Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Toxicological Study on Nonylphenol using the Soil Nematode, Caenorhabditis elegans

토양선충 Caenorhabditis elegans를 이용한 Nonylphenol의 독성 영향 연구

  • Roh, Ji-Yeon (Faculty of Environmental Engineering, College of Urban Science, University of Seoul) ;
  • Choi, Jin-Hee (Faculty of Environmental Engineering, College of Urban Science, University of Seoul)
  • 노지연 (서울시립대학교 환경공학과) ;
  • 최진희 (서울시립대학교 환경공학과)
  • Published : 2006.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of current study was to evaluate the toxicity of nonylphenol(NP) on soil nematode, Caenorhabditi elegans. The stress-related gene expression, growth, reproduction and development have been employed to monitor soil toxicity. The 24-h median effect concentrations $(LC_{50s})$ of NP was $0.15mg/L$. The expressions of vitellogenin-6, vitellogenin-2, cytochrome P450 family protein 35a2 and apoptosis enhancer-1 genes were upregulated in C. elegans by NP exposure. Alterations in growth, reproduction and development were also observed in NP-exposed group and especially hatching failure was observed. The overall results indicate that C. elegans has considerable potential as sensitive markers for NP toxicity monitoring.

Keywords

References

  1. Balch G and Metcalfe C. Developmental effects in Japanese medaka (Oryzias latipes) exposed to nonylphenol ethoxylates and their degradation products, Chemosphere 2006; 62: 1214-1223 https://doi.org/10.1016/j.chemosphere.2005.02.100
  2. Boyd WA and Williams PL. Availability of metals to the nematode Caenorhabditis elegans: toxicity based on total concentrations in soil and extracted fractions, Environ. Toxicol Chem 2003; 22: 1100-1106 https://doi.org/10.1897/1551-5028(2003)022<1100:AOMTTN>2.0.CO;2
  3. Brenner S. The genetics of Caenorhabditis elegans, Genetics 1974; 77: 71-94
  4. Brooke LT. Acute and chronic toxicity of nonylphenol to ten species of aquatic organisms. Report to the U.S. EPA for Work Assignment No. 02 of Contract No. 68-C1-0034. Lake Superior Research Institute, University of Wisconsin-Superior, Superior, WI. March 24. 30pp. 1993a
  5. Brooke LT. Accumulation and lethality for two freshwater fishes (fathead minnow and bluegill) to nonylphenol. Report to the U.S. EPA for Work Assignment No. 1-15 of Contract No. 68-C1-0034. Lake Superior Research Institute, University of Wisconsin-Superior, Superior, WI. 1994. May 31. 49pp
  6. EPA. Ambient Aquatic Life Water Quality Criteria for Nonylphenol-Draft, 2003
  7. EPA. Research Plan for Endocrine Disruptors, 1998
  8. Fliedner A. Daphnia magna, Reproduction test (OECD No. 202). Fraunhofer-Institute fur Umweltchemie und Okotoxikologie, Postfach 1260, W-5948 Schmallenberg-Grafschaft, Germany. 1993. Report No. UBA-002/4-22 February
  9. Garcia-R N, Raldua D, Quiros L, Llaveria G, Cerda J, Barcelo D, Grimalt JO and Pina B. Use of vitellogenin mRNA as a biomarker for endocrine disruption in feral and cultured fish, Anal Bioanal Chem 2004; 378: 670-675 https://doi.org/10.1007/s00216-003-2295-1
  10. Ghekiere A, Verslycke T and Janssen C. Effects of methoprene, nonylphenol, and estrone on the vitellogenesis of the mysid Neomysis integer, Gen Comp Endocrinol 2006; 147: 190-195 https://doi.org/10.1016/j.ygcen.2005.12.021
  11. Gibson R, Wang MJ, Padgett E and Beck AJ. Analysis of 4-nonylphenols, phthalates, and polychlorinated biphenyls in soils and biosolids, Chemosphere 2005; 61: 1336-1344 https://doi.org/10.1016/j.chemosphere.2005.03.072
  12. Hood TE, Calabrese EJ and Zuckerman BM. Detection of an estrogen receptor in two nematode species and inhibition of binding and development by environmental chemicals, Ecotoxicol Environ Saf 2000; 47: 74-81 https://doi.org/10.1006/eesa.2000.1917
  13. Hoss S, Juttner I, Traunspurgerd W, Pfisterb G, Schramm KW and Steinberg CE. Enhanced growth and reproduction of Caenorhabditis elegans (Nematoda) in the presence of 4-nonylphenol, Environ Pollut 2002; 120: 169-172 https://doi.org/10.1016/S0269-7491(02)00161-6
  14. Hseu ZY. Response of microbial activities in two contrasting soils to 4-nonylphenol treated with biosolids, Chemosphere 2006; in press
  15. Kahl MD, Makynen EA, Kosian PA and Ankley GT. Toxicity of 4-nonylphenol in a life-cycle test with the midge Chironomus tentans, Ecotoxicol Environ Saf 1997; 38: 155-160 https://doi.org/10.1006/eesa.1997.1572
  16. Kohra S, Kuwahara K, Takao Y, Ishibashi Y, Lee HC, Arizono K and Tominaga N. Effect of Bisphenol A on the Feeding Behavior of Caenorhabditis elegans, J Health Science 2002; 48: 93-95 https://doi.org/10.1248/jhs.48.93
  17. Lee SM, Lee SB, Park CH and Choi J. Expression of heat shock protein and hemoglobin genes in Chironomus tentans (Diptera, chironomidae) larvae exposed to various environmental pollutants: A potential biomarker of freshwater monitoring, Chemosphere 2006; 65: 1074-1081 https://doi.org/10.1016/j.chemosphere.2006.02.042
  18. Li MH and Wang ZR. Effect of nonylphenol on plasma vitellogenin of male adult guppies (Poecilia reticulata), Environ Toxicol 2005; 20: 53-59 https://doi.org/10.1002/tox.20077
  19. Menzel R, Rodel M, Kulas J and Steinberg CE. CYP35: xenobiotically induced gene expression in the nematode Caenorhabditis elegans, Arch Biochem Biophys 2005; 438: 93-102 https://doi.org/10.1016/j.abb.2005.03.020
  20. Peredney CL and Williams PL. Utility of Caenorhabditis elegans for assessing heavy metal contamination in artificial soil, Arch Environ Contam Toxicol 2000; 39: 113-118
  21. Reichert K and Menzel R. Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray, Chemosphere 2005; 61: 229-237 https://doi.org/10.1016/j.chemosphere.2005.01.077
  22. Roh JY, Lee J and Choi J. Assessment of stress-related gene expression in the heavy metal-exposed nematode Caenorhabditis elegans: a potential biomarker for metalinduced toxicity monitoring and environmental risk assessment, Environ Toxicol Chem 2006; 25: 2946-2956 https://doi.org/10.1897/05-676R.1
  23. Skovlund G, Damgaard C, Bayley M and Holmstrup. Does lipophilicity of toxic compounds determine effects on drought tolerance of the soil collembolan Folsomia candida, Environ Pollut 2006; 31: inpress
  24. Sonnenschein C and Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists, J Steroid Biochem Mol Biol 1998; 65: 143-150 https://doi.org/10.1016/S0960-0760(98)00027-2
  25. Sumpter JP. Xenoendorine disrupters-environmental impacts, Toxicol Lett 1998; 102-103: 337-342 https://doi.org/10.1016/S0378-4274(98)00328-2
  26. Sun H and Gu X. Comprehensive toxicity study of nonylphenol and short-chain nonylphenol polyethoxylates on Daphnia magna, Bull Environ Contam Toxicol 2005; 75: 677-683 https://doi.org/10.1007/s00128-005-0805-x
  27. Ura K, Kai T and Sakata S. Aquatic Acute Toxicity Testing Using the Nematode Caenorhabditis elegans, J Health Science 2002; 48: 583-586 https://doi.org/10.1248/jhs.48.583
  28. Ward TJ and Boeri RL. Acute flow through toxicity of nonylphenol to the mysid, Mysidopsis bahia. Study Number 8974-CMA. EnviroSystems, Hampton, NH. 35 pp. 1990b
  29. Widarto TH, Holmstrup M and Forbes VE. The influence of nonylphenol on life-history of the earthworm Dendrobaena octaedra Savigny: linking effects from the individual-to the population-level, Ecotoxicol Environ Saf 2004; 58: 147-159 https://doi.org/10.1016/j.ecoenv.2004.03.006
  30. Williams PL, Anderson GL, Johnstone JL, Nunn AD, Tweedle MF and Wedeking P. Caenorhabditis elegans as an alternative animal species, J Toxicol Environ Health A 2000; 61: 641-647 https://doi.org/10.1080/00984100050195125
  31. Yang FX, Xu Y and Hui Y. Reproductive effects of prenatal exposure to nonylphenol on zebrafish (Danio rerio), Comp Biochem Physiol C Toxicol Pharmacol 2006; 142: 77-84 https://doi.org/10.1016/j.cbpc.2005.10.012
  32. Yao G, Yang L, Hu Y, Liang J, Liang J and Hou Y. Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization, Mol Immunol 2006; 43: 915-926 https://doi.org/10.1016/j.molimm.2005.06.031