• 대한한방내과학회지
• /
• 제37권5호
• /
• pp.796-805
• /
• 2016

Objective: To examine the effects of Gagam-Samryoungbeakchul-san (加減 蔘苓白朮散) on a premature ventricular contraction patient with dizziness and chest discomfort. Methods: A patient diagnosed with premature ventricular contraction was treated with herbal medicine and acupuncture. The period of admission was 15 days, and we measured the electrocardiogram before and after treatment. We evaluated the improvement in symptoms by Global Assessment (G/A), and checked the pulse rate by oximetry three times a day. We estimated the efficacy of treatment by analyzing the relationship between the average pulse rate and symptoms. Results: After Gagam-Samryoungbeakchul-san treatment and acupuncture therapy, the average pulse rate increased from 36.5 to 58. This increase in average pulse rate was accompanied by a reduction in dizziness of 40%, chest discomfort of 30%, and frequency of bigeminy in the electrocardiogram. Conclusions: This case report confirmed the effectiveness of Gagam-Samryoungbeakchul-san on premature ventricular contraction, but further study is warranted.

• Journal of Chest Surgery
• /
• 제38권5호
• /
• pp.377-381
• /
• 2005

해부학적 회로 조성술을 이용할 수 없는 환자에게서 시행되는 해부외 회로 조성술에 대하여 이술식의 적정성을 알아보고자 본 연구를 시행하였다. 대상 및 방법: 부산대학교병원 흉부외과에서 해부외 회로 조성술을 시행받은 31명의 환자를 대상으로 동반질환, 원인질환, 수술 당시의 증상, 개존율과 개존율에 영향을 미치는 요인 등을 분석하였다. 결과: 31예의 수술 중 대퇴-대퇴동맥 우회술이 26예, 액와-대퇴동맥 우회술이 5예였고 평균 연령은 70.23세였다. 동반질환은 고혈압, 고지혈증, 허혈성심질환의 순이었고 수술 적응증은 파행, 조직괴사, 휴식기 통증 등의 순이었다. 대퇴-대퇴동맥 우회술을 대상으로 이식편의 일차 개존율에 영향을 미치는 요인들을 분석하였으나 나이(65세 이상), 흡연력, 고혈압, 허혈성 심장질환, 심한 하지 허혈, 고지혈증 등의 유무에 따른 개존율은 통계학적으로 유의한 차이가 없었다. Kaplan-Meier법을 이용한 이식편의 일차 개존율은 1년 $73.65\%$, 2년 $73.65\%$, 3년$65.46\%$였다. 결론: 수술의 위험도가 높은 환자들에게서 해부외 회로 조성술은 해부학적 회로 조성술에 비해서 개존율이 낮다고 알려져 있지만 술식이 간단하고 덜 위험하며 이식혈관 부전시 교정도 상대적으로 쉽게 할 수 있는 장점을 가진 치료법임을 알 수 있었다.

• Tuberculosis and Respiratory Diseases
• /
• 제61권2호
• /
• pp.143-149
• /
• 2006

연구배경: Toptisomerase I 억제제인 irinotecan 과 소세포폐암 치료의 근간인 cisplatin의 복합화학용법을 확장기 소세포폐암 환자에게 1차 치료법으로 실시하여 반응률, 생존율 및 부작용을 확인하였다. 방 법: 2002년 6월부터 2005년 2월까지 확진된 확장기 소세포폐암 환자 39명에게 irinotecan $60mg/m^2$, 제 1, 8, 15일째 cisplatin $60mg/m^2$ 제1일째에 28일 간격으로 4회 투여하였다. 결 과: 반응률은 77%(완전반응 8%), 중앙생존기간은 14.8개월, 1-및 2-년 생존율은 60.9%, 27.6%였으며, 중앙 무진행생존기간은 8.4개월, 6-및 12-개월 무진행생존율은 75.0%, 18.8%였다. WHO grade 3 이상의 부작용은 백혈구 감소증 23%, 설사 26%였으나, 심한 설사때문에 2명은 치료방법을 바꾸었고, 1명은 사망하였다. 결 론: Irinotecan과 cisplatin 복합화학요법은 확장기 소세포폐암 환자의 1차 치료법으로 유용하며, 부작용으로서 설사에 대해서는 치명적일수 있으므로 심각한 주의가 요망된다.

• 한국임상약학회지
• /
• 제10권3호
• /
• pp.111-119
• /
• 2000

The objective of this study was to evaluate the efficacy and the pattern of regimens prescribed for the treatment of peptic ulcer disease in a regional community hospital. 226 patients were treated as an outpatient and followed for one year. 88 patients $(38.9\%)$ had gastric ulcer (GU) alone, 6 patients $(2.7\%)$ had duodenal ulcer (DV) alone, 5 patients $(2.2\%)$ had gastroesophageal reflux disease (GERD) alone, 25 patients $(11.1\%)$ had both GU and DU, 88 patients $(38.9\%)$ had both GU and GERD, and 14 patients $(6.2\%)$ had both DU and GERD. During this study period no one was treated for Zollinger-Ellison Syndrome. The disease showed higher occurrence in male population (139 patients, $61.5\%$) and among the ages of 30 and 40 $(62.4\%)$. The average age of these patients was 41.3 years and there was no difference between the genders. $81.4\%$ of these patients underwent CLO test to check for the existence of Helicobacter and $66.3\%$ of these Patients showed the positive response. $65.6\%$ of patients with GU and $80\%$ of patients with DU showed the positive response and there was no difference between the genders $(65.4\%\;vs.\;67.6\%)$. 184 patients $(81.4\%)$ were deemed to be cured based on the disappearance of their symptoms after completing the regimens. Compliance rate did not differ for gender or different diseases, while showing a difference in age. Patients between the ages of 20 to 30 years old showed the worst compliance rate. In addition, the compliance was lower among the patients who had previous occurrence of the disease, and this was more evident among female patients. Although 184 patients out of the total 226 patients were deemed to be cured, 36 patients $(20.65\%)$ of these returned to the hospital for relapsed diseases within one year. The factors that affected for patients to relapse were the diseases accompanied by ulcer and social environments, such as smoking, alcohol consumption, and previous history of the diseases (smoking P<0.001, alcohol consumption P<0.02, previous history of disease P<0.05). The regimen using $H_2$ receptor antagonists+tripotassium dicitrato bismuthate+clarithromycin showed the lower rate of relapse, and the regimens of omeprazole (OMP)+amoxicillin+tripotassium dicitrato bismuthate and OMP+amoxicillin+metronidazole showed better compliance rate. Patient education by pharmacists on the importance of compliance to regimens and the risk factors fer relapse can provide a better patient care. This would ultimately result in more cost-effective treatments by preventing additional cost for treating relapsed symptoms in approximately $20\%$ of patients.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5957-5961
• /
• 2015

Background: We designed this randomized controlled trial (RCT) to assess whether lobaplatin-based concurrent chemotherapy might be superior to cisplatin-based concurrent chemotherapy for FIGO stage II and III cervical cancer in terms of efficacy and safety. Materials and Methods: This prospective, open-label RCT aims to enroll 180 patients with FIGO stage II and III cervical cancer, randomly allocated to one of the three treatment groups (cisplatin $15mg/m^2$, cisplatin $20mg/m^2$ and lobaplatin $35mg/m^2$), with 60 patients in each group. All patients will receive external beam irradiation (EBRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT). Patients in cisplatin $15mg/m^2$ and $20mg/m^2$ groups will be administered four cycles of $15mg/m^2$ or $20mg/m^2$ cisplatin intravenously once weekly from the second week to the fifth week during EBRT, while patients inthe lobaplatin $35mg/m^2$ group will be administered two cycles of $35mg/m^2$ lobaplatin intravenously in the second and fifth week respectively during pelvic EBRT. All participants will be followed up for at least 12 months. Complete remission rate and progression-free survival (PFS) will be the primary endpoints. Overall survival (OS), incidence of adverse events (AEs), and quality of life will be the secondary endpoints. Results: Between March 2013 and March 2014, a total of 61 patients with FIGO stage II and III cervical cancer were randomly assigned to cisplatin $15mg/m^2$ group (n=21), cisplatin $20mg/m^2$ group (n=21) and lobaplatin $35mg/m^2$ group (n=19). We conducted a preliminary analysis of the results. Similar rates of complete remission and grades 3-4 gastrointestinal reactions were observed for the three treatment groups (P=0.801 and 0.793, respectively). Grade 3-4 hematologic toxicity was more frequent in the lobaplatin group than the cisplatin group. Conclusions: This proposed study will be the first RCT to evaluate whether lobaplatin-based chemoraiotherapy will have beneficial effects, compared with cisplatin-based chemoradiotherapy, on complete remission rate, PFS, OS, AEs and quality of life for FIGO stage II and III cervical cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3451-3455
• /
• 2014

Background: The serum carcinoembryonic antigen (CEA) level can reflect tumor growth, recurrence and metastasis. It has been reported that epidermal growth factor receptor (EGFR) mutations in exons 19 and 21may have an important relationship with tumor cell sensitivity to EGFR-TKI therapy. In this study, we investigated the clinical value of EGFR mutations and serum CEA in patients with non-small cell lung cancer (NSCLC). Materials and Methods: The presence of mutations in EGFR exons 19 and 21 in the tissue samples of 315 patients with NSCLC was detected with real-time fluorescent PCR technology, while the serum CEA level in cases who had not yet undergone surgery, radiotherapy, chemotherapy and targeted therapy were assessed by electrochemical luminescence. Results: The mutation rates in EGFR exons 19 and 21 were 23.2% and 14.9%, respectively, with the two combined in 3.81%. Measured prior to the start of surgery, radiotherapy, chemotherapy and targeted treatment, serum CEA levels were abnormally high in 54.3% of the patients. In those with a serum CEA level <5 ng/mL, the EGFR mutation rate was 18.8%, while with 5~19 ng/mL and ${\geq}20ng/mL$, the rates were 36.4% and 62.5%. In addition, in the cohort of patients with the CEA level being 20~49 ng/mL, the EGFR mutation rate was 85.7%, while in those with the CEA level ${\geq}50ng/mL$, the EGFR mutation rate was only 20.0%, approximately the same as in cases with the CEA level<5 ng/mL. Conclusions: There is a positive correlation between serum CEA expression level and EGFR mutation status in NSCLC patients, namely the EGFR mutation-positive rate increases as the serum CEA expression level rises within a certain range (${\geq}20ng/mL$, especially 20~49 ng/mL). If patient samples are not suitable for EGFR mutation testing, or cannot be obtained at all, testing serum CEA levels might be a simple and easy screening method. Hence, for the NSCLC patients with high serum CEA level (${\geq}20ng/mL$, especially 20~49 ng/mL), it is worthy of attempting EGFR-TKI treatment, which may achieve better clinical efficacy and quality of life.

• Radiation Oncology Journal
• /
• 제13권4호
• /
• pp.369-375
• /
• 1995

목적 : 종양의 크기가 큰 외장성 이나 내장성의 병기 IIa, IIb 자궁경부암 환자에서 방사선치료와 hydroxyurea 동시병합치료의 효과에 대한 후향적 연구를 시행하였다. 방법 : 1989년 8월부터 1991년 5월까지 계명대학교 동산의료원 치료방사선과에서 방사선치료와 방사선 감작제로 hydroxyurea 병합치료를 받은 종양의 크기가 3cm 이상인 외장성이나 재장성의 병기 IIa, IIb 자궁경부암환자 64명을 대상으로 하였다. 병기 IIa가 29명, 병기 IIb가 35명이었고 평균연령은 53.8세이었다. 최장기 및 평균 추적기간은 각각 68개월, 57개원이었다. 방사선치료는 외부방사선치료로 전골반강에 하루에 180cGy로 분할하여 3600-5400 cGy 조사하고 양편자궁주위에 조사량이 4500-6300 cGy 되도록 $4{\times}10cm$ 중간차폐를 하여 조사한 후 강내조사를 하였다(전체 조사량이 A 지점에 7100-7500cGy). Hydroxyurea는 방사선치료를 하는동안 1.0gm/day 1회 경구투약 하였다. 결과 : 완전관해율은 89.1%, 5년생존율은 병기 IIa에서 78.8%, 병기 IIb에서 72.8% 이었고 전체 재발률은 25% (16/64) 이었다. 23%에서 3도이상의 백혈구 감소증을 보였고 4%에서 3도이상의 혈소판감소증을 보였으나 자연적으로 회복되었고 3도이상의 빈혈, 위장관계 및 비뇨생식계 합병증은 없었고 치료에의한 사망은 없었다. 결론 : 위와 같은 결과로 볼때 종양의 크기가 큰 외장성 또는 내장성의 병기 IIa 자궁경부암에서 방사선치료과 방사선 감작제로써 hydroxyurea의 병용은 심각한 합병증 없이 생존률을 향상시킬 수 있을것으로 사료된다.

• Radiation Oncology Journal
• /
• 제16권2호
• /
• pp.139-145
• /
• 1998

목적 : 성문상부암에서 근치적 방사선치료의 효율성을 알아보고자 하였다. 대상 및 방법 : 성문상부 편평상피세포암으로 확진되어 1990년 3월부터 1994년 12월까지 경상대학교병원 치료방사선과에서 근치적 방사선치료를 시행한 21예를 대상으로 분석을 시행하였다. 환자의 연령 분포는 52세부터 75세로 중앙값은 62세 이었다. 남자가 19예이었고 여자는 2예이었다. AJCC TNM 병기에 따른 환자의 분포는 병기 I이 4예, 병기 II가 7예, 병기 III이 3예, 병기 IV가 7예이었다. 추적조사기간의 중앙값은 36개월이었고 95%가 추적이 가능하였다. 결과 : 성문상부암 환자 21예의 전체 5년 생존율은 39.3%이었다. 병기에 따른 5년 생존율은 병기 I이 75.0%, 병기 II가 42.9%, 병기 III이 33.3%, 병기 IV이 28.6%이었다. 전체 5년 국소제어율은 52.0%이었고, 병기에 따른 국소제어율은 병기 I가 75.0%, 병기 II이 57.1%, 병기 III이 66.7%, 병기 IV가 28.6%이었다. 성문상부암의 치료 후 3예의 환자에서 이차 원발종양이 식도에 발생하였고, 진단 후 각기 5개월, 6개월, 5개월에 사망하였다. 결론 : 병기 I, II의 조기 성문상부암의 치료시 우선 근치적 방사선치료를 시행하고, 치료실패시 구제수술을 시행하는 것이 높은 국소제어율과 성대 보존율을 기대할 수 있는 효과적인 치료방법이라고 판단된다. 진행된 병기에서는 수술이 가능한 경우 근치적 수술과 방사선요법을 병행하고 수술이 불가능한 경우에만 근치적 방사선치료를 시행하는 것이 권장된다.

• Journal of Acupuncture Research
• /
• 제22권3호
• /
• pp.201-213
• /
• 2005

봉약침(蜂藥鍼)을 위주로한 한의학적 치료로 경추 신경근 병변의 3증상(일측의 경부 동통과 상완부의 방사통, 수부나 수지의 지각이상)을 호소하는 환자(患者)들을 치료하면서 시각적상사척도(Visual Analogue Scale, VAS), JOA score 및 Odom의 평가기준에 따른 호전 양상을 측정한 결과 다음과 같은 결론을 얻었다. 1. 객관적 치료 성적을 살펴보면 Excellent인 경우가 7예(50%)로 가장 많았으며, Good이 4례 (28.57%), Fair가 3예(21.43%)의 순이며, 불량으로 평가된 경우는 하나도 없었다. 2. 시술 전 pain rate의 평균 8.82(${\pm}1.27$)에서 시술 후 평균 3.25(${\pm}2.21$)로 평균 차이가 5.57로 매우 유의성 있는 차이를 보였으며(p=0.000), 이는 객관적인 호전율과도 일치하였다. 3. 시술 전 JOA score의 평균이 11.00(${\pm}1.57$)에 서 시술 후 평균 12.79(${\pm}0.58$)로 평균 차이가 1.79로 매우 유의성 있는 차이를 보였다 (p=0.000). 4. 시술 전후의 성별, 나이, 수지비증유무, Disc Type에 따른 pain rate에는 유의한 차이가 없다. (P<0.05) 5. 시술 전후의 성별, 연령별, Disc Type 에 따른 JOA score는 유의한 차이가 없으나 (p<0.05), 수지비증유무에 따른 JOA는 유의한 차이가 있었다(p=.025). 수지비증이 있는 경우 가 좀더 유의하게 증가하였다. 이상의 결과로 보아 봉약침(蜂藥鍼) 위주로 한 한의학적 치료가 경추 신경근 병변을 호소하는 환자에게 유의한 효과가 있었으며 다른 한방적 보존적 요법과 더불어 시행시키면 전반적인 경추의 퇴행성 변화에 대한 치료(治療)에 더욱 더 유익하리라 판단된다.

• 한국전문물리치료학회지
• /
• 제3권3호
• /
• pp.67-81
• /
• 1996

This study was performed to assess the efficacy of high voltage pulsed galvanic current for the healing of wounds in rabbits. Skin wounds were created laterally on the flank of 12 domestic rabbits($3{\times}3cm$). The wounds of each group were treated with an intensity of 170 V at a frequency of 70 pulses per second, which was applied for 30 minutes a day for 10 days. The experimental groups were randomly assigned to either EXP I (n=3), EXP II(n=3), EXP III(n=3) or control(n=3). Each group was stimulated under the following conditions : 1) EXP I (Negative polarity), 2) EXP II (Change in polarity, negative electrode stimulation during the first 3 days and then positive electrode stimulation from 4 to 10 days), 3) EXP III(Positive polarity), 4) control(No stimulation). An active electrode was placed over the wound and a dispersive electrode on the buttock. The rate of wound closure was compared with the original wound size, evaluated by a tracing film in each measurement period. Finally, on the wound in each group, skin tissue was excised for histological evaluation after treatment for 10 days. The results obtained are as follows : 1) It was found that the control group did not show a complete remodeling of epitherial layer and had a chronic inflammatory response. Judging from the irregularity of intercellular space and the loose alignment of connective tissue, these findings show that wound healing was delayed. 2) EXP I showed a significant bactericidal effect, but a moderate response of vasodilation. The rate of wound closure was slower when compared with EXP II, III. 3) EXP II showed a complete remodeling of epitherial layer and a positive repair of connective tissue. Its rate of wound closure was best when compared with the others. 4) EXP III had a slower rate of wound closure than EXP II, but judging from the greater proliferation of collagen fibers and the dense alignment of connective tissue, this positive electrode was very effective in the formation of neo - connective tissue.