• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.12-22
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• 1997

Intravenous and oral acute toxicity tests in ICR mice and SD rats and percutaneous acute toxicity tests in SD rats and NZW rabbits were conducted to evaluate the toxicity of DA-5018 and DA-5018 cream, respectively Clinical signs observed in mice and rats after the administration of DA-5018 were similar regardless of administration route. The observed clinical signs were jumping, wild running, lacrimation, ataxia, reddening of extremities and ears, ventral or lateral recumbency, respiratory distress, cyanosis, convulsion and death. Pulmonary enlargement and hemorrhage were observed in the animals died immediately after the dosing of DA-5018. At terminal necropsy, pulmonary enlargement and hemorrhage, corneal opacity and focal scabbing and depilation around nose were seen. LD$_{50}$ Values of DA-5018 are 11.5 mg/kg (mice, male), 12.6 mg/kg (mice, female), 88.3 mg/kg (rat, male) and 73.2 mg/kg (rat, female) in oral toxicity tests and 11.0 mg/kg (mice, male), 18.7 mg/kg (mice, female), 0.12 mg/kg (rat, male) and 0.32 mg/kg (rat, female) in i.v. toxicity tests. In the percutaneous acute toxicity tests of DA-5018 cream, no deaths occured in all the tested groups during 14-day observation period. There were also no abnormalities in the general conditions, body weight changes and on necropsy findings in all groups. LD$_{50}$ values of 0.1 ~0.9% DA-5018 creams in male and female rats and rabbits are >2000 mg/kg./kg.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2005.05a
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• pp.93-98
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• 2005

The purpose of this study was to analyze the compression strength research by aerated concrete as mixing ratio This Study used foaming-agent and produced aerated concrete by pre-foam way that is used in construction site. An experiment changes unit cement amount, w/c and the glass fiber mixing rate and 'measured capacity change, unit capacity weight and compressive strength. The results obtained from experimental study are as following; Research to reduce unit capacity weight in condition more than unit cement amount 500kgf is considered should be gone side by side. The highest compressive strength result appeared in aerated concrete that cement amount 600kgf and w/c ratio $45\%$, $50\%$. compressive strength was increased maximum $34%$ when glass fiber $0.7\%$ addition cause by coherence enlargement to enlargement of cement paste and glass fiber addition per unit volume

• Journal of Chest Surgery
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• v.35 no.1
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• pp.56-59
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• 2002

The four most common types of congenital malformations involving the right atrium(RA) and the coronary sinus(CS) are congenital enlargement of the RA, single RA diverticulum, multiple diverticula of the RA, and aneurysm of the RA or CS. A previously healthy 6year-old child was presented with signs of upper respiratory tract infection. Chest X-ray and echocardiogram revealed a severely isolated right atrial enlargement. The abnormally dilated right atrim was widely resected under cardiopulmonary bypass. Pathology revealed multifocal myocardial loss associated with mild fibrotic changes of the endocardium and epicardium Our experience on this rare congenital disease is presented along with a review of the literature.

• Journal of Chest Surgery
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• v.18 no.2
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• pp.299-304
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• 1985

The partial A-V canal defect consist of ostium primum type atrial septal defect with a cleft mitral anterior leaflet. The clinical findings depend upon the site and size of the left-to-right shunt, the degree of A-V valvular regurgitation, and the degree of resultant pulmonary artery hypertension. We experienced 3 cases of similar condition. The data were as follow: 1. Chest P-A showed increased pulmonary vascularity and moderate cardiomegaly with left atrial enlargement. 2. E.K.G. showed left axis deviation, left atrial enlargement, and left ventricular hypertrophy. 3. Right heart catheterization showed significant 02 step up of SVC-RA and left-to-right shunt. 4. Left ventriculogram showed mitral regurgitation and filling of both atrium. Operative findings were as follow: 1. Primum type atrial septal defect [2x2 cm]. 2. Cleft in the anterior leaflet of the mitral vave. 3. No evidence of ventricular septal defect and tricuspid anomaly. Through a right atriotomy with moderate hypothermia, the mitral cleft was approximated with interrupted sutures. The interatrial communication was closed by a patch of Dacron/pericardium. The patch was attached to junction of the mitral and tricuspid valves along the crest of the ventricular septum using interrupted sutures and the other site using continuous sutures. Postoperative course was uneventful and discharged in good general condition except postoperative bleeding in case 3.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.3
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• pp.267-271
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• 2006

Lymphangiomas are benign tumors of the lymphatic system characterized by congenital lymphatic malformation such as anastomosis or obstruction of the lymphatic channels. They are most frequently diagnosed in children younger than 2 years, and the lymphangiomas in head and neck represent about 50-75% of all lymphangiomas. Spontaneous regression is rare, and rapid enlargement occurs secondary to infection or trauma. Enlargement may cause serious sequence such as airway obstruction, feeding difficulties, and cosmetic problems. Treatments previously used for lymphangiomas include surgical excision and intralesional injection of sclerosing agents. Problems associated with surgical excision include the risk of scarring, damage to surrounding vital structure and the high risk of incomplete excision. The sclerosing agents previously used have numerous local and systemic side effects as their problems. We present a case of lymphangioma occured in tongue that was treated by surgical excision and sclerotherapy with OK-432.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1993.10a
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• pp.129-138
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• 1993

The shortage of agricultural labour due to industrial growth has greatly induced the mechanization in Korean agriculture. However small and scattered land holdings have been the main constraints in the process of mechanization. This paper describes the interrelationships of farm land structure, machinery selection and machinery operation areas. The sandy silt loam irrigated paddy land having single crop a year was selected as a target areas for this study. Machine operation cost is greatly influenced by operation period, plot geometry and operation area. On the improved geometry plots, optimal machine size increases slowly with increase in operation area. Operable area increases due to increased effective machine capacity on better geometry plot. The difference between the effects of operation period and plot geometry is that in the former case, the cost reduction is caused by delay in increase of machine size, whereas in the latter case timeliness cost is reduced by increase ffective capacity. The effect of farmland consolidation is greater on small plots than that on big plots. Increasing wage rates have induced the adoption of more labor saving machinery. Bigger labor saving machines require enlargement of operation area and larger plots through improvement in farm land structure. Machine cost on poor plot geometry increases more rapidly than that on the good plot geometry and as operation area increases machine cost reduces significantly. It is concluded that the development of agricultural mechanization ion Korea will depend on the improvement in farm land structure and enlargement of operation area.

• Proceedings of the KIPE Conference
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• 2004.07a
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• pp.402-405
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• 2004

In this paper, the parallel operation of the IGBT and power stack for easy capacity enlargement series in the medium power capacity inverter system of the 660V voltage class is described. The parallel operation of the IGBT and power stack for 1.5MVA medium power inverter system's design is applied. The results of the parallel operation are described in this paper. The designed stack capacity for parallel operation is 800kVA class. For 1.5MVA inverter system, the 800kVA stack is applied with 2 parallel configurations. The 800kVA stack is designed with 3 parallel configurations of the IGBT Module. In this paper, the feasibility for easy capacity enlargement series in the medium power inverter by applying the parallel operation of the IGBT and power stack is verified. The experimental results show the good characteristics for the parallel operation of the IGBT and power stack.

• Korean Journal of Plant Taxonomy
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• v.36 no.3
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• pp.209-216
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• 2006

Arisaema thunbergii supsp. geomundoense, a new taxon in Arisaema sect. Tortuosa subsect. Flagellarisaema (Araceae), from Is1. Geomun-do, Dadohae National Park, Korea, is described. It is distinct from subsp. thunbergii in having bright purple enlargement at the base of spadix appendage, and in having wrinkled enlargement at the base of spadix appendage from subsp. urashima.

• Korean Journal of Veterinary Service
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• v.29 no.2
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• pp.89-96
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• 2006

Bovine viral leukosis is a viral disease of cattle characterized by the development of tumors in the lymphatic tissue. A female Holstein, 3-year-old, was submitted for diagnosis at the Diagnostic laboratory, Chonbuk National University. Clinical sign of the affected animal showed emaciation, enlargement of superficial lymph node and mild diarrhea. Remarkable lesions were enlargement of many internal lymph nodes. Histopathology revealed excessive neoplastic lymphoid cells characteristic of BVL infection. Subsequently, serums from all cattle were collected and serological examination was done where a 85% seropositive rate was detected using ELISA test. ELISA method showed a comparatively 75% higher detection rate than the agar gel immunodiffusion (AGID) test (85% vs 40%). Serologically positive cattle were variably detected in all ages from under 1 year to over 6 year of age. Hematological examination consistently showed leukocytosis and a differential lymphocytosis of seropositive cattle. Detailed comparative pathological and serological data diagnosed the presence of bovine viral leukosis.

• Journal of Chest Surgery
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• v.27 no.7
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• pp.576-580
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• 1994

For 26 months since August 1991, 10 consecutive patients with congenital left ventricular outflow tract obstruction underwent corrective surgery in Pusan Paik Hospital. Their ages ranged from 2 to 18 years. There were 6 male and 4 female patients. According to stenotic site, obstruction were classified into supravalvular [n = 5], subvalvular [n = 4], valvular stenosis [n = 1]. We have performed patch enlargement of ascending aorta [n = 2], supravalvular membrane resection and patch enlargement of ascending aorta [n = 3], subvalvular membrane resection [n = 2], subvalvular membrane resection and left ventricular myectomy [n = 2] and aortic annuloplasty with Dacron patch and aortic valve replacement [n = 1]. Preoperative mean value of systolic pressure gradient were 85.0 $\pm$29.2mmHg[supravalvular], 70.0mmHg[valvular], 72.5 $\pm$ 22.5mmHg[subvalvular], and 78.5 $\pm$ 24.3mmHg[total]. Postoperative mean value of systolic pressure gradient were 31.0 $\pm$ 8.9mmHg[supravalvular], 0mmHg[valvular], 15.0 $\pm$ 10.8mmHg[subvalvular], and 21.5 $\pm$ 13.9mmHg[total]. Postoperative systolic pressure gradient was decreased significantly[p = 0.001]. Postoperative course and short-term follow up results were good except one case of transient heart failure.