Browse > Article
http://dx.doi.org/10.5483/BMBRep.2021.54.7.246

Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers  

Ko, Eun-Ji (Department of Parasitology and Genetics, Kosin University College of Medicine)
Song, Kyoung Seob (Department of Physiology, Kosin University College of Medicine)
Ock, Mee Sun (Department of Parasitology and Genetics, Kosin University College of Medicine)
Choi, Yung Hyun (Department of Biochemistry, College of Oriental Medicine, Dongeui University)
Kim, Suhkmann (Department of Chemistry, College of Natural Sciences, Pusan National University)
Kim, Heui-Soo (Department of Biological Sciences, College of Natural Sciences, Pusan National University)
Cha, Hee-Jae (Department of Parasitology and Genetics, Kosin University College of Medicine)
Publication Information
BMB Reports / v.54, no.7, 2021 , pp. 368-373 More about this Journal
Abstract
The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore, the expression patterns of both protein and correlation with various clinical data in each tissue were analyzed. The expressions of both HERV-K Env and HERV-R Env protein were identified to be significantly high in most of the tumors compared with normal surrounding tissues. Correlations between HERV Env expressions and clinical investigations varied depending on the HERV types and cancers. Overall expression patterns of HERV-K Env and HERV-R Env proteins were different in every individual but a similar pattern of expressions was observed in the same individual. These results demonstrate the expression profiles of HERV-K and HERV-R Env proteins in various cancer tissues and provide a good reference for the association of endogenous retroviral Env proteins in the progression of various cancers. Furthermore, the results elucidate the relationship between HERV-Env expression and the clinical significance of certain cancers.
Keywords
Cancer; Env; Expression pattern; HERV;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yun KY, Ko EJ, Kim HY et al (2017) Long interspersed element-1 open reading frame 1 protein expression profiles in ovarian cancers. Genes Genom 39, 1157-1162   DOI
2 Zhao J, Rycaj K, Geng S et al (2011) Expression of human endogenous retrovirus type K envelope protein is a novel candidate prognostic marker for human breast cancer. Genes Cancer 2, 914-922   DOI
3 Buscher K, Trefzer U, Hofmann M, Sterry W, Kurth R and Denner J (2005) Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res 65, 4172-4180   DOI
4 Bannert N and Kurth R (2004) Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci U S A 101 Suppl 2, 14572-14579   DOI
5 Romanish MT, Cohen CJ and Mager DL (2010) Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer. Semin Cancer Biol 20, 246-253   DOI
6 Serafino A, Balestrieri E, Pierimarchi P et al (2009) The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation. Exp Cell Res 315, 849-862   DOI
7 Rhyu DW, Kang YJ, Ock MS et al (2014) Expression of human endogenous retrovirus env genes in the blood of breast cancer patients. Int J Mol Sci 15, 9173-9183   DOI
8 Blond JL, Lavillette D, Cheynet V et al (2000) An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 74, 3321-3329   DOI
9 Mi S, Lee X, Li X et al (2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789   DOI
10 Tugnet N, Rylance P, Roden D, Trela M and Nelson P (2013) Human endogenous retroviruses (HERVs) and autoimmune rheumatic disease: is there a link? Open Rheumatol J 7, 13-21   DOI
11 Lindeskog M and Blomberg J (1997) Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes: alternative splicing pattern of HERV-H transcripts. J Gen Virol 78 (Pt 10), 2575-2585   DOI
12 Kewitz S and Staege MS (2013) Expression and regulation of the endogenous retrovirus 3 in Hodgkin's lymphoma cells. Front Oncol 3, 179   DOI
13 Wang-Johanning F, Frost AR, Jian B et al (2003) Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma. Cancer 98, 187-197   DOI
14 Reiche J, Pauli G and Ellerbrok H (2010) Differential expression of human endogenous retrovirus K transcripts in primary human melanocytes and melanoma cell lines after UV irradiation. Melanoma Res 20, 435-440   DOI
15 Kaufmann S, Sauter M, Schmitt M et al (2010) Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor. J Gen Virol 91, 1494-1502   DOI
16 Hahn S, Ugurel S, Hanschmann KM et al (2008) Serological response to human endogenous retrovirus K in melanoma patients correlates with survival probability. AIDS Res Hum Retroviruses 24, 717-723   DOI
17 Jo JO, Kang YJ, Ock MS et al (2016) Expression profiles of HERV-K Env protein in normal and cancerous tissues. Genes Genom 38, 91-107   DOI
18 Oja M, Peltonen J, Blomberg J and Kaski S (2007) Methods for estimating human endogenous retrovirus activities from EST databases. BMC Bioinformatics 8 Suppl 2, S11
19 Contreras-Galindo R, Kaplan MH, Leissner P et al (2008) Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol 82, 9329-9336   DOI
20 Conley AB, Piriyapongsa J and Jordan IK (2008) Retroviral promoters in the human genome. Bioinformatics 24, 1563-1567   DOI
21 Perot P, Mugnier N, Montgiraud C et al (2012) Microarray-based sketches of the HERV transcriptome landscape. PLoS One 7, e40194   DOI
22 Ishida T, Obata Y, Ohara N et al (2008) Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity. Cancer Immun 8, 15
23 Wang-Johanning F, Frost AR, Jian B, Epp L, Lu DW and Johanning GL (2003) Quantitation of HERV-K env gene expression and splicing in human breast cancer. Oncogene 22, 1528-1535   DOI
24 Kang YJ, Jo JO, Ock MS et al (2014) Human ERV3-1 env protein expression in various human tissues and tumours. J Clin Pathol 67, 86-90   DOI
25 Jeong BH, Lee YJ, Carp RI and Kim YS (2010) The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt-Jakob disease. J Clin Virol 47, 136-142   DOI
26 Li M, Radvanyi L, Yin B et al (2017) Downregulation of Human endogenous retrovirus type K (HERV-K) viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth. Clin Cancer Res 23, 5892-5911   DOI
27 Wang-Johanning F, Rycaj K, Plummer JB et al (2012) Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors. J Natl Cancer Inst 104, 189-210   DOI
28 Lee SH, Kang YJ, Jo JO et al (2014) Elevation of human ERV3-1 env protein expression in colorectal cancer. J Clin Pathol 67, 840-844   DOI
29 Cegolon L, Salata C, Weiderpass E, Vineis P, Palu G and Mastrangelo G (2013) Human endogenous retroviruses and cancer prevention: evidence and prospects. BMC Cancer 13, 4   DOI
30 Kurth R and Bannert N (2010) Beneficial and detrimental effects of human endogenous retroviruses. Int J Cancer 126, 306-314   DOI
31 Freimanis G, Hooley P, Ejtehadi HD et al (2010) A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesis. Clin Exp Immunol 160, 340-347   DOI
32 Krone B and Grange JM (2010) Melanoma, Darwinian medicine and the inner world. J Cancer Res Clin Oncol 136, 1787-1794   DOI