• 생명과학회지
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• 제21권6호
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• pp.819-828
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• 2011

본 연구에서는 2009년부터 2010년까지 부산, 경남 및 울산 지역의 145 개 지하수 시료들을 대상으로 norovirus의 오염실태를 조사하였다. 먼저 norovirus의 검출을 위한 두 세트의 primer를 제작하였으며 이를 이용하여 최적 nested reverse transcription (RT)-PCR 조건을 확립하였다. 지하수의 norovirus 오염실태 조사에 의하면, 건기(4월~6월)와 우기(7월~8월)에 각각 21개(25.9%)와 15개(23.4%)의 시료에서 norovirus가 검출되었다. 부산, 울산 및 경상남도의 시료에서 각각 15%, 7% 및 32%의 norovirus가 검출되어 지역적인 차이를 나타내었다. norovirus 양성시료에서 GI과 GII가 각각 5개와 31개가 검출되어GI에 비하여 GII가 우세함을 알 수 있었다. norovirus 분리주들의 계통분류학적 분석 결과에 의하면, GI 분리주들은 모두 GI.5 유전자형으로 분류되었으며, GII 분리주들은 GII.3과 GII.4로 양분되었다. norovirus의 검출은 pH, 온도, 산화-환원전위 및 용존산소 등의 이화학적 인자들과 일반세균, 총대장균군 및 대장균과 같은 미생물 수질지표들과 통계적인 유의성이 있는 상관관계를 나타내지 않았다. 반면에 norovirus의 검출과 저탁도(<0.50 NTU) 사이에는 밀접한 상관성이 있음이 밝혀졌다. 본 연구를 통하여 지하수 중 norovirus의 분포실태를 어느 정도 파악할 수 있었으며 수인성 질병의 예방과 국민 보건위생을 위해서는 지하수의 주기적인 norovirus 모니터링이 필요함을 제시하였다.

• Journal of Preventive Medicine and Public Health
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• 제27권2호
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• pp.175-185
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• 1994

In order to anticipate disease pattern and health problems of Koreans in the 1st part of 21st century (by the year 2020), transition of population characteristics, mortality and morbidity data during the last 30 years Koreans have experienced were reviewed. On the actual basis of epidemiologic transition process that has undergone during last 30 years since 1960 along with socioeconomic development and successful implementation of selective national health policies (family planning, medical insurance and etc.), following changes can be expected in the 21st century in Korea, under the assumption that the current rate of progress is maintained. The population of South Korea alone will be doubled the population of 1960 by the year 2013 : aged Population older than 65 years will be increased from 3.3% in 1960 to 11.4% in 2020 with increased average age of the population from 23.6 year in 1970 to 39.2 year in 2020; urban population from 28% in 1960 to 83% in 2005. GNP/capita has increased tremendously from U.S. $120 in 1970 to $6,749 in 1992, and the government estimated it would be 519,350 in 2010 and $29,460 in 2020. Growth and developmental indices of children, educational achievement and social status of women also showed a remarkable improvement and anticipated to make futher progress. Leading causes of mortality and morbidity have shown a striking change during the last 30 years, from infectious diseases to chronic degenerative diseases and man-made injuries. Occurrence of communicable diseases may become minimal although viral hepatitis, venereal diseases Including AIDS, and well adapted herpes virus infections will maintain their endemic level. Newly evolving infectious agents, however, should be carefully monitored because of rapidly changing environments and human behaviours. Tuberculosis may increase up to the epidemic level when AIDS prevails. Ischemic heart diseases may increase steadily with increasing occurrence of hypertension and diabetes mellitus whereas cerebrovascular diseases may be decreased slowly. Musculaskeletal diseases which contribute a lot to the disability of aged people may be a major health problems due to increased aged population. Mental diseases, particularly that caused by alcohol and drug abuse, and senile dementia may become a prominent health problem. On the other hand injuries caused by traffic and industrial accidents that have shown most striking increase till now may be decreased considerably by intensive intervention. The health policies in the 21st century will be oriented to the health promotion for good quality life rather than life-savings.

• 대한수의학회지
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• 제40권1호
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• pp.173-186
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• 2000

This experiment was carried out to investigate the tendency of incident diseases in pre- and post- weaning piglets which ages were 1 to 7 weeks old by laboratory diagnosis and in order to minimize death in preweaning piglets and of stunted growth in postweaning piglets. The result of this experiment used as the basic data for the preventive programs in pre- and post- weaning piglets and were as follows: 23 different diseases diagnosed in 331 cases were studied in relation to age, season, and etiology. The most prevelent diseases of pre- and post- weaning piglet were Colibacillosis(79 case, 23.9%) and the major diseases were Salmonellosis(44 cases, 13.3%), Anemia(37 cases, 11.2%). Unknown viral disease(20 case, 6.1%), Rota viral infection(19 case, 5.8%), Porcine reproductive & respiratory syndrome(PRRS; 15 case 4.5%), Transmissible gastroenteritis(TGE; 12 case, 3.6%). The gastrointestinal disease, such as Colibacillosis, Salmonellosis, Swine dysentery, Clostridial infection, Rotaviral infection, TGE, Porcine epidemic diarrhea(PED) and Ballantidiosis occured pro- dominently in the period of pre- and post- weaning, which were 178 cases(53.8%) and not related to occurrence according to age and season. The respiratory diseases were Atrophic rhinitis(AR), Swine enzootic pneumonia, Pneumonic pasteurellosis, Pleuropneumonia, Branchopneumonia, PRRS and which were 48 cases(14.5%) and higher prevalent in spring and summer. The viral diseases was 73 cases(22.1%) that occurred in the period of 5 weeks piglet and prevalent mainly in spring. The bacterial diseases were 188 cases(56.8%) that were not related to occurrence according to age and season. Salmonellosis was prevalent in 3 to 5 weeks piglet and mainly occurred in summer. Viral septicemia and rotaviral infection occurred after 5 weeks piglets intensively and 3 to 5 weeks, respectively. And the both occurred without relation with season. PRRS occurred after 4 weeks piglet and prevalent in summer. TGE occurred 1 to 7 days old piglets and prevalent in spring and winter. Hematologic values of anemia was decrease in number of Red Blood Cell, concentration of Hemoglobin and Hematocrit. Amikacin, cephalothin, colistin, norfloxacin were effective to E coli, and amikacin, cephalothin, nortloxacin, neomycin were effective to Salmonellra spp. but clindamycin, erythromycin, penicillin, sulfonamides were resistant to E coli and Salmonella spp.

• 한국학교보건학회지
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• 제6권1호
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• pp.69-77
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• 1993

The purpose of this study is to obtain some basic data necessary for more effective health education by questionnaire survey on the knowledge, attitude and preventive health behavior. The questionnaire forms were delivered to 500 university students in seoul during periods from 24 to 28, september, from 7 to 19, October, 1991. The result of this study can be summarized as follows: 1) Washing hands after using toilet has relationship to sex (fece: $X^2=51.55$, urine: $X^2=36.25$, p<0.05). Index of female was higher than that of male. 2) Tooth brushing has relationship to sex ($X^2=13.28$, p<0.05). The tendency of practice of male and female was similar. 3) Changing of underwear 1~3 days were the highest and it has relationship to sex ($X^2=162.846$, p<0.05), birth place ($X^2=97.18$, p<0.05). Index of female was higher than that of male. 4) Bathing has relationship to sex ($X^2=80.92$, p<0.05). birth place ($X^2=54.18$, p<0.05, pocket money ($X^2=33.04$, p<0.05). 5) The attitude on occurrence of epidemic disease has relationship to sex ($X^2=70.33$, p<0.05). A female was more senstive than male. 6) In case of slight disease, a cold, illness from fatigue, the utilization of drug store was higher. The utilization of medical center according to disease has relationship to sex ($X^2=69.84$, p<0.05). 7) Medical behaviorism has relationship to school year ($X^2=35.18$, p<0.05), sex ($X^2=42.18$, p<0.05). 8) The utilization of school health center has relationship to sex ($X^2=10.73$, p<0.05), the school year ($X^2=72.09$, p<0.05), the pocket money ($X^2=38.80$, p<0.05). 9) The experience of health education has relationship to school year ($X^2=10.96$, p<0.05). No experence is 95.4%. 10) The subject for health-medical knowledge is necessary. The need for subject has relationship to sex ($X^2=10.86$, p<0.05).

• 기독교교육논총
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• 제62권
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• pp.285-311
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• 2020

최근 코로나 19 전염병의 확산을 비롯해 다양한 위기들로 인해 수많은 사람들이 경제적인 어려움을 겪는 가운데 기독교교육은 어떤 역할을 수행할 수 있을지를 고민하는 과정 속에서 본고는 구약의 희년사상에 초점을 맞춰 현대적 맥락에서 주빌리 정의가 어떻게 구현될 수 있을지를 모색한다. 희년법은 노예해방과 부채면제, 토지반환과 휴경의 네 가지 내용으로 구성되어 있으며, 궁극적으로 인간의 노예화를 막고 평등을 보존하려는 데 그 주된 목적이 있다. 그럼에도 불구하고, 희년사상은 그동안 신학적으로나 상황적으로 왜곡되어 기독교교육의 현장에서 간과됨으로써 사회정의를 위한 기독교적 실천에 있어서 한계가 존재했다. 하지만 희년사상은 기독교의 사사화 문제라든지, 신자유주의적 세계화로 인한 양극화의 심화 등 현대 사회의 다양한 문제들을 극복할 수 있게 하는 한 가지 대안이 될 수 있으며, 사회정의를 실천하는 데 긍정적인 기여를 할 수 있다. 즉, 희년사상은 제도적 차원에서 잘못된 법률과 제도를 개혁하며 가난한 사람들을 위한 제도를 확립하는 데 있어서, 또한 개인적 차원에서 공유경제의 실천 및 인식 변화의 측면에 있어서 성서적 모티브로 작용할 수 있다. 이처럼 가난으로 고통 받는 사람들을 위한 주빌리 정의를 지향하는 주빌리 교육은 다양한 간학문적인 지식들을 토대로 하여 인식적 차원으로는 기존의 잘못된 통념을 깨뜨림으로써 학습자들의 의미관점의 전환을 돕고, 실천적 차원에서는 사회구조의 변화를 위해 여론의 활성화 등 사회적 행동을 지원한다. 이로써 기독교교육의 학습자들이 불의한 사회를 변혁하기 위한 공적 역할을 책임 있게 수행할 수 있기를 기대한다.

• Tuberculosis and Respiratory Diseases
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• 제72권4호
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• pp.360-366
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• 2012

Background: Carbapenem-resistance is rapidly evolving among the pathogenic microbes in intensive care units (ICUs). This study aimed to determine annual trend of carbapenem-resistance in the ICU for 4 years, since the opening of a university-affiliated hospital in South Korea. Methods: From 2005 to 2008, microbial samples from consecutive 6,772 patients were screened in the ICU. Three hundred and ninety-seven patients (5.9%) and their first isolates of carbapenem-resistant pathogens were analyzed. Results: The percentage of patients infected with carbapenem-resistant organisms increased constantly during the initial three years (2.3% in 2005, 6.2% in 2006, 7.8% in 2007), then it declined to 6.5% in 2008. Acute Physiology and Chronic Health Evaluation (APACHE) III score at admission was $58.0{\pm}23.5$, the median length of the ICU stay was 37 days, and the mortality rate was 37.5%. The sampling sites were endotracheal suction (67%), catheterized urine (17%), wound (6%) and others (10%). Bacteria with carbapenem-resistance were Pseudomonas aeruginosa (247 isolates, 62%), Acinetobacter baumannii (117 isolates, 30%), Enterobacteriaceae (12 isolates, 3%), and others (21, 5%). Of note, peak isolation of carbapenem-resistant microorganisms in medical ICU was followed by the same epidemic at surgical ICU. Conclusion: Taken together, carbapenem-resistant pathogens are of growing concern in the ICU.

• 대한수의학회지
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• 제46권2호
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• pp.107-117
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• 2006

This paper described the epidemiological characteristics of 2002 outbreak of classical swine fever (CSF) in Korea. A total of thirteen CSF-infected farms could be classified into two clusters according to the location and time of outbreak. Two farms located in the same county of Gangwon province and 11 farms located in several different districts of Incheon metropolitan/Gyeonggi province were identified as CSF-infected from April 16 to 30 and from October 7 to December 21 in 2002, respectively. As the result of epidemiological analysis, the two clusters of outbreaks were turned out to be independent epidemics which had different sources of virus introduction. Three farms were found to have been infected primarily; one located in Cheolwon county of Gangwon province and two located in Kangwha county of Incheon metropolitan area. The most likely factors of virus introduction into these primary infected farms were considered to be direct or indirect contact by foreign workers and/or owners of the infected farms who had come back from traveling in China before outbreaks. This was supported by the genetic typing of CSF viruses isolated from the pigs of infected farms. All the virus isolates of 2002 outbreak were found to be genetic type 2, whereas the viruses isolated before 2000 were type 3 and the reference strains, such as attenuated live vaccine virus (LOM strain) and high virulent challenge virus (ALD strain), were type 1. Accordingly, we concluded that the 2002 CSF outbreak must have been caused by a newly introduced virus from overseas and the type 3 virus must have been eradicated after the last outbreak of 1999 by the national CSF eradication campaign which were implemented since 1996. Based on the combined analysis of epidemiological data and genetic typing, the transmission routes of classical swine fever virus were found to be the movement of vehicles (60%) and persons (10%), neighbourhood spread (20%) and unknown (10%). It is expected that the analyzed data and findings of classical swine fever outbreak epidemic could be very useful to establish the disease control and eradication program for the country in the future.

• 생명과학회지
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• 제14권4호
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• pp.620-626
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• 2004

2001년부터 2003년까지 3년간 부산지역의 안과 병ㆍ의원으로부터 채취한 급성 바이러스성 결막염 환자의 가검물 675 건을 대상으로 유행한 눈병 원인 바이러스의 분리 결과, 유행성각결막염의 원인바이러스인 Adenovirus 8ㆍ37형, 급성 출혈성결막염(아폴로눈병)의 원인바이러스인 Coxsackievirus A24ㆍB3형, Echovirus 6ㆍ7형을 분리하였고 인두결막열을 일으키는 Adenovirus 3ㆍ4형을 분리하였으며 Coxsackievirus A24는 2002년 아폴로눈병의 대유행과 관련하여 2002 년 8월 국내 최초로 분리하였다. 2002년과 2003년에 분리된 Coxsackievirus B3와 Echovirus 6은 지금까지 뇌수막염을 유발시키는 원인바이러스로 널리 알려져 있으나, 눈병환자에서의 분리된 것은 특징적이었다. 월별 발생양상은 주로 하절기에 집중적으로 분포하였고, 2003년에는 4월과 10월에도 높은 발생율을 보였다. 연령별 발생분포도는 10대에서 50대까지 높은 발생율을 나타내었고 유아와 60대 이상에서도 발생하였고 남녀 발생비는 1.2ㆍ1이었다.

• 대한한의학회지
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• 제19권1호
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• pp.271-298
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• 1998

During these days of new understanding, western medicine has developed remarkably and a revaluation of traditional medicine has been achieved. This appears to have resulted from the sound criticisms of what western medicine has achieved up to now; excessive subdivisions of clinical medicine, severe toxicity of chemical drugs, lack of understanding about patients complaints which cannot be understood objectively, and etc. It is thought that the role of traditional medicine will be more important in the future than it is now. Someone said that the research methods of traditional medicine depends on the way of experimental science too much. That there was no consideration of a system for traditional medicine and the critic also went so far as to assert that in some cases the characteristics of eastern ideas is to permit irrationalism itself. In view of this thinking, the term traditional medicine seems to have been used somewhat too vaguely. However, traditional medicine is a medical treatment which has existed since before the appearance of modern medicine and it was formed from a traditional culture with a long history. One form of traditional medicine, oriental medicine based upon ancient Chinese medicine, was received in such countries as Korea, Japan, Thailand, Vietnam, Tibet, and Mongolia. Oriental medicine then developed in accordance with its own environment, race, national characteristics, and history. Although there are some simultaneous differences between them, three nations in Eastern Asia; Korea, Japan, and China, have especially similar features in their clinical prescriptions and medical literature. These three nations are trying to understand each others unique traditional medicines through numerous exchanges. Even though many differences in their ways of studying have developed over history exist, recent academic discussions have been made to explore new ways into oriental medicine. Therefore a comparative study of oriental medicine has gradually been thought to be more important. In Korea the formation of a new future-oriented paradigm for oriental medicine is being demanded. The purpose of the new paradigm is to create a new recognition of traditional culture which creates an understanding of oriental medicine to replace the diminished understanding of oriental medicine that was brought about by the self-denial of traditional culture in modem history and cultural collisions between oriental and occidental points of view. Therefore, to make a new paradigm for oriental medicine which is suitable for these days, and fortifies the merit of oriental medicine while compensating its defects, the author has compared the characteristics of oriental medicines in Korea, Japan, and China. The conclusions of this research are as follows: 1. The fundamental differences of the traditional medicines of these three nations are caused by the differences in the systems of Naekyung and Sanghannon. 2. The pattern-identification of illnesses is generally divided into two categories; the pattern identification of Zang-Fu and the pattern identification of prescription. 3. There are many differences in the definition of terms, such as Yin and Yang, Deficiency and Excess, and etc. 4. Chinese traditional medicine has some new concepts about pattern identification and epidemic febrile disease. 5. Japanese traditional medicine has some characteristics about pattern identification of the whole bodys condition and signs of abdominal palpation. 6. In terms of the effects of herbal drugs, Chinese traditional medicine attaches great importance to the experiential efficacy of the herb, and Japanese traditional medicine is taking a serious view of the effects of experimental medical actions.

• 한국수산과학회지
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• 제44권6호
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• pp.577-583
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• 2011

In 2007, pet food contaminated with melamine caused hundreds of dogs and cats to develop renal failure all over the world. In 2008, over 294,000 infants consumed infant formula and developed kidney stones in China. Further investigation revealed that fish feed also contained melamine; this raised concerns about melamine residues in edible fish tissues, which could have caused the urinary tract stone epidemic. In Korea, catfish fed with assorted feed that included cuttlefish organs that contained melamine developed whitening syndrome and fell dead in some populations in 2008. This event raised suspicions about the toxicity of melamine and all feeds containing melamine were immediately recalled. In this study, we investigated the rates of melamine accumulation and depletion in muscle and viscera of catfish to propose proper withdrawal periods. One group of catfish was fed a commercially available diet that contained 30, 100 and 300 mg melamine per kg diet for 14 days. To investigate residual melamine contents in muscle and viscera, other experimental groups were fed a melamine free diet after being fed melamine for 7 days. The residual amount of melamine was analyzed by LC-MS/MS. The melamine concentration in muscle was estimated to be 3.7 mg/kg after 6 days of feeding with a diet containing 300 mg melamine/kg. After 2 days of culture with a melamine free diet, the residual melamine was depleted and the concentration had decreased from 1.15 mg/kg to 0.19 mg/kg in the muscle of catfish fed a diet containing 300 mg melamine/kg for 7 days. The residual amount of melamine was reduced to 0.03 mg/kg in muscle after 7 days of culture with a melamine free diet and was undetectable after a prolonged culture period of 14 days. Catfish tend to excrete melamine rapidly after oral administration and changes in body color were not observed during the short dosing period.