• The Korea Journal of Herbology
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• v.35 no.4
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• pp.17-23
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• 2020

Objectives : In this study, we investigated the protective effects of Charybdis japonica (C. japonica) water extract on the acute reflux esophagitis in rat models. Methods : Twenty rats were divided into four groups for examination: normal control group (n=6), the reflux esophagitis group (n=6), reflux esophagitis treated with positive control group (ranitidine 40 mg/kg, n=6), reflux esophagitis treated with C. japonica group (100 mg/kg, n=6). All rats fasted for 18 hr and then were induced with reflux esophagitis by a pylorus and forestomach ligation operation. After 4 hr, the rats were sacrificed. The proinflammatory cytokine and proteins expression measured by western bolt assay, and the histopathological analysis of the esophageal mucosa measured by hematoxylin and eosin staining. Results : C. japonica administration significantly was protecting esophageal mucosal damage upon histological analysis of reflux esophagitis in rats. The C. japonica treatment confirmed the protection of the reduction of claudin-5, an evaluation index of the damage of tight junctions in the reflux esophagitis. C. japonica was also found to inhibit the expression of proteins such as COX-2 and TNF-α in the rat esophagus. C. japonica markedly attenuated the activation of NF-κB and phosphorylation of IκBα at the same time. Conclusion : These results indicated that C. japonica suppressed the development of esophagitis through the modulation of inflammation by regulating NF-κB activation. Based on these findings, we concluded that C. japonica can prevent reflux esophagitis.

• Journal of the Earthquake Engineering Society of Korea
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• v.15 no.2
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• pp.43-51
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• 2011

Probabilistic seismic hazard analysis (PSHA), which can effectively apply inevitable uncertainties in seismic data, considers a number of seismotectonic models and attenuation equations. The calculated hazard by PSHA is generally a value dependent on peak ground acceleration (PGA) and expresses the value as an annual exceedance probability. To represent the uncertainty range of a hazard which has occurred using various seismic data, a hazard curve figure shows both a mean curve and percentile curves (15, 50, and 85). The percentile performs an important role in that it indicates the uncertainty range of the calculated hazard, could be calculated using various methods by the relation of the weight and hazard. This study using the weight accumulation method, the weighted hazard method, the maximum likelihood method, and the moment method, has calculated the percentile of the computed hazard by PSHA on the Shinuljin 1, 2 site. The calculated percentile using the weight accumulation method, the weighted hazard method, and the maximum likelihood method, have similar trends and represent the range of all computed hazards by PSHA. The calculated percentile using the moment method effectively showed the range of hazards at the source which includes a site. This study suggests the moment method as effective percentile calculation method considering the almost same mean hazard for the seismotectonic model and a source which includes a site.

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.5
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• pp.47-56
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• 2008

This study was performed to evaluate the effect of Response modification factors (R-factor) in 3-, 9- and 20- story steel Moment Resisting Frame (MRF) buildings. Each structure was designed using a R-factor of 8, as tabulated in the 2000 International Building Code provision (IBC 2000) and Korea Building Code (KBC) 2008. In order to evaluate the maximum and minimum performance expected for such structures, an upper bound and lower bound design were adopted for each model. Next, each analytical model was designed using different R-factors (8, 9, 10, 11, 12) and four different structural periods with the original fundamental period. For a detailed case study, a total of 150 analytical models were subjected to 20 ground motions representing a hazard level with a 2% probability of being exceeded in 50 years. In order to evaluate the performance of the structures, static push-over and non-linear time history analysis (NTHA) were performed, and displacement ductility demand was investigated to consider the ductility capacity of the structures. The results show that the dynamic behaviors for the 3- and 9-story buildings are relatively stable and conservative, while the 20-story buildings show a large displacement ductility demand due to dynamic instability factors. (e.g. P-delta effect and high mode effect)

• Journal of the Computational Structural Engineering Institute of Korea
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• v.26 no.1
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• pp.59-67
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• 2013

Complex-shaped tall building causes many structural challenges due to its structural characteristics regarding inclined members and complexed shape. This paper is aimed at development of design process using computational-platform which is effective design tool for responding frequent design changes, particularly as to overseas projects. StrAuto, a parametric structural modeling and optimizing system, provides the optimized alternatives according to design intent and realize a swift process converting a series of structural information necessary to nonlinear analytical models. The application of the process was to a 45-story hotel building in Ulanbator, Mongolia adopting shear wall and special moment frame with outrigger systems. To investigate the safety of lateral force resisting system against maximum considered earthquake(MCE), nonlinear response history analysis was conducted using StrAuto.

• Tuberculosis and Respiratory Diseases
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• v.52 no.1
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• pp.54-61
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• 2002

Background: Tracheal stenosis is an urgent but uncommon disease. Therefore, primary care clinicians have limited clinical experience. Animal models of a tracheal stenosis can be used conveniently for the learning, teaching, and developing new diagnostic and therapeutic modalities for tracheal stenosis. Recently, a canine model of a tracheal stenosis was developed using a Nd-YAG laser. To describe the methods and results of developed animal model, we performed this study. Methods : Six Mongrel dogs were generally anesthetized and the anterior 180 degree of tracheal cartilage of the animal was photo-coagulated using a Nd-YAG laser. The animals were bronchoscopically evaluated every week for 4 weeks and a pathologic evaluation was also made. Results : Two weeks after the laser coagulation, the trachea began to stenose and the stenosis progressed through 4 weeks. All animals suffered from shortness of breath, wheezing, and weight loss in the 3 weeks after the laser treatment, and two died of respiratory failure just before the fourth week. The gross pathologic findings showed the loss of cartilage and a dense fibrosis, which resulted in a fibrous stricture of the trachea. Microscopy also showed that the fibrous granulation tissue replaced destroyed cartilage. Conclusion : The canine model can assist in the understanding and development of new diagnostic and therapeutic modalities for tracheal stenosis.

• The Journal of Society for e-Business Studies
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• v.15 no.1
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• pp.61-87
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• 2010

This study is based on the analysis of technology innovation performance for Inno-biz. The primary purposes of this study are to help the government formulate Inno-biz related supporting policies and improve the fitness of evaluation models for Inno-biz. In this study the definition of "the outcome of technology innovation" includes technology competitiveness changes, technology forecasting as well as the outcome of technology innovation. For this analysis, 55 independent variables were used and categorized into ability of technology innovation, ability of commercialization, and ability of technology management. The results indicate that all three variable groups have positively influenced the outcome of technology innovation. Especially ability of technology innovation is highly related to technology competitiveness and business in future. The ability of commercialization enhances technology competitiveness and predictability in major business indexes; however it doesn't influence business performance in a short-term period. The ability of technology management enables businesses to forecast technology changes, but doesn't effect short-term business outcomes.

• Journal of the Korean Society of Marine Environment & Safety
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• v.16 no.1
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• pp.11-20
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• 2010

Oyster production is playing an important role in domestic aquaculture, but facing some problems such as exports decrease, a slowdown in domestic demand and marine environmental deterioration. In order to obtain the suitable and sustainable oyster production, suitable sites selection is an important step in oyster aquaculture. This study was conducted to identify the suitable sites for lunging culture of oyster using Geographic Information System(GIS)-based multi-criteria evaluation methods. Most of the parameters were extracted by Inverse Distance Weighted(IDW) methods in GIS and eight parameters were grouped into two basic sub-models for oyster aquaculture, namely oyster growth sub-model(Sea Temperature, Salinity, Hydrodynamics, Chlorophyll-a) and environment sub-model(Bottom DO, TOC, Sediment AVS, Benthic Diversity). Suitability scores were ranked on a scale from 1(leased suitable) and 8(most suitable), and about 80.1% of the total potential area had the highest scores 5 and 6. These areas were shown to have the optimum condition for oyster culture in GeojeHansan Bay. This method to identify suitable sites for oyster culture may be used to develop bivalve culture management system for supporting a decision making.

• Korean Journal of Agricultural and Forest Meteorology
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• v.18 no.4
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• pp.298-306
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• 2016

Planting date shift is one of the means of adapting to climate change in Kimchi Cabbage growers in major production areas in Korea. This study suggests a method to estimate the potential yield of Kimchi Cabbage based on daily temperature accumulation during the growth period from planting to maturity which is determined by a plant phenology model tuned to Kimchi Cabbage. The phenology model converts any changes in the thermal condition caused by the planting date shift into the heat unit accumulation during the growth period, which can be calculated from daily temperatures. The physiological maturity is estimated by applying this model to a variable development rate function depending either on growth or heading stage. The cabbage yield prediction model (Ahn et al., 2014) calculates the potential yield of summer cabbage by accumulating daily heat units for the growth period. We combined these two models and applied to the 1km resolution climate scenario (2000-2100) based on RCP8.5 for South Korea. Potential yields in the current normal year (2001-2010) and the future normal year (2011-2040, 2041-2070, and 2071-2100) were estimated for each grid cell with the planting dates of July 1, August 1, September 1, and October 1. Based on the results, we divided the whole South Korea into 810 watersheds, and devised a three - dimensional evaluation chart of the time - space - yield that enables the user to easily find the optimal planting date for a given watershed. This method is expected to be useful not only for exploring future new cultivation sites but also for developing cropping systems capable of adaptation to climate change without changing varieties in existing production areas.

• Journal of Korea Water Resources Association
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• v.53 no.11
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• pp.985-997
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• 2020

SWAT (Soil and Water Assessment Tool)-MODFLOW (Modular Groundwater Flow) is a coupled model that linking semi-distributed watershed hydrology with fully-distributed groundwater behavior. In this study, the groundwater simulation results of SWAT and SWAT-MODFLOW were compared for Bokhacheon watershed in Namhan river basin. The models were calibrated and validated with 9 years (2009~2017) daily streamflow (Q) data of Heungcheon (HC) water level gauge station and the daily groundwater level observation data of Yulheon (YH). For SWAT, the groundwater parameters of GW_DELAY, GWQMN, and ALPHA_BF affecting baseflow and recession phase were treated. The SWAT results showed the coefficient of determination (R²) of 0.7 and Nash-Sutcliffe model efficiencies (NES_Q, NSE_inQ) for Q and 1/Q with 0.73 and -0.1 respectively. For SWAT-MODFLOW, the spatio-temporal aquifer hydraulic conductivity (K, m/day), specific storage (S_s, 1/m), and specific yield (S_y) were applied. The SWAT-MODFLOW showed R², NSE_Q, and NSE_inQ of 0.69, 0.74, and 0.51 respectively. The SWAT-MODFLOW considerably enhanced the low flow simulation with the help of aquifer physical information. The total streamflow of SWAT and SWAT-MODFLOW were 718.6 mm and 854.9 mm occupying baseflow of 342.9 mm and 423.5 mm respectively.

• Korea Journal of Hospital Management
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• v.7 no.4
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• pp.1-23
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• 2002

This study examined the influence of the separation of prescribing and dispensing roles(SPD) policy implemented in Korea in July 2000, especially on the change in the net profit of medical institutions. Using the data set from the Korea's National Health Insurance and the previous research, this study elicited the following main results. First, tertiary care institutions was estimated to lose about 631 billion won after the SPD policy. Second, general hospitals and hospitals gained about 557 billion and 564 billion won, respectively. Third, it is shown that clinics also gained 389-659 billion won. Finally, however, the change in net profit of medical institutions after the SPD policy largely depends on different estimation models. Moreover, it also varies from the assumptions on the price differential of a reimbursable drug which worked as cross-subsidy to insufficient physician's fee before the SPD policy. Despite such limitations as lack of data outside of the National Health Insurance's coverage, this study differs from others. This is the first research to explore the effect of the SPD policy on different types of medical institutions and to attempt to purely focus on the SPD policy. In this study, we can draw the policy implication that preparing for a policy change, the government should set up the policy evaluation system to collect the concerned data and develop the methodologies in advance to the policy implementation.