• Journal of Animal Science and Technology
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• 제53권3호
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• pp.195-202
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• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• 대한의생명과학회지
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• 제21권4호
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• pp.181-187
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• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• 한국환경보건학회지
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• 제40권1호
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• pp.17-26
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• 2014

Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.

• Journal of Korean Neurosurgical Society
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• 제61권2호
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• pp.258-266
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• 2018

Objective : The diagnosis of insufficiency fractures of the sacrum in an elder population increases annually. Fractures show very different morphology. We aimed to classify sacral insufficiency fractures according to the position of cortical break and possible need for intervention. Methods : Between January 1, 2008 and December 31, 2014, all patients with a proven fracture of the sacrum following a low-energy or an even unnoticed trauma were prospectively registered : 117 females and 13 males. All patients had a computer tomography of the pelvic ring, two patients had a magnetic resonance imaging additionally : localization and involvement of the fracture lines into the sacroiliac joint, neural foramina or the spinal canal were identified. Results : Patients were aged between 46 and 98 years (mean, 79.8 years). Seventy-seven patients had an unilateral fracture of the sacral ala, 41 bilateral ala fractures and 12 patients showed a fracture of the sacral corpus : a total of 171 fractures were analyzed. The first group A included fractures of the sacral ala which were assessed to have no or less mechanical importance (n=53) : fractures with no cortical disruption ("bone bruise") (A1; n=2), cortical deformation of the anterior cortical bone (A2; n=4), and fracture of the anterolateral rim of ala (A3; n=47). Complete fractures of the sacral ala (B; n=106) : parallel to the sacroiliac joint (B1; n=63), into the sacroiliac joint (B2; n=19), and involvement of the sacral foramina respectively the spinal canal (B3; n=24). Central fractures involving the sacral corpus (C; n=12) : fracture limited to the corpus or finishing into one ala (C1; n=3), unidirectional including the neural foramina or the spinal canal or both (C2; n=2), and horizontal fractures of the corpus with bilateral sagittal completion (C3; n=8). Sixty-eight fractures proceeded into the sacroiliac joint, 34 fractures showed an injury of foramina or canal. Conclusion : The new classification allowes the differentiation of fractures of less mechanical importance and a risk assessment for possible polymethyl methacrylate leaks during sacroplasty in the direction of the neurological structures. In addition, identification of instable fractures in need for laminectomy and surgical stabilization is possible.

• Journal of the Korean Data and Information Science Society
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• 제28권1호
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• pp.131-142
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• 2017

매년 폐렴 입원 환자 수는 증가하는 추세이며, 국내 질환 중 입원율 1위이기도 하다. 주로 박테리아와 바이러스가 주된 원인인 폐렴은 날씨의 영향을 받기도 한다. 본 연구에서는 날씨 변수로는 습도, 일조량, 일교차, 평균온도, 미세먼지 농도를 각각 1일 전부터 27일 전까지의 총 135개 변수를 고려하였다. 날씨와 입원 환자 수에 잠재적으로 영향을 미치는 위험 요인으로 연도 효과, 휴일 효과, 계절 효과를 추가적으로 고려하였다. 벌점화 일반화 선형 모형을 이용하여 폐렴 입원 환자 수와 관련된 변수를 선택하였다.

• 농촌의학ㆍ지역보건
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• 제45권1호
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• pp.1-12
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• 2020

본 연구는 지역사회 보건진료소를 이용하는 농촌노인의 상실감과 자살생각과의 관계에서 우울의 매개효과를 확인하기 위한 서술적 조사연구이다. 연구대상자는 전남지역 보건진료소의 건강증진프로그램을 3년 이상 꾸준히 이용하고 이는 65세 이상의 노인으로 총 345명으로, 자료분석은 SPSS 21.0을 이용하여, 기술통계, 상관분석, 위계적 회귀분석, Sobel test 방법으로 분석하였다. 본 연구결과, 지역사회 보건진료소를 이용하는 노인의 상실감과 우울 및 자살생각은 모두 정적상관을 나타내었다. 또한 지역사회 보건진료소를 이용하는 노인의 상실감과 자살생각과의 관계에서 우울의 부분매개효과가 있음을 확인하였다. 본 연구결과에 근거하여 지역사회 노인의 자살생각을 감소시키기 위해서는 보건진료소를 이용하는 노인들의 상실감과 우울을 감소시킬 수 있는 중재방안이 필요할 것으로 보인다. 이에 본 연구자는 보건진료소에서 제공하고 있는 건강증진프로그램과 함께 우울을 감소시킬 수 있는 정신건강프로그램을 결합하여 확장시키는 것이 바람직할 것으로 사료된다.

• 농촌의학ㆍ지역보건
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• 제19권1호
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• pp.15-23
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• 1994

In order to find out the frequencies of symptoms and the relations between the symptoms and working hours, the numbers of spraying pesticides authors investigated 145 farmers(96 male, 49 female persons) from 6 Myon's of 3 Gun's in Kyeongnam Province. The results were as follows; 1. The most frequent farming years were 1-5 years, fruits were the most common, and working hours were over 9 hours in 41.4%. The commonly used pesticides were insecticides, herbicides, herbicides in order. Only 52.4% of the farmers used masks, and 69.0% bathed after spraying pesticides. 2. The most common symptoms being complained were sweating, lumbago, shoulder pain, dizziness, headache, fatigue, decreased vision, weight loss, dyspnea and nausea in order. 3. Dizziness was more common in younger ages and decreased vision was more common in elder ages. Dyspnea and shoulder pain were more common in female farmers. 4. The more longer the working hours, the more complained indigestion, lumbago, shoulder pain and nausea. The more faster came into vinyl-house after spraying pesticides, the more common fatigue and dizziness. 5. The farmers who sprayed more pesticides complained headache, dyspnea, weight loss. 6. Vinyl house workers who worked more than 7 hours complained headache, nausea, decreased vision, lumbago more frequently than who worked less than 6 hours. 7. The farmers who entered in 1-2 hours after spraying pesticides complained fatigue more frequently than those entered after 3 hours. 8. Vinyl house workers without using masks complained dizziness and dyspnea more commonly than those using masks. But headache was more common among those using masks contrary to expectation.

• 전기전자학회논문지
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• 제17권1호
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• pp.22-28
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• 2013

노인의 생활안전 사고 유형 중 가장 높은 비율을 차지하는 낙상은 50% 이상이 가정에서 발생하는 것으로 조사되었다. 또한 만 65세 이상 노인의 67.1%는 자녀와 동거를 희망하지 않으며 점점 더 독거노인의 비율은 늘어나, 낙상으로 인한 사고의 발생률은 더 높아질 것이다. 본 연구에서는 실내 바닥의 진동을 측정, 분석하여 낙상의 유무를 판별하고자 하였으며 이를 위해 피에조 필름 센서와 Op-Amp, DAQ를 이용하여 하드웨어를 구성하였다. 여기서 제안한 시스템은 바닥 진동을 측정할 수 있는 신호 처리부, 낙상 발생 시 사용자의 의식 확인을 위한 경보부로 구성하였다. 진동 신호는 k-NN분류기를 이용하여 낙상 유무를 판별한다. 실험결과, 분류기는 3.8%의 오차를 나타내어, 진동을 이용한 낙상 검출 가능성을 보여주고 있다.

• 한국실내디자인학회논문집
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• 제25권1호
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• pp.56-64
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• 2016

Housing for the elderly should be planned on the base of elder's needs and preferences as well as their physical, emotional, and socio-psychological characteristics. This study examined the interior style of bedroom and living room the elderly preferred and these preferences are significantly different depending on their characteristics and cognitive ages, or not. This study was carried out by face to face interview with a questionnaire and 6 colored printed 3D images. The subjects were 202 old aged who lives in Busan. The interior style of bedroom and living room were classified into 3 styles; Korean traditional style, Western classical style, and modern style. The subjects made a choice their preferred interior style among three 3D images per each room and answered the reasons. Also, they answered their cognitive ages and general characteristics, and their preferences for the layout of living room-dining room-kitchen, use pattern, floor finishes, and furniture of bedroom and living room. The results were as follows; 1) The subjects preferred bed in bedroom and sofa in living room. Also, they wanted to finish the floor of bedroom and living room by using synthetic material, traditional floor paper, and wood. 2) The elderly preferred Western classical style of bedroom. The reasons were general mood such as warm, comfort, or bright, and the color. 3) These preferred styles were not any significant differences according to their characteristics and cognitive ages. 4) They preferred Korean traditional style, Western classical style, and modern style, in order. They preferred them for their general mood and window. 5) Their preferred styles were significantly different according to their housing types and cognitive ages.

• 대한지역사회영양학회지
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• 제10권3호
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• pp.290-302
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• 2005

The nutrients intake and health-related habits of nonagenarian subjects in Korean representative longevity belts of Damyang, Gokseong, Kurye, Sunchang were evaluated for the purpose of providing the information on the desirable food selection and dietary pattern of elderly population. A survey was conducted with 91 subjects (26 males and 65 females) and their food intakes were measured by the combination of one meal weighing and 24-hr recall, and their general background information was collected by visit. The mean age of the subjects was 93.6 $\pm$ 2.2 (male) and 97.6 $\pm$ 4.6 (female) The average smoking rate was $20.9\%$, the rate of regular drinking was $26.4\%$. The average energy intake was 1,284.9 kcal comprising $77.1\%$ of RDA for elder people over 75. The energy ratio of carbohydrate, protein and fat were 66.5 : 18.2 : 15.3. The average intake of protein, calcium, iron and zinc were $107.4\%,\;59.9\%,\;106.3\%$ and $60\%$ of RDA respectively. The lower intake of vitamins as low as $70\%$ was found except vitamin $B_6$ and niacin. The majority of the subjects consumed rice as staple diet and mostly consumed white plain rice rather than mixed grain rice. The animal and plant food intakes were 88.4 : 11.6 in males and those of females were 83.0 : 17.0 showing a tendency of plant-based meals. Nutrients that showed NAR over 0.7 were protein, iron, vitamin $B_6$, niacin and phosphate, but those with INQ over 1. Nutrient with INQ below 0.7 was only vitamin E. Even though their nutritional quantity did not appear to be enough, but their nutritional quality was relatively high. The adding dairy products, nuts and fruits for the purpose of proving sufficient vitamin and minerals can achieve the optimal nutritional intake patterns. Further research on RDA of this age population should be followed.