• Journal of Life Science
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• v.20 no.6
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• pp.831-837
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• 2010

KR-31125 (2-butyl-5-dimethoxymethyl-6-phenyl-7-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine) is a potent inhibitor of angiotensin II type 1 ($AT_1$) receptors in human recombinant $AT_1$ receptors and rabbit aorta. These in vitro studies revealed that KR-31125 inhibited specific [$^{125}I$] [$Sar^1$, $Ile^8$]-angiotensin II binding to human recombinant $AT_1$ receptors in a concentration dependent manner with an $IC_{50}$ value of $19.72{\pm}2.65$ nM. However, no interaction with $AT_2$ receptors was detected as displayed by the competition binding of [$^{125}I$] CGP 42112A to human recombinant $AT_2$ receptor. The binding action was also confirmed as a competitive mode that was identical to the previously studied compound, losartan. In addition, KR-31125 caused a nonparallel shift to the right in the concentration response curves to angiotensin II with a 30-80% decrease in the maximum contractile responses ($pK_B$: 7.63). Compared to the previous studies with losartan that showed a parallel right shift in the maximum contractile responses to AII ($pA_2$: 7.59), KR-31125 presented a different mode of action with a similar potency to losartan. These results demonstrate that KR-31125 is a highly potent and $AT_1$ selective angiotensin II receptor antagonist that can be applied to the fields of new diagnostic and research tools with upcoming in vivo study results.

• KIPS Transactions on Software and Data Engineering
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• v.7 no.6
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• pp.221-228
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• 2018

With an increase in demand for the high added value of shipbuilding and marine industry based on the information and communications technology (ICT), software technology has become more important than ever in the industry. In this paper, we present the result of our preliminary investigation on the current software development environment in the shipbuilding and marine industry in order to develop reusable software component, which can enhance the competitiveness of software development. The investigation is performed based on the survey answers from 34 developers who are working in different shipbuilding and marine companies. The questionnaire is composed of items to gather the information of each company such as the number of employees and product domain, and actual software development environment such as operating system, programming languages, deployment format, obstacles for developing components, and the adoption of software development methods and tools. According to the results of the survey, the most important consideration to select their development platform was the number of available utilities and the technical supports, followed by performance, price and security problems. In addition, the requirements of various platforms supporting and the higher reliability, and the limitations of low development cost and manpower made it difficult for them to develop reusable software components. Finally, throughout the survey, we find out that only 15% of developers used software development processes and managed the quality to systematically develop their software products, therefore, shipbuilding and marine companies need more technical and institutional support to improve their ability to develop high qualified software.

• Journal of the Economic Geographical Society of Korea
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• v.15 no.1
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• pp.26-41
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• 2012

This study investigates the time-space characteristics of intra-urban passenger flows in the Metropolitan Seoul area. In particular, we analyze the relationships between transit ridership and land use through the use of the subway passenger flow data obtained from the transit transaction databases. For this purpose, the strength of each subway station, i.e., the number of total in-coming and out-going passengers at each station, in the morning, afternoon, and evening, is calculated and visualized, which reflects urban land use patterns. Then the subway stations are classified into four groups via a hierarchical analysis of the in-coming and out-going passenger flows at 353 stations. Each group appears to have characteristic properties according to the region, e.g., residential areas and central business districts. This has been confirmed by the analysis which probes explicitly the relationship between the local socio-economic variables and station groups. This analysis, disclosing the inter-relationship between the subway network and urban land use, may be useful at various stages in urban as well as transportation planning, and provides analytical tools for a wide spectrum of applications ranging from impact evaluation to decision-making and planning support.

• Applied Biological Chemistry
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• v.19 no.2
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• pp.99-103
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• 1976

The experiment was tested with fruits of eight varieties which were produced in Kyung Pook and Kyung Nam District and was carried out to investigate the changes of sobuble tannin content, hardness and sugar content during the removal of astringency, and, further more, the changes of quality after the removal of astringency. The results were as follows: 1. Soluble tannin content of Sagoksi was most in eight varieties and than was Euisung-Bansi and Chungdo-Bansi in that order. The time required of the removal of astringency tools 2.5 days in Dansungsi, 4.5days in Sagoksi. 2. Hardness was the firmest in Sagoksi and Chungdo-Bansi and it was gradually decreased as the harvest time of fruits was delayed. 3. In content of sugar, Gojongsi was most amount and Sagoksi was least amount in all varieties. Changes of sugar content showed a gradual decrease during the removal of astringency. 4. Quality of fruit after the removal of astringency was of a very superior quality in Chungdo-Bansi, Sagoksi and Euisung-Bansi.

• Journal of the Korean Society of Marine Environment & Safety
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• v.13 no.2 s.29
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• pp.111-118
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• 2007

Simple box budgets models are useful tools to understand the phenomena of natural system and to provide an insight into the complex processes including physical, chemical and biological processes occurring in natural system. Budgets of fresh water, salt and nutrients were estimated in order to clarify the characteristics of seasonal material cycle in the Masan Bay. Outflow volume of freshwater into system was approximately $307.4\times10^3\sim1,210\times10^3\;m^3/day$. Inflow masses of DIP and DIN were approximately $410.8\sim795.7\;kg/day$ and $4081.4\sim6525.3\;kg/day$, respectively. DIN is expected to accumulate in the system. The removal of nutrients from bottom sediments will contribute to the reduction of 21.0% of COD concentration in the system.

• Clean Technology
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• v.2 no.1
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• pp.32-43
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• 1996

The interactions of the societal-industrial system with the environment form one of the most critical issues in today's world. The inadequacy of current environmental regulatory structures and of traditional ways of analyzing environmental issues, together with the continuing need to mitigate the environmental perturbations arising from this complex relationship, have led to the development of a new conceptual framework termed industrial ecology. Industrial ecology (IE), defined by Graedel and Allenby, is the means by which humanity can deliberately and rationally approach and maintain a desirable carrying capacity, given continued economic, cultural and technological evolution. The concept requires that an industrial system be viewed not in isolation from its surrounding systems, but in concert with them. IE is a systems view in which one seeks to optimize the total materials cycle from virgin material, to finished material, to component, to product, to obsolete product, and to ultimate disposal. Factors to be optimized include resources, energy, and capital. In the present paper, the concept of Industrial Ecology and its application through efficient and practical Design for Environment (DFE) methodologies and tools will be introduced to Korea. This paper will also emphasis on the industrial environment within which DFE methodologies must be used, including the fundamentals of industrial design activities, concurrent engineering, constraints on design choices and existing technological infrastructure.

• Korean Journal of Agricultural and Forest Meteorology
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• v.14 no.4
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• pp.143-154
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• 2012

As demand of water resources and attentions to changes in climate (e.g., due to ENSO) increase, long/short term prediction of precipitation is getting necessary in water planning. This research evaluated the ability of MM5 to predict precipitation in the Tampa Bay region over 23 year period from 1986 to 2008. Additionally MM5 results were statistically bias-corrected using observation data at 33 stations over the study area using CDF-mapping approach and evaluated comparing to raw results for each ENSO phase (i.e., El Ni$\tilde{n}$o and La Ni$\tilde{n}$a). The bias-corrected model results accurately reproduced the monthly mean point precipitation values. Areal average daily/monthly precipitation predictions estimated using block-kriging algorithm showed fairly high accuracy with mean error of daily precipitation, 0.8 mm and mean error of monthly precipitation, 7.1 mm. The results evaluated according to ENSO phase showed that the accuracy in model output varies with the seasons and ENSO phases. Reasons for low predictions skills and alternatives for simulation improvement are discussed. A comprehensive evaluation including sensitivity to physics schemes, boundary conditions reanalysis products and updating land use maps is suggested to enhance model performance. We believe that the outcome of this research guides to a better implementation of regional climate modeling tools in water management at regional/seasonal scale.

• Industry Promotion Research
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• v.3 no.1
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• pp.43-48
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• 2018

This study is focusing on activating and developing the right model of win-win partnership innovative activity for the purpose of win-win relationship among companies. These are the following studies that are conducted for that objective. First, This study systematically analyzes the best cases of the win-win partnership focusing on the proceedings of the companies participating in the field of win-win Partnership at the national quality-circle contest for the last three years(2014~2016). This study reveals the underlying problems of win-win partnership innovative activity and draws the conclusion in the way of improvement about the win-win partnership innovative activity. Second, This study suggests the efficient method of the function and improvement of a system for activating win-win partnership innovative activity by analyzing screening criterion and selecting excellent cases in the field of win-win Partnership at the national quality-circle contest in 2017. Third, This study suggests the method of strengthening the system of sharing result for invigorating and motivating the win-win partnership innovative activity. It is expected that this methodology for reinforcing the system of Win-win Partnership among companies will help to create the environment where a sound and new corporate culture can be settled. And It is also expected that this study can contribute to attaining the goal of growing together through enhancing the competitiveness, productivity and quality among Win-win Cooperation companies.

• Journal of the Korean Geotechnical Society
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• v.20 no.9
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• pp.25-32
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• 2004

Some amount of cements can be added into the soil with high water content to improve the engineering properties. In such a case, it is difficult to predict and figure out the phase changes of the soil-cement mixture which is closely associated with workability of the soil-cement mixture. Changes in heat of hydration and hardness of the cement pastes are known to provide the useful information about the phase changes of the soil-cement mixtures. In this study, heat of hydration and cone penetration depth were measured from the specimens of cement paste and 3 soil-cement mixtures. From the experimental results, it was found that the phase changes of the soil-cement mixtures are the same as those of cement paste, and that shear strength of the mixtures abruptly increases when the heat of hydration is minimum. Initial setting time of the mixtures coincides with the state when fall cone penetration depth was 1.0 mm and it is defined as plastic limit of the mixtures. Initial setting time of the mixtures is retarded as soil/cement ratio is increased. Measurements of heat of hydration and fall cone apparatus could be the useful tools to predict the phase changes of tile soil-cement mixtures.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.27-30
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• 2018

We design an expert system for tomato smart farm using decision trees and construct a control system with decision structure similar to that of farmers by using the data generated by factors that vary depending on the surrounding environment of each house. At present, Smart farm's control system does not control itself like the way farmers have done so far. Therefore, the dependency of smart farm control system is still not high. Direct intervention by farmers is indispensable for environmental control based on surrounding environment such as sensor value in smart farm. Therefore, we aimed to design a controller that incorporates decision trees into the expert system to make a system similar to the decision making of farmers. Prior to controlling the equipment in the house, it automatically selects the most direct effect among the various environmental factors, and then builds an expert system for complex control by including criteria for decision making by farmers. This study focused on deriving results using data without using heavy tools. Data is coming out of many smart farms at present. We expect this to be a standard for a methodology that allows farmers to access quickly and easily and reduce direct intervention.