• Journal of the Korean Geotechnical Society
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• v.30 no.9
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• pp.41-55
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• 2014

In performing seismic analysis of tunnels, it is a common practice to ignore the rock joints and to assume that the rock mass surrounding the tunnel is continuous. The applicability of this assumption has not yet been validated in detail. This study performs a series of pseudo-static discrete element analyses to evaluate the effect of rock joint on the seismic response of tunnels. The parameters considered are joint intersection location, joint spacing, joint stiffness, joint dip, and interface stiffness. The results show that the joint stiffness has the most critical influence on the tunnel response. The tunnel response increases with the spacing, resulting in localized concentration of moment and shear stress. The response of the tunnel is the lowest for joints dipping at $45^{\circ}$. This is because large shear stresses result in rotation of the principal planes by $45^{\circ}$. In summary, the weathered and smooth, vertical or horizontal, and widely spaced joint set will significantly increase the tunnel response under seismic loading. The tunnel linings are shown to be most susceptible to damage due to induced shear stress, and therefore should be checked in the seismic design.

• Toxicological Research
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• v.31 no.4
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• pp.415-420
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• 2015

The purpose of the present study is to investigate the correlations between food intake behavior and job stress level and neuropeptide hormone concentrations. Job strain and food intake behavior were first identified using a self-reported questionnaire, concentrations of neuropeptide hormones (adiponectin, brain derived neurotrophic factor [BDNF], leptin, and ghrelin) were determined, and the correlations were analyzed. In the results, job strain showed significant correlations with adiponectin (odds ratio [OR], 1.220; 95% confidence interval [CI], 1.001~1.498; p < 0.05) and BDNF (OR, 0.793; 95% CI, 0.646~0.974; p < 0.05), and ghrelin exhibited a significant correlation with food intake score (OR, 0.911; 95% CI, 0.842~0.985, p < 0.05). These results suggest that job stress affects food intake regulation by altering the physiological concentrations of neuropeptide hormones as well as emotional status.

• BMB Reports
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• v.48 no.4
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• pp.209-216
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• 2015

Stress is now recognized as a universal premorbid factor associated with many risk factors of various chronic diseases. Acute stress may induce an individual's adaptive response to environmental demands. However, chronic, excessive stress causes cumulative negative impacts on health outcomes through "allostatic load". Thus, monitoring the quantified levels of long-term stress mediators would provide a timely opportunity for prevention or earlier intervention of stressrelated chronic illnesses. Although either acute or chronic stress could be quantified through measurement of changes in physiological parameters such as heart rate, blood pressure, and levels of various metabolic hormones, it is still elusive to interpret whether the changes in circulating levels of stress mediators such as cortisol can reflect the acute, chronic, or diurnal variations. Both serum and salivary cortisol levels reveal acute changes at a single point in time, but the overall long-term systemic cortisol exposure is difficult to evaluate due to circadian variations and its protein-binding capacity. Scalp hair has a fairy predictable growth rate of approximately 1 cm/month, and the most 1 cm segment approximates the last month's cortisol production as the mean value. The analysis of cortisol in hair is a highly promising technique for the retrospective assessment of chronic stress. [BMB Reports 2015; 48(4): 209-216]

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.4
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• pp.827-838
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• 1994

Numerous pavement response models rely on constitutive relationships to describe the response of granular materials. In this study, a nonlinear elastic constitutive model which is a function of bulk stress and octahedral shear stress is proposed to describe the resilient behavior of thick granular base courses under flexible airfield pavements. Special features of this model are its accuracy to predict the nonlinear resilient behavior, its simplicity to determine the material constants and its ability to model the secondary effect of decreasing the resilient modulus due to shear effects. In laboratory tests, the nonlinear resilient behavior of granular materials is investigated and values of resilient moduli are determined to provide data for verifying the proposed model. It is found that the resilient modulus is much more dependent on the states of stresses in terms of bulk stress and deviator stress than any other factors. Result of comparison shows that predicted values of resilient moduli are in good agreement with the measured values indicating that the proposed model is suitable to describe the nonlinear resilient behavior of the granular material with wide range of stress states which meet in airfield pavements.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.312-320
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• 2020

Background: Ginseng (Panax ginseng Meyer) is an essential source of pharmaceuticals and functional foods. Ginseng productivity has been compromised by high light (HL) stress, which is one of the major abiotic stresses during the ginseng cultivation period. The genetic improvement for HL tolerance in ginseng could be facilitated by analyzing its genetic and molecular characteristics associated with HL stress. Methods: Genome-wide analysis of gene expression was performed under HL and recovery conditions in 1-year-old Korean ginseng (P. ginseng cv. Chunpoong) using the Illumina HiSeq platform. After de novo assembly of transcripts, we performed expression profiling and identified differentially expressed genes (DEGs). Furthermore, putative functions of identified DEGs were explored using Gene Ontology terms and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis. Results: A total of 438 highly expressed DEGs in response to HL stress were identified and selected from 29,184 representative transcripts. Among the DEGs, 326 and 114 transcripts were upregulated and downregulated, respectively. Based on the functional analysis, most upregulated and a significant number of downregulated transcripts were related to stress responses and cellular metabolic processes, respectively. Conclusion: Transcriptome profiling could be a strategy to comprehensively elucidate the genetic and molecular mechanisms of HL tolerance and susceptibility. This study would provide a foundation for developing breeding and metabolic engineering strategies to improve the environmental stress tolerance of ginseng.

• Computers and Concrete
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• v.1 no.4
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• pp.417-432
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• 2004

An analytical model which can simulate the post-cracking nonlinear behavior of reinforced concrete (RC) members such as bars and panels subject to uniaxial and biaxial stresses is presented. The proposed model includes the description of biaxial failure criteria and the average stress-strain relation of reinforcing steel. Based on strain distribution functions of steel and concrete after cracking, a criterion to consider the tension-stiffening effect is proposed using the concept of average stresses and strains. The validity of the introduced model is established by comparing the analytical predictions for reinforced concrete uniaxial tension members with results from experimental studies. In advance, correlation studies between analytical results and experimental data are also extended to RC panels subject to biaxial tensile stresses to verify the efficiency of the proposed model and to identify the significance of various effects on the response of biaxially loaded reinforced concrete panels.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.162-162
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• 2005

• Environmental Analysis Health and Toxicology
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• v.19 no.3
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• pp.251-259
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• 2004

Xenoestrogens are chemicals with diverse structure that mimic estrogen. Bisphenol A, a monomer of polycarbonate and epoxy resins, has been detected in canned food and human saliva. Bisphenol A stimulate cell proliferation and induce expression of estrogen -response genes in vitro. The purpose of the this study was to evaluate cell proliferation of bisphenol A in the presence of a rat liver 59 mix contaning cytochrome P450 enzymes and Cu (II). The fragmentation of intact DNA, a parameter of apoptotic cell death, was evaluated quantitatively by diphenylamine reaction method. Bisphenol A induced apoptotic cell death in a dose-dependent manner The effect of radical scavenger on the apoptotic cell death induced bisphenol A was investigated. The DNA fragmentation induced by bisphenol A was significantly inhibited by addition of radical scavenger to the culture medium. This indicated that elevated oxidative stress caused by imbalance between the production and removal of free radicals occurred in cells. Taken together, these results suggest that free radical reacts with Cu (II) leading oxidative stress.

• Journal of Microbiology and Biotechnology
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• v.13 no.1
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• pp.99-103
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• 2003

An Escherichia coli strain containing the recA promoter that fused to the luxCDABE operon originating from Photorhabdus luminescens was shown to respond sensitively to genotoxic stresses. Two different recombinant bacteria, one (DPDI 657) harboring a plasmid with the recA promoter that fused to the luxCDABE operon, and the other (DPD1710) containing a chromosomally-integrated recA promoter that fused with luxCDABE, were compared and it was found that the sensitivity of 'the two strains was significantly different in terms of their bioluminescent level, response time, and the minimum detectable concentration of a chemical causing DNA damaging stress. DPDI 710, with a chromosomally-integrated single copy, generally led to lower basal luminescence levels, faster responses, increased response ratios, and an enhanced sensitivity to mutagens, when compared to DPD 1657 with a multi-copy plasmid.

• Journal of the Korean earth science society
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• v.28 no.2
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• pp.179-186
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• 2007

The response spectrum is one of the important basic materials for the aseismic design. Numerous strong ground motions based on the seismic source characteristics for the earthquakes occurring in the Korean Peninsula were simulated to obtain the response spectra by using the computer program, SMSIM, developed by Boore (2005). Through the extensive review of other study outcomes, the input data for the simulation such as seismic source and attenuation characteristics were selected. The spectra obtained from the simulated ground motions were normalized to 1.0 g of zero period acceleration and compared with the standard response spectrum proposed by the U.S. Atomic Energy Commission (AEC, 1973). In this study, we found that the spectral values for the response spectra appeared to be larger than those of the standard spectrum in the frequency band above roughly 10 Hz. The variation of resulting response spectra was evaluated with the variable stress drops. It was shown that the spectral amplitude of the spectrum for the larger stress drop denotes higher value in the low frequency range.