• Title/Summary/Keyword: elucidation

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Synthesis of Some Novel N7-tetrazolo[5,1-f]-1,2,4-triazin-8-(7H)-one Compounds as Potential Antimicrobial Agents

  • El-Badry, Susan M.;Taha, Mamdouh A.M.
    • Journal of the Korean Chemical Society
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    • v.58 no.4
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    • pp.381-387
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    • 2014
  • A series of new $N^7$-tetrazolo[5,1-f ]-1,2,4-triazin-8-(7H)-one derivatives 4-16 were designed and synthesized from 3 with different reagents. The newly prepared compounds were characterized by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains.

Isolation and Structure Elucidation of a New Glycolipid from the Soft Coral Lobophytum microlobulatum Collected from Havellock Island of Andaman and Nicobar Group of Islands

  • Anjaneyulu, Ammanamanchi S.R.;Rao, Nidasanametla S. Kameswara;Garg, H.S.
    • Natural Product Sciences
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    • v.2 no.2
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    • pp.102-105
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    • 1996
  • A new glycolipid, 2-hydroxy-3 $(octadecyloxy)-propyl-{\alpha}-D-arabinopyranoside$ (1) has been isolated from Lobophytum microlobulatum and its structure has been elucidated by physical and spectral $(UV,\;IR,\;^1H,\;^{13}C\;NMR,\;FABMS)$ data.

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Taxoids from the Heartwood of Taxus baccata L. Growing in Turkey

  • Erdemoglu, Nurgun;Sener, Bilge
    • Natural Product Sciences
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    • v.6 no.2
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    • pp.96-101
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    • 2000
  • The ethanolic extract of the heartwood of Taxus baccata L. afforded six taxoids, belonging to the skeletally three different groups, $2{\alpha},\;5{\alpha},\;10{\beta}-triacetoxy-14{\beta}-(2-methyl)-butryloxy-4(20)$,11-taxadiene (1), taxusin (2), baccatin VI (3), baccatin III (4), $1{\beta}-hydroxybaccatin$ I (5) and taxol (6). The isolation and structure elucidation of three taxoids (3-5) have been presented in this study. This is the first report for the presence of these taxoids in Taxus baccata L. growing in Turkey.

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Analytical Separation of Isomeric Saponins by LC/MS

  • Young, Han-Suk;Park, Jong-Cheol;Choi, Jae-Sue
    • Korean Journal of Pharmacognosy
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    • v.19 no.4
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    • pp.248-250
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    • 1988
  • The application of LC/MS system with FRIT-FAB LC/MS interface in both positive and negative ion modes to the analytical separation of isomeric saponins was studied. The two isomeric saponins such as rosamultin and arjunetin were well separated and analyzed FRIT, FAB LC/MS system. This is another examples to structure elucidation of natural products.

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Structure Elucidation for New Sestertepene Alkaloids from the Sponge Sacotragus sp.

  • Rho, Jung-Rae;Shin, Jong-Heon;Lee, Hyi-Seung
    • Journal of the Korean Magnetic Resonance Society
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    • v.7 no.1
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    • pp.55-61
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    • 2003
  • Sarcotragins C(1) and D(2), two novel compounds, have been isolated from the sponge Sarcotragus sp. collected from Jaeju Island, Korea. The structures of these compounds have been determined to be linear sesterterpene alkaloids on the basis of combined 1D and 2D NMR experiments. The stereochemistry involved was established by comparison of the NMR data with those reported for a similar compound.

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A study of the electrical neuronal model (신경세포의 전기적 모델화)

  • 박상희;이명호
    • 전기의세계
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    • v.24 no.6
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    • pp.97-101
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    • 1975
  • The electrical neuronal model described in this paper simulates the most important functional properties of nerve cells. An model circuit incorporating many of the digital and analog properties of neurons is described. Having such properties as variable threshold level, action potential, summation, all-or-none output, absolute and relative refract oriness, and ingibition, it exhibits a considerable amount of functional equivalence to biological structures. This electrical neuronal model has utility not only for studying single unit properties but also for investigating group interactions. Such studies may be relevent to elucidation of neuronal network behavior.

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NMR and Molecular Modeling Studies on the Structures of AA Mismatched DNA Oligomers

  • Lee, Chulhyun;Chaejoon Cheong;Lee, Jo-Woong
    • Proceedings of the Korean Biophysical Society Conference
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    • 1998.06a
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    • pp.21-21
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    • 1998
  • Since the repair efficiency of non-Watson-Crick base pairs in DNA is affected by the mismatched base-pairs and their neighbor sequences, the structural studies are necessary for the elucidation of the repair efficiency. NMR and molecular modeling studies on the DNA duplexes including AA mismatches were performed.(omitted)

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A Search for Endogenous Digitalis-like Factors (인체 및 고등 동물에서 생성되는 디기탈리스 유사체의 탐색)

  • 송영순
    • YAKHAK HOEJI
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    • v.30 no.4
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    • pp.198-201
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    • 1986
  • The successful elucidation of the opiate receptor and its natural ligands has generated speculation that other drugs might interact with cellular sites designed to accommodate endogenous mediators. The properties of binding sites for the cardiac glycosides(CG), together wit the potency and specificity of the digitalis drugs suggest that CG mimic an endogenous digitalis-like factor. Recenthy, several laboratories have reported the potency in mammalian tissues and fluids of unidentified materials that share certain specific propeties of the CG. Identification of body's own digitalis might yield a natural co pound whose synthetic analogs may provide safer and more effective drugs than can be achieved by structural edification of the CG of plant origin.

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