• Structural Engineering and Mechanics
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• 제74권1호
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• pp.69-82
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• 2020

A significant defect of space structures is the progressive collapse issue which may restrict their applicability. Force limiting devices (FLDs) have been designed to overcome this deficiency, though they don't operate efficiently in controlling the force displacement characteristics. To overcome this flaw, a new type of FLD is introduced in the present study. The "all steel accordion force limiting device" (AFLD) which consists of three main parts including cylindrical accordion solid core, tubular encasing and joint system is constructed and its behavior has been studied experimentally. To improve AFLD's behavior, Finite element analysis has been carried out by developing models in ABAQUS software. A comprehensive parametric study is done by considering the effective design parameters such as core material, accordion wave length and accordion inner diameter. From the results, it is found that AFLD can obtain a perfect control on the force-displacement characteristics as well as attaining the elastic-perfect plastic behavior. Obtaining higher levels of ultimate load carrying capacity, dissipated energy and ductility ratio can be encountered as the main privileges of this device. Ease of construction and erection are found to be further advantages of AFLD. Based on the obtained results, a procedure for predicting AFLD's behavior is offered.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2003년도 추계학술대회 논문집 Vol.16
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• pp.571-574
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• 2003

The thin films fabricated by using the layer-by-layer sputtering was compared with the thin film fabricated by using the evaporation method. Re-evaporation in the form of Bi atoms or $Bi_2O_3$ molecules easily bring out the deficiency of Bi atoms in thin film due to the long sputtering time of the layer-by-layer deposition. On the other hand, the respective atom numbers corresponding to BiSrCaCuO phase is concurrently supplied on the film surface in the evaporation deposition process and leads to BiSrCaCuO phase formation. Also, it is cofirmed that by optimizing the deposition condition, each single phase of the Bi2201 phase and the Bi2212 phase can be fabricated, the sticking coefficient of Bi element is clearly related to the changing of substrate temperature and the formation of the Bi2212 phase.

• 대한토목학회논문집
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• 제13권3호
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• pp.25-34
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• 1993

지하구조물은 일반적으로 영역의 무한성, 다양한 하중, 복합적인 구성재료 등으로 인하여 그 거동의 해석이 난이하다. 특히, 장기거동이 중요시되는 연약지반의 굴착문제 등에 있어서는 시간에 의존하는 점탄소성거동을 해석에 고려하여야만 한다. 본 연구에서는 점탄소성거동을 해석하는 방법으로서, 내부요소를 사용하지 않은 경계요소 해석방법을 유도하고, 정계요소와 유한요소를 조합하여 해석하는 방법을 도출하였다. 점탄소성을 고려한 지배적분방정식에서 점소성응력에 대한 영역적분은 극좌표를 이용한 직접적분방법을 적용하여 경계적분화하였고, 이에 따른 계방정식을 이용하여 프로그램화하였다. 또한 경제요소 프로그램을 점소성 유한요소 프로그램과 조합하여 굴착면 주위에 발생하는 시간의존 비탄성거동을 합리적으로 해석하도록 하였다. 경계요소해석 및 조합해석 결과는 정해 및 유한요소해석의 결과와 비교하여 검토하였다. 비교결과 내부요소를 사용하지 않은 경계요소법으로는 국부적인 응력집중으로 인한 비선형성이 충분히 고려되지 못함을 알 수 있었다. 반면에 유한요소-경계요소 조합방법으로는 상대적으로 많은 자유도를 가진 타 방법에 비교하여 합리적인 결과를 얻음을 알 수 있었다. 따라서 시간에 의존되는 비탄성체의 해석에 있어서 조합방법을 사용하면 하중조건과 경계조건에 따르는 구조물의 거동을 합리적으로 예측할 수 있으며, 유한요소와 경계요소의 장점을 살려 보다 효용적인 해석의 수행이 가능할 것으로 판단된다.

• Toxicological Research
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• 제23권3호
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• pp.279-287
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• 2007

Copper (Cu) is an essential trace element indispensable for brain development and function; either excess or deficiency in Cu can cause brain malfunction. While it is known that Cu and Fe homeostasis are strictly regulated in the brain, the question as to how systemic Fe status may influence brain Cu distribution was poorly understood. This study was designed to test the hypothesis that dietary Fe condition affects Cu transport into the brain, leading to an altered brain distribution of Cu. Rats were divided into 3 groups; an Fe-deficient (Fe-D) group which received an Fe-D diet ($3{\sim}5 mg$ Fe/kg), a control group that was fed with normal diet (35mg Fe/kg), and an Fe-overload group whose diet contained an Fe-O diet (20g carbonyl Fe/kg). Following a 4-week treatment, the concentration of Cu/Fe in serum, CSF (cerebrospinal fluid) and brain were determined by AAS, and the uptake rates of Cu into choroids plexus (CP), CSF, brain capillary and parenchyma were determined by an in situ brain perfusion, followed by capillary depletion. In Fe-D and Fe-O, serum Fe level decreased by 91% (p<0.01) and increased by 131% (p<0.01), respectively, in comparison to controls. Fe concentrations in all brain regions tested (frontal cortex, striatum, hippocampus, mid brain, and cerebellum) were lower than those of controls in Fe-D rats (p<0.05), but not changed in Fe-O rats. In Fe-D animals, serum and CSF Cu were not affected, while brain Cu levels in all tested regions (frontal cortex, striatum, hippocampus, mid brain, and cerebellum) were significantly increased (p<0.05). Likewise, the unidirectional transport rate constants $(K_{in})$ of Cu in CP, CSF, brain capillary and parenchyma were significantly increased (p<0.05) in the Fe-D rats. In contrast, with Fe-O, serum, CSF and brain Cu concentrations were significantly decreased as compared to controls (p<0.05). Cu transport was no significant change of Cu transport of serum in Fe-O rats. The mRNA levels of five Cu-related transporters were not affected by Fe status except DMT1 in the CP, which was increased in Fe-D and decreased in Fe-O. Our data suggest that Cu transport into brain and ensuing brain Cu levels are regulated by systemic Fe status. Fe deficiency appears to augment Cu transport by brain barriers, leading to an accumulation of Cu in brain parenchyma.

• Journal of Preventive Medicine and Public Health
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• 제37권4호
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• pp.329-336
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• 2004

Objectives : Iron (Fe) is an essential element in biological processes; however excessive Fe is harmful to human health. Some air pollutants contain a high level of Fe, and the human lung could therefore be over-exposed to Fe through inhaled air pollutants. This study was performed to investigate the role of metal transporters (divalent metal transporter 1, DMT1, and metal transporter protein 1, MTP1) in the lung under the environments of Fe deficiency in the body and Fe over-exposure in the lung. Methods : Rats were fed Fe deficient (FeD, 2-6 mg Fe/kg) or Fe supplemented (FeS, 120 mg Fe/kg) diet for 4 weeks, followed by a single intratracheal instillation of ferrous sulfate at low (10 mg/kg) or high (20 mg/kg) dose. Fe concentration was analyzed in the serum, lung and liver, and histopathological findings were observed in the lung at 24 hours after Fe administration. The level of DMT1 and MTP1 expression in the lung was analyzed by RT-PCR. Also, the effect of Fe deficiency in the body was evaluated on the level of Fe concentration and metal transporters compared to FeS-diet fed rats at the end of 4-week FeD or FeS diet. Results : The 4-week FeD diet in rats induced an Fe deficiency anemia with decreased serum total Fe, increased unsaturated Fe binding capacity and hypochromic microcytic red blood cells. The concentration of Fe in the lung and liver was lower in the FeD-diet fed rats than in the FeS-diet fed rats. The level of metal transporters mRNA expression was higher in the FeD-diet fed rats than in the FeS-diet. The concentration of Fe in the lung was increased in a dose-dependent pattern after intratracheal instillation of Fe into the rats, while the level of Fe in the serum and liver was not increased in the low-dose Fe administered rats. Therefore, DMT1 and MTP1 mRNA was highly expressed in both FeD-diet and FeS-diet fed rats, after intratracheal instillation of Fe. Conclusions : DMT1 and MTP1 mRNA were more highly expressed in FeD-diet fed rats than in FeS-diet fed rats. The over-exposure of Fe intratracheally induced high expression of metal transporters and increased Fe deposition in the lung in both FeD-diet and FeS-diet fed rats, but did not increase the Fe level of the serum and liver in low-dose Fe administered rats. These results suggest that the role of metal transporters in the lung might be different in a part from the duodenum under the environment of over-exposure to Fe.

• 한국컴퓨터정보학회논문지
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• 제18권9호
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• pp.121-129
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• 2013

본 논문은 아직까지 정확한 해를 다항시간으로 구하는 알고리즘이 존재하지 않아 NP-완전 문제로 알려진 지배집합 (DS) 문제의 정확한 해를 선형시간으로 구하는 알고리즘을 제안하였다. 제안된 알고리즘은 그래프의 간선이 존재하지 않을 때까지 최소차수 ${\delta}(G)$를 가진 정점 u의 인접정점들 중 최대차수 ${\Delta}(G)$를 가진 정점 v를 최소 독립지배집합(MIDS)의 원소로 포함시키고 v의 부속 간선을 삭제하는 방법을 반복적으로 수행하여 구하였다. MIDS로부터 최소 지배집합 (MDS)으로 변환시키고, MDS로부터 최소연결 DS (MCDS)로 변환시키는 방법으로 DS 관련 모든 문제의 정확한 해를 구할 수 있었다. 제안된 알고리즘을 10개의 다양한 그래프에 적용한 결과 정확한 해를 선형 시간복잡도 O(n)으로 구하는데 성공하였다. 결국, 제안된 지배집합 알고리즘은 지배집합 문제가 P-문제임을 증명하였다.

• Nutrition Research and Practice
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• 제14권6호
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• pp.568-579
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• 2020

BACKGROUD/OBJECTIVES: Hepatic steatosis is the most common liver disorder, particularly in postmenopausal women. This study investigated the protective effects of standardized rice bran extract (RBS) on ovariectomized (OVX)-induced hepatic steatosis in rats. MATERIALS/METHODS: HepG2 cells were incubated with 200 µM oleic acid to induce lipid accumulation with or without RBS and γ-oryzanol. OVX rats were separated into three groups and fed a normal diet (ND) or the ND containing 17β-estradiol (E2; 10 ㎍/kg) and RBS (500 mg/kg) for 16 weeks. RESULTS: RBS supplementation improved serum triglyceride and free fatty acid levels in OVX rats. Histological analysis showed that RBS significantly attenuated hepatic fat accumulation and decreased hepatic lipid, total cholesterol, and triglyceride levels. Additionally, RBS suppressed the estrogen deficiency-induced upregulation of lipogenic genes, such as sterol regulatory element-binding protein 1 (SREBP1), acetyl-CoA carboxylase 1, fatty acid synthase, glycerol-3-phosphate acyltransferase, and stearoyl-CoA desaturase 1. CONCLUSIONS: RBS and γ-oryzanol effectively reduced lipid accumulation in a HepG2 cell hepatic steatosis model. RBS improves OVX-induced hepatic steatosis by regulating the SREBP1-mediated activation of lipogenic genes, suggesting the benefits of RBS in preventing fatty liver in postmenopausal women.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.487-492
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• 2012

Trace element zinc deficiency or excess is implicated in the development or progression of some cancers. The exact role of zinc in the etiology of colon cancer is unclear. To cast light on this question, an experimental model of colon carcinogenesis was applied here. Six week old rats were given sub cutaneous injections of DMH (30 mg/kg body weight) twice a week for three months and sacrificed after 4 months (precancer model) and 6 months (cancer model). Plasma zinc levels showed a significant decrease (p<0.05) at 4 months and a greater significant decrease at 6 months (p<0.01) as compared with controls. In the large intestine there was a significant decrease in tissue zinc levels (p<0.005) and in CuZnSOD, and alkaline phosphatase activity (p<0.05) in the pre-cancerous model and a greater significant decrease in tissue zinc (p<0.0001), and in CuZnSOD and alkaline phosphatase activity (p<0.001), in the carcinoma model. The tissue zinc levels showed a significant decrease in the small intestine and stomach (p<0.005) and in liver (p<0.05) in the cancer model. 87% of the rats in the precancer group and 92% rats in the cancer group showed histological evidence of precancerous lesions and carcinomas respectively in the colon mucosa. This study suggests that the decrease in plasma zinc, tissue zinc and activity of zinc related enzymes are associated with the development of preneoplastic lesions and these biochemical parameters further decrease with progression to carcinoma in the colon.

• Computers and Concrete
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• 제17권5호
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• pp.673-692
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• 2016

In the standards, minimum reinforcement ratios are presented as the least reinforcement ratios that bearing elements should have in a way to include all systems and in general. However, naturally these general minimum ratios might be presented as being lower than the normally required reinforcement ratios by criteria such as system size, bearing system arrangement, section situation and distributions of the elements and earthquake effect. In this case, minimum reinforcement ratios may remain as meaningless restrictions. Then grouping the criterion that might affect reinforcement ratios according to certain parameters and creating minimum reinforcement ratios regarding preliminary design will provide ease and safety during the project designing. Moreover, it will enable fast and simple examinations in the beginning of project control and evaluation process. By means of the data which could be defined as "preliminary design & minimum reinforcement ratios", a more realistic and safe restriction compared to general minimum reinforcement ratios could be presented. As a result of numerous comprehensive studies, reinforcement ratios to include all certain systems might be obtained. Today, thanks to the development level of finite elements programs which can make reinforced concrete modelling, with the studies that are impossible to carry out beforehand, this deficiency in the minimum reinforcement ratios in the standarts may at least be partially made up with the advisory regulation of preliminary design & minimum reinforcement ratios. As the structure of the system to be examined and the diversity of the parameters range from the specific to the general, preliminary design & minimum reinforcement ratios will approximate to general minimum reinforcement ratios in real terms. By focusing on a more specific system structure and diversity of the parameters, preliminary design and even design reinforcement ratios will be approximated. In this preliminary study, a route between these two extremes was attempted to be followed. Today, it is possible to determine suggested practical ratios for project designs through carrying out numerous studies.

• Steel and Composite Structures
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• 제27권5호
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• pp.577-598
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• 2018

The imperfect steel-concrete interface bonding is an important deficiency of the concrete-filled double skin tubular (CFDST) columns that led to separating concrete and steel surfaces under lateral loads and triggering buckling failure of the columns. To improve this issue, it is proposed in this study to use longitudinal and transverse steel stiffeners in CFDST columns. CFDST columns with different patterns of stiffeners embedded in the interior or exterior surfaces of the inner or outer tubes were analyzed under constant axial force and reversed cyclic loading. In the finite element modeling, the confinement effects of both inner and outer tubes on the compressive strength of concrete as well as the effect of discrete crack for concrete fracture were incorporated which give a realistic prediction of the seismic behavior of CFDST columns. Lateral strength, stiffness, ductility and energy absorption are evaluated based on the hysteresis loops. The results indicated that the stiffeners had determinant role on improving pinching behavior resulting from the outer tube's local buckling and opening/closing of the major tensile crack of concrete. The lateral strength, initial stiffness and energy absorption capacity of longitudinally stiffened columns with fixed-free end condition were increased by as much as 17%, 20% and 70%, respectively. The energy dissipation was accentuated up to 107% for fixed-guided end condition. The use of transverse stiffeners at the base of columns increased energy dissipation up to 35%. Axial load ratio, hollow ratio and concrete strength affecting the initial stiffness and lateral strength, had negligible effect of the energy dissipation of the columns. It was also found that the longitudinal stiffeners and transverse stiffeners have, respectively, negative and positive effects on ductility of CFDST columns. The conclusions, drawn from this study, can in turn, lead to the suggestion of some guidelines for the design of CFDST columns.