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홍경원;김희수
- 생명과학회지
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- 제13권2호
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- pp.175-183
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- 2003
침팬지와 고릴라는 영장목의 사람상과에 속한다. 이들은 아프리카 대형 유인원이라 불리며, 그들의 기원은 아프리카이다. 최근 영장류 학자들은 침팬지와 고릴라 각각 2종 5아종으로 분류하고 있다. 인간 게놈 프로젝트가 완성되었지만, 인간의 유전적 질병을 극복하고 인간의 진화를 풀기 위해서는 인간과 가장 유사한 아프리카 대형 유인원에 대한 연구가 요구된다. 인간의 21번에 상응하는 침팬지의 22번 염색체의 서열이 완성되었고, 현재 Y염색체 염기 서열이 분석되고 있다. 인간, 침팬지, 고릴라의 비교 연구로부터 인간이 가지는 다양한 질병에 대한 이해와 실마리를 제공해 줄 것이다. 영장류의 진화 과정에서 인간만이 가지는 기능성 유전자 및 가동성 유전자 (HERV, LINE, SINE)를 탐지해 냄으로 인해, 인간이란 무엇인가\ulcorner 라는 근본적인 의문점을 해명 할 수 있을 것이다. 이러한 영장류의 비교연구를 위해, 우리는 인간을 포함한 아프리카 대형 유인원에 대한 특징, 진화 및 계통 등의 기본적인 지식을 종합정리하여 보고하고자 한다.
https://doi.org/10.5352/JLS.2003.13.2.175 인용 PDF KSCI

Hasegawa, Hideo
- Parasites, Hosts and Diseases
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- 제37권4호
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- pp.197-213
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- 1999
Phylogeny is the evolutionary history of a group or the lineage of organisms and is reconstructed based on morphological, molecular and other characteristics. The genealogical relationship of a group of taxa is often expressed as a phylogenetic tree. The difficulty in categorizing the phylogeny is mainly due to the existence of frequent homoplasies that deceive observers. At the present time, cladistic analysis is believed to be one of the most effective methods of reconstructing a phylogenetic tree. Excellent computer program software for phylogenetic analysis is available. As an example, cladistic analysis was applied for nematode genera of the family Acuariidae, and the phylogenetic tree formed was compared with the system used currently. Nematodes in the genera Nippostrongylus and Heligmonoides were also analyzed, and the validity of the reconstructed phylogenetic trees was observed from a zoogeographical point of view. Some of the theories of parasite evolution were briefly reviewed as well. Coevolution of parasites and humans was discussed with special reference to the evolutionary relationship between Enterobius and primates.
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Greiss, Sebastian;Gartner, Anton
- Molecules and Cells
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- 제28권5호
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- pp.407-415
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- 2009
The sirtuins are a protein family named after the first identified member, S. cerevisiae Sir2p. Sirtuins are protein deacetylases whose activity is dependent on $NAD^+$ as a cosubstrate. They are structurally defined by two central domains that together form a highly conserved catalytic center, which catalyzes the transfer of an acetyl moiety from acetyllysine to $NAD^+$, yielding nicotinamide, the unique metabolite O-acetyl-ADP-ribose and deacetylated lysine. One or more sirtuins are present in virtually all species from bacteria to mammals. Here we describe a phylogenetic analysis of sirtuins. Based on their phylogenetic relationship, sirtuins can be grouped into over a dozen classes and subclasses. Humans, like most vertebrates, have seven sirtuins: SIRT1-SIRT7. These function in diverse cellular pathways, regulating transcriptional repression, aging, metabolism, DNA damage responses and apoptosis. We show that these seven sirtuins arose early during animal evolution. Conserved residues cluster around the catalytic center of known sirtuin family members.
https://doi.org/10.1007/s10059-009-0169-x 인용 KSCI

Kim, Heui-Soo
- Journal of Life Science
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- 제11권1호
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- pp.34-38
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- 2001
The cDNA encoding ribosomal protein S4(RPS 4) from an ovary cDNA library of the Japanese monkey (Macaca fuscata) was cloned and sequenced. The RPS4X gene from monkey X chromosome encodes a deduced protein of 263 amino acids and share 99.1% cDNA sequence similarity and 100% amino acid sequence identify with the human RPS4X. Rate of synonymous substitution was higher in RPS4Y than in RPS4X in comparison to the monkey and human. The ratio of synonymous and nonsynonymous substitutions per site indicated that directional selection has nor occurred in RPS4 genes. Phylogenetic analysis using the neighbor-joining method revealed that X and Y-linked RPS4 genes have evolved independently.
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