• The Journal of Korean Physical Therapy
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• 제33권2호
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• pp.106-113
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• 2021

Purpose: This study examined the effectiveness of action observation training (AOT) and mirror therapy in improving the electroencephalograms (EEG) of stroke patients. Methods: Patients were allocated randomly to three groups: an action observation training with activity (AOTA) group (n=12), a mirror therapy with activity (MTA) group (n=11), and an AOT-only group (n=12). All groups received conventional physiotherapy in five 60-minute sessions over six weeks. The AOTA, MTA, and AOT groups practiced AOTA, MTA, and AOT, respectively, in three 30-minute sessions over six weeks. The differences between the pre- and post-treatment EEGs were assessed using a paired t-test. Comparisons between the groups were performed using one-way ANOVA. Results: The participants in the AOTA and MTA groups showed significant improvement in the EEG. AOTA improved the alpha waves of the prefrontal, temporal, and parietal lobes significantly (p<0.05). MTA improved the alpha waves of the temporal lobe significantly (p<0.05). AOT did not result in significant improvement Conclusion: AOTA and MTA improve stroke patients' EEGs. Mirror neuron activation combined with conventional stroke physiotherapy promotes motor recovery and functioning. The effect is enhanced when the actions are executed after observation. Further research into mirror neuron activation will be needed to develop methods to improve the EEGs of stroke patients.

• 대한의용생체공학회:의공학회지
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• 제39권2호
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• pp.94-102
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• 2018

It is known that gamma-band activity (GBA) and phase synchrony (GBPS) are induced by emotional visual stimuli. However, the characteristics of GBA and GBPS according to different emotional states have not been identified. The purpose of this study is to investigate the changes in gamma-band neuronal synchronization induced by positive and negative emotional visual stimuli using electroencephalograms (EEGs). Thirteen healthy male subjects have participated in the experiment. The induced spectral power in gamma-band was the highest for negative stimuli, and the lowest for neutral stimuli in 300-2,000 ms after the stimulus onset. The inter-regional phase synchronization in gamma-band was increased in 500-2,000 ms, mainly between the bilateral frontal regions and the parieto-occipital regions. Larger number of significant connections were found by negative stimuli compared to positive ones. Judging from temporal and spatial characteristics of the gamma-band activity and phase synchrony increases, the results may imply that affective visual stimuli cause stronger memory encoding than non-emotional stimuli, and this effect is more significant for negative emotional stimuli than positive ones.

• 한국멀티미디어학회논문지
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• 제14권9호
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• pp.1202-1209
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• 2011

Neuro feedback training using ElectroEncephalo Grams (EEGs) is commonly utilized in the treatment of Alzheimer's disease, and Attention Deficit Hyperactivity Disorder (ADHD). Recently, BCI (Brain-computer Interface) contents have developed, not for the purpose of treatment, but for concentration improvement or brain relaxation training. However, as each user has different wave forms, it is hard to develop contents controlled by such different wave. Therefore, an EEG process that allows the ability to transform the variety of wave forms into one standard signal and use it without taking a user's characteristic of EEG into account, is required. In this paper, a framework that can reduce users' characteristics by normalizing and converting measured EEGs is proposed for contents. This framework also contains the process that controls different brainwave measuring devices. In experiment a handling process applying the proposed framework to the developed BCI contents is introduced.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1998년도 춘계학술발표 논문집
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• pp.70-74
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• 1998

Liner complexity(LC), which could quantify the modal structure, were calculated from electroencephalograms(EEGs) in four states such as a pleasant and relaxed, a pleasant and aroused, an unpleasant and relaxed, and an unpleasant and aroused state. Each state was evoke by visual stimuli of relaxed or aroused state, LC could discriminate statistically state(t-test; p<0.01). LCs in pleasant states were larger than those in unpleasant ones.

• 대한의용생체공학회:의공학회지
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• 제39권3호
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• pp.124-133
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• 2018

We tried to investigate the changes in cortical activities according to emotional valence states during watching video clips. We examined the neural basis of two emotional states (positive and negative) using spectral power analysis and brain functional connectivity analysis of cortical current density time-series reconstructed from high-density electroencephalograms (EEGs). Fifteen healthy participants viewed a series of thirty-two 2 min emotional video clips. Sixty-four channel EEGs were recorded. Distributed cortical sources were reconstructed using weighted minimum norm estimation. The temporal and spatial characteristics of spectral source powers showing significant differences between positive and negative emotion were examined. Also, correlations between gamma-band activities and affective valence ratings were determined. We observed the changes of cortical current density time-series according to emotional states modulated by video clip. Gamma-band activities showed significant difference between emotional states for thirty seconds at the middle and the latter half of the video clip, mainly in prefrontal area. It was also significantly anti-correlated with the self-ratings of emotional valence. In addition, the gamma-band activities in frontal and temporal areas were strongly phase-synchronized, more strongly for negative emotional states. Cortical activities in frontal and temporal areas showed high spectral power and inter-regional phase synchronization in gamma-band during negative emotional states. It is inferred that the higher amygdala activation induced by negative stimuli resulted in strong emotional effects and caused strong local and global synchronization of neural activities in gamma-band in frontal and temporal areas.

• The Korean Journal of Physiology and Pharmacology
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• 제23권2호
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• pp.131-139
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• 2019

Manually reviewing electroencephalograms (EEGs) is labor-intensive and demands automated seizure detection systems. To construct an efficient and robust event detector for experimental seizures from continuous EEG monitoring, we combined spectral analysis and deep neural networks. A deep neural network was trained to discriminate periodograms of 5-sec EEG segments from annotated convulsive seizures and the pre- and post-EEG segments. To use the entire EEG for training, a second network was trained with non-seizure EEGs that were misclassified as seizures by the first network. By sequentially applying the dual deep neural networks and simple pre- and post-processing, our autodetector identified all seizure events in 4,272 h of test EEG traces, with only 6 false positive events, corresponding to 100% sensitivity and 98% positive predictive value. Moreover, with pre-processing to reduce the computational burden, scanning and classifying 8,977 h of training and test EEG datasets took only 2.28 h with a personal computer. These results demonstrate that combining a basic feature extractor with dual deep neural networks and rule-based pre- and post-processing can detect convulsive seizures with great accuracy and low computational burden, highlighting the feasibility of our automated seizure detection algorithm.

• 국제물리치료학회지
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• 제10권1호
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• pp.1687-1694
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• 2019

Background: Although cranial electrotherapy stimulation (CES) is reported to have positive effects on mental functions such as depression and sleep improvement, detailed studies regarding awakening, attention and concentration among brain waves reflecting brain activity are lacking. Objective: To examine the effects of cranial electrotherapy stimulation (CES) on various electroencephalograms (EEGs) reflecting brain activities. Design: Randomized controlled clinical trial (single blind) Methods: This study selected 30 healthy adult women in their 20s who volunteered for this experiment. A total of 30 subjects were randomly assigned to three groups (Sham group, 0.5 Hz CES group, and 100 Hz CES group). EEGs were measured before and after the single CES, and the results were compared and analyzed. Results: The relative theta, alpha, and gamma waves indicated no significant differences in the interaction effects between time and group. The relative fast alpha wave only showed significant differences in the interaction effects between time and group in P4. The relative slow beta wave only indicated statistically significant differences in the interaction effects between time and group in T3 and T4. The relative mid and fast beta waves showed statistically significant differences in the interaction effects between time and group in all areas. Conclusions: These results suggest that a CES of 0.5 Hz awakens consciousness and has a positive influence on brain activity, while a CES of 100 Hz has a positive influence on thinking activity accompanying mental load during concentrating on one subject.

• Clinical and Experimental Pediatrics
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• 제51권12호
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• pp.1324-1328
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• 2008

목 적: 주의력 결핍/과잉 운동 장애(ADHD)를 진단받은 환아를 대상으로 뇌파 결과의 차이 및 이에 따른 역학적 비교를 하고자 하였으며 뇌파의 차이에 따른 경련 발현의 차이를 비교해보고자 하였다. 또한 ADHD의 치료제로 사용되는 중추신경자극제의 사용과 경련 발현과의 연관성을 비교하고자 하였다. 방 법: 2001년 1월부터 2005년 12월까지 주의산만을 주소로 충북대학교병원 소아청소년과 및 소아정신과 외래를 내원한 환아를 대상으로 의무기록지 고찰을 통해 후향적으로 분석하였다. 결과: 이전 경련의 병력이 없는 환아중 주의산만을 주소로 본원 신경정신과를 방문한 환아를 대상으로 하였다. 대상 연령은 4세에서 17세 사이로 총 308명의 환아들 중 84명의 환아에서 뇌파를 시행하였으며 그중 남자가 72명(85.7%, 평균 연령 9.3세), 여자가 12명(14.3%, 평균 연령 8.0세)이었다. 정상뇌파소견을 보인 환아가 65명(77.4%), 이상뇌파소견을 보인 환아가 19명(22.6%)였으며 이중 경련증상을 보인 환아는 각각 1명(0.15%), 3명(15.7%)이었다. 중추신경자극제를 처방 받은 환자는 59명, 그렇지 않은 환자는 25명이었고 그중 경련증상을 보인경우는 각각 2명(3.4%), 2명(8.0%)로 나타났다. 결 론: ADHD 환아들은 임상에서는 표출되지 않으나 뇌파에서의 잠재적인 이상 소견 보일 수 있다. 본 연구에서는 이러한 뇌파의 이상 소견과 추후 경련 발현 여부와는 매우 높은 연관성을 보이고 있으며, ADHD의 치료로써 사용된 methylphenidate의 사용에 따른 경련 발현과의 통계적 유의성은 보이지 않았다. 따라서 ADHD 환아들에서 뇌파의 이상 소견이 보일 경우는 향후 경련 발현에 대한 보다 주의 깊은 추적 관찰과 함께 ADHD 환아들의 삶의 질 향상에 대한 적극적인 치료가 필요할 것으로 사료된다.

• 사상체질의학회지
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• 제12권1호
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• pp.37-47
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• 2000

작업자의 기질적 특성, 능력 등을 고려하지 않고 이루어진 작업들은 제조현장의 많은 문제점들이 되고 있으며 이런 결과들은 산업재해 및 직업병의 원인을 제공할 뿐만 아니라 제조경영 관점에서 품질 및 생산성 저하의 결과들을 초래하고 있는 실정이다. 따라서 본 연구에서는 이와 같은 제반 문제점들을 해결하기 위해 중소기업의 작업특성과 사상체질간의 구명을 시도한다. 체질의 기존의 이론인 사상체질(태양인, 태음인, 소양인, 소음인)을 QSCC II와 한의사의 도움으로 실질적인 구분을 실시하고, 체질이론의 공학적 응용의 기존문헌을 고찰한다. 또한 본 연구에서는 농기계 전문생산 업체를 중심으로 특정 사상체질의 작업자 중심으로 주요 작업특성을 해석하고 그 결과 작업자의 체질에 따라 작업특성이 다르게 나타남을 알 수 있다. 한편, 실증적 연구로서 비디오 카메라로 촬영한 작업현장의 장면을 가상현실 장비 및 EEGs를 사용하여 체질변화에 따른 작업자의 뇌파효과를 조사한다. 조사된 뇌파 데이터를 통계분석 처리하여 그 다양한 뇌파 변화의 관계성을 보여준다. 최종 연구결과들은 추후 작업특성간의 비교 연구과정을 통해 기업의 생산성 향상과 품질 증진에 크게 공헌할 것으로 추측된다.

• Clinical and Experimental Pediatrics
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• 제54권9호
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• pp.380-384
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• 2011

Purpose: To investigate the efficacy of topiramate monotherapy in West syndrome prospectively. Methods: The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a maximum of 12 mg/kg/day. Clinical assessment was based on the parents' report and a neurological examination every 2 weeks for the first 2 months of treatment. The baseline electroencephalograms (EEGs) were compared with the post-treatment EEGs at 2 weeks and 1 month. Results: West syndrome was considered to be cryptogenic in 7 of the 28 patients and symptomatic in 21 patients. After treatment, 11 patients (39%) became spasm-free, 6 (21%) had more than 50% spasms-reduction, 3 (11%) showed less than 50% reduction, and 8 (29%) did not respond. The effective daily dose for achieving more than 50% reduction in spasm frequency, including becoming spasm-free, was found to be $5.8{\pm}1.1$ mg/kg/day. Nine patients (32%) showed complete disappearance of spasms and hypsarrhythmia, and 11 (39%) showed improved EEG results. Despite adverse events (4 instances of irritability, 3 of drowsiness, and 1 of decreased feeding), no patients discontinued the medication. Conclusion: Topiramate monotherapy seems to be effective and well tolerated as a first line therapy for West syndrome and is not associated with serious adverse effects.