• Clinical and Experimental Reproductive Medicine
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• v.42 no.3
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• pp.86-93
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• 2015

Polycystic ovary syndrome (PCOS) is one of the most common hormonal endocrine disorders in women of reproductive age. It consists of a heterogeneous collection of signs and symptoms that together form a disorder spectrum. The diagnosis of PCOS is principally based on clinical and physical findings. The extent of metabolic abnormalities in women with PCOS varies with phenotype, body weight, age, and ethnicity. For general population, the prevalence of hyperandrogenism and oligomenorrhea decreases with age, while complications such as insulin resistance and other metabolic disturbances increase with age. Obese women with PCOS have a higher risk of developing oligomenorrhea, amenorrhea, hyperandrogenemia, insulin resistance, and lower luteinizing hormone (LH) to follicle stimulation hormone (FSH) ratios than non-obese women with PCOS. The LH to FSH ratio is a valuable diagnostic tool in evaluating Taiwanese women with PCOS, especially in the diagnosis of oligomenorrhea. Overweight/obesity is the major determinant of cardiovascular and metabolic disturbances in women of reproductive age.

• YAKHAK HOEJI
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• v.3 no.1
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• pp.51-55
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• 1957

It has been suggested that the fluorine content of crude sea salt may have special value in the prevention of tooth decay, by A.E.Schaefer and J/H/.Shaw. Shaw calculated that if crude sea salt containing about 40 ppm of fluorine were used, the consumption of 26-44 grams of the salt per day for each prison would be sufficient for the prevention of tooth decay. He also suggested that this level of salt consumption is actually quite common among many population in the far and near east. In order to examine the fluorine contents of sea salt in Korea, several kinds of solar-evaporating salt and pan-evaporating salt were studied. The experimental results may be summarized as follows; 1. Fluorine contents of 9 kinds of solar-evaporating salt ranged from 3.8 to 15.0 ppm and the average was 7.52 $\pm$ 3.89 ppm. 2. Fluorine contents of 7 kinds of pan-evaporating salt ranged from 2.5 to 7.1 ppm. 3. The more the salt is refined, the less becomes the fluorine content. 4. Even the crudest sea salt can not contain about 40 ppm of fluorine. 5. Statistically, daily consumption of sea slat for each person in Korea is 28 grams.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.148-149
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• 2014

In modern society, population overcrowding and concentration of facilities are happened because of the concentration on to city. So this phenomenon demands improvement of material's performance, technical development of structure analysis and design and improvement of constructing ability .High strength concrete has some merits. High strengthening makes the cross section reduced, and that cause decrease of structure weight. And using high durable and superplasticizer promote liquidity, thus high quality concrete can be produced. Because of these advantages, this study is for showing validity of using it by compression/tensile strength experiment. As this experiment's result, when concrete become stronger, interface intensity coefficient between cement and aggregate is different and they don't adhere to each other. So there is brittle failure. Fragility factor also steadily increase with strong concrete, it tells high strength concrete has problem. Therefore the sources used in high strength concrete like cement and aggregate must have great quality. So the source's performance must be supervised well because their quality decides performance criteria.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.1-5
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• 2009

Children are not small adults and there is a need to carry out specific trials that cannot be performed in adults. In general, children (minors) are unable to consent but their assent should be obtained using age appropriate information. Institutional Review Board (IRB) need paediatric expertise to balance the benefits and risks of research in children. The lack of consent has implications on the design, analysis and the choice of comparators used in the trials, which should only be performed by trained investigators with paediatric experience. Pain, fear, distress and parental separation should be prevented and minimised when unavoidable. The children requires even more careful review. Children represent a vulnerable population with developmental, physiological and psychological differences from adults, which make age- and development- related research important for their benefit. Finally, criteria for the protection of children in clinical trials therefore need to be laid down. Specific protection should be defined for research performed in children, at all stages and ages.

• Clinical and Experimental Pediatrics
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• v.57 no.6
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• pp.257-263
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• 2014

The incidence of people living with congenital heart disease (CHD) has been increasing every year owing to remarkable advances in surgical and catheter intervention techniques and devices, and improved knowledge of critical care for patients with CHD. However, these patients continue to face physical, psychosocial, and environmental challenges, and a number of studies have shown higher rates of depression and anxiety disorders than the general population. To improve psychosocial functioning and quality of life for adults with CHD, health care providers are recommended to inform CHD patients of an accurate diagnosis, and overall treatment process, beginning in adolescence to facilitate a smooth transition from adolescence to adulthood. Active cooperation with psychiatrists, psychologists, social workers, chaplains, and family members is highly recommended to help CHD patients feel normal and optimistic and to promote good social interactions, close family relationships, and a strong sense of coherence.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.1071-1076
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• 2003

Evolutionary algorithm is recognized as a promising approach to solving multi-objective combinatorial optimization problems. When no preference information of decision makers is given, multi-objective optimization problems have been commonly used to search for diverse and good Pareto optimal solution. In this paper we propose a new multi-objective evolutionary algorithm based on competitive coevolutionary algorithm, and demonstrate the applicability of the algorithm. The proposed algorithm is designed to promote both population diversity and rapidity of convergence. To achieve this, the strategies of fitness evaluation and the operation of the Pareto set are developed. The algorithm is applied to job shop scheduling problems (JSPs). The JSPs have two objectives: minimizing makespan and minimizing earliness or tardiness. The proposed algorithm is compared with existing evolutionary algorithms in terms of solution quality and diversity. The experimental results reveal the effectiveness of our approach.

• Proceedings of the IEEK Conference
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• 1999.06a
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• pp.1013-1016
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• 1999

Simple Genetic Algorithm(SGA) proposed by J. H. Holland is a population-based optimization method based on the principle of the Darwinian natural selection. The theoretical foundations of GA are the Schema Theorem and the Building Block Hypothesis. Although GA does well in many applications as an optimization method, still it does not guarantee the convergence to a global optimum in GA-hard problems and deceptive problems. Therefore as an alternative scheme, there is a growing interest in a co-evolutionary system, where two populations constantly interact and co-evolve. In this paper we propose an extended schema theorem associated with a schema co-evolutionary algorithm(SCEA), which explains why the co-evolutionary algorithm works better than SGA. The experimental results show that the SCEA works well in optimization problems including deceptive functions.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.4
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• pp.587-596
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• 2001

In the last decade, rapid developments in molecular biotechnology and of genomic tools have enabled the creation of dense linkage maps across whole genomes of human, plant and animals. Successful development and implementation of interval mapping methodologies have allowed detection of the quantitative trait loci (QTL) responsible for economically important traits in experimental and commercial livestock populations. The candidate gene approach can be used in any general population with the availability of a large resource of candidate genes from the human or rodent genomes using comparative maps, and the validated candidate genes can be directly applied to commercial breeds. For the QTL detected from primary genome scans, two incipient fine mapping approaches are applied by generating new recombinants over several generations or utilizing historical recombinants with identity-by-descent (IBD) and linkage disequilibrium (LD) mapping. The high resolution definition of QTL position from fine mapping will allow the more efficient implementation of breeding programs such as marker-assisted selection (MAS) or marker-assisted introgression (MAI), and will provide a route toward cloning the QTL.

• Clinical and Experimental Pediatrics
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• v.56 no.2
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• pp.45-51
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• 2013

Because nonalcoholic steatohepatitis can progress towards cirrhosis even in children, early detection of hepatic fibrosis and accurate diagnosis of nonalcoholic fatty liver disease (NAFLD) are important. Although liver biopsy is regarded as the gold standard of diagnosis, its clinical application is somewhat limited in children due to its invasiveness. Noninvasive diagnostic methods, including imaging studies, biomarkers of inflammation, oxidative stress, hepatic apoptosis, hepatic fibrosis, and noninvasive hepatic fibrosis scores have recently been developed for diagnosing the spectrum of NAFLD, particularly the severity of hepatic fibrosis. Although data and validation are still lacking for these noninvasive modalities in the pediatric population, these methods may be applicable for pediatric NAFLD. Therefore, noninvasive imaging studies, biomarkers, and hepatic fibrosis scoring systems may be useful in the detection of hepatic steatosis and the prediction of hepatic fibrosis, even in children with NAFLD.

• Clinical and Experimental Pediatrics
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• v.56 no.11
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• pp.459-464
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• 2013

Improving mental health and reducing the burden of mental illness are complementary strategies which, along with the treatment and rehabilitation of people with mental disorders, significantly improve population health and well-being. A Institute of Medicine report describes a range of interventions for mental disorders that included treatment and maintenance, reserving the term "prevention" for efforts that occur before onset of a diagnosable disorder. Mental health problems affect 10-20% of children and adolescents worldwide. Despite their relevance as a leading cause of health-related disability and their long lasting consequences, the mental health needs of children and adolescents are neglected. Early intervention can help reduce the significant impacts that children and adolescents with serious mental health problems may experience. Screening is the first step in early intervention, recognizing emotional and behavioral problems and providing help at an early stage. It is essential to implement early intervention in a sensitive and ethical manner to avoid any of the negative outcomes.