Tuberculosis and Respiratory Diseases
- Volume 44 Issue 5
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- Pages.1019-1029
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- 1997
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
Resting Energy Expenditure in Patients with Lung Cancer
폐암 환자의 안정시 에너지 소비
- Lee, Jae-Lyun (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
-
Kim, Ki-Beom
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Hak-Jun (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Jung, Jin-Hong (Department of Internal Medicine, College of Medicine, Yeungnam University) ;
-
Lee, Kwan-Ho
(Department of Internal Medicine, College of Medicine, Yeungnam University) ;
- Lee, Hyun-Woo (Department of Internal Medicine, College of Medicine, Yeungnam University)
- 이재련 (영남대학교 의과대학 내과학교실) ;
-
김기범
(영남대학교 의과대학 내과학교실) ;
- 이학준 (영남대학교 의과대학 내과학교실) ;
- 정진홍 (영남대학교 의과대학 내과학교실) ;
-
이관호
(영남대학교 의과대학 내과학교실) ;
- 이현우 (영남대학교 의과대학 내과학교실)
- Published : 1997.10.31
Abstract
Background : Elevation of resting energy expenditure(REE) in patients with lung cancer has been described in earlier studies and may contribute to cancer cachexia, but limited information is available regarding the prevalence and determinants of the increased REE. The aim of this study was to assess the prevalence and contributing factors of a hypermetabolic state in newly detected patients with lung cancer and to assess the energy balance in order to improve our knowledge about weight loss in patients with lung cancer. Method : Thirty one consecutive, newly detected patients with lung cancer and 20 control patients with benign lung diseases were included in this study. Resting energy expenditure(REE) was measured by indirect calorimetry using ventilated hood system and predicted REE was calculated by the Harris-Benedict formular. Results : The energy balance in newly detected lung cancer patients was disturbed in a high proportion of patients, and hypermetabolic state occurred in 61% of the patients. Tumor volume, cancer type, location, stage, the presence of atelectasis or infiltration, pulmonary function, or smoking behavior were not associated with increase in REE. But patients with distant metastasis had significantly higher REE comparing with patients without metastasis. Thirty nine percents of the patients with lung cancer had substantial loss of more than 10% of their pre-illness weight. Weight losing patients with lung cancer were not accompanied by an increase in REE. Conclusion : We concluded that the REE was elevated in a higher proportion of patients with lung cancer and distant metastasis was found to be contributing factor to the elevated REE.
연구배경 : 폐암 환자에서 체중감소와 영양결핍은 흔히 동반되며 체중감소가 있는 폐암 환자는 체중감소가 없는 환자보다 항암제 치료에 대한 반응이 좋지 않으며 예후도 나쁘다. 폐암환자에서의 체중감소는 안정시 에너지 소비(resting energy expenditure : REE)와 관계가 있다. 저자들은 폐암 환자에서 안정시 에너지 소비자 증가된 빈도를 알아보고 안정시 에너지 소비에 영향을 주는 인자를 알아보고자 하였다. 방 법 : 처음 진단된 31명의 폐암 환자를 대상을 안정시 에너지 소비를 측정하여 대조군과 비교하였다. 안정시 에너지 소비량은 ventilated hood system을 사용하여 간접 칼로리측정법(indirect calorimetry)으로 측정하였다. 안정시 에너지 소비량은 칼로리측정기로 측정한 산소 소모량과 이산화탄소 생성량을 이용하여 Weir공식으로 계산하였으며 안정시 에너지 소비량의 예측치는 Harris-Benedict공식으로 구하여 비교하였다. 결 과 : 안정시 에너지 소비량은 폐암 환자와 대조군에서 각각