• Journal of Microbiology and Biotechnology
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• 제28권9호
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• pp.1413-1425
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• 2018

Shiga toxins (Stxs) are the main virulence factors expressed by the pathogenic Stx-producing bacteria, namely, Shigella dysenteriae serotype 1 and certain Escherichia coli strains. These bacteria cause widespread outbreaks of bloody diarrhea (hemorrhagic colitis) that in severe cases can progress to life-threatening systemic complications, including hemolytic uremic syndrome (HUS) characterized by the acute onset of microangiopathic hemolytic anemia and kidney dysfunction. Shiga toxicosis has a distinct pathogenesis and animal models of Stx-associated HUS have allowed us to investigate this. Since these models will also be useful for developing effective countermeasures to Stx-associated HUS, it is important to have clinically relevant animal models of this disease. Multiple studies over the last few decades have shown that mice injected with purified Stxs develop some of the pathophysiological features seen in HUS patients infected with the Stx-producing bacteria. These features are also efficiently recapitulated in a non-human primate model (baboons). In addition, rats, calves, chicks, piglets, and rabbits have been used as models to study symptoms of HUS that are characteristic of each animal. These models have been very useful for testing hypotheses about how Stx induces HUS and its neurological sequelae. In this review, we describe in detail the current knowledge about the most well-studied in vivo models of Stx-induced HUS; namely, those in mice, piglets, non-human primates, and rabbits. The aim of this review is to show how each human clinical outcome-mimicking animal model can serve as an experimental tool to promote our understanding of Stx-induced pathogenesis.

• 산업경영시스템학회지
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• 제38권4호
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• pp.117-131
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• 2015

Conventional data envelopment analysis (DEA) models require that inputs and outputs are given as crisp values. Very often, however, some of inputs and outputs are given as imprecise data where they are only known to lie within bounded intervals. While a typical approach to addressing this situation for optimization models such as DEA is to conduct sensitivity analysis, it provides only a limited ex-post measure against the data imprecision. Robust optimization provides a more effective ex-ante measure where the data imprecision is directly incorporated into the model. This study aims to apply robust optimization approach to DEA models with imprecise data. Based upon a recently developed robust optimization framework which allows a flexible adjustment of the level of conservatism, we propose two robust optimization DEA model formulations with imprecise data; multiplier and envelopment models. We demonstrate that the two models consider different risks regarding imprecise efficiency scores, and that the existing DEA models with imprecise data are special cases of the proposed models. We show that the robust optimization for the multiplier DEA model considers the risk that estimated efficiency scores exceed true values, while the one for the envelopment DEA model deals with the risk that estimated efficiency scores fall short of true values. We also show that efficiency scores stratified in terms of probabilistic bounds of constraint violations can be obtained from the proposed models. We finally illustrate the proposed approach using a sample data set and show how the results can be used for ranking DMUs.

• Earthquakes and Structures
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• 제4권1호
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• pp.41-62
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• 2013

A comprehensive experimental program of cyclic tests on 1:3-scale models of bridge piers is going to be carried out at the Laboratory of Structures and Materials of the University of Basilicata. The testing models include eight RC single shaft piers with hollow circular cross section. Four piers have been realised using corroded steel rebars. In this paper, the results of preliminary numerical simulation analyses of the cyclic behaviour of the piers, carried out with Opensees using fiber-based models, are presented. Pull-out and lap-splice effects of steel rebars have been taken into account in the numerical analyses. First, the experimental specimens and the test set up are presented. Next, the results of the numerical analyses are discussed. In the numerical analyses, different configurations and levels of corrosion have been considered. The effective stiffness and equivalent damping of the piers is reported as a function of pier ductility and pier drift.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.807-810
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• 1997

Digital control of robot manipulator employs discrete-time robot models. It is important to explore effective discrete-time robot models and to analyze their properties in control system designs. This paper presents a new type discrete-time robot model. The model is derived by using trapezoid rule to approximate the convolution integral term, then eliminating nonlinear force terms from robot dynamical equations. The new model obtained has very simple structure, and owns the properties of independence to the nonlinear force terms. According to evaluation criteria, three aspects of the model properties: model accuracy, model validity range and model simplicity are examined and compared with commonly used discrete-time robot models. The validity of the proposed model and its advantages to control system designs are verified by simulation results.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2000년도 봄 학술발표회논문집
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• pp.168-173
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• 2000

Design of experiments is utilized for exploring the design space and for building response surface models in order to facilitate the effective solution of multi-objective optimization problems. Response surface models provide an efficient means to rapidly model the trade-off among many conflicting goals. In robust design, it is important not only to achieve robust design objectives but also to maintain the robustness of design feasibility under the effects of variations, called uncertainties. However, the evaluation of feasibility robustness often needs a computationally intensive process. To reduce the computational burden associated with the probabilistic feasibility evaluation, the first-order Taylor series expansions are used to derive individual mean and variance of constraints. For robust design applications, these constraint response surface models are used efficiently and effectively to calculate variances of constraints due to uncertainties. Robust optimization of automotive seat is used to illustrate the approach.

• 대한교통학회지
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• 제14권1호
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• pp.81-99
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• 1996

This study aims to assess the potential competition among road, rail, and coastal transport under various scenarios concerning the future inland container transport systems in Pusan-KyungIn corridor. For this SP approaches are adopted to collect data from shippers and carriers, and multinomial logit models are estimated at disaggragate level. The results of the analysis indicate that the SP data are reliable, and that the mode choice models estimated are valid. The results also indicate that the most effective policy to divert the freight volume from road to other modes is to reduce freight rates for the railway, and is to transport time for the coastal water with improved reliability.

• 한국주거학회논문집
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• 제6권1호
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• pp.39-50
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• 1995

The Plan for effective usage of living room must be suggested because families primarily use living room for public space. And from the viewpoint of function and decoration. the kind of furniture. furniture occupancy quantity. and the arrangement of furniture have much affect on using a dwelling space. So this study will suggest basic data for a good furniture usage through experiment using scale down models. To analyze the data. frequency and percentage were used by running SPSS $PC^＋$ program. The major results are as follows. In an experiment using living room and furniture models(Scale 1/20). according to the size of space. TV sizes and furniture occupancy quantity were in proportion to size and space of the living room. Also they chose various types of tea-table and side-tables. In small spaces. subjects chose simple arrangement types (no sofa or I type sofa and cabinet). but in large spaces. they chose \ulcorner type or \ulcorner type sofa and cabinet.

• 한국환경과학회지
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• 제26권4호
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• pp.521-527
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• 2017

Solar radiation forecasts are important for predicting the amount of ice on road and the potential solar energy. In an attempt to improve solar radiation predictability in Jeju, we conducted machine learning with various data mining techniques such as tree models, conditional inference tree, random forest, support vector machines and logistic regression. To validate machine learning models, the results from the simulation was compared with the solar radiation data observed over Jeju observation site. According to the model assesment, it can be seen that the solar radiation prediction using random forest is the most effective method. The error rate proposed by random forest data mining is 17%.

• 전기학회논문지
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• 제56권3호
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• pp.457-464
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• 2007

Micro-Grid comprising Micro-Sources supplying several $kW{\sim}MW$ power to local customers is environmentally friendly and reliable. This paper deals with the development of simulation models of Micro-Grid on the PSCAD/EMTDC platform for analyzing various aspects of the interaction of the Micro-Grid. The developed switching level model adopts the space vector PWM. Both switching level and power frequency Micro-Source models are developed, which shows that power frequency modeling is sufficient for analyzing the phenomena of interest. Control characteristics of the Micro-Sources with the parameter and load power variation are analyzed for power quality enhancement. The simulation results show that the developed models are effective for studying Micro-Grid.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 2003년도 추계학술대회 및 정기총회
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• pp.15-18
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• 2003

There are plenty of optimization models for the signal-system of a single intersection and area traffic. Some of those models are adopted for the real traffic signal control system. The simulators for a single crossroad have been developed, so that we could evaluate optimization models and traffic control systems. However, the simulators for the area traffic are still being developed. Therefore, there are many limitations in the analysis and evaluation for area traffic control systems. The area traffic is consist of several intersections interconnected which are very complicated and many traffic strategy are adopted for the control system. This paper features an effective area traffic control system by High Lever Architecture(HLA) which is a new developed simulation tool. In this paper, we discuss the design of HLA-based area traffic control simulation. We describe technical motivations for the HLA, the key elements of the architecture and how they are minimum and essential to the goal of reuse and interoperability.