• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.45-46
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• 1995

Alzheimer's disease is believed to be associated with the loss of cholinergic activity in the cortex and hippocampus. In addition, it has been reported that the monoaminergic systems which also controls brain functions are disturbed in Alzheimer's patients. Based on these neurochemical background, a number of cholinesterase inhibitors including tacrine and its analogues and some monoamine oxidase inhibitors such as L-deprenyl and monoamine reuptake inhibitors have been developed for the treatment of dementia, but all of the known drugs are not truly effective. We thought that a drug that activates only one neurotransmitter system is not effective enough for the treatment of the symptoms associated with Alzheimer's disease and vascular dementia, and we conceived that an agent enhancing both central cholinergic and monoaminergic functions would be useful for the treatment of dementia

• Biomolecules & Therapeutics
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• v.5 no.4
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• pp.357-363
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• 1997

The effects of formulation variables of topical lotion on the skin permeation of ketoprofen were evaluated using excised rat skins. The formulation variables were the amounts of poloxamer 407, drug and ethanol, and penetration enhancers. The Keshary-Chien diffusion cells were used for the diffusion study. The flux of ketoprofen linearly decreased as the concentration of poloxamer increased from 5% to 15% in the preparation, and linearly increased as the amount of drug increased. Penetration enhancers such as fatty acids and fatty alcohols showed markedly enhancing effects at the level of 5%. Among them, the highest flux was shown in linolenic acid. From these results, optimum formula containing 3% ketoprofen, 5% poloxamer 407, 40% ethanol and 5% linolenic acid having the flux of 537.6 $\mu$g/$\textrm{cm}^2$/hr were noted.

• Archives of Pharmacal Research
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• v.17 no.2
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• pp.57-59
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• 1994

The effect of sodium taurodihydrofusidate (STDHF) on drug permeation across nasal mucosa was studied in vitro using Ussing type diffusion chamber. Disodium cromoglicate (DSCG, M.W.5123) and fluorescein isothiocyanate-dextran (FD) of different molecular wieghts (M.W. 4400-71200) were used as model drugs. Pemeation profiles of DSCG and FDs showed a typical pseudo steady-state curve with short lag time. The pemeability coefficient of FD (M.W. 9400) sigmodially increased with increasing STDHF concentration. It also enhanced the DSCG pemeation. Interestingly the enhancement efficacy was independent of molecular weight of penetrants.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.776-777
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• 2006

The powder forging (PF) process is used to produce fully dense powder metallurgy (PM) parts for high performance automotive applications. PF connecting rods have been widely accepted in the US, Japan, and other countries due to higher performance and lower manufacturing costs when compared to conventionally forged steel connecting rods [1]. In order to meet and exceed requirements for higher fatigue strength and better machinability of PF connecting rods, a newly developed machinability enhancer, named KSX, was introduced [2]. A comparison study between powder forged materials prepared with 0.3% MnS and with 0.1% KSX additions showed excellent properties in the case of the mix with KSX.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.323-330
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• 2006

The aim of current study was to evaluate the toxicity of nonylphenol(NP) on soil nematode, Caenorhabditi elegans. The stress-related gene expression, growth, reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations $(LC_{50s})$ of NP was $0.15mg/L$. The expressions of vitellogenin-6, vitellogenin-2, cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth, reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10e
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• pp.52-54
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• 2002

최근 하루가 다르게 증가하는 이동전화 가입자의 통화 품질을 보장하기 위해CDMA중계기의 중요도가 증가하고 있으며 자동화된 모니터링 시스템의 필요성이 대두되었다. Embedded Internet하에 CDMA중계기를 임베디드 리눅스 시스템과 연동하여 리눅스 커널 레벨에서의 모니터링 방안으로 EKMM(Embedded internet based Kernel level Monitoring Modules)시스템을 제시한다. 본 시스템은 SA-1110 마이크로 프로세스로 구현된 하드웨어에 시리얼 디바이스 드라이브와 네트웍 디바이스 드라이브를 설계하였다. 또한 리눅스 커널을 재구성하며 동적 로딩 방식으로 EKMM이 탑재되어 기존의 중계기 임베디드 시스템 보다 기능 확장성이 뛰어나고 성능이 향상된 중계기 모니터링 시스템을 설계 구현하였다.

• Proceedings of the IEEK Conference
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• 2000.07a
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• pp.225-228
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• 2000

It is well known that a Frequency Domain Adaptive Filter (FDAF) converges faster than a Time Domain Adaptive Filter (TDAF) even when the input signal is colored such as a speech signal. We have proposed the FDAF using the Modified Discrete Fourier Transform Pair (MDFTP) and its realization and effectiveness has been confirmed through the computer simulations. In this paper, we apply the FDAF using the MDFTP to the noise cancellation system. The proposed system is based on the Adaptive Line Enhancer (ALE) and utilizes single microphone; therefore it is suitable for the portable electronic equipment. Moreover, we propose to utilize the MDFT for detecting of the pitch in the speech because the number of data points in the MDFT must be equal to the pitch to confirmed that the noise can be removed to near the level of SNR.

• Proceedings of the Botanical Society of Korea Conference
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• 1987.07a
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• pp.19-49
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• 1987

Recent development of recombinant DNA techniques such as gene cloning and DNA sequencing has led to understanding of genetic information coded on plant genes and their application to crop improvements. Nuclear genes so far isolated and characterized at the molecular level from various plants are those involved mainly in photosynthesis, nitrogen fixation, seed development and defensive responses to environmental stresses. Most of plant genes contain intervening sequences (introns) flanked with GT and AG, as it typical of animal genes. The 5' flanking regions of plant gene revealed the presence of promoter elements such as TATAAA and CCAAT, which have been identified at animal genes to be involved in transcrip- tion initiation. The 3' untranslated regions include a sequence similar to AATAAA whcih functions as a polyadenylation signal in other eukaryotic genes. Furthermore, enhancer-type sequences were found at the 5' flanking regions of various plant genes. This indicates that the structure of plant genes is very similar to animal genes and mechanisms governing the synthesis and processing of mRNAs may be identical in higher eukaryotes. However, genes expression studies involving transformation revealed their differ ences within plants and between plant and animal systems.

• Bulletin of the Korean Chemical Society
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• v.34 no.2
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• pp.673-676
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• 2013

• Molecules and Cells
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• v.41 no.6
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• pp.506-514
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• 2018

The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies.