• Korean Journal of Exercise Nutrition
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• v.25 no.4
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• pp.38-44
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• 2021

[Purpose] Exercise can prevent conditions such as atrophy and degenerative brain diseases. However, owing to individual differences in athletic ability, exercise supplements can be used to improve a person's exercise capacity. Schisandra chinensis (SC) is a natural product with various physiologically active effects. In this study, we analyzed SC using a pharmacological network and determined whether it could be used as an exercise supplement. [Methods] The active compounds of SC and target genes were identified using the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). The active compound and target genes were selected based on pharmacokinetic (PK) conditions (oral bioavailability (OB) ≥ 30%, Caco-2 permeability (Caco-2) ≥ -0.4, and drug-likeness (DL) ≥ 0.18). Gene ontology (GO) was analyzed using the Cytoscape software. [Results] Eight active compounds were identified according to the PK conditions. Twenty-one target genes were identified after excluding duplicates in the eight active compounds. The top 10 GOs were analyzed using GO-biological process analysis. GO was subsequently divided into three representative categories: postsynaptic neurotransmitter receptor activity (53.85%), an intracellular steroid hormone receptor signaling pathway (36.46%), and endopeptidase activity (10%). SC is related to immune function. [Conclusion] According to the GO analysis, SC plays a role in immunity and inflammation, promotes liver metabolism, improves fatigue, and regulates the function of steroid receptors. Therefore, we suggest SC as an exercise supplement with nutritional and anti-fatigue benefits.

• Korean Journal of Exercise Nutrition
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• v.24 no.4
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• pp.28-33
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• 2020

[Purpose] This study aimed to investigate the effects of branched-chain amino acid (BCAA) supplement on delayed onset muscle soreness (DOMS) by analyzing the maximum muscle strength and indicators of muscle damage. [Methods] Twelve men with majors in physical education were assigned to the BCAA group and placebo group in a double-blinded design, and repeated measurements were conducted. DOMS was induced with an isokinetic exercise. Following BCAA administration, the changes in the knee extension peak torque, flexion peak torque, aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) concentrations were analyzed. The maximum knee muscle strength was measured at the baseline (pre-D0) following BCAA administration for 5 days before exercise (-D5, -4D, -3D, -2D, -1D). In contrast, the post-treatment measurements (D3) were recorded after BCAA administration for 3 days (post-D0, D1, D2). Blood samples were obtained before (pre-D0), immediately after (post-D0), 24 h (D1), 48 h (D2), and 72 h (D3) after the exercise to analyze the indicators of muscle strength. BCAA was administered twice daily for 8 days (5 days and 3 days before inducing DOMS and during the experimental period, respectively). [Results] There was no difference in the flexion peak torque between the groups. However, the BCAA group showed a significantly higher extension peak torque at D3 (second isokinetic exercise), compared to the placebo group (p<.05). There was no difference in AST changes between the groups. Nonetheless, the CK and LDH were significantly reduced in the BCAA group, compared to the placebo group. There was no correlation between the extension peak torque and flexion peak torque. However, the CK and LDH increased proportionately in DOMS. Moreover, their concentrations significantly increased with a decreasing peak torque (p<.01). [Conclusion] An exercise-induced DOMS results in a decrease in the peak torque and a proportional increase in the CK and LDH concentrations. Moreover, the administration of BCAA inhibits the reduction of the extension peak torque and elevation of CK and LDH concentrations. Therefore, BCAA might be administered as a supplement to maintain the muscle strength and prevent muscle damage during vigorous exercises that may induce DOMS in sports settings.

• Korean Journal of Exercise Nutrition
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• v.23 no.2
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• pp.34-44
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• 2019

[Purpose] The composition of protein supplements, the consumption timing immediately before and after resistance exercise training (RET), and the quantity of protein supplementation may be important factors for the im-provement of muscle mass and function. Although these factors should be considered comprehensively for effective improvement of muscular function in protein supplementation, relatively few studies have focused on this area. Therefore, this study was designed to investigate whether a protein blend supplement before and after resistance exercise for 12 weeks would be effective in increasing muscular function. [Methods] In total, 18 participants were randomly assigned to a placebo (PLA) or protein blend supplement (PRO) group. All subjects followed the same training routine 3 times per week for 12 weeks, taking placebo or protein supplements immediately before and after each exercise session. The protein supplement consisted of 40 g of blend protein, including hydrolyzed whey protein. The RET consisted of lower body (barbell squat, dead lift, seated leg extension, and lying leg curl) and upper body (bench press, barbell rowing, preacher bench biceps curl, and dumbbell shoulder press) exercises. A repetition was defined as three sets of 10-12 times with 80% of one repetition maximum (1RM). [Results] Although the PRO group had a lower protein intake in terms of total food intake than the PLA group, the mean changes in muscle circumference, strength, and exercise volume increased, especially at week 12, compared to the PLA group. [Conclusion] These results suggest that the composition and timing of protein intake are more important than the total amount.

• Journal of Nutrition and Health
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• v.23 no.4
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• pp.287-297
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• 1990

The status of the nutrient supplement usage of the adults in Seoul was investigated. One thousand two hundred adults from various age groups were chosen as the subject of this study. Data of this study were obtained by means of self administered questionnaire for demog-raphic characteristics(sex,age,edcation,income,occupation) and behavioral characteristics (reason for using nutrient supplement or not using,exercise,drinking & smoking). The overall response rate was 85%(n=1031). As a result, a substantial percentage(40%) of the subjects were used some kinds of nutrient supplement. The higher the age, educational level, and family income were, the higher the percentage of nutrient supplement usage was. But there was not the significant difference between sexes(38% in men vs 34% in women). And supple-ment usage was higher in the thin and obese groups than the average weight groups. Majority of subjects indicated that the information source of supplement was "Family/Friends" or "Phy-sician/Pharmacist". KEY WORDS: supplement usage vitamin/mineral supplement health food.

• Journal of Life Science
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• v.17 no.4 s.84
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• pp.503-509
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• 2007

The purpose of this study was to investigate the effect of Gi exercises and soybean milk supplement on the body composition and the physiological parameters including blood level of lipids and related hormones in middle-aged women. The Gi exercise program was composed of warming-up(10 min), main exercise(40 min) and cooling-down(10 min). The 40 middle-aged women between 40 and 60 years old were divided into four groups; the control group(12 women), the Gi exercise group(14 women), the soybean milk supplement group(11 women), and the Gi exercise group with soybean milk supplement(14 women). The Gi exercise program was applied three times a week and two packs of the soybean milk per day were given. The result of this study was as follows 1. The control group showed the increase of body weight, percent body fat, and fat mass than other groups. 2. The blood level of T-C was increased in the control group and the Gi exercise group and exercise with supplemented group were decreased 3. The blood level of HDL-C was significantly decreased in the control group than other groups. 4. The blood level of LDL-C was significantly increased in the control group than other groups. 5. The level of TG were not significantly changed in all groups 6. The follicular stimulating hormone (FSH) and luteinizing hormone (LH) hormone levels were not significantly changed in all study groups

• Journal of Life Science
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• v.16 no.6
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• pp.890-897
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• 2006

The purpose of this study is to investigate the effects of BCAA and additional OKG or albumin supplementation on energy metabolism and hormone changes in prolonged submaximal exercise. The subjects of this study were 5 male college students, and they took participated in each experiment. In each experiment (control, BCAA, BCAA+OKG, BCAA+albumin), the subject ran for 90 minutes on the treadmill. Blood was drawn and analyzed as glucose, FFA, ammonia, growth hormone, insulin, cortisol, $T_3$, and $T_4$. The obtained results were analyzed via two-way repeated ANOVA using SPSS program. A value of p<.05 was considered statistically significant. The concentration of glucose was the lowest in the BCAA supplement group, and there was significant difference between times of exercise (p<.05). In concentration of FFA, there was a significant difference between times of exercise and supplemented groups (p<.05). The concentration of blood ammonia was the lowest in the BCAA+albumin supplement group, and was the highest in the BCAA supplement group. Concentration of growth hormone, cortisol, $T_3$ and $T_4$ were increased as exercise progressed and decreased after all exercise. But concentration of insulin was decreased as exercise progressed. In these results, BCAA and additional OKG or albumin supplement with BCAA may make better effect to the increasing energy generation and inhibiting protein degradation during prolonged submaximal exercise.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.1
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• pp.143-152
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• 2020

PURPOSE: This study examined the effects of videoconferencing-based telerehabilitation exercise program on the gait, knee function, and quality of life of patients with knee osteoarthritis. METHODS: Forty-eight subjects, who were diagnosed with osteoarthritis of the knee by the radiologic findings, history, and a physical examination, were assigned randomly to a Control group, Experiment group I, and Experiment group II. The control group did not perform any exercise program and were educated in understanding and managing the disease of knee osteoarthritis for only one hour. Experimental groups I and II were provided with an exercise guidelines book for knee osteoarthritis, and the same exercise programs were conducted by face-to-face visits and non-face-to-face using telerehabilitation for eight weeks, respectively. To verify the effectiveness of each exercise program, the gait speed, knee disability index, and health related quality of life were measured. All assessments were conducted twice before and after the intervention. RESULTS: The participants who underwent both face-to-face and telerehabilitation exercise programs showed an improved gait speed, knee function, and health-related quality of life. In particular, there was no significant difference between the telerehabilitation exercise group and the direct face-to-face exercise group in improving the knee joint function and health related quality of life. CONCLUSION: A these findings the telerehabilitation exercise program for patients with knee osteoarthritis can alternate or supplement the face-to-face exercise program. Therefore, the telerehabilitation exercise program should be used not only as a substitute supplement program but also as an intervention for various diseases.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.4
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• pp.95-104
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• 2023

Purpose : This study aimed to introduce a 12-week muscular endurance exercise program and β-glucan consumption to obese elderly people with sarcopenia. We evaluated the program's impact on appendicular skeletal muscle strength and function, muscle function-related physical strength, blood lipids, and IGF-1. The results will serve as foundational data for preventing and improving sarcopenia. Methods : Forty elderly people aged 65 or older were recruited and underwent dual-energy X-ray absorptiometry. Based on criteria related to appendicular skeletal muscle mass (ASM/Height2: less than 5.4 kg/m2) and body fat percentage (at least 30% for women and 25% for men), we selected 24 obese elderly people with sarcopenia and excluded 56 who did not meet the criteria. Variables related to sarcopenia, blood lipids, IGF-1, and muscle function were measured before the 12-week muscular endurance exercise program. Results : In sarcopenic obese elderly participants, the 12-week muscular endurance exercise program significantly increased bone density and muscle mass while decreasing fat mass and percentage (p<.05). This program also improved grip strength, static balance, and SPPB in sarcopenic obese older adults. Furthermore, their 6-minute walk distance significantly increased (p<.05). Conclusion : Muscular endurance exercises combined with supplement intake can increase appendicular skeletal muscle and improve muscle strength and function, thereby improving the daily physical performance of the elderly.

• Journal of Life Science
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• v.16 no.7 s.80
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• pp.1090-1096
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• 2006

The purpose of this study was to investigate the effects of p. Linteus and C. militaris supplement on lactate, phosphorous, ammonia, MDA(malondialdehyde), GPX(glutathione peroxidase) and TAS(total antioxidant status) following $VO_{2max}$, and 85% $VO_{2max}$ exercise. The 15 male college students were divided into three groups: 5 P. liteus supplied(PL), 5 C. militaris supplied(CM), and 5 placebos supplied(PB) and compared the differences between supplement before and after. Obtained results were as follows: In the exercise performance time, there were no differences in PL, CM and PB groups. Regular supplement of P. linteus or C. militaris partially reduces fatigue induction factors. Also, P. linteus or C. militaris supplement decreases MDA, increases GPX and TAS. Therefore, it can be concluded that P. linteus or C. militaris supplement not only have a pharmacological effect for clinical treatment, but also have a maintenance effects on the tissue oxidant-antioxidant system after exercise.

• Journal of Nutrition and Health
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• v.39 no.1
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• pp.3-10
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• 2006

Effects of garlic powder supplementation on blood lipid profile and antioxidant system were investigated in rats with and without swimming exercise. Sprague-Dawley rats of four experimental groups were fed for 4 weeks diets containing $15\%$ beef tallow and $1\%$ cholesterol; control without garlic and exercise, Go with $2\%$ garlic alone, Ex with exercise alone, GoEx with $2\%$ garlic and exercise. Rats were trained 40 min a days a days a week. Group Ex and GoEx showed significant lowering in body weight gain and fat accumulation. In Go, Ex and GoEx, plasm TG and LDL-C were lower and HDL-C was higher, although not significantly, compared to levels in control. Total cholesterol was significantly reduced in group Go, and Ex and GoEx were lower than control. The total/HDL cholesterol ratio was also found to be significantly different, decreasing the ratios in Go, Ex and GoEx. The hepatic TBARS increased significantly in group Ex $(51.7{\pm}3.43nM/g\;liver)$, while TBARS in Go and GoEx were low $(35.68{\pm}3.61,\;39.30{\pm}5.55nM/g\;liver)$ and similar to control's one. The activity of hepatic SOD in Go and GoEx tended higher than control and Ex without garlic. The hepatic catalase showed significantly the highest activity in Go. Activity of GSH-px was significantly low in Ex with $0.14{\pm}0.03$ unit/mg protein, and control, Go and GoEx had higher activities of $0.23{\pm}0.08,\;0.20{\pm}0.07,\;0.22{\pm}0.01\;unit/mg$ protein, respectively. Lower activities of antioxidant enzymes in Ex are likely to associated with the highest level of TBARS. It seems that a decrease in TBARS in GoEx relative to Ex was related to the increase in GSHpx and SOD with garlic supplemented, which led to compensate the oxidative stress from exercise. The results suggests that exercise or garlic supplement exerts blood lipid attenuating effect. In adition, garlic supplementation could strengthen the antioxidant potential against exercise-induced oxidants, partly by modulating oxidant enzyme activity. These effects of garlic may make it a beneficial agent on CVD.