• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.3
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• pp.1-10
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• 2010

Objective : Erysipelas is an acute inflammation caused by pyogenic bacteria. This mainly involves the upper part of dermis. It begins as erythematous patches with tenderness, followed by fever, headache, chills and fatigue etc. It may results in edema, obstruction of lymphatics and sepsis. So this experiment is carried out for test whether the Bojeasodok-um subtracted Scrophulariae Radix, Lasiosphaera seu Calvatia, Isatidis Radix added indigo Naturalis, Lithospermi Radix have an anti-inflammatory effect and have suppression effect on immunocyte in the state of inflammation which induced by Erysipelas. Method : Experimental animals made use of 4-5 week-age(weight 20-25g) ICR(male) mouse. In the breeding farm, the lighting time was controlled from 7:00 am till 7:00 pm, the temperature was controlled So we concluded that BS is prospected as an anti-inflammatory agent to cure inflammation induced bywithin 18-23$23^{\circ}C$ and water and food were not limited.The freezing lyophilization powder which were extracted from Bojesodok-Um divided low dose group(200mg/kg-BSL) and high dose group(500mg/kg-BSH) and after melting in water, it was orally administered to the mouse. Compared with inflammation induced group which were induced by triggering-inflammation reagent Carageenan and Zymosan and normal contrast group, we measured the edema decrement effect,macrophage and spleen cell activation. Result : 1. BS has suppress inflammatory reaction induced by Carageenan. 2. BS has suppress increasing activation of abdominal cavity macrophage in the Carageenan and Zymosan induced inflammation. 3. BS has suppress increasing activation of spleen cell in the Carageenan and Zymosan induced inflammation. Based on the above result, BS was improved its suppression effect to the inflammatory reaction through the suppression of spleen cell and macrophage activation. So we concluded that BS is prospected as an anti-inflammatory agent to cure inflammation induced by Erysipelas.

• Korean Journal of Veterinary Research
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• v.57 no.3
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• pp.175-180
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• 2017

Porcine parvovirus, Erysipelothrix (E.) rhusiopathiae, and Leptospira (L.) interrogans are considered major etiologic agents of reproductive failure in pigs, causing economic loss in the swine industry. In this study, the safety and immunogenicity of a new octavalent inactivated vaccine were evaluated. The vaccine contained inactivated porcine parvovirus, E. rhusiopathiae, and six L. interrogans serovars (Bratislava, Canicola, Grippotyphosa, Hardjo, Icterohaemorrhagiae, and Pomona). Safety test results showed no notable side effects or clinical signs after vaccination in mice, guinea pigs, and sows. In addition, we assessed immunogenicity of the vaccine in 25 sows under field conditions. The vaccinated group (n = 20) had a significantly higher antibody level than the non-vaccinated group (n = 5). Moreover, the stillbirth rate decreased in piglets born from vaccinated sows, resulting in an increased fertility rate. The results of this study demonstrate that the new octavalent inactivated vaccine can be applied safely and effectively to improve reproductive performance in sows.

• Proceedings of the SCSK Conference
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• 2003.09b
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• pp.545-547
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• 2003

A tyrosinase inhibitor, Lonjapoin, was isolated from the ethanolic extracts of Flos Lonicera by activity-guided fractionation. Lonjapoin ($IC_{50}$/; 2.07 $\mu\textrm{g}$/mL) was found to be potentially as effective inhibitor of production of melamin. Flos Lonicera (Jinyinhua) is the dry flower buds of Lonicera japonica. Thunb. It is used as an antibacterial and antiphlogistic agent in the treatment of abscess, laryngeal catarrh, erysipelas, dysentery, cold and fever. In our continuing search for natural source as cosmetic ingredients from Chinese medicinal herbs and found the extracts of Flos Lonicera showed the significant tyrosinase inhibition activity. In this study the active constituent of Lonicera japonica. obtained with the process of tyrosinase activity assay and column chromatography.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.14 no.2
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• pp.39-43
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• 2001

Lichen planus is a unique inflammatory cutaneous and mucous membrane reaction pattern of unknown etiology. Lichen planus of the soles generally occurs as an isolated phenomenon. The lesions differ from classic lesions of lichen planus in that the papules are larger and aggregate into semitransluecent plaques with a globular waxy surface. We report a 38-year-old female patient with lichen planus of right sole. The lesion shows erythematous eroded patch, swelling and severe pain. We thought that she might have envolved erysipelas. So, we gave her oriental medicine and antibiotics, so she was improved. But after long walking, lesion began to getting worse. There appeared oozing, ulcer, pus, pain and swelling in her lesion. We gave her oriental medicine and wet dressinf. But it didn't work.

• Korean Journal of Food Science and Technology
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• v.5 no.2
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• pp.108-112
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• 1973

Zoonoses are very important disease. But little attention has been given to the study of zoonoses in Korea. The author reviewed publications about zoonoses outbreakings in Korea and evaluated and analyzed the data available. It is hoped that the information will be use for reference in future endeavors of study in the field of zoonoses in Korea. The information obtained are as follows: 1) From 1962 to 1966. there have been 3 cases of anthrax. 2 cases of brucellosis and 140 cases of erysipeloid. 2) Throughout Korea, there are 670 slaughther houses and for last ten years cows and swines were condemned by the inspection before slaugter the ranges were as follows: cows : $0.45{\sim}0.98%$ swines : $0.005{\sim}0.05%$ 3) Epidemiological pattern of zoonoses in animals: a) Direct zoonoses are anthrax brucellosis and erysipelos. Encidence rate of anthrax 1.7 per 100,000 in 1964, burcellosis 1338.4 in 1960, erysipelos of swine 1897.2 in 1962. b) It is noticed that $1.0{\sim}2.7%$ of swine in mainland and $3.8{\sim}8.5%$ in Chechu island were infected by cysticercus cellulose.

• Korean Journal of Veterinary Research
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• v.31 no.2
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• pp.201-208
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• 1991

In studies on Erysipelothrix rhusiopathiae infection of pigs, a series of investigations were conducted for isolation, biochemical properties, pathogenicity, serotyping and susceptibility to antimicrobial agents. The results could be summarized as follows: 1. A total of 14 isolates of E rhusiopathiae were made from an acute form of swine erysipelas and the incidence was high during the hot summer season. 2. The biochemical properties of the 14 isolates were identical to the reference strain of E rhusiopathiae. 3. Pathogenicity of the isolated strain(89368) were ascertained that $LD_{50}$ for mice was $1.8{\times}10 $ cfu and also typical urticarious lesions and acute septicemia for pigs were induced by intradermal and intravenous inoculation with isolates, respectively. 4. All isolates were serotyped by the agarose gel slide double-diffusion system and proved to be serotype 1. 5. In susceptibility test to antimicrobial agents, 14 isolates of E rhusiopathiae were highly sensitive to ampicillin, baytril, cephalothin, chloramphenicol, penicillin and tetracycline.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.1
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• pp.74-80
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• 2002

Necrotizing fasciitis is rare acute infection showing rapidly necrosis involve the subcutaneous tissue and fascia. If treatment is delayed, infection can spread to involve the subcutaneous tissue, skin, deep fascia, and even muscle in rapid sequence, resulting in widespread necrosis and moderate to severe systemic toxicity. Most commonly this disease presents in the extremities, trunk, and perineum; it is relatively rare in the head and neck regions. If not diagnosed and treated in its early stages, necrotizing fasciitis can be potentially fatal, with a motality rate approaching 40%. Historically, the clinical entity now referred to as necrotizing fasciitis was described in the literature under various name. : hospital gangrene, necrotizing erysipelas, streptococcal gangrene, suppurative fasciitis. Necrotizing fasciitis was first described by Wilson in 1952. We experienced 3 cases of necrotizing fasciitis and will report review of literature with diagnosis, treatment, complication and consideration.

• Korean Journal of Veterinary Research
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• v.36 no.3
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• pp.621-626
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• 1996

The changes of concentration of serum haptoglobin, body temperature, hematological result and antibody titers were compared in pigs given intravenously injection of E rhusiopathiae and control pigs. Pigs administered with E rhusiopathiae injections showed acute septicemia and arthritis. Also, statistically significant changes observed in the total white cell counts and body temperature. An increased haptoglobin concentration in serum was detected after E rhusiopathiae infection, but not during antibiotics treatment. The results indicated that measurement of the concentration of serum haptoglobin may be useful in the early diagnosis of infectious disease, such as Erysipelas.

• Korean Journal of Veterinary Research
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• v.7 no.2
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• pp.1-7
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• 1967

돈단독(豚丹毒)에 대한 돼지 항체(抗體)를 검출(檢出)할 수 있는 실용적(實用的)인 혈청학적(血淸學的) 방법(方法)은 아직까지 없다. 그리고 보체결합반응(補體結合反應)은 가장 우수(優秀)하고 예민(銳敏)한 혈청학적반응(血淸學的反應)이긴 하지만 돼지 혈청(血淸)이 항체(抗體)이면 면양적혈구항가토혈청(緬羊赤血球抗家兎血淸) 및 기니픽 보체(補體)로 구성되는 용혈계하(溶血系下)에서는 돼지 혈청(血淸)의 친보체작용(親補體作用) 때문에 보체결합반응(補體結合反應)이 불가능하다. 이 연구(硏究)에서는 정상가토혈청(正常家兎血淸)이나 다른 정상소(正常素)를 반응계(反應系)에 첨가하여 친보체작용(親補體作用)을 없애는 개량보체결합반응(改良補體結合反應)으로 돈단독(豚丹毒) 항체(抗體) 1 항원(抗原)의 특이적(特異的)인 결합(結合)을 가능하게 하였다. 즉, 1/2 단위(單位)의 항원(抗原), 2정확단위(正確單位)의 기니픽보체(補體), 2단위(單位), 2% 감작면양적혈구(感作緬羊赤血球) 그리고 0.04 ml의 가토정상소(家兎正常素)는 돈단독(豚丹毒) 항원일항체결합물(抗原一抗體結合物)에 보체(補體)가 특이적(特異的)으로 결합(結合)되게 하였다.

• Journal of Haehwa Medicine
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• v.14 no.1
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• pp.155-165
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• 2005

I have come to conclusion as follows about Bangpungtongsungsan after literatural study. 1. Bangpungtongsungsan is the medical treatment of heat, wind and dryness. 2. Bangpungtongsungsan is used in head-wind, dizziness, both eye disease, tinnitus, both ear deafness, nasal polyp, uriticaria, sajuabi, beard and hair falling, apoplexy, paralysis of hands and feet, dull mentality, tetanus, epidemic disease characterized by swelling and redness of face, carbuncle, daepungchang, pustule, syphilis, tinea capitis and so on. 3. Bangpungtongsungsan is used in the disease of cerebral hemorrhage, hypertension, arteriosclerosis, constipation, rosacea, hemorrhoids, cutaneous disease, empyema, eye disease, diabetes, asthma, obesity, beriberi, erysipelas, baldhead, fatty heart, chronic nephritis and so on. 4. Bangpungtongsungsan fits in Taeumin who has much wetness-heat and those who have much heat or have much heat but don't give off well. And it doesn't fit in the disease of intolerance to cold and fever in the form of weakness headache, asthenia of the spleen and stomach, cold by internal disorder and so on.