and set a priority of development by phases. A methodology to measure exposure factors was established to develop measuring techniques and test their validity. Data were processed or a survey was conducted according to the availability of data. The study thus produced recommended values for 24 exposure factors grouped by general exposure factors, food ingestion factors, and activity factors by setting up a database of exposure factors and carrying out statistical analysis. The study has significantly contributed to reducing the potential uncertainty of the risk and exposure assessment derived by the application of foreign data or research findings lacking representativeness or grounds by developing a set of exposure factors reflecting the characteristics of the Korean people. It will be necessary to conduct revisions in light of the changing statistical values of national data and the exposure factors based on Korean characteristics.

• 한국환경보건학회지
• /
• 제49권3호
• /
• pp.169-177
• /
• 2023

Background: The Korea Centers for Disease Control and Prevention (KCDC) has identified cases of people suspected of suffering lung disease potentially caused by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) used in humidifier disinfectants (HDs). The Korean Ministry of Environment (MoE) epidemiological investigation and toxicity test study found that HDs caused health damage such as asthma and lung disease. Objectives: The main purposes of this study were to classify the HD exposure rating and to analyze the exposure characteristics that affect exposure to CMIT/MIT HDs. Methods: The exposure characteristics and socio-demographic characteristics of victim participants using CMIT/MIT HDs were investigated through questionnaires. An inhalation no observed adverse effect level (NOAEL) for CMIT/MIT was produced based on inhalation toxicity values. Exposure ratings (class 1~class 2) were cross-tabulated with clinical ratings (acceptable~unacceptable). A correlation analysis was conducted with the main exposure characteristics that affect the exposure concentration of CMIT/MIT HDs. Results: The concentration in indoor air of CMIT/MIT was 8.75±25.40 ㎍/m³, and the exposure concentration was 2.30±6.29 ㎍/m³. The CMIT/MIT exposure rating of 67 participants with high exposures of not more than MOE 100 were evaluated as 14.5%, while the damage participants who matched the clinical rating made up 4.5%. The exposure concentration of CMIT/MIT showed a positive correlation with the daily usage amount and usage frequency, and a negative correlation with volume of the indoor environment. Conclusions: A new exposure rating could be suggested and calculated based on the MOE, and the factors affecting the exposure concentration could be identified.

• 한국산업보건학회지
• /
• 제1권1호
• /
• pp.47-55
• /
• 1991

Exposure level of respirable coal dust of underground coal mines in Taebaek area was evaluated. Personal air samplers with 10-mm nylone cyclones were attached to the coal workers including drillers, coal cutters, their assistants, haulers, and separators. Log-normality of respirable dust exposure concentration were tested by Kolmogorov-Smirnov one-sample test. Differences of means of respirable dust exposure concentration between work sites were tested by one-way ANOVA test and multiple comparison(Scheffe) test. And differences of respirable dust exposure concentration of principal and assistant workers in drilling sites and in coal faces were tested by paired t-test. Relation of respirable dust exposure concentration for the principal workers and their assistants in drilling sites and in coal faces were tested by regression analysis. The results were as follows : 1. All of the respirable dust concentration were log-normally distributed. 2. There were not only significantly different means of exposure concentration between drillers and coal cutters but between coal cutters and haulers. 3. Means of exposure concentration of drillers and drilling assistants were not significantly different. And means of exposure concentration of coal cutters and coal cutting assistants were not different.

• 한국환경과학회지
• /
• 제7권3호
• /
• pp.301-310
• /
• 1998

Recently, bathes have been suspected to an Important source of indoor exposure to volatile organic compounds(VOCs). Two experiments were conducted to evaluate chloroform exposure and corresponding body burden by exposure routes while bathing. Another experiment was conducted to ekamine the chloro- form dose during dermal exposure and the chloroform decay In breath after dermal exposure. The chioroform dose was determined based on exhaled breath analysis. The ekamine breath concentration measured after normal baths (2.8 Vg/$m^3$) was approxidmately 13 tomes higher that measured prior to normal bathes (0.2 ug/$m^3$). Based on the means of the normalized post exposure chloroform breath concentration. the dermal exposure was estimated to contribute to 74% of total chloroform body burden while bathing. The Internal dose from bathing (Inhalation plus dermal) was comparable to the dose ostimated Srom dally water Ingestion. The rusk associated 10 a weekly, 30-min bath was estimated to be 1 x 10.5, while the rusk firom dally Ingestion of tap water was to be $0.5{\times}0^{-5} for 0.151 and 6.5{\times}10^{-5}$ for 2. 0 1. Chloroform breath concentration Increased gradually during the 60 minute dermal exposure. The breath decay after the dermal exposure showed two-phase mechanism, with early raped decay and the second slow decay. The mathematical model was developed to describe the relationship between water and air chloroform concentrations, with $R^2$ : 0.4 and p<0.02.

• 방사성폐기물학회지
• /
• 제19권1호
• /
• pp.123-132
• /
• 2021

Radiological impact analyses were carried out for a near-surface radioactive waste repository at Gyeongju in South Korea. The RESRAD-ONSITE code was applied for the estimation of maximum exposure doses by considering various exposure pathways based on a land area of 2,500 ㎡ with a 0.15 m thick contamination zone. Typical influencing input parameters such as shield depth, shield materials' density, and shield erosion rate were examined for a sensitivity analysis. Then both residential farmer and industrial worker scenarios were used for the estimation of maximum exposure doses depending on exposure duration. The radiation dose evaluation results showed that 60Co, 137Cs, and 63Ni were major contributors to the total exposure dose compared with other radionuclides. Furthermore, the total exposure dose from ingestion (plant, meat, and milk) of the contaminated plants was more significant than those assessed for inhalation, with maximum values of 5.5×10-4 mSv·yr-1 for the plant ingestion. Thus the results of this study can be applied for determining near-surface radioactive waste repository conditions and providing quantitative analysis methods using RESRAD-ONSITE code for the safety assessment of disposing radioactive materials including decommissioning wastes to protect human health and the environment.

• 한국구조물진단유지관리공학회 논문집
• /
• 제21권2호
• /
• pp.53-59
• /
• 2017

본 연구에서는 고온에 노출된 GFRP 보강근과 고온에 노출된 후 알칼리용액에 노출된 보강근의 단면을 현미경을 통해 관찰하고 발생된 손상의 특징을 고찰하였다. 또한, 각 시험체에 발생한 레진 균열과 공극에 대한 정량적 분석을 실시하였다. 알칼리로 인한 손상은 주로 표면에 집중되며 레진균열과 작은 공극을 발생시키는 것으로 확인되었다. 고온노출에 의한 손상은 레진균열과 공극을 발생시키는 것은 알칼리와 동일하지만 전단면에서 발생하며, 공극의 크기가 훨씬 크다. 또한 정량분석 결과, 동일한 알칼리 용액 노출조건에도 불구하고, $200^{\circ}C$ 이상의 고온에 노출된 시편에서 발견된 레진 균열과 공극이 고온노출이력이 전혀 없는 보강근에서 발견된 것 보다 1.5 및 1.4배 큰 것으로 확인되었다. 그러므로 동일한 알칼리 노출 조건이라 할지라도 $200^{\circ}C$ 이상의 고온에 노출된 보강근은 고온노출이력이 없는 보강근에 비하여 레진의 열화가 가속화 될 가능성이 있음을 알 수 있다.

• 한국산업보건학회지
• /
• 제28권3호
• /
• pp.319-329
• /
• 2018

Objectives: The object of this paper is to analyze difference of general and occupational characters, risk exposure and ill health symptom depending on the special type of employment. Methods: 50,007 participants from Fourth Korean Working Condition Survey conducted in 2014 was analyzed. Cross-tabulation analysis was conducted for deriving difference in general and occupational characters, mulitvariate logistic regression analysis was conducted after controlling general and occupational characters for deriving difference in risk exposure and ill health symptom depending on the special type of employment. Results: In the special type of employment, female, ages of 50, education levels of high school, monthly income of 2,000-3,000 thousand won, job types of sales person, enterprises of less than 100 workers, working duration of 2-10 years and long working hours worker's proportion was higher than general employment. Physical(OR: 0.84, 95% CI: 0.76-0.94) and ergonomic (OR: 0.48, 95% CI: 0.42-0.55) risk exposure was lower, psychological(OR: 1.77, 95% CI: 1.54-2.04) risk exposure was higher than general employment, and there was no significant difference between the special type of employment and general employment in chemical/biological risk exposure(OR: 1.06, 95% CI: 0.94-1.20) and ill health symptom(OR: 0.98, 95% CI: 0.89-1.09). Conclusions: This article offers the analysing difference between the special type of employment and general employment using huge size cross sectional data represent Korean employees.

• Clinical and Experimental Pediatrics
• /
• 제64권7호
• /
• pp.341-346
• /
• 2021

Background: The results differ among published studies regarding exposure to meconium and the risk of developing autism spectrum disorders (ASDs). Purpose: The present study pooled all of the epidemiologic studies retrieved from broader databases on the association between meconium exposure and risk of developing ASD in children. Methods: The Web of Science, PubMed, Scopus, and Google Scholar databases were searched without language restrictions for articles published between their inception to February 20, 2020, using relevant keywords. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated as random-effect estimates of the associations among studies. A subgroup analysis was conducted to explore any potential sources of heterogeneity among studies. Results: The pooled estimate of OR reported a weakly significant association between meconium exposure and ASD development in children (OR, 1.13; 95% CI, 1.03-1.24). There was low heterogeneity among the articles reporting risk for ASD among children (I²=19.3%; P=0.259). The results of subgroup analysis based on meconium exposure showed a significant association between a meconium-stained neonate and ASD development (OR, 1.18; 95% CI, 1.11-1.24). Couclusion: Meconium exposure was weakly associated with an increased risk of ASD. However, more evidence based on large prospective cohort studies is required to provide conclusive evidence about whether meconium exposure is associated with an increased risk of ASD development.

• 한국환경보건학회지
• /
• 제48권6호
• /
• pp.324-330
• /
• 2022

Background: Lung injuries due to exposure to humidifier disinfectants (HDs) were reported in 2011 in South Korea. As a result of the government's epidemiological investigation and toxicity test study, it was found that HDs caused health damage such as lung disease. Objectives: The purpose of this study was to classify HD exposure ratings and analyze the affecting factors that could identify the relationship with lung disease. Methods: Exposure assessment for HDs was conducted using a questionnaire during face-to-face interviews with the applicants. Ratings of high exposure (Class 1) and low exposure (Class 2) were cross-tabulated with clinical ratings (acceptable and unacceptable). Logistic regression analysis was carried out by setting the clinical rating of lung disease as a dependent variable and the socio-demographic and exposure characteristics obtained through the questionnaire as independent variables. Results: The concentration in air of polyhexamethylene guanidine (PHMG) was 71.96±107.47 ㎍/m³, and the exposure concentration was 15.21±23.28 ㎍/m³ . The exposure rating was overestimated with 97.1% of affected subjects having high exposure using margin of exposure (MOE), but only 9.9% matching the clinical class. In the overestimated group, it could be explained by the fact that the exposure time was long and the subjects had already recovered from damage symptoms. As a result of logistic regression analysis, ten variables were found to be significant influencing factors. Conclusions: A new exposure rating could be calculated based on the MOE, and factors affecting lung disease could be estimated through comparative evaluation with the clinical rating.

• 대한안전경영과학회지
• /
• 제9권1호
• /
• pp.23-35
• /
• 2007

Present time there are many risk analysis method in the world. A hazard is an exposure that has the potential to induce and adverse event. Risk is the probability of an adverse event given exposure to hazard. The evaluation of scientific information on the hazardous properties of environmental agents and the extent of exposure to these agents. But operation risk analysis method is not enough for manufacturing industry even if it is existence, it will be separated to improve Safety. In this paper, I will develop the AHP Weighted operation risk analysis method to improve Safety.