• Natural Product Sciences
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• v.21 no.2
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• pp.104-110
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• 2015

The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis of leaves of Acanthopanax gracilistylus W.W. Smith (AGS). The cytotoxicity and inhibition of NO on LPS-induced RAW 264.7 cells of the extract and triterpenoids were determined. Optimal conditions of HPLC analysis were established as follows. The separation was performed with an ODS-C₁₈ column at $30^{\circ}C$, the detected wavelength was 210 nm, the flow rate was 1 mL/min, and the mobile phase consisted of acetonitrile (0.05% phosphoric acid)-0.05% phosphoric acid solution with gradient elution. Our results showed that impressic acid and acankoreaogenin was more effective on the inhibition of NO than the methanol extract and other compounds. There were seventeen peaks coexisted with similarities above 0.95 and nine lupane-triterpenoids including acankoreaogenin and impressic acid detected and identified. The result of anti-inflammatory activities provides a potential explanation for the use of AGS leaves as a herbal medicine in the treatment of inflammatory diseases. Our results also show that acankoreanogenin and impressic acid may be potentially useful in developing new anti-inflammatory agents. In addition, the fingerprint chromatography clearly illustrated and confirmed the material basis for the anti-inflammatory activities of this plant.

• Journal of Korean Medical classics
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• v.22 no.2
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• pp.1-22
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• 2009

The existing interpretations and translations do not give adequate explanations about hidden meanings of the oriental theory, making it not easy for other researchers not majoring in oriental medicine to understand oriental medical classics. For other researchers who are trying to understand oriental medical classics and perform interdisciplinary co-research, we suggest there should be more detailed explanations about the hidden meaning of oriental theory such as Eumyang(陰陽, Yinyang) theory, Five-phase[五行] theory, Un-gi(運氣) theory. This paper, interpreting and translating the east(東), the west(西), the south(南), the north(北) in "Hwangjenaegyeong Somun(黃帝內經 素問)" focusing on the meaning of each character, will be a good example of such detailed explanation.

• Journal of KIISE:Software and Applications
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• v.30 no.3_4
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• pp.293-307
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• 2003

Object-oriented development has been generalized, but object-oriented project planning and scheduling techniques have not been studied enough. Furthermore, it is difficult to apply the conventional software management techniques to object-oriented projects. Especially, the large scaled projects are increasing, but the project planing techniques for these large scaled projects have not been proposed enough. In this paper, we propose systematic techniques for OO based project scheduling. We suggest a 7 step-process for deriving the OO project schedule from the use-case diagram which is describing the functional requirements of the system. The proposed process includes identifying use-cases, drawing preliminary chart through interdependency analysis, identifying characteristics of each use case, determining the number of iteration, assigning use-cases to iteration, considering available resource and constraints, drawing revised PERT chart. Each step has the explanation of the input, output, and the guidelines needed to perform the step. The project scheduling technique proposed in this paper ran be used effectively in the planning phase which the purpose is to plan a development schedule to yield the high quality software in minimum time.

• Journal of Korean Academy of Nursing Administration
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• v.1 no.1
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• pp.112-131
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• 1995

The purpose of this study is to know experiences and process of patients' healing relation with nurses. This study had been conducted from July to September in 1994. The subjects were 7 patients who had hospitalized within 10 days at general surgery unit in C university hospital. The data were collected through in-depth interview and observation on the basis of Grounded Theory. In-depth interview were performed 3-6 times for each patient and taken 10-15 minutes at once. The result were as follows : (1) The main concepts are worry to operation, worry to hospital environment, worry to their children, worry to nurses, general appraisal, appraisal of appearance, appraisal of attitude, appraisal of nurses' response, appraisal of nurses' help, interest to patients, appraisal of explanation, appraisal of direct nursing, appraisal of nursing role, appraisal of nursing fairness, empathy, feeling of jung, discontent exposure, content, rapport. (Jung is a unique feeling that appeared in only korean culture) (2) The main categories are worry, general appraisal, concrete appraisal, empathy, and rapport. (3) These process is worry, appraisal, empathy, and rapport in the order. (4) The core category is the need of relation formation. The hospitalized patients have had need of relation formation with nurses. In order to satisfy this need, patients in the early of hospitalization had the worries to nurses, hospital environment, their children and themselves. The more patients have information about themselves, the more they have worries. In addition to, patients have general appraisal through the first impression or feeling to nurses. A time goes by, general appraisal has changed concrete appraisal. High educated group (above bachelor degree) have expressed concretely and variousely their needs. The patients who have empathy to nurses are content with nurses and form rapport to be shown frankly thier discontents. Therefore, patients' healing relation formation is the process of being filled up the need of relation formaton with Nurses. As mentioned above, researcher suggests that nurses need study nursing strategies to make earlier the last phase of the healing relation formation, rapport.

• Progress in Superconductivity
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• v.3 no.2
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• pp.135-139
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• 2002

We have fabricated high-quality c-axis-oriented $MgB_2$ thin films by using a pulsed laser deposition technique. The thin films grown on (1 1 0 2) $Al_2$$O_3$ substrates show an onset transition temperature of 39.2 K with a sharp transition width of ~0.15 K. X-ray diffraction patterns indicate a c-axis-oriented crystal structure perpendicular to the substrate surface. We observed high critical current densities ($J_{c}$) of ~ 16 $MA/\textrm{cm}^2$ at 15 K and under self-field, which is comparable to or exceeds those of cuprate high-temperature superconductors. The extrapolation $J_{c}$ at 5 K was estimated to be ~ 40 MA/$\textrm{cm}^2$, which is the highest record for $MgB_2$ compounds. At a magnetic field of 5 T, the $J_{c}$ of~ 0.1 $MA/\textrm{cm}^2$ was detected at 15 K, suggesting that this compound is very promising candidate for the practical applications at high temperature with lower power consumption. As a possible explanation for the high current-carving capability, the vortex-glass phase will be discussed.d.d.d.

• Journal of Technology Innovation
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• v.21 no.2
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• pp.225-254
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• 2013

This paper examines an explanatory power of primary alliance motivation theories, such as 'Transaction-Cost Economics (TCE)' and 'Resource-Based View (RBV)', on the technological alliance partner selection criteria, governance and performance. Adopting perspectives of integration provided by TCE and RBV, this work examines the impact of both theories on the alliance processes such as alliance partner selection, governance and performance. Empirical findings show that both TCE and RBV are effective in explaining the choice of technological alliance partners. In addition, TCE appears to be more effective in providing explanation of technological alliance governance structure. Also, both TCE and RBV are effective in evaluating the technological alliance performance phase, though RBV appears to be slightly more effective.

• Analytical Science and Technology
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• v.5 no.2
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• pp.223-228
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• 1992

$Bi_2Sr_2Ca_2Cu_3Oy$-based superconductor phases were synthesized by the wet process using acetate precursors. Superconducting transition temperature ($T_c$) was determined from both measurements of electrical resistivity and magnetic susceptibility for the samples which were sintered at the temperatures of $850^{\circ}C$, $860^{\circ}C$, and $870^{\circ}C$ for 40 hours, respectively. The values of carrier concentration from Hall measurements were compared with $T_c$ data as a function of the sintering temperature. The formation mechanism of the superconducting phase was tentatively discussed on a basis of the distribution profile concept of the carrier concentration and the amount of superconducting phases in a ceramic bulk. This explanation may be supported by the experimental results of correlation between the relative amount of superconducting phases and the difference of $T_c$ values between superconducting onset temperature and cutoff temperature at each sintering temperature.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.13-13
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• 2010

Switching an elementary excitation by injecting a single carrier would offer the exciting opportunity for the ultra-high data storage technologies. However, there has been no methodology available to investigate the interaction of low energy discrete carriers with nano-structures. In order to map out the spatial dependency of such single carrier level interactions, we developed a pulse-and-probe algorithm, combining with low temperature scanning tunneling microscopy. The new tool, which we call single carrier spectroscopy, allows us to track the interaction with the target macrostructure with tunneling carriers on a single carrier basis. Using this tool, we demonstrate that it is possible not only to locally write and erase individual bi-solitons, reliably and reversibly, but also to track of creation yields of single and multiple bi-solitons. Bi-solitons are pairs of solitons that are elementary out-of-phase excitations on anti-ferromagnetically ordered pseudo-spin system of Si dimers on Si(001)-c(42) surfaces. We found that at low energy tunneling the single bisoliton creation mechanism is not correlated with the number of carriers tunneling, but with the production of a potential hole under the tip. An electric field at the surface determines the density of the local charge density under the tip, and band-bending. However a rapid, dynamic change of a field produces a potential hole that can be filled by energetic carriers, and the amount of energy released during filling process is responsible for the creation of bi-solitons. Our model based on the field-induced local hole gives excellent explanation for bi-soliton yield behaviors. Scanning tunneling spectroscopy data supports the existence of such a potential hole. The mechanism also explains the site-dependency of bi-soliton yields, which is highest at the trough, not on the dimer rows. Our study demonstrates that we can manipulate not just single atoms and molecules, but also single pseudo-spin excitations as well.

• The Korean Journal of Pharmacology
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• v.23 no.1
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• pp.25-31
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• 1987

The present study examines firstly, the inhibition of collagen gelation to explore the possible involvement of $Cu^{++}$-catalyzed peroxidation in rheumatoid arthritis and secondly, the effect of sodium salicylate on this peroxidative reaction to provide a possible explanation for its mechanism of anti-inflammatory action. Incubation of collagen obtained from rat skin with $Cu^{++}$ and $H_2O_2$ resulted in the inhibition of gelation in terms of maximal turbidity and lag phase, but either $Cu^{++}$ or $H_2O_2$ alone essentially gave no effect in the collagen gelation. In the presence of sodium salicylate the inhibited gelation of collagen induced by $Cu^{++}$ and $H_2O_2$ was reversed with the dependency of the concentration of sodium salicylate. Moreover, the rate of $H_2O_2$ decomposition by $Cu^{++}$ was accelerated by sodium salicylate and this decomposition of $H_2O_2$ was found to be saturable in terms of concentration of this drugs. Thus it can be expected that $Cu^{++}$ -catalyzed peroxidation attacks collagen resulting in change of structural or functional integrity of collagen, and sodium salicylate may act on this peroxidative process, possibly through the enhancement of catalatic action of $Cu^{++}$. From these results $Cu^{++}$-catalyzed peroxidation can be in part responsible for degradation of joint tissue in rheumatoid arthritis and sodium salicylate may exert its anti-inflammatory action by this peroxidative reaction.

• Journal of the Korean earth science society
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• v.28 no.2
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• pp.227-239
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• 2007

The MT data at the Okchon Belt show peculiar phase responses exceeding $90^{\circ}$. A reasonable explanation is that those responses are due to an electrical anisotropy structure which is composed of a narrow anisotropic block and an anisotropic layer. Considering the dominant anisotropic strikes of the block (NE-trend) and the layer (NW-trend) inferred from the MT data, if existing, the electrical anisotropy in the Okchon Belt was probably produced by the deformations in the pre-Jurassic period, since the NE-trending shearing or thrusting should create alternating bands of metamorphic rocks and fractures with NE-trending. Correlation of the structural strike of 2-D block with the latest EW-trending deformation events demonstrates that the geometrical structure of the anisotropic block was formed by the latest Daebo and Bulgugsa orogeny.