• Genomics & Informatics
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• 제14권4호
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• pp.160-165
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• 2016

Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. However, such tests are computationally demanding and methodologically challenging. Recently, a simple but powerful method, named "BOolean Operation-based Screening and Testing" (BOOST), was proposed for genome-wide gene-gene interaction analyses. BOOST was designed with a Boolean representation of genotype data and is approximately equivalent to the log-linear model. It is extremely fast, and genome-wide gene-gene interaction analyses can be completed within a few hours. However, BOOST can not adjust for covariate effects, and its type-1 error control is not correct. Thus, we considered two-step approaches for gene-gene interaction analyses. First, we selected gene-gene interactions with BOOST and applied logistic regression with covariate adjustments to select gene-gene interactions. We applied the two-step approach to type 2 diabetes (T2D) in the Korea Association Resource (KARE) cohort and identified some promising pairs of single-nucleotide polymorphisms associated with T2D.

• 한국농공학회논문집
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• 제48권6호
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• pp.45-56
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• 2006

The finite element method is a practical tool to compute the response of the irregularly layered soil deposit to the base-rock motions. The method is useful not only in estimating the interaction between the structure and the surrounding soil as a whole and the local behavior of the contacting area in detail, but also in predicting the resulting behavior of the superstructure affected by such soil-structure interactions. However, the computation of finite element analysis is marched in the time domain (TD), while the site response analysis has been carried out mostly in the frequency domain (FD) with equivalent linear analysis. This study is intended to compare the results of the TD and FD analysis with focus on the peak response accelerations and the predominant frequencies, and thus to evaluate the applicability and the validity of the finite element analysis in the site response analysis. The comparison shows that one can obtain the results very close to that of FD analysis, from the finite element analysis by including sufficiently large width of foundation in the model and further by applying partial mode superposition. The finite element analysis turned out to be well agreeing with FD analysis in their computed results of the peak acceleration and the acceleration response spectra, especially at the surface layer.

• 전력전자학회논문지
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• 제20권2호
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• pp.175-181
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• 2015

In this study, a lithium polymer battery (LiPB) is simply expressed by a primary RC equivalent model. The PI state observer is designed in Matlab/Simulink. The non-linear relationship with the OCV-SOC is represented to be linearized with 0.1 pu intervals by using battery parameters obtained by constant-current pulse discharge. A state equation is configured based on battery parameters. The state equation, which applied Peukert's law, can estimate SOC more accurately. SOC estimation capability was analyzed by utilizing reduced Federal Test Procedure (FTP-72) current profile and using a bi-directional DC-DC converter at temperature ($25^{\circ}C$). The PI state observer, which is designed in this study, indicated a SOC estimation error rate of ${\pm}2%$ in any of the initial SOC states. The PI state observer confirms a strong SOC estimation performance despite disturbances, such as modeling errors and noise.

• 한국인공지능학회지
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• 제4권1호
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• pp.11-13
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• 2016

These days, medical technology has been developed rapidly to meet desire of living healthy life. Average lifespan was extended to let people see a doctor because of many reasons. This study has shown rate of leaving of hospitals to investigate the rate of not only department of surgery but also department of internal medicine. Linear model, tree, classification rule, association and algorithm of data mining were used. This study investigated by using J48 and AD tree of decision-making tree In this study, J48 and AD tree of decision-making tree of data mining were used to investigate based on result of both data. Both algorithms were found to have similar performance. Both algorithms were not equivalent to require detailed experiment. Collect more experimental data in the future to apply from various points of view. Development of medical technology gives dream, hope and pleasure. The ones who suffer from incurable diseases need developed medical technology. Environment being similar to the reality shall be made to experiment exactly to investigate data carefully and to let the ones of various ages visit hospital and to increase survival rate.

• Journal of Mechanical Science and Technology
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• 제18권3호
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• pp.513-525
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• 2004

This paper reports an experimental study on flow boiling of pure refrigerants R l34a and R l23 and their mixtures in a uniformly heated horizontal tube. The flow pattern was observed through tubular sight glasses with an internal diameter of 10㎜ located at the inlet and outlet of the test section. Tests were run at a pressure of 0.6 MPa in the heat flux ranges of 5-50㎾/㎡, vapor quality 0-100 percent and mass velocity of 150-600㎏/㎡s. Both in the nucleate boiling-dominant region at low quality and in the two-phase convective evaporation region at higher quality where nucleation is supposed to be fully suppressed, the heat transfer coefficient for the mixture was lower than that for an equivalent pure component with the same physical properties as the mixture. The reduction of the heat transfer coefficient in mixture is explained by such mechanisms as mass transfer resistance and non-linear variation in physical properties etc. In this study, the contribution of convective evaporation, which is obtained for pure refrigerants under the suppression of nucleate boiling, is multiplied by the composition factor by Singal et al. (1984). On the basis of Chen's superposition model, a new correlation is presented for heat transfer coefficients of mixture.

• Smart Structures and Systems
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• 제1권3호
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• pp.235-256
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• 2005

The non-linear behaviour of electrorheological (ER) and magnetorheological (MR) dampers makes it difficult to design effective control strategies, and as a consequence a wide range of control systems have been proposed in the literature. These previous studies have not always compared the performance to equivalent passive systems, alternative control designs, or idealised active systems. As a result it is often impossible to compare the performance of different smart damper control strategies. This article provides some insight into the relative performance of two MR damper control strategies: on/off control and feedback linearisation. The performance of both strategies is benchmarked against ideal passive, semi-active and fully active damping. The study relies upon a previously developed model of an MR damper, which in this work is validated experimentally under closed-loop conditions with a broadband mechanical excitation. Two vibration isolation case studies are investigated: a single-degree-of-freedom mass-isolator, and a two-degree-of-freedom system that represents a vehicle suspension system. In both cases, a variety of broadband mechanical excitations are used and the results analysed in the frequency domain. It is shown that although on/off control is more straightforward to implement, its performance is worse than the feedback linearisation strategy, and can be extremely sensitive to the excitation conditions.

• Radiation Oncology Journal
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• 제37권1호
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• pp.1-12
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• 2019

Despite recent innovation in treatment techniques and subsequently improved outcomes, the majority of glioblastoma (GBL) have relapses, especially in locoregional areas. Local re-irradiation (re-RT) has been established as a feasible option for recurrent GBL of all ages with safety, tolerability, and effectiveness both in survival and quality of life regardless of fractionation schedule. To keep adverse effects under acceptable range, cumulative dose limit in equivalent dose at 2 Gy fractions by the linear-quadratic model at α/β = 2 for normal brain tissue (EQD2) with narrow margin should be observed and single/hypofractionated re-RT should be undertaken very carefully to recurrent tumor with large volume or adjacent to the brainstem. Promising outcome of re-operation (re-Op) plus re-RT (re-Op/RT) need to be validated and result from re-RT with temozolomide/bevacizumab (TMZ/BV) or new strategy is expected. Development of new-concept prognostic scoring or risk group is required to select patients properly and make use of predictive biomarkers such as O(6)-methylguanine-DNA methyltransferase (MGMT) promotor methylation that influence outcomes of re-RT, re-Op/RT, or re-RT with TMZ/BV.

• 제어로봇시스템학회논문지
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• 제6권9호
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• pp.768-776
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• 2000

A robust high-speed motion controller is proposed. The proposed controller consists of the proximate time optimal servomechai는 (PTOD) for high-speed motion, disturbance observer (DOB) for robustness, friction compensator, and saturation handling element, In the proposed controller, DOB basically provides the chance to apply PTOS to non-double integrator systems by drastically reducing disturbances as well as unwanted signals due to difference between real system and the double integrator model. But, in DOB-based systems, if control input is saturated due to control input PTOS and/or DOB, overall system stability cannot be guaranteed. To solve this problem, ribust stability, when the control input is saturated. Eventually, a simple saturation handling element is inserted to maintain internal stability of overall system. Also, we explain the our two saturation handling methods, Additional Saturation Element (ASE_ and Self Adjusting Saturation (SAS), are the equivalent solutions of the saturation problem to maintain internal stability. The stability and performance of the proposed controller are verified through numerical simulations and experiments using a precision linear motor system.

• 근관절건강학회지
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• 제23권1호
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• pp.61-69
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• 2016

Purpose: The purpose of this study was to determine the effect of the Tai Chi exercise program (Sun style 31 forms) on fatigue, anxiety, and sleep patterns in nursing students. Methods: A quasi-experimental study with a non-equivalent control group pretest-posttest design was used. Nursing students who participated in this study were assigned to an experimental group (n=24), and a control group (n=26). The experimental group participated in Tai Chi exercise program for 60 minutes per session, and 3 times a week for 7 weeks. The Tai Chi exercise program consisted of 10 minutes for warm-up, 45 minutes for main session, and 5 minutes for cooling down exercises. The data were collected prior and after the intervention using self-administered questionnaires. Data were analyzed using descriptive statistics, $x^2$-test, Fisher's exact probability, t -test, and the general linear model. Results: After the application of the program, the experimental group showed a significant difference in fatigue (F=20.62, p<.001), anxiety (F=16.96, p<.001), and sleep pattern (F=15.70, p<.001) scores. Conclusion: These findings show that the Tai Chi exercise program can be an effective nursing intervention to improve sleep pattern and to reduce fatigue and anxiety in nursing students.

• 전기학회논문지
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• 제57권8호
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• pp.1362-1370
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• 2008

This paper describes the design and characteristic analysis of a novel 3-DOF(Degree of Freedom) spherical motor. For multi DOF actuating, several numbers of motors have been used. By the using of normal motors they connected each other in single joint, is necessary to a several type of complex power transmission devices. The 3-DOF spherical motor can drive roll, pitch, and yaw motion in only one unit and it is not necessary to use additional gears and links parts. Therefore the using of 3-DOF spherical motor can eliminate; combined effects of inertia, backlash, non-linear friction, and elastic deformation of gears. In this paper, we propose the novel structured 3-DOF spherical motor and derive its principles of operation. Firstly, we designed concept model of novel structured 3-DOF spherical motor. Next, we derive the control method by calculating the currents. Also, to have intuitive driving control, we express the rotor position in equivalent angle-axis system and determine the exciting period of currents from the calculation result of the currents. To verify the control method, we calculated the currents by the position of rotor. and then we analyzed the characteristics by 3D Finite Element Method when the calculated currents are excited.