• Korean System Dynamics Review
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• v.10 no.1
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• pp.5-32
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• 2009

This paper revisited the key advances on System Dynamics modeling about traditional macro-economic models and economic growth structures, and then tries to elaborate a new model based on the endogenous growth theory that incorporates new growth factors, relevant to knowledge/technology as well as the Environment, into traditional growth models. Accordingly, the new model augments the acceleration and multiplier loops and the balancing ones representing market clearing mechanism with a simple numerical example. The authors thus provides macroeconomic System Dynamics analysts with a milestone to model macro-economic structures reflecting on traditional and cutting-edge theories on sustainable economic growth and general equilibrium modeling.

• Journal of Microbiology and Biotechnology
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• v.24 no.4
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• pp.577-583
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• 2014

Three major classes of retroviral restriction factors (APOBEC3G, Tetherin, and TRIM5${\alpha}$) have been identified in mammals. Restriction factors are cellular proteins that are able to limit viral replication by targeting specific steps of the viral life cycle. To evaluate which restriction factor is the most effective to inhibit the replication of porcine endogenous retroviruses (PERVs), the antiviral activity of each restriction factor was compared. In pseudotype assay, the antiviral activity of human tetherin against PERV pseudotype was slightly weaker than that of human APOBEC3G (hA3G). A combination of tetherin and hA3G was more potent than each individual restriction factor. We questioned whether a combination of tetherin and hA3G could also inhibit the spreading replication of PERV. In agreement with the pseudotype assay, two restriction factors inhibit infectious PERV replication in a spreading infection. In this study, hA3G could strongly inhibit the replication of PERV, but tetherin modestly restricted it. Based on these results, we concluded that a combination of tetherin and hA3G is the most effective way to restrict PERV. A combination of different restriction factors will encourage the development of a new approach to treat retroviral disease.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.1
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• pp.140-152
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• 2016

It is very important for the competitiveness and sustainable management of enterprises that the rapid changes in the managerial environments quickly and accurately are responded. For example, the large-scale investment accompanied by bad alternatives in accordance with misunderstanding of the managerial environments yields the huge cost and effort to modify and improve. In firm management, the quality of products and the productivity are influenced by changes of the endogenous factors yielded in manufacturing process and the exogenous factors as market, etc. These changes include not only changes in 4M (man, machine, material, method) but also those in the market, competitors, and technologies in the process of commodification, i.e., first, such disturbances make dispersion of the process big and odd. By Shewhart chart it can be checked that the process monitored is control-in or out. Business administration executes activities for input stabilization by monitoring changes in 4Ms, comparing with the standards, and taking measures for any abnormality. Second, TRM (technology road map) is to prospect product deployment and technological trend by predicting technologies in the competitive environment as the market, and to suggest the future directions of business. So, TRM must be modified and improved according to DR (design review) stages and changes in mass-production like input material change. Therefore, a role of TRM in input stabilization for reducing cost and man-hour is important. This study purposed to suggest that the environment changes are classified into endogenous factors and exogenous factors in production process, and then, quality and productivity should be stabilized efficiently through connection between TRM and input stabilization, and to prove that it is more effective for the display industry to connect TRM with input stabilization rather than to use TRM separately.

• The Journal of Information Systems
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• v.12 no.1
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• pp.47-66
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• 2003

This study was examined the relationship between the exogenous and endogenous variables in our model to measure ERP system performance using path analysis. The exogenous variables are system quality, user participation, user training, top management support and self-efficacy, and the endogenous variables are system usage, user satisfaction, and work efficiency. The results of the study are shown as follows. First, all the exogenous variables in our model have a direct effect on user satisfaction, and system quality, training, and self-efficacy have a direct effect on system usage. Second, system usage has a direct effect on user satisfaction and user satisfaction has a direct effect on work efficiency. The findings show that the exogenous variables in the model are important to increase ERP implementation success.

• BMB Reports
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• v.42 no.8
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• pp.475-481
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• 2009

Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's disease (AD). Insulin and insulin-like growth factors (IGFs) regulate neuronal survival, energy metabolism, and plasticity, which are required for learning and memory. Hence, endogenous brain-specific impairments in insulin and IGF signaling account for the majority of AD-associated abnormalities. However, a second major mechanism of cognitive impairment has been linked to obesity and Type 2 diabetes (T2DM). Human and experimental animal studies revealed that neurodegeneration associated with peripheral insulin resistance is likely effectuated via a liver-brain axis whereby toxic lipids, including ceramides, cross the blood brain barrier and cause brain insulin resistance, oxidative stress, neuro-inflammation, and cell death. In essence, there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.

• Journal of Digital Convergence
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• v.11 no.9
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• pp.29-43
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• 2013

The dominant perspective on institutional change of the GRI is the environment-dependence. GRI's institutions are, however, prone to change due to the endogenous factors. Therefore, we need a dynamic alternative model to analyze the interaction between the exogenous and endogenous factors around the GRI's institutions. In this paper, authors examined the changes in GRI's funding system. The results were verified in the layering which is a one of the dynamic institutional change forms. Owing to the interaction between the exogenous and endogenous factors, institutional reform's layers of the institution funding expansion have been continuously accumulated in order to modify the Project-Based System(PBS). Eventually expansion layers of the institution funding have grown more quickly than the Project-Based System(PBS), as a result, GRI's funding system has been changing centered on the Block funding.

• Reproductive and Developmental Biology
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• v.36 no.1
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• pp.13-19
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• 2012

In order to provide the basis for developing practical mouse embryonic stem cells (mESCs) culture method, how the endogenous level of self-renewal-stimulating factor genes was altered in the mESCs by different extracellular signaling was investigated in this study. For different extracellular signaling, mESCs were cultured in 2 dimension (D), 3D and integrin-stimulating 3D culture system in the presence or absence of leukemia inhibitory factor (LIF) and transcriptional level of $Lif$, $Bmp4$ and $Wnt3a$ was evaluated in the mESCs cultured in each system. The expression of three genes was significantly increased in 3D system relative to 2D system under LIF-containing condition, while only $Wnt3a$ expression was increased by 3D culture under LIF-free condition. Stimulation of integrin signaling in mESCs within 3D system with exogenous LIF significantly up-regulated transcriptional level of $Bmp4$, but did not induce transcriptional regulation of $Lif$ and $Wnt3a$. In the absence of LIF inside 3D system, the expression of $Lif$ and $Bmp4$ was significantly increased by integrin signaling, while it significantly decreased $Wnt3a$ expression. Finally, the signal from exogenous LIF significantly caused increased expression of $Lif$ in 2D system, decreased expression of $Bmp4$ in both 2D and 3D system, and decreased expression of $Wnt3a$ in integrin-stimulating 3D system. From these results, we identified that endogenous expression level of self-renewal-stimulating factor genes in mESCs could be effectively regulated through artificial and proper manipulation of extracellular signaling. Moreover, synthetic 3D niche stimulating endogenous secretion of self-renewal-stimulating factors will be able to help develop growth factor-free maintenance system of mESCs.

• BMB Reports
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• v.54 no.7
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• pp.368-373
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• 2021

The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore, the expression patterns of both protein and correlation with various clinical data in each tissue were analyzed. The expressions of both HERV-K Env and HERV-R Env protein were identified to be significantly high in most of the tumors compared with normal surrounding tissues. Correlations between HERV Env expressions and clinical investigations varied depending on the HERV types and cancers. Overall expression patterns of HERV-K Env and HERV-R Env proteins were different in every individual but a similar pattern of expressions was observed in the same individual. These results demonstrate the expression profiles of HERV-K and HERV-R Env proteins in various cancer tissues and provide a good reference for the association of endogenous retroviral Env proteins in the progression of various cancers. Furthermore, the results elucidate the relationship between HERV-Env expression and the clinical significance of certain cancers.

• Korean System Dynamics Review
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• v.4 no.2
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• pp.95-130
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• 2003

The purpose of this study is to find what causes make public projects hold off, going beyond the planned deadline and budget. Using System Dynamics(SD) and their derivative Urban Dynamics(UD) models, it intends to analyze major feedback loops based on VENSIM and to simulate them with STELLA software, all of which are interrelated with various causes of project delay. To prevent or ameliorate project delay, first of all it advises to focus on endogenous delaying factors not exogenous ones. These factors either reinforce or balance certain loops in complex causal structure, In the case example on the Cremation Building Project in Cheongju, Residents’ participation demand make negotiation put off and delayed negotiation reinforces administrative-expediency planning in order to observe a time limit, on the other hand, once building consensus, it increase both the level of planning performance and public trust. In the meantime, the real planning process used to neglect residents opinions and manage public grievance only through compensation, he a result of simulation, visible fruit of negotiation in the initial phase seems to be not satisfactory owing to funds and time consumed, but after reaching an mutual agreement among stakeholders, planning performance is effective and strategic than administrative-expediency planning viewed in both financial and time angle. It proposes to devise specific tools schematizing project implementation. In order to upgrade the quality of project management, it recommends for planners to adopt key concepts based on SD/UD diagrams and causal loops, which would contribute to enriching Planning abbots.

• Korean Journal of Legislative Studies
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• v.15 no.1
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• pp.65-92
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• 2009

Political trust is defined as the degree to which people perceive that government is producing outcomes consistent with their expectations. Political trust as a concept has endogenous as well as exogenous characteristics in that it can cause and be caused by other political factors. The purpose of this study is to introduce and evaluate various theoretical perspectives related to the causes and effects of political trust. With respect to its causes, this study focuses on the following five factors: government policies, unethical behaviors of politicians, citizens' penchant for participatory democracy, the public's misperceptions on government, and political culture. On the other hand, this study discusses the impacts of political trust on each stage of political process by paying attention to the following factors: government's governability, election outcomes, political recruitment, and the directions of government policies.