• Journal of Animal Science and Technology
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• v.53 no.3
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• pp.195-202
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• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• Biomedical Science Letters
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• v.21 no.4
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• pp.181-187
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• 2015

Osteoporosis is one of the diseases caused by accumulation of effects from complex interactions between genetic and environmental factors. Aging is the major cause for osteoporosis, which normally increases skeletal fragility and bone fracture especially among the elder. "Omics" refers to a specialized research field dealing with high-throughput biological data, such as genomics, transcriptomics, proteomics or metabolomics. Integration of data from multi-omics has been approved to be a powerful strategy to colligate biological phenomenon with multiple aspects. Actually, integrative analyses of "omics" datasets were used to present pathogenesis of specific diseases or casual biomarkers including susceptible genes. In this study, we evaluated the proposed relationship of novel susceptible genes (TREML2, HTR1E, and GLO1) with osteoporosis, which genes were obtained using multi-omics integration analyses. To this end, SNPs of the susceptible genes in the Korean female cohort were analyzed. As a result, one SNP of HTR1E and five SNPs of TREML2 were identified to associate with osteoporosis. The highest significant SNP was $rs6938076^*$ of TREML2 (OR=0.63, CI: 0.45~0.89, recessive P=0.009). Consequently, the susceptible genes identified through the multi-omics analyses were confirmed to have association with osteoporosis. Therefore, multi-omics analysis might be a powerful tool to find new genes associated with a disease. We further identified that TREML2 has more associated with osteoporosis in females than did HTR1E.

• Journal of Environmental Health Sciences
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• v.40 no.1
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• pp.17-26
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• 2014

Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.

• Journal of Korean Neurosurgical Society
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• v.61 no.2
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• pp.258-266
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• 2018

Objective : The diagnosis of insufficiency fractures of the sacrum in an elder population increases annually. Fractures show very different morphology. We aimed to classify sacral insufficiency fractures according to the position of cortical break and possible need for intervention. Methods : Between January 1, 2008 and December 31, 2014, all patients with a proven fracture of the sacrum following a low-energy or an even unnoticed trauma were prospectively registered : 117 females and 13 males. All patients had a computer tomography of the pelvic ring, two patients had a magnetic resonance imaging additionally : localization and involvement of the fracture lines into the sacroiliac joint, neural foramina or the spinal canal were identified. Results : Patients were aged between 46 and 98 years (mean, 79.8 years). Seventy-seven patients had an unilateral fracture of the sacral ala, 41 bilateral ala fractures and 12 patients showed a fracture of the sacral corpus : a total of 171 fractures were analyzed. The first group A included fractures of the sacral ala which were assessed to have no or less mechanical importance (n=53) : fractures with no cortical disruption ("bone bruise") (A1; n=2), cortical deformation of the anterior cortical bone (A2; n=4), and fracture of the anterolateral rim of ala (A3; n=47). Complete fractures of the sacral ala (B; n=106) : parallel to the sacroiliac joint (B1; n=63), into the sacroiliac joint (B2; n=19), and involvement of the sacral foramina respectively the spinal canal (B3; n=24). Central fractures involving the sacral corpus (C; n=12) : fracture limited to the corpus or finishing into one ala (C1; n=3), unidirectional including the neural foramina or the spinal canal or both (C2; n=2), and horizontal fractures of the corpus with bilateral sagittal completion (C3; n=8). Sixty-eight fractures proceeded into the sacroiliac joint, 34 fractures showed an injury of foramina or canal. Conclusion : The new classification allowes the differentiation of fractures of less mechanical importance and a risk assessment for possible polymethyl methacrylate leaks during sacroplasty in the direction of the neurological structures. In addition, identification of instable fractures in need for laminectomy and surgical stabilization is possible.

• Journal of the Korean Data and Information Science Society
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• v.28 no.1
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• pp.131-142
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• 2017

The number of hospital admissions for pneumonia tends to increase annually and even more, pneumonia, the fifth leading causes of death among elder adults, is one of top diseases in terms of hospitalization rate. Although mainly bacteria and viruses cause pneumonia, the weather is also related to the occurrence of pneumonia. The candidate weather variables are humidity, amount of sunshine, diurnal temperature range, daily mean temperatures and density of particles. Due to the delayed occurrence of pneumonia, lagged weather variables are also considered. Additionally, year effects, holiday effects and seasonal effects are considered. We select the related variables that influence the occurrence of pneumonia using penalized generalized linear models.

• Journal of agricultural medicine and community health
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• v.45 no.1
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• pp.1-12
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• 2020

Purpose: The purpose of this study was to examine the mediating effects of depression on relationship between sense of loss and suicidal ideation among Rural Elders use Primary Health Care Post's Services. Methods: This study was conducted using a descriptive survey design. Participants were 345 rural elders use Primary Health Care Post's Services in Jeollanam-do. Data were collected from August 1 to 31, 2017 using self-report questionnaires. Data were analyzed using descriptive statistics, Pearson's correlation coefficient, hierarchical regression and Sobel test with SPSS 21.0. Results: There were significant positive correlations between sense of loss, depression and suicidal ideation. It was found that physical loss is very high and significantly different only subjective health status on suicidal ideation. Also, Depression partially mediated the relationship between sense of loss and suicidal ideation of Rural Elders. Addtionally, The results show that depression plays a key role in suicidal ideation of Rural Elders. Conclusions: Based on the present findings, nursing interventions should be developed to decrease depression, with additional consideration towards sense of loss, specially physical loss, in order to prevent suicidal ideation among Rural Elders use Primary Health Care Post's Services.

• Journal of agricultural medicine and community health
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• v.19 no.1
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• pp.15-23
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• 1994

In order to find out the frequencies of symptoms and the relations between the symptoms and working hours, the numbers of spraying pesticides authors investigated 145 farmers(96 male, 49 female persons) from 6 Myon's of 3 Gun's in Kyeongnam Province. The results were as follows; 1. The most frequent farming years were 1-5 years, fruits were the most common, and working hours were over 9 hours in 41.4%. The commonly used pesticides were insecticides, herbicides, herbicides in order. Only 52.4% of the farmers used masks, and 69.0% bathed after spraying pesticides. 2. The most common symptoms being complained were sweating, lumbago, shoulder pain, dizziness, headache, fatigue, decreased vision, weight loss, dyspnea and nausea in order. 3. Dizziness was more common in younger ages and decreased vision was more common in elder ages. Dyspnea and shoulder pain were more common in female farmers. 4. The more longer the working hours, the more complained indigestion, lumbago, shoulder pain and nausea. The more faster came into vinyl-house after spraying pesticides, the more common fatigue and dizziness. 5. The farmers who sprayed more pesticides complained headache, dyspnea, weight loss. 6. Vinyl house workers who worked more than 7 hours complained headache, nausea, decreased vision, lumbago more frequently than who worked less than 6 hours. 7. The farmers who entered in 1-2 hours after spraying pesticides complained fatigue more frequently than those entered after 3 hours. 8. Vinyl house workers without using masks complained dizziness and dyspnea more commonly than those using masks. But headache was more common among those using masks contrary to expectation.

• Journal of IKEEE
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• v.17 no.1
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• pp.22-28
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• 2013

According to a survey, more than 50% of the elders fall which is the most frequent daily safety accident of the elders takes place at home. Furthermore, the elders fall is anticipated to increase as more elderly people are expected to live alone since, 67.1% of the elders of 65 or more do not hope to live with their children. This research aims to verify the fall by measuring and analyzing the floor vibration, and the hardware system was also designed was Piezo Film Sensor, Op-Amp, and DAQ. The system is consists of signal processing part for measuring floor vibration and alarm part for identifying the consciousness of the user when the fall occurs. The fall detection by vibration signals verified by k-Nearest Neighbor verification, and the results showed the error rate of 3.8%.

• Korean Institute of Interior Design Journal
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• v.25 no.1
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• pp.56-64
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• 2016

Housing for the elderly should be planned on the base of elder's needs and preferences as well as their physical, emotional, and socio-psychological characteristics. This study examined the interior style of bedroom and living room the elderly preferred and these preferences are significantly different depending on their characteristics and cognitive ages, or not. This study was carried out by face to face interview with a questionnaire and 6 colored printed 3D images. The subjects were 202 old aged who lives in Busan. The interior style of bedroom and living room were classified into 3 styles; Korean traditional style, Western classical style, and modern style. The subjects made a choice their preferred interior style among three 3D images per each room and answered the reasons. Also, they answered their cognitive ages and general characteristics, and their preferences for the layout of living room-dining room-kitchen, use pattern, floor finishes, and furniture of bedroom and living room. The results were as follows; 1) The subjects preferred bed in bedroom and sofa in living room. Also, they wanted to finish the floor of bedroom and living room by using synthetic material, traditional floor paper, and wood. 2) The elderly preferred Western classical style of bedroom. The reasons were general mood such as warm, comfort, or bright, and the color. 3) These preferred styles were not any significant differences according to their characteristics and cognitive ages. 4) They preferred Korean traditional style, Western classical style, and modern style, in order. They preferred them for their general mood and window. 5) Their preferred styles were significantly different according to their housing types and cognitive ages.

• Korean Journal of Community Nutrition
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• v.10 no.3
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• pp.290-302
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• 2005

The nutrients intake and health-related habits of nonagenarian subjects in Korean representative longevity belts of Damyang, Gokseong, Kurye, Sunchang were evaluated for the purpose of providing the information on the desirable food selection and dietary pattern of elderly population. A survey was conducted with 91 subjects (26 males and 65 females) and their food intakes were measured by the combination of one meal weighing and 24-hr recall, and their general background information was collected by visit. The mean age of the subjects was 93.6 $\pm$ 2.2 (male) and 97.6 $\pm$ 4.6 (female) The average smoking rate was $20.9\%$, the rate of regular drinking was $26.4\%$. The average energy intake was 1,284.9 kcal comprising $77.1\%$ of RDA for elder people over 75. The energy ratio of carbohydrate, protein and fat were 66.5 : 18.2 : 15.3. The average intake of protein, calcium, iron and zinc were $107.4\%,\;59.9\%,\;106.3\%$ and $60\%$ of RDA respectively. The lower intake of vitamins as low as $70\%$ was found except vitamin $B_6$ and niacin. The majority of the subjects consumed rice as staple diet and mostly consumed white plain rice rather than mixed grain rice. The animal and plant food intakes were 88.4 : 11.6 in males and those of females were 83.0 : 17.0 showing a tendency of plant-based meals. Nutrients that showed NAR over 0.7 were protein, iron, vitamin $B_6$, niacin and phosphate, but those with INQ over 1. Nutrient with INQ below 0.7 was only vitamin E. Even though their nutritional quantity did not appear to be enough, but their nutritional quality was relatively high. The adding dairy products, nuts and fruits for the purpose of proving sufficient vitamin and minerals can achieve the optimal nutritional intake patterns. Further research on RDA of this age population should be followed.