• Endocrinology and Metabolism
• /
• v.31 no.1
• /
• pp.1-6
• /
• 2016

Immoderate energy intake, a sedentary lifestyle, and aging have contributed to the increased prevalence of obesity, sarcopenia, metabolic syndrome, type 2 diabetes, and cardiovascular disease. There is an urgent need for the development of novel pharmacological interventions that can target excessive fat accumulation and decreased muscle mass and/or strength. Adipokines, bioactive molecules derived from adipose tissue, are involved in the regulation of appetite and satiety, inflammation, energy expenditure, insulin resistance and secretion, glucose and lipid metabolism, and atherosclerosis. Recently, there is emerging evidence that skeletal muscle and the liver also function as endocrine organs that secrete myokines and hepatokines, respectively. Novel discoveries and research into these organokines (adipokines, myokines, and hepatokines) may lead to the development of promising biomarkers and therapeutics for cardiometabolic disease. In this review, I summarize recent data on these organokines and focus on the role of adipokines, myokines, and hepatokines in the regulation of insulin resistance, inflammation, and atherosclerosis.

• Asian Journal of Business Environment
• /
• v.12 no.2
• /
• pp.1-12
• /
• 2022

Purpose: This study aims to analyze the inclusive growth in Central Sulawesi Province, an eastern province of Indonesia, up to the districts/cities level. The inclusive growth is analyzed by using Ramos, Ranieri, and Lammens' index that has three indicators which are employment, poverty, and income inequality. Research design, data, and methodology: This study uses panel data of 13 districts/cities in Central Sulawesi Province from 2015 to 2019. The statistical regression used is the panel regression method to analyze the determinants of inclusive growth there. Results: The study found that the average inclusive growth of districts/cities in Central Sulawesi is increasing from the low-level in 2015 to mid-level in 2019. The panel's data regression using fixed effect model FGLS-SUR found Investment (GFCF), Road Infrastructure, HDI, and Processing Industry have a significant positive effect. Regional minimum wage (RMW) has a significant negative effect. Government Expenditure on Education and Health Function has no significant positive effect on inclusive growth. Conclusions: throughout the study period, gini coefficient and poverty rate is slowly decreasing, while employment to population ratio remains volatile in districts/cities of Central Sulawesi.

• Tuberculosis and Respiratory Diseases
• /
• v.44 no.5
• /
• pp.1019-1029
• /
• 1997

Background : Elevation of resting energy expenditure(REE) in patients with lung cancer has been described in earlier studies and may contribute to cancer cachexia, but limited information is available regarding the prevalence and determinants of the increased REE. The aim of this study was to assess the prevalence and contributing factors of a hypermetabolic state in newly detected patients with lung cancer and to assess the energy balance in order to improve our knowledge about weight loss in patients with lung cancer. Method : Thirty one consecutive, newly detected patients with lung cancer and 20 control patients with benign lung diseases were included in this study. Resting energy expenditure(REE) was measured by indirect calorimetry using ventilated hood system and predicted REE was calculated by the Harris-Benedict formular. Results : The energy balance in newly detected lung cancer patients was disturbed in a high proportion of patients, and hypermetabolic state occurred in 61% of the patients. Tumor volume, cancer type, location, stage, the presence of atelectasis or infiltration, pulmonary function, or smoking behavior were not associated with increase in REE. But patients with distant metastasis had significantly higher REE comparing with patients without metastasis. Thirty nine percents of the patients with lung cancer had substantial loss of more than 10% of their pre-illness weight. Weight losing patients with lung cancer were not accompanied by an increase in REE. Conclusion : We concluded that the REE was elevated in a higher proportion of patients with lung cancer and distant metastasis was found to be contributing factor to the elevated REE.

• Korean Journal of Social Welfare
• /
• v.56 no.3
• /
• pp.5-35
• /
• 2004

This research is about the change of the occupation and the income of the subscriber of the medical expenditure due to the economic influence on them. The data of this study are based on 4,215 of medical cost payers among respondents of the survey on "Health and Retirement", which was the fourth additional research of Korea Labor and Income Panel Survey. The main findings of this study are as follows: First, the average medical cost is 5.5% of the income. The ratio of the medical cost to an earned income is highly different between low-income group and high income group. For the low income group, the medical cost reaches up to 1/3 of the total family income. That proves that the medical cost si a heavy burden on them. The group with the high medical expenditure seems to be supported by their own private property and other family members whenever it is needed. But it doesn't show the exact sources of the property, which includes the fund from the interests and real estates. On the other hand, only 14.4% of the subscribers changed their job status on the 5th year, and 85.6% of those kept their job status until the 5th year from the 4th year. This shows that the amount of the medical cost could be the important factor for them to change their job; for example, it is crucial whether the medical expenditure is over the average rate or not. Furthermore, the change of the occupation caused by the medical cost has the negative influence on the gross income. It makes the economic conditions of the family get worse. Therefore, the health insurance in Korea is lack of the compensational function, which substitutes the family income reduced by the change of the job status due to the high medical cost.

• Environmental and Resource Economics Review
• /
• v.24 no.2
• /
• pp.365-410
• /
• 2015

Block-rate structures are widely used in utility-pricing, including the Korean residential electricity sector. In the case of the current pricing structure, Korean citizens are highly concerned about incurring excessive electricity costs. For these reasons, there have been many discussions concerning mitigation of the strict pricing structure. Existing studies on the residential electricity demand function under block-rate structure have the following three issues - the consumer's budget constraint is non-linear, perceived price under block-rate structure is uncertain, block-rate structure has endogeneity in the price variable. In this context, this paper estimates the residential electricity demand function using micro-level household expenditure data and simulates the impact of alternative block-pricing schedules.

• Health Policy and Management
• /
• v.4 no.1
• /
• pp.107-122
• /
• 1994

Many alternatives have been discussed to reduce the medical expenditure and to use the medical resources effectively. Many studies about the economies of scale have been done for the last several decades. This study has analyzed the relationship between the number of beds and the mean expense per hospitalization day in Korea. A Cost Function Model was identified and we wanted to see the minimum optimal size with the cheapest mean expense per hospitalization day. The result is as follows; 1. In the Cost Function Mode, (the number of beds)$^{2}$, the number of personnel, productivity and training institutions are the factors that statisticaly influence the mean expenses. 2. By the univariate analysis the mean expense proved to be the smallest as the level of 150-200bed, The breaked down of the components of expenses shows that the mean labor cost is much different from the mean value of material and administration costs, and that hospital with 150-200 beds also have the minimal expense. The mean expense goes up dramatically in hospitals of 450 beds or more. 3. When the other conditions are constant, according to the multiple regression analysis of the mean expense per adjusted hospitalization day the minimum optimal size with the cheapest expense is a hospital with 191 beds and the hospital with 230 beds takes the lowest mean labor cost. The material or administration costs are not influenced by hospital size. This research has limitation in measuring the variables that influence hospital xpenses, in estimating hospital output by the number of beds in considering outpatient cost and in securing representativeness of hospitals because many hospitals made no responses to the research questionnare. But it is valuable and helpful for development of health policy to figure out the number of beds with the cheapest expense per hospitalization day.

• The Journal of the Korea Contents Association
• /
• v.12 no.2
• /
• pp.331-338
• /
• 2012

The purpose of this study is to investigate the cardiopulmonary function and the energy metabolism of stroke patients and normal persons of graded load exercise using lower ergometer. Targeting 11 normal persons(male: 6, female: 5) and 9 stroke patients (male: 4, female: 5), an graded load exercise was performed with the use of lower ergometer by increasing 25 watts every 6 minute and Quark $b_2$ were used for the cardiopulmonary function and the energy metabolism. With respect to normal persons, there were significant increases in the phase of graded load exercise, maximum oxygen uptake time, exercise time with respect to the cardiopulmonary function. In addition, there was a significant correlation between cardiopulmonary function and energy metabolism, but there was no significant difference energy metabolism. As a result, there were no significant differences between stroke patients and normal persons of the cardiopulmonary function and the energy metabolism within 18 minutes, but it had significant differences between maximum oxygen uptake and exercise time. Moreover, it was possible to identify that the cardiopulmonary function and the energy metabolism of stroke patients and normal persons are related with maximum oxygen uptake.

• Korea journal of population studies
• /
• v.18 no.2
• /
• pp.115-168
• /
• 1995

It is a common wisdom that the long-term economic development of Korea chiefly depends not only on the steady increase of the capital formation but also on the stable increase of the national saving. And also it is a widely accepted opinion that household saving plays a significant role for the smooth supply of investment funds. For the empirical analysis on the determining factors of household saving, consumption function of the household of Korea was utilized indirectly. The reason is that consumption function is regarded as a stable function whereas saving function is considered to be an unstable function of the relevant independent variables. In order to carry out the regression process of the consumption functions, data on the family income and expenditure survey and the farm household economy survey was used. The regression result could be summarized as follows : Firstly, household income and the number of the employed in the household have the negative effect in determining the consumption ratio of the Korean households. On the other hand, ages and the educational attainment of the household heads as well as the number of the household members have the positive effect. During the early part of 21st century, the consumption ratio of the Korean households is expected to be decreased because of the increasing trend of household income, and the ever increasing number of the employed member of the household based on the increasing trend of the labor force participation rate of women and the decrease of the average size of the number of household members owing to widespread nuclear family system. On the other hand, the consumption ratio of the household of Korea is expected to be increased because of the continuous increase of the average ages of the household heads caused by the population aging phenomena and improvement of the educational attainment of the household heads. But on the whole, household saving ratio is expected to be increased owing to the secular downward trend of the consumption and therefore no significant difficulties are anticipated for the smooth provision of investment resources needed to have long-term economic progress of Korea.

• Journal of the Korean Regional Science Association
• /
• v.31 no.1
• /
• pp.21-42
• /
• 2015

This paper investigates whether urban expansion and the vitalization of the local economy can be achieved through new city development. The results show that regardless of the starting point (origin) or destination point, traffic increases closer to the origin for the purpose of transportation and decreases farther from the origin. However, traffic tends to increase in districts 20 to 40 km away from the origin. Hence, building a new city in this district may be effective in terms of geography and functionality.

• BMB Reports
• /
• v.48 no.12
• /
• pp.647-654
• /
• 2015

Energy homeostasis in our body system is maintained by balancing the intake and expenditure of energy. Excessive accumulation of fat by disrupting the balance system causes overweight and obesity, which are increasingly becoming global health concerns. Understanding the pathogenesis of obesity focused on studying the genes related to familial types of obesity. Recently, a rare human genetic disorder, ciliopathy, links the role for genes regulating structure and function of a cellular organelle, the primary cilium, to metabolic disorder, obesity and type II diabetes. Primary cilia are microtubule based hair-like membranous structures, lacking motility and functions such as sensing the environmental cues, and transducing extracellular signals within the cells. Interestingly, the subclass of ciliopathies, such as Bardet-Biedle and Alström syndrome, manifest obesity and type II diabetes in human and mouse model systems. Moreover, studies on genetic mouse model system indicate that more ciliary genes affect energy homeostasis through multiple regulatory steps such as central and peripheral actions of leptin and insulin. In this review, we discuss the latest findings in primary cilia and metabolic disorders, and propose the possible interaction between primary cilia and the leptin and insulin signal pathways which might enhance our understanding of the unambiguous link of a cell's antenna to obesity and type II diabetes.