• The Journal of Korean Medical History
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• v.30 no.2
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• pp.133-143
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• 2017

Objectives : This paper summarizes results from review of 36 cases and medical records extracted from Yeoksimanpil, involving treatment of exogenous disease in the last Joseon dynasty, and considers significance of treatment protocols. Methods : About 130 medical records from Yeoksimanpil related to exogenous disease were reviewed, and 36 cases were extracted for closer investigation. The author examined the characteristics of exogenous diseases treated in Yeoksimanpil during the Joseon dynasty, employing Yi Suki's theory about exogenous febrile disease, and analyzed the theory from the viewpoint of epidemic febrile disease (溫病學). Results : The majority of exogenous diseases recorded in Yeoksimanpil include Sanghan (傷寒); Seo (暑); Ryeohwan (厲患); and Hongjin (紅疹). Sanghan was found to be prevalent among the exogenous diseases, but diseases caused by warmth and epidemic are recognized separately from Sanghan. Yi Suki's theory about exogenous febrile disease is similar to the basic theory of modern epidemic febrile disease, although his theory was developed independently during the last Joseon dynasty. Conclusions : Although some exogenous diseases in Yeoksimanpil were recognized separately, Yi Suki did not specify each feature nor did he focus on each symptom. Instead, the author's research suggests that Yi Suki was able to identify and treat a variety of various exogenous diseases due to his accumulation of medical knowledge and skill.

• Animal Bioscience
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• v.34 no.8
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• pp.1365-1374
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• 2021

Objective: This study was conducted to investigate the synergistic effect of exogenous multienzyme and phytase on growth performance, nutrients digestibility, blood metabolites, intestinal microflora, and morphology in broilers fed corn-wheat-soybean meal diets. Methods: A 2×2 factorial design was used in this study. Four dietary treatments consisted of i) basal diets (corn-wheat-soybean meal based diets without multi-enzyme and phytase), ii) basal diets with phytase (0.05%), iii) basal diets with exogenous multi-enzyme (0.05%), and iv) basal diets with exogenous multi-enzyme including phytase (0.05%). A total of 480 broiler chickens (Ross 308 - one day old) were weighed and allotted to thirty-two cages (15 birds per cage), and chicks were randomly allocated to four dietary treatments. Results: The body weight gain and feed conversion rate were improved by supplementation of exogenous multi-enzyme containing phytase during the finisher period (p<0.05). The birds fed diets with exogenous multi-enzyme containing phytase had a significantly greater digestibility of dry matter, gross energy, crude protein, calcium, and phosphorus compared with birds fed non-supplemented diets (p<0.05). The chickens fed diets with exogenous multi-enzyme containing phytase showed a higher concentration of Ca and P in the serum (p<0.05). The population of Lactobacillus spp., Escherichia coli, and Clostridium were not affected in the ileum and cecum of chickens fed enzyme-supplemented diets. The dietary supplemental exogenous multi-enzyme containing phytase showed a significant improvement in villus height, crypt depth, and villus height and crypt depth ratio, compared to basal diets or dietary supplemental phytase (p<0.05). Conclusion: The supplementation of the exogenous multi-enzyme containing phytase synergistically improved the growth performance, nutrients digestibility, and villus height of the small intestine of broiler chickens fed a corn-wheat-soybean meal based diets.

• Biomedical Science Letters
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• v.7 no.1
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• pp.17-25
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• 2001

This study was performed to assess the effects of exogenous collagen gel for the re-epithelialization of partial thickness skin wound healing in rabbits. Adult male rabbits (New Zealand White Rabbit) 1.5~2 kg, were used for experimental animals. Skin wounds (1.5$\times$2 cm length) were created bilaterally on the flank of 10 rabbits and then treated a periods of 9 days. Wounds on the experimental site were treated with exogenous collagen gel as well as fabric material gauze dressing. Control site wounds were covered with fabric material gauze dressing alone. Histological findings indicated that the epithelial migration of the experimental site of rabbits was far more rapid than that in the other control wound sites. Moreover, exogenous collagen gel provided a moist environment to keep wound clean, and facilitate keratinocyte proliferation. The wound dressed with exogenous collagen gel demonstrated a significant increase in the healing rate and re-epithelialization.

• Molecules and Cells
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• v.45 no.12
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• pp.963-975
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• 2022

Exogenous polyamines are able to induce life span and improve glucose homeostasis and insulin sensitivity. However, the effects of exogenous polyamines on adipocyte differentiation and which polyamine transporters mediate them have not been elucidated yet. Here, we identified for the first time that exogenous polyamines can clearly stimulate adipocyte differentiation through polyamine transporters, solute carrier family 3 member A2 (SLC3A2) and SLC7A1. Exogenous polyamines markedly promote 3T3-L1 adipocyte differentiation by increasing the intracellular lipid accumulation and the expression of both adipogenic and lipogenic genes in a concentration-dependent manner. In particular, exogenous putrescine mainly regulates adipocyte differentiation in the early and intermediate stages. Moreover, we have assessed the expression of polyamine transporter genes in 3T3-L1 preadipocytes and adipocytes. Interestingly, the putrescine-induced adipocyte differentiation was found to be significantly suppressed in response to a treatment with a polyamine transporter inhibitor (AMXT-1501). Furthermore, knockdown experiments using siRNA that specifically targeted SLC3A2 or SLC7A2, revealed that both SLC3A2 and SLC7A2 act as important transporters in the cellular importing of exogenous putrescine. Thus, the exogenous putrescine entering the adipocytes via cellular transporters is involved in adipogenesis through a modulation of both the mitotic clonal expansion and the expression of master transcription factors. Taken together, these results suggest that exogenous polyamines (such as putrescine) entering the adipocytes through polyamine transporters, can stimulate adipogenesis.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.380-384
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• 1997

This study was performed to understand the exogenous-water-drop induced thermomechanical effect on the tooth in the free-running Er:YAG laser mode for the proper use of water as a laser energy absorber and coolant in dentistry. The ree-running Er:YAG laser was used in the dental hard tissue ablation study. A Microjet system was employed to dispense precise water drops. Ablation rate, recoil momentum, and temperature rise in the pulp cavity were measured with and without an exogenous water drop on the tooth surface. Exogenous water enhanced ablation rate in the thick tooth in which the ablation rate on the dry surface does not increase linearly but shows plateau. Optimal exogenous water volume was shifted from 2 nl to 4 nl as the laser energy was increased from 48 mJ to 145 mJ. The magnitude of the recoil momentum was increased as the volume of exogenous water increased. The results of this study suggest that we must pay attention to the recoil momentum or recoil pressure study or the optimal and safe usage of water in the dental treatment because these mechanical effects depend on the volume of exogenous water on the tooth surface.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.9 no.2
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• pp.83-93
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• 2005

It is well known that Treatise on Exogenous Febrile Disease is one of the oldest and most authoritative books in Oriental Medicine, suggesting the concept of Exogenous Febrile and Six channels as a theoretical basis of clinical experience and prescription. But, since Thang Thongjing had written the book, the numberous medical practitioners and theorists asserted their various and different views on the concept of Exogenous Febrile and its Six channels. 3UM-3YANG of Treatise on Exogenous Febrile Disease is basically the thing of specialization UM-YANG, eventually UM-YANG are two functional characteristics in human body. It is specialized to 3UM-3YANG by spatial and time criteria Therefore, it is important to apprehend the concept correctly that was written on Treatise on Exogenous Febrile Disease. I'd like to look into a bodily state by answering the question that is easy to access and based on Six Channels.

• 제어로봇시스템학회:학술대회논문집
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• 1998.10a
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• pp.362-366
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• 1998

This paper proposes a fast H$\sub$$\infty$/ gain scheduled controller that stabilizes the uncertain nonlinear system with exogenous signals. The controller is constructed at a distinct and fixed value of exogenous signals using H$\sub$$\infty$/ syn-thesis methodology. Then the constructed controller set is switched for the wide range of variation of exogenous signals. Using the derivative gain, the number of constructed and engaged controllers for the fast varying exogenous signal is reduced.

• Proceedings of the KSAR Conference
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• 2002.06a
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• pp.91-91
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• 2002

There are many methods to introduce exogenous DNA into embryo for the purpose of producing transgenic animals. Exogenous gene can be integrated into oocyte as a form of sperm vector. In this study, sperm was used as a vector for transgene that is enhanced green fluorescent protein (EGFP). The objective of this study was to investigate the expression of exogenous gene in bovine embryos after injection of spermatozoa cocultured with EGFP fragment. Spermatozoa were plunged into liquid nitrogen and thawed several times or shaked in 0.2% Triton X-100 to remove sperm membrane which followed by DTT treatment. (omitted)

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.421-426
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• 2006

Objective To learn if there were different characteristics of tongue demonstration between diseases caused by exogenous pathogenic factor and disorder of internal organs. Methods Choosing 3059 cases from 51 medical records of Qing Dynasty, in which 1397 cases were diagnosed as diseases caused by exogenous pathogenic factor and 1110 were disorder of internal organs. Contrasting the constituent ratio of tongue demonstration using chi-square test. Results There were significant deviation between diseases caused by exogenous pathogenic factor and disorder of internal organs in color of tongue, color of fur and quality of fur (p<0.01). Conclusions the characteristics of tongue demonstration in diseases caused by exogenous pathogenic factor were high frequency of bright red tongue, yellow fur, blank fur and dry fur; and which in disorder of internal organs were high frequency of white tongue, thin fur, greasy fur and exfoliative fur.

• The Journal of Internal Korean Medicine
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• v.13 no.2
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• pp.35-47
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• 1992

This study has been carried out to compare the exogenous cough(外感咳嗽) to western medicine. The results were as follows: 1. The exogenous cough(外感咳嗽) on the oriental medicine was similar to U.R.I., Infectious pneumonia, acute bronchitis on the western medicine and acute bronchitis was most similar to the exogenous cough(外感咳嗽). 2. The exogenous cough(外感咳嗽) was caused by the six devils of the environment(六淫) involving the lung and clinically divided into poonghan cough(風寒咳嗽), poongyul cough(風熱咳嗽) and poongjo cough(風燥咳嗽). 3. The symptom of the exogenous cough(外感咳嗽). a. poonghan cough(風寒咳嗽): sputum-rare and white color, laryngeal voice and tickel, stuffed-up and running nose, chilling and fever, headache and generalache, seoltae(舌苔) - thin and white color, pulse - boogin(浮緊). b. poongyul cough(風熱咳嗽): sputum-thick and yellow color, difficult expectoration sore thraot and thirsty, fever and chilling, sweating or headache, seoltae(舌苔) - thin and white color, pulse - boosak(浮數). c. poongjo cough (風燥咳嗽): dry cough with no or a little sputum and difficult expectoration, chest pain, dryness on the pharynx and lips, chilling and fever, seoltae(舌苔) - thin and dry, yellow color, pulse - sesak(細數) 4. The treatment of the exogenous cough(外感咳嗽). a. poonghan cough(風寒咳嗽) : sopoongsanhan sunpyuegihae (疎風散寒 宣肺止咳) b. poongyul cough(風熱咳嗽) : sopoongcheongyul sunpyuegihae (疎風淸熱 宣肺止咳) c. poongjo cough(風操咳嗽) : chungpyueyunjo saenggingihae (淸肺潤燥 生津止咳)