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Analysis of the shelf life of chitosan stored in different types of packaging, using colorimetry and dentin microhardness

  • da Cruz-Filho, Antonio Miranda;de Vito, Angelo Rafael;Souza-Flamini, Luis Eduardo;da Costa Guedes, Debora Fernandes;Saquy, Paulo Cesar;Silva, Ricardo Gariba;Pecora, Jesus Djalma
    • Restorative Dentistry and Endodontics
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    • v.42 no.2
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    • pp.87-94
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    • 2017
  • Objectives: Chitosan has been widely investigated and used. However, the literature does not refer to the shelf life of this solution. This study evaluated, through the colorimetric titration technique and an analysis of dentin micro-hardness, the shelf life of 0.2% chitosan solution. Materials and Methods: Thirty human canines were sectioned, and specimens were obtained from the second and third slices, from cemento-enamel junction to the apex. A 0.2% chitosan solution was prepared and distributed in 3 identical glass bottles (v1, v2, and v3) and 3 plastic bottles (p1, p2, and p3). At 0, 7, 15, 30, 45, 60, 90, 120, 150, and 180 days, the specimens were immersed in each solution for 5 minutes (n = 3 each). The chelating effect of the solution was assessed by micro-hardness and colorimetric analysis of the dentin specimens. 17% EDTA and distilled water were used as controls. Data were analyzed statistically by two-way and Tukey-Kramer multiple comparison (${\alpha}=0.05$). Results: There was no statistically significant difference among the solutions with respect to the study time (p = 0.113) and micro-hardness/time interaction (p = 0.329). Chitosan solutions and EDTA reduced the micro-hardness in a similar manner and differed significantly from the control group (p < 0.001). Chitosan solutions chelated calcium ions throughout the entire experiment. Conclusions: Regardless of the storage form, chitosan demonstrates a chelating property for a minimum period of 6 months.

Effect of the Microtip Length in a Slot-die Head on Fine Stripe Coatings (미세 스트라이프 코팅에 미치는 슬롯 다이 헤드 마이크로 팁 길이의 영향)

  • Lee, Jinyoung;Park, Jongwoon
    • Journal of the Semiconductor & Display Technology
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    • v.18 no.4
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    • pp.69-74
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    • 2019
  • The aim of this work is to investigate the effect of the microtip length in a slot-die head on coating of a fine poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) stripe. To this end, we have employed a meniscus guide with a 150-㎛-wide microtip and performed roll-to-roll slot-die coatings by varying its length between 500 ㎛ and 50 ㎛. When the microtip length is 150 ㎛ or shorter, we have observed three unexpected phenomena; 1) though the solution spreads much wider than the microtip width, yet the coated stripe width is almost the same as the microtip width, 2) the stripe width decreases, but the stripe thickness is rather increased with increasing coating speed at a fixed flow rate, 3) we obtain stripes much narrower than the microtip width at high coating speeds. It is due to the fact that 1) the meniscus is not well controlled by a short microtip, 2) the main stream of solution from the outlet is very close to the substrate and thus the distributed solution along the head lip merges with the main stream, and 3) the solution is not spread over the entire microtip end at high coating speeds, causing a tiny wobble in the meniscus. Using the 150-㎛-wide and 250-㎛-long microtip, we have fabricated 153-㎛-wide and 94-nm-thick PEDOT:PSS stripe at the maximum coating speed of 13 mm/s. To demonstrate its applicability in solution-processable organic light-emitting diodes (OLEDs), we have also fabricated an OLED device with the fine PEDOT:PSS stripe and obtained strong light emission from it.

A Case Report of Korean Medicine Treatment for A Patient with Variant Angina and Asthma Symptoms (천식 증상을 가진 변형 협심증 환자에 대한 한방치료 증례보고)

  • Kim, Min-joo;Kwo, Tae-ha
    • The Journal of Internal Korean Medicine
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    • v.43 no.5
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    • pp.864-873
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    • 2022
  • Objective: The purpose of this case study was to report the symptom improvement effect of integrative Korean medicine treatment based on Pyongsim Solution: Cheonwangbosim-dan in a patient with variant angina and asthma symptoms. Methods: This 68-year-old male patient was treated with Pyongsim Solution, Gamihyangsayukgunja-tang, Gwakhyangjunggi-san, acupuncture, pharmacopuncture, and cupping therapy for 24 days. The European Quality of Life-5 Dimensions-5 Levels profile, Numerical Rating Scale score, and pulse rate per minute were measured on admission, at two weeks of hospitalization, and upon discharge to assess the clinical outcomes. Results: After treatment, the "mobility" dimension profile of the European Quality of Life-5 Dimensions-5 Levels changed from 1 to 1, "self-care" changed from 1 to 1, "usual activity" changed from 3 to 2, "pain/discomfort" changed from 4 to 3, and "anxiety/depression" changed from 3 to 2. The Numerical Rating Scale score for chest pain decreased from 7 to 5, chest tightness decreased from 6 to 4, sleep disturbance decreased from 6 to 3, polydipsia decreased from 5 to 3, and stomach discomfort decreased from 5 to 3. All the profiles of these five dimensions were unchanged for 11 days in the period between the two weeks of hospitalization and discharge. There were also no changes in the profiles of either "mobility" or "self-care" throughout the entire 24-day hospitalization period. Conclusion: This case report shows that integrative Korean medicine treatment based on Pyongsim Solution can improve the symptoms of patients with variant angina and mild intermittent asthma, suggesting that Pyongsim Solution could be an important herbal medication for treatment.

Passive Earth Pressure Transition Behind Retaining Walls (옹벽의 변위에 따른 정지토압에서 수동토압까지의 변화)

  • 김홍택
    • Geotechnical Engineering
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    • v.3 no.2
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    • pp.55-70
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    • 1987
  • An analytical solution procedure is described to estimate the developed passive lateral earth Pressures behind a vertical rigid retaintng wall rotating about its toe into a mass of cohesionless soil. Various stases of wall rotation, starting from an at-rest state to an initial Passive state to a full Passive state, are considered in the analysis. Condition of failure defined by a modified Mohr-coulomb criterion, together with equilibrium conditions, is used to obtain the necessary equations for the solution. Using methods of stress characteristics and numerical finite difference, a complete solution within and on the boundaries of the entire solution domain is made possible. The variations of the soil shear strength and the wall friction at various depths and stages of wall rotation are also taken into account in the analysis. The results predicted by the developed method of analysis are compared with those obtained from the experimental model tests on loose and dense sand. The comparisons show good agreements at various stages of retaining wall rotation Fin- ally, results of analytical parametric study are presented to demonstrate the effects of wall fric- tion on the resultant thrust and distribution of developed lateral earth pressures.

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Applicability Evaluation of Electrodes Exchange and Mixed Solution for Enhanced Electrokinetic Process (Electrokinetic Process의 효율 향상을 위한 전극교환 방식과 혼합용매 적용 가능성 평가)

  • Lee, Noh-Sup;Park, Sung-Soo;NamKoong, Wan
    • Applied Chemistry for Engineering
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    • v.18 no.4
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    • pp.391-395
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    • 2007
  • This study investigated the feasibility of enhanced electrokinetic (EK) remediation of soil contaminated with approximately 20000 Pb-mg/kg. Enhanced EK remediation was evaluated by using mixed solution (0.3 M acetic acid and 0.03 M EDTA, EK-M) and by exchanging electrodes for preventing precipitation of metal hydrate. For the EK-M, the lead removal efficiency was only 2% lower than the case where 0.03 M EDTA was solely used (EK-Blank, EK-B). Considering the costly expense of EDTA, the application of EK-M would be economically viable. The efficiency of of EK-E was higher by 2% than the EK-B method. More impertantly, the pH values of entire soil packed column presented to be neutral (7~8) in the EK-E process. Unlike to EK-B and EK-M, the deposition of heavy metals to any specific area was avoided in the EK-E process.

Non-linear time-dependent post-elastic analysis of suspended cable considering creep effect

  • Kmet, S.;Tomko, M.;Brda, J.
    • Structural Engineering and Mechanics
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    • v.22 no.2
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    • pp.197-222
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    • 2006
  • In this paper, the non-linear time-dependent closed-form, discrete and combined solutions for the post-elastic response of a geometrically and physically non-linear suspended cable to a uniformly distributed load considering the creep effects, are presented. The time-dependent closed-form method for the particularly straightforward determination of a vertical uniformly distributed load applied over the entire span of a cable and the accompanying deflection at time t corresponding to the elastic limit and/or to the elastic region, post-elastic and failure range of a suspended cable is described. The actual stress-strain properties of steel cables as well as creep of cables and their rheological characteristics are considered. In this solution, applying the Irvine's theory, the direct use of experimental data, such as the actual stress-strain and strain-time properties of high-strength steel cables, is implemented. The results obtained by the closed-form solution, i.e., a load corresponding to the elastic limit, post-elastic and failure range at time t, enable the direct use in the discrete non-linear time-dependent post-elastic analysis of a suspended cable. This initial value of load is necessary for the non-linear time-dependent elastic and post-elastic discrete analysis, concerning incremental and iterative solution strategies with tangent modulus concept. At each time step, the suspended cable is analyzed under the applied load and imposed deformations originated due to creep. This combined time-dependent approach, based on the closed-form solution and on the FEM, allows a prediction of the required load that occurs in the post-elastic region. The application of the described methods and derived equations is illustrated by numerical examples.

Damage detection of plate-like structures using intelligent surrogate model

  • Torkzadeh, Peyman;Fathnejat, Hamed;Ghiasi, Ramin
    • Smart Structures and Systems
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    • v.18 no.6
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    • pp.1233-1250
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    • 2016
  • Cracks in plate-like structures are some of the main reasons for destruction of the entire structure. In this study, a novel two-stage methodology is proposed for damage detection of flexural plates using an optimized artificial neural network. In the first stage, location of damages in plates is investigated using curvature-moment and curvature-moment derivative concepts. After detecting the damaged areas, the equations for damage severity detection are solved via Bat Algorithm (BA). In the second stage, in order to efficiently reduce the computational cost of model updating during the optimization process of damage severity detection, multiple damage location assurance criterion index based on the frequency change vector of structures are evaluated using properly trained cascade feed-forward neural network (CFNN) as a surrogate model. In order to achieve the most generalized neural network as a surrogate model, its structure is optimized using binary version of BA. To validate this proposed solution method, two examples are presented. The results indicate that after determining the damage location based on curvature-moment derivative concept, the proposed solution method for damage severity detection leads to significant reduction of computational time compared with direct finite element method. Furthermore, integrating BA with the efficient approximation mechanism of finite element model, maintains the acceptable accuracy of damage severity detection.

Tropospheric Anomaly Detection in Multi-Reference Stations Environment during Localized Atmospheric Conditions-(2) : Analytic Results of Anomaly Detection Algorithm

  • Yoo, Yun-Ja
    • Journal of Navigation and Port Research
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    • v.40 no.5
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    • pp.271-278
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    • 2016
  • Localized atmospheric conditions between multi-reference stations can bring the tropospheric delay irregularity that becomes an error terms affecting positioning accuracy in network RTK environment. Imbalanced network error can affect the network solutions and it can corrupt the entire network solution and degrade the correction accuracy. If an anomaly could be detected before the correction message was generated, it is possible to eliminate the anomalous satellite that can cause degradation of the network solution during the tropospheric delay anomaly. An atmospheric grid that consists of four meteorological stations was used to detect an inhomogeneous weather conditions and tropospheric anomaly applied AWSs (automatic weather stations) meteorological data. The threshold of anomaly detection algorithm was determined based on the statistical weather data of AWSs for 5 years in an atmospheric grid. From the analytic results of anomaly detection algorithm it showed that the proposed algorithm can detect an anomalous satellite with an anomaly flag generation caused tropospheric delay anomaly during localized atmospheric conditions between stations. It was shown that the different precipitation condition between stations is the main factor affecting tropospheric anomalies.

X-ray and dielectric study of the phase transition in PbFe1/2Nb1/2O3-PbCo1/2W1/2O3 ceramics

  • Park, Yung;Lee, Hong-Min;Kim, Ho-Gi
    • Proceedings of the KIEE Conference
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    • 1997.07d
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    • pp.1239-1243
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    • 1997
  • A phase analysis in the solid solution of (1-x) PbFe1/2Nb1/2O3-xPbCo1/2W1/2O3 is conducted by dielectric properties, heat capacity and E-P hysteresis at x=0.1 interval. Lattice constants and superlattice intensity are analyzed by the x-ray diffraction, and the temperature - composition phase diagram is determined. The system is found to form a solid solution of perovskite structure throughout the entire composition range, but the nature of phase transitions changes from ferroelectric-paraelectric for $0{\leq}x{\leq}0.5$ to antiferroelectric-paraelectric for $0.6{\leq}x{\leq}1.0$. The transitions of ferroelectric-paraelectric and antiferroelectric-paraelectric for $0.2{\leq}x{\leq}0.5$ and for $0.6{\leq}x{\leq}0.8$, respectively, are diffuse, while those of the ferroelectric-paraelectric and the antiferroelectric-paraelectric for $0.0{\leq}x{\leq}0.1$ and $0.9{\leq}x{\leq}1.0$, respectively are sharp.

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A Symbiotic Evolutionary Algorithm for Balancing and Sequencing Mixed Model Assembly Lines with Multiple Objectives (다목적을 갖는 혼합모델 조립라인의 밸런싱과 투입순서를 위한 공생 진화알고리즘)

  • Kim, Yeo-Keun;Lee, Sang-Seon
    • Journal of the Korean Operations Research and Management Science Society
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    • v.35 no.3
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    • pp.25-43
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    • 2010
  • We consider a multi-objective balancing and sequencing problem in mixed model assembly lines, which is important for an efficient use of the assembly lines. In this paper, we present a neighborhood symbiotic evolutionary algorithm to simultaneously solve the two problems of balancing and model sequencing under multiple objectives. We aim to find a set of well-distributed solutions close to the true Pareto optimal solutions for decision makers. The proposed algorithm has a two-leveled structure. At Level 1, two populations are operated : One consists of individuals each of which represents a partial solution to the balancing problem and the other consists of individuals for the sequencing problem. Level 2, which is an upper level, works one population whose individuals represent the combined entire solutions to the two problems. The process of Level 1 imitates a neighborhood symbiotic evolution and that of Level 2 simulates an endosymbiotic evolution together with an elitist strategy to promote the capability of solution search. The performance of the proposed algorithm is compared with those of the existing algorithms in convergence, diversity and computation time of nondominated solutions. The experimental results show that the proposed algorithm is superior to the compared algorithms in all the three performance measures.