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Toxicological Study on Nonylphenol using the Soil Nematode, Caenorhabditis elegans  

Roh, Ji-Yeon (Faculty of Environmental Engineering, College of Urban Science, University of Seoul)
Choi, Jin-Hee (Faculty of Environmental Engineering, College of Urban Science, University of Seoul)
Publication Information
Environmental Analysis Health and Toxicology / v.21, no.4, 2006 , pp. 323-330 More about this Journal
Abstract
The aim of current study was to evaluate the toxicity of nonylphenol(NP) on soil nematode, Caenorhabditi elegans. The stress-related gene expression, growth, reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations $(LC_{50s})$ of NP was $0.15mg/L$. The expressions of vitellogenin-6, vitellogenin-2, cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth, reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.
Keywords
Caenorhabditis elegans; nonylphenol; stress-related gene expressions; growth; reproduction; development;
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