• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.331-336
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• 2011

The instability of hirsutenone (HST), a potential therapeutic candidate for the treatment of atopic dermatitis (AD) and ovarian carcinoma, is one of the main concerns for the development of drug product. In the present study, aqueous stability of HST was investigated by kinetic analysis, and the effect of several factors covering temperature, nitrogen gas ($N_2$) flushing, and selection of proper antioxidant was compared. Cosolvent system composed of distilled water and methanol (9:1 v/v) was used as a vehicle to dissolve HST at the concentration of $200{\mu}g/mL$. Samples of aqueous solution were prepared under the absence or presence of antioxidants, such as ascorbic acid (AA), sodium edetate (EDTA), and ascorbyl palmitate (AP), and subjected for stability test. The degradation of HST in aqueous solution was followed by the first order kinetics with an extremely short half life of less than a week at room temperature, and was accelerated as the temperature increased. $N_2$ flushing brought a little enhancement in stability compared to control solution, but the effect was insufficient. The addition of AA and EDTA (0.1%) significantly enhanced the stability of HST at $40^{\circ}C$, but the addition of AP (0.01%) was limited due to its water insolubility and revealed no promising result. The stability of HST was increased proportionally by the amount of AA added, showing the difference in degree of stabilization as an order of magnitude. Finally, we conclude that HST was stabilized by the addition of a suitable antioxidant, suggesting AA as the most effective stabilizer.

• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.559-571
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• 2020

This study was conducted to analyze the effects of person-environment fit on the job performance in the National Assembly legislative support organization. Job performance was classified into task performance, contextual performance, and adaptive performance. Impacts of each factors on the job performance were identified through structural equation model. From the results of analysis, it was confirmed that supplementary fit of officials of legislative support organization of the National Assembly had a positive effect on task performance, contextual performance, and adaptive performance. However, complementary-fit does not directly affect task performance, contextual performance, and adaptive performance. Rather complementary-fit affects job performance by the mediating role of variable self-efficacy. The implications of this study confirm that it is important to match between organization members and jobs in order to improve the job performance of civil servants in the legislative support organization. The necessity of introducing self-efficacy enhancement program into the education and training process of the legislative support organization was proposed.

• Journal of The Korean Society of Grassland and Forage Science
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• v.38 no.3
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• pp.190-195
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• 2018

Cold, salt and heat are the most critical factors that restrict full genetic potential, growth and development of crops globally. However, clarification of genes expression and regulation is a fundamental approach to understanding the adaptive response of plants under unfavorable environments. In this study, we applied an annealing control primer (ACP) based on the GeneFishing approach to identify differentially expressed genes (DEGs) in Italian ryegrass (cv. Kowinearly) leaves under cold, salt and heat stresses. Two-week-old seedlings were exposed to cold ($4^{\circ}C$), salt (NaCl 200 mM) and heat ($42^{\circ}C$) treatments for six hours. A total 8 differentially expressed genes were isolated from ryegrass leaves. These genes were sequenced then identified and validated using the National Center for Biotechnology Information (NCBI) database. We identified several promising genes encoding light harvesting chlorophyll a/b binding protein, alpha-glactosidase b, chromosome 3B, elongation factor 1-alpha, FLbaf106f03, Lolium multiflorum plastid, complete genome, translation initiation factor SUI1, and glyceraldehyde-3-phosphate dehydrogenase. These genes were potentially involved in photosynthesis, plant development, protein synthesis and abiotic stress tolerance in plants. However, this study provides new insight regarding molecular information about several genes in response to multiple abiotic stresses. Additionally, these genes may be useful for enhancement of abiotic stress tolerance in fodder crops as well a crop improvement under unfavorable environmental conditions.

• The Korean Journal of Health Service Management
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• v.7 no.3
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• pp.83-93
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• 2013

This study was conducted on 350 students of health and medical department of universities in Busan from June 3, 2013 to June 21, 2013, and a total of 350 questionnaires were researched. Among them 337 responses were used after 13 unfaithful responses were excluded. The effects of oral health belief on use of dental service of students of health and medical department of universities were examined and analyzed to provide basic data which can be used to expand understanding about oral health belief, to promote changes in behaviors regarding oral health and to improve oral health of the public. Collected data was analyzed through SPSS (Statistical Packages for Social Science 15.0. SPSS Inc. USA). For verification of differences of oral health belief depending on general matters and oral health behavior, t-test and ANOVA analysis were conducted, and for examination of the effects of oral health belief on use of medical service, logistic regression and regression analysis were conducted. The study results suggest that those who had higher sensitivity among oral health belief variables had higher probability of needing dental treatment and seeing the dentist immediately. And those who showed higher sensitivity and importance had higher frequency of seeing the dentist for six months. Future studies need to be conducted on the methods to change oral health belief for sustainable and systematic oral health enhancement in consideration of the factors affecting oral health belief and oral health behavior of the students of dental hygiene department.

• Structural Engineering and Mechanics
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• v.52 no.6
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• pp.1135-1156
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• 2014

The ratcheting effect greatly challenges the design of piping components. With the assistance of the quasi-three point bending apparatus, ratcheting and the ratcheting boundary of pressurized straight Z2CND18.12N stainless steel pipe under bending loading and vertical displacement control were studied experimentally. The characteristics of progressive inelastic deformation in axial and hoop directions of the Z2CND18.12N stainless steel pipes were investigated. The experiment results show that the ratcheting strain occurs mainly in the hoop direction while there is less ratcheting strain in the axial direction. The characteristics of the bending ratcheting behavior of the pressure pipes were derived and compared under load control and displacement control, respectively. The results show that the cyclic bending loading and the internal pressure affect the ratcheting behavior of the pressurized straight pipe significantly under load control. In the meantime, the ratcheting characteristics are also highly associated with the cyclic displacement and the internal pressure under displacement control. All these factors affect not only the saturation of the ratcheting strain but the ratcheting strain rate. A series of multi-step bending ratcheting experiments were conducted under both control modes. It was found that the hardening effect of Z2CND18.12N stainless steel pipe under previous cyclic loadings no matter with high or low displacement amplitudes is significant, and the prior loading histories greatly retard the ratcheting strain and its rate under subsequent loadings. Finally, the ratcheting boundaries of the pressurized straight Z2CND18.12N stainless steel pipe were determined and compared based on KTA/ASME, RCC-MR and the experimental results.

• Steel and Composite Structures
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• v.36 no.2
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• pp.163-177
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• 2020

Concentrically Braced Frames (CBFs) are commonly used in the construction of steel structures because of their ease of implementation, rigidity, low lateral displacement, and cost-effectiveness. However, the principal disadvantage of this kind of braced frame is the inability to provide deformation capacity (ductility) and buckling of bracing elements before yielding. This paper aims to present a novel Composite Buckling Restrained Fuse (CBRF) to be utilized as a bracing segment in concentrically braced frames that allows higher ductility and removes premature buckling. The proposed CBRF with relatively small dimensions is an enhancement on the Reduced Length Buckling Restrained Braces (RL-BRBs), consists of steel core and additional tensile elements embedded in a concrete encasement. Employing tensile elements in this composite fuse with a new configuration enhances the energy dissipation efficiency and removes the tensile strength limitations that exist in bracing elements that contain RL-BRBs. Here, the optimal length of the CBRF is computed by considering the anticipated strain demand and the low-cyclic fatigue life of the core under standard loading protocol. An experimental program is conducted to explore the seismic behavior of the suggested CBRF compare with an RL-BRB specimen under gradually increased cyclic loading. Moreover, Hysteretic responses of the specimens are evaluated to calculate the design parameters such as energy dissipation potential, strength adjustment factors, and equivalent viscous damping. The findings show that the suggested fuse possess a ductile behavior with high energy absorption and sufficient resistance and a reasonably stable hysteresis response under compression and tension.

• Journal of Microbiology and Biotechnology
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• v.23 no.5
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• pp.699-706
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• 2013

We have previously reported that N-acetylcysteine (NAC) not only delayed apoptosis but also enhanced the production of recombinant erythropoietin (EPO) in Chinese hamster ovary (CHO) cell culture. To investigate the production enhancement mechanism, the effects of similar thiol-reducing agents were studied. Intriguingly, all mild reducing agents examined including mercaptoethanesulfonic acid (MESNA), thiolactic acid (TLA), and thioglycolate (TG) were shown to block apoptosis and increase EPO production. A pulse-chase study of EPO secretion revealed that all four thiol-reducing agents increased the EPO secretion rate; among them TLA showed the highest rate. In terms of product quality, the sialic acid content of the glycoprotein is one of the most important factors. It was reported that a number of glycoproteins produced by CHO cells often have incomplete sialylation, particularly under high-producing conditions. Human ${\alpha}2,3$-sialyltransferase (${\alpha}2,3$-ST) was introduced into EPO-producing CHO cells in order to compensate for the reduced sialylation during supplementation with NAC. When ${\alpha}2,3$-ST was expressed in the presence of NAC, reduced sialylation was restored and an even more sialylated EPO was produced. Thus, our study is significant in that it offers increased EPO production while still allowing the prevention of decreased sialylation of EPO.

• The Journal of the Korea Contents Association
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• v.20 no.5
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• pp.367-374
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• 2020

The purpose of this study was to identify the relationship between empathy, communicative competence, and cultural competence among nursing students and investigate the factors influencing cultural competence. The subjects of the study consisted of 173 nursing students. Data were analyzed based on Pearson's correlations, and multiple regressions using the SPSS 18.0 program. The mean value of cultural competence was 3.44, showing significant positive correlations with empathy(r=.450, p<.001) and communicative competence(r=.579, p<.001) in nursing students. Empathy, communicative competence and foreign language skill accounted for 37.1% of the total variance in cultural competence among nursing students. Overall cultural competence can be improved by empathy, communicative competence enhancement program.

• Journal of Korea Multimedia Society
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• v.8 no.10
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• pp.1360-1368
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• 2005

PDP is the flat panel display, suitable for high definition television because of large-sire and high-brightness. It has many advantages such as fast response, wide viewing angle, low weight, and simple manufacturing process for fabrication. However, there are some disadvantages and one of them is the image quality degradation, which is dependent on the digital signal processing. Although image quality of PDP is improving by many researches and experimentations, it still isn't as good as that of CRT because of various factors. One of them is worm-like pattern generated by an error diffusion process. And the worm-like pattern is severely increased after an APL process. An increased worm-like pattern occur a drop of resolution in image and a change of CCT according to each grayscale. In this paper, a method for improvement of image quality using the error diffusion which considers the APL process is proposed. In the proposed method, the APL process is performed before the error diffusion process. Simulation results showed that the proposed method has better performances for resolution in images and CCT uniformity according to each grayscale than the conventional method.

• Journal of Korean Neurosurgical Society
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• v.42 no.2
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• pp.92-96
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• 2007

Objective : The authors have speculated that metastatic brain lesions from renal cell carcinoma (RCC) show diverse radiological patterns and tumor responses after Gamma knife surgery (GKS), and have hypothesized that these can be predicted from tumor radiological characteristics. The goal of the current study was to identify the radiological characteristics of RCC brain metastases and the predictors of initial radiosurgical response after GKS. Methods : A retrospective analysis was performed on 48 lesions in 18 patients with RCC brain metastasis treated by GKS. The radiological characteristics of these lesions in magnetic resonance images (MRI) were classified into 3 categories according to enhancement patterns in T1-weighted images and signal intensity characteristics in T2-weighted images. Responses to GKS were analyzed according to these categories, and in addition, other potential predictive factors were also evaluated. Results : MRI findings in the three categories were diverse, though numbers of the lesion were comparable. At 2-month MRI follow-ups after GKS, response rate was 54% and the local tumor control rate 83%. T2 signal intensity was found to be the principal predictive factor of response to GKS, namely negative predictive factor. Other variables such as age, sex, tumor volume, dose, duration from initial diagnosis to GKS, and previous systemic therapies failed to show significant relationships with treatment response by multivariate analysis. Conclusion : Careful evaluation of the radiological characteristics of brain metastases from RCC is important prior to GKS because MRI heterogeneity has predictive value in terms of determining initial tumor response.