• 한국지반공학회논문집
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• 제30권9호
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• pp.41-55
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• 2014

일반적으로 암반 터널 지진해석 시 절리의 영향을 무시하며 암반을 연속체라 가정한다. 하지만 이와 같은 가정의 적절성에 관해서는 연구된 바 없다. 본 연구에서는 응답변위법을 적용하여 지진동에 의하여 유발되는 암반 절리의 변위가 터널의 응답에 미치는 영향을 일련의 개별요소법을 이용하여 수치적으로 규명하였다. 해석에는 절리와 터널의 교차위치, 절리의 강성, 경사, 간격, 그리고 암반과 터널 사이의 인터페이스 강성이 고려되었다. 해석 결과, 절리의 강성이 터널에 가장 지배적인 영향을 미치는 것으로 나타났다. 절리의 간격은 클수록 변위가 국부적으로 집중되어 응답이 증가하는 것으로 나타났다. 절리의 경사는 정적인 경우와는 상반되게 $45^{\circ}$에서 응답이 가장 작게 계산되었다. 이는 전단변형으로 인하여 수직면과 수평면에 큰 전단응력이 작용하여 주응력면이 $45^{\circ}$로 회전하기 때문인 것으로 판단된다. 결과적으로 절리의 경사, 간격, 강성 모두 터널의 응답에 큰 영향을 미치며 특히 간격이 큰 미끈한 수직 또는 수평방향 절리가 터널을 통과하는 경우가 가장 위험한 것으로 나타났다. 또한 터널 라이닝에는 휨응력보다는 전단응력이 큰 폭으로 증가하므로 내진설계 시 이를 반드시 검토해야 할 것으로 판단된다.

• Toxicological Research
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• 제31권4호
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• pp.415-420
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• 2015

The purpose of the present study is to investigate the correlations between food intake behavior and job stress level and neuropeptide hormone concentrations. Job strain and food intake behavior were first identified using a self-reported questionnaire, concentrations of neuropeptide hormones (adiponectin, brain derived neurotrophic factor [BDNF], leptin, and ghrelin) were determined, and the correlations were analyzed. In the results, job strain showed significant correlations with adiponectin (odds ratio [OR], 1.220; 95% confidence interval [CI], 1.001~1.498; p < 0.05) and BDNF (OR, 0.793; 95% CI, 0.646~0.974; p < 0.05), and ghrelin exhibited a significant correlation with food intake score (OR, 0.911; 95% CI, 0.842~0.985, p < 0.05). These results suggest that job stress affects food intake regulation by altering the physiological concentrations of neuropeptide hormones as well as emotional status.

• BMB Reports
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• 제48권4호
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• pp.209-216
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• 2015

Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases. Acute stress may induce an individual's adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through "allostatic load". Thus, monitoring the quantified levels of long-term stress mediators would provide a timely opportunity for prevention or earlier intervention of stressrelated chronic illnesses. Although either acute or chronic stress could be quantified through measurement of changes in physiological parameters such as heart rate, blood pressure, and levels of various metabolic hormones, it is still elusive to interpret whether the changes in circulating levels of stress mediators such as cortisol can reflect the acute, chronic, or diurnal variations. Both serum and salivary cortisol levels reveal acute changes at a single point in time, but the overall long-term systemic cortisol exposure is difficult to evaluate due to circadian variations and its protein-binding capacity. Scalp hair has a fairy predictable growth rate of approximately 1 cm/month, and the most 1 cm segment approximates the last month's cortisol production as the mean value. The analysis of cortisol in hair is a highly promising technique for the retrospective assessment of chronic stress. [BMB Reports 2015; 48(4): 209-216]

• 대한토목학회논문집
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• 제14권4호
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• pp.827-838
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• 1994

많은 포장구조 거동 모델은 입상재료의 거동을 묘사하는 구성방정식에 의존하고 있다. 본 연구에서는 비행장 포장의 입상재료 기층의 거동 예측을 위하여, 체적응력(bulk stress)과 팔면체 전단응력(octahedral shear stress)의 함수로 표시된 구성모델이 제안되었다. 이 모델의 특징은 비선형거동을 정확히 예측할 수 있고, 모델상수를 간단히 구할 수 있으며 전단효과에 의한 회복탄성계수의 감소현상을 나타낼 수 있다. 실내시험을 통하여 입상재료의 비선행 회복탄성거동을 관찰하였으며, 제안된 모델을 입증하기 위해 회복탄성계수를 측정하였다. 체적응력과 축차응력이 회복탄성계수의 변화에 가장 주요한 변수임이 관찰되었으며, 실내시험 결과 제안된 모델식에 의한 회복탄성계수의 예측치가 실측치와 잘 일치함을 알 수 있었다. 따라서 제안된 모델식은 비행장 포장에서 일어날 수 있는 광범위한 응력조건하의 입상재료의 회복탄성거동을 잘 묘사할 수 있음을 알 수 있다.

• Journal of Ginseng Research
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• 제44권2호
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• pp.312-320
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• 2020

Background: Ginseng (Panax ginseng Meyer) is an essential source of pharmaceuticals and functional foods. Ginseng productivity has been compromised by high light (HL) stress, which is one of the major abiotic stresses during the ginseng cultivation period. The genetic improvement for HL tolerance in ginseng could be facilitated by analyzing its genetic and molecular characteristics associated with HL stress. Methods: Genome-wide analysis of gene expression was performed under HL and recovery conditions in 1-year-old Korean ginseng (P. ginseng cv. Chunpoong) using the Illumina HiSeq platform. After de novo assembly of transcripts, we performed expression profiling and identified differentially expressed genes (DEGs). Furthermore, putative functions of identified DEGs were explored using Gene Ontology terms and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis. Results: A total of 438 highly expressed DEGs in response to HL stress were identified and selected from 29,184 representative transcripts. Among the DEGs, 326 and 114 transcripts were upregulated and downregulated, respectively. Based on the functional analysis, most upregulated and a significant number of downregulated transcripts were related to stress responses and cellular metabolic processes, respectively. Conclusion: Transcriptome profiling could be a strategy to comprehensively elucidate the genetic and molecular mechanisms of HL tolerance and susceptibility. This study would provide a foundation for developing breeding and metabolic engineering strategies to improve the environmental stress tolerance of ginseng.

• Computers and Concrete
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• 제1권4호
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• pp.417-432
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• 2004

An analytical model which can simulate the post-cracking nonlinear behavior of reinforced concrete (RC) members such as bars and panels subject to uniaxial and biaxial stresses is presented. The proposed model includes the description of biaxial failure criteria and the average stress-strain relation of reinforcing steel. Based on strain distribution functions of steel and concrete after cracking, a criterion to consider the tension-stiffening effect is proposed using the concept of average stresses and strains. The validity of the introduced model is established by comparing the analytical predictions for reinforced concrete uniaxial tension members with results from experimental studies. In advance, correlation studies between analytical results and experimental data are also extended to RC panels subject to biaxial tensile stresses to verify the efficiency of the proposed model and to identify the significance of various effects on the response of biaxially loaded reinforced concrete panels.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 추계학술대회 및 한일 식물생명공학 심포지엄
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• pp.162-162
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• 2005

• Environmental Analysis Health and Toxicology
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• 제19권3호
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• pp.251-259
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• 2004

Xenoestrogens are chemicals with diverse structure that mimic estrogen. Bisphenol A, a monomer of polycarbonate and epoxy resins, has been detected in canned food and human saliva. Bisphenol A stimulate cell proliferation and induce expression of estrogen -response genes in vitro. The purpose of the this study was to evaluate cell proliferation of bisphenol A in the presence of a rat liver 59 mix contaning cytochrome P450 enzymes and Cu (II). The fragmentation of intact DNA, a parameter of apoptotic cell death, was evaluated quantitatively by diphenylamine reaction method. Bisphenol A induced apoptotic cell death in a dose-dependent manner The effect of radical scavenger on the apoptotic cell death induced bisphenol A was investigated. The DNA fragmentation induced by bisphenol A was significantly inhibited by addition of radical scavenger to the culture medium. This indicated that elevated oxidative stress caused by imbalance between the production and removal of free radicals occurred in cells. Taken together, these results suggest that free radical reacts with Cu (II) leading oxidative stress.

• Journal of Microbiology and Biotechnology
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• 제13권1호
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• pp.99-103
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• 2003

An Escherichia coli strain containing the recA promoter that fused to the luxCDABE operon originating from Photorhabdus luminescens was shown to respond sensitively to genotoxic stresses. Two different recombinant bacteria, one (DPDI 657) harboring a plasmid with the recA promoter that fused to the luxCDABE operon, and the other (DPD1710) containing a chromosomally-integrated recA promoter that fused with luxCDABE, were compared and it was found that the sensitivity of 'the two strains was significantly different in terms of their bioluminescent level, response time, and the minimum detectable concentration of a chemical causing DNA damaging stress. DPDI 710, with a chromosomally-integrated single copy, generally led to lower basal luminescence levels, faster responses, increased response ratios, and an enhanced sensitivity to mutagens, when compared to DPD 1657 with a multi-copy plasmid.

• 한국지구과학회지
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• 제28권2호
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• pp.179-186
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• 2007

응답스펙트럼은 내진설계에 있어서 중요한 기초자료의 하나이다. 응답스펙트럼을 얻기 위하여, 한반도에서 발생하는 지진들의 지진원 특성에 근거하여 다수의 강진동을 Boore(2005)에 의해 개발된 컴퓨터 프로그램 SMSIM을 사용하여 모사하였다. 여러 연구결과들에 대한 충분한 검토를 통하여, 모사에 필요한 입력자료들을 선정하였다. 모사된 강진동으로부터 얻은 응답스펙트럼은 가속도 1.0 g에 대하여 정규화하여 미국 원자력위원회(1973)의 표준응답스펙트럼과 비교하였다. 이 연구에서 얻어진 응답스펙트럼의 스펙트럼 진폭은 대략 10 Hz 이상의 고주파 대역에서 표준 응답스펙트럼 값에 비하여 큰 것으로 나타났다. 또한 응력강하량의 변화에 따른 응답스펙트럼의 변화를 평가하였다. 그 결과 큰 응력강하량에 대한 응답스펙트럼의 스펙트럼 진폭은 저주파 범위내에서 큰 값을 나타냄을 제시하였다.