• Journal of Ginseng Research
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• v.43 no.4
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• pp.600-605
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• 2019

Background: The leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositions of the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years, the aerial parts of members of the Panax genus have received great attention from natural product chemists as producers of bioactive ginsenosides. The aim of this study was the isolation and structural elucidation of novel, minor ginsenosides in the leaves of P. ginseng and evaluation of their antiinflammatory activity in vitro. Methods: Various chromatographic techniques were applied to obtain pure individual compounds, and their structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry, as well as chemical methods. The antiinflammatory effect of the new compounds was evaluated on lipopolysaccharide-stimulated RAW 264.7 cells. Results and conclusions: Two novel, minor triterpenoid saponins, ginsenoside $LS_1$ (1) and 5,6-didehydroginsenoside $Rg_3$ (2), were isolated from the leaves of P. ginseng. The isolated compounds 1 and 2 were assayed for their inhibitory effect on nitric oxide production in LPS-stimulated RAW 264.7 cells, and Compound 2 showed a significant inhibitory effect with $IC_{50}$ of $37.38{\mu}M$ compared with that of NG-monomethyl-L-arginine ($IC_{50}=90.76{\mu}M$). Moreover, Compound 2 significantly decreased secretion of cytokines such as prostaglandin $E_2$ and tumor necrosis factor-${\alpha}$. In addition, Compound 2 significantly suppressed protein expression of inducible nitric oxide synthase and cyclooxygenase-2. These results suggested that Compound 2 could be used as a valuable candidate for medicinal use or functional food, and the mechanism is warranted for further exploration.

• Journal of Magnetics
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• v.20 no.2
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• pp.161-165
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• 2015

The Permanent Magnet Brushless DC (PMBLDC) motors have been used in modern industrial factories, hazardous chemical process, modern medical devices, and especially in advanced military devices such as army drones. By considering their sensitive role in the industrial and military applications, their optimal design has a real concern. This paper proposes a method for optimal eco-design of a PMBLDC motor using improved tabu search optimization. The objective function is based on losses, volume and cost. Electrical and mechanical requirements and other limitations are combined into constraints of problem. Also, finite element analysis has been used for verifications in magnetic mode.

• Korean Journal of Veterinary Research
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• v.33 no.1
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• pp.43-51
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• 1993

Mitochondrial DNA(mt DNA) of Mammalian is the circular one which the 16.5K base pairs and show the maternal inheritance. Evolutional speed of nucleotide sequence is very fast. So that polymorphic analysis of mt DNA provide the useful informations to investigate the genetic relations of interspecies. Authors trials were focussed to compare with the polymorphic differences of mitochondrial DNA between Jindo and Japanese mongrel dogs. DNA was extracted from bloods of 21 head of Jindo dogs and 20 head of Japanese dogs and isolated using 10 kinds of restriction endonucleases(Apa I, BamH I, Bgl II, EcoR I, EcoR V, Hinc II. Hind III, Pst I, Sty I, Xba I) and then separated by the agarose gel electrophoresis. After sourthern blotting hybridization was completed using the mtDNA of Japanese mongrel dogs as a probe. Autoradiography was used to compare the polymorphism of mtDNA both dogs. The results obtained were as follows; 1. mt DNA of Jindo dog showed polymorphism resulting cleavage with four kinds of restriction endonuclease, Apa I, EcoR V, Hinc II, Sty I. While in the Japanese mongrel dogs observed the polymorphism in the five kinds of restriction endonuclease supplemented with EcoR I. 2. Compared with both dogs the frequency differences of DNA polymorphism were recognized in the specific restriction endonuclease Apa I. Consequently in the restriction endonuclease Apa I both dogs classified with three types as A, B, C however in the Jindo dogs frequency of C type was 71.5 percent but in Japanese mongrel dogs observed 45 percent in the A type. 3. DNA polymorphism obtained from the use of five kinds of restriction endonuclease were classified with seven types. In Jindo dogs frequency was highest in the type 6 as 71.4 percent but in the Japanese mongrel dogs showed 35 percent in the type 5. 4. Genetic distances calculated by NEI method showed 0.0089 in Jindo dogs and was 0.0094 in the Japanese mongrel dogs.

• Journal of the Korea Convergence Society
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• v.12 no.4
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• pp.87-94
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• 2021

While the shielding substances of radiation shields in medical institutions are beginning to be replaced by environmentally friendly materials, radiation protection according to the shielding properties of environmentally friendly substances is becoming an important factor rather than the existing lead shielding properties. Tungsten and barium sulfate are representative shielding materials similar to lead, and are made in sheets or fiber form with eco-friendly materials. Ytterbium is an impermeable material used as a fluorine compound in the dental radiation field. This study aims to evaluate the shielding performance in the x-ray shielding area by comparing the shielding properties of ytterbium by energy band and that of existing eco-friendly materials. When three types of shielding sheets were fabricated and tested under the same process conditions, the shielding performance of the medical radiation area was about 5 % difference from tungsten. Furthermore, shielding performance was superior to barium sulfate. In the cross-sectional structure of the shielding sheet, there was a disadvantage that the arrangement of particles was not uniform. Ytterbium oxide showed sufficient potential as a medical radiation shielding material, and it is thought that it can improve the shielding performance by controlling the particle arrangement structure and particle size.

• Clinical and Experimental Reproductive Medicine
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• v.49 no.4
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• pp.248-258
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• 2022

Objective: This research investigated the effects of human chorionic gonadotropin (HCG)-producing peripheral blood mononuclear cells (PBMCs) on the implantation rate and embryo attachment in mice. Methods: In this experimental study, a DNA fragment of the HCG gene was cloned into an expression vector, which was transfected into PBMCs. The concentration of the produced HCG was measured using enzyme-linked immunosorbent assay. Embryo attachment was investigated on the co-cultured endometrial cells and PBMCs in vitro. As an in vivo experiment, intrauterine administration of PBMCs was done in plaque-positive female mice. Studied mice were distributed into five groups: control, embryo implantation dysfunction (EID), EID with produced HCG, EID with PBMCs, and EID with HCG-producing PBMCs. Uterine horns were excised to characterize the number of implantation sites and pregnancy rate on day 7.5 post-coitum. During an implantation window, the mRNA expression of genes was evaluated using real-time polymerase chain reaction. Results: DNA fragments were cloned between the BamHI and EcoRI sites in the vector. About 465 pg/mL of HCG was produced in the transfected PBMCs. The attachment rate, pregnancy rate, and the number of implantation sites were substantially higher in the HCG-producing PBMCs group than in the other groups. Significantly elevated expression of the target genes was observed in the EID with HCG-producing PBMCs group. Conclusion: Alterations in gene expression following the intrauterine injection of HCG-producing PBMCs, could be considered a possible cause of increased embryo attachment rate, pregnancy rate, and the number of implantation sites.

• Journal of the Korea Convergence Society
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• v.10 no.10
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• pp.231-240
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• 2019

For the development of school meals, this study was designed to identify the status of middle school students who eat eco-friendly school meals with a view to converging on their awareness, interest, and operational satisfaction. The results of the survey of 468 K middle school students in Gwangju were all based on a significant level of p.Validated at 05. There were achievements in the recognition of students' awareness, interest, and operational satisfaction contributing to the improvement of school meal satisfaction, but there were also limitations in the operation of eco-friendly school meals, such as various family composition and budget expansion, and not the entire school. If the disclosure of data on future results is expanded to the whole, it could be used as a valuable resource for improving school meal satisfaction and developing school meals.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.573-575
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• 2019

Recently, augmented reality (AR) technology has been widely used in a variety of fields such as defense, medical, education, and entertainment. In the augmented reality environment, a user can interact a virtual object by the user 's specific behaviors. Also, it is necessary to use a technique to automatically interacts among the generated virtual objects. In this paper, we propose an authoring model to apply augmented reality environments based on quantum computing inspired entanglement and overlapping phenomenon. For example, it is possible to allow the user to automatically increase and decrease the number of the object with the characteristics of the virtual object without user intervention. As a tested platform for this purpose, this paper provide an augmented reality eco-system environment with automatic interaction among virtual animals.

• Journal of the Korean Applied Science and Technology
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• v.38 no.6
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• pp.1533-1542
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• 2021

Eco-friendly polyurethane can be defined as a highly utilized material used in various fields. The various structural properties of the synthesis of isocyanates and polyols provide versatility and customization for use in the manufacturing field. The characteristics of polyurethane vary widely from soft touch coatings to hard building materials like rocks. These mechanical, chemical and biological properties and ease of alignment are drawing tremendous attention not only in the field of research but also in related industries. In order to improve the performance of water-dispersible polyurethane materials, it can be derived through processes such as adjusting the blending of raw materials and adding additives and nanomaterials. This study highlights the basic chemical structure of eco-friendly water-dispersible polyurethane in the fields of medical science, automobiles, coatings, adhesives, paints, textiles, marine industries, wood composite materials, and clothing.

• Journal of the Ergonomics Society of Korea
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• v.31 no.6
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• pp.765-772
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• 2012

Objective: The purpose of this research was to aid creating an effective sizing system for the vacation wear intended for Jeju's medical tourists, specifically females from the major countries including the USA, Japan, and Korea. Background: Medical tourism makes the gains of every year 40,000,000,000 dollar, every year 30% it is increasing. Thus the Jeju-do is propelling medical tourism. The body size each country is different. Consequently must set the body size standard for the women. Method: (1) It observed the body size of the Korean women of 2004 years and 2010 years. (2) It analyzed the body size of the women of the USA, China, Japan and Korea. (3) It set the sizing system of the women of the USA(ASTM), China (GB), Japan(JIS) and Korea(KS). Results: Korean adult females' height in 2010 has increased from 2004. The Waist Back Length, Waist Front Length, Arm Length etc has also increased along with the Height. The upper body has become slimmer at the same time; the Chest Circumference, Bust Circumference, and Underbust Circumference have decreased. The lower body on the other hand has become bigger: the Waist Circumference and Hip Circumference have increased. The BMI has decreased by 0.4 from 2004 - the Height has increased while Weight has decreased. The Chest Circumference and Under Bust Circumference of Korean women across all age groups have increased at a proportional rate to other parts of body; however, the rate of increase in Chest Circumference was far greater. American females(Caucasians) had the greatest ratio of waist to bust (Waist Circumference/Chest Circumference), smallest ratio of Neck Base Circumference to Bust Circumference (neck/bust). Korean females had smallest ratio of Waist Circumference to Underbust Circumference(waist/bust). As for the drop of Chest Circumference and Waist Circumference, American females had the highest and Koreans had the lowest. As for the drop of Hip Circumference and Chest Circumference, Japanese had the highest and Americans had the lowest, but Japanese women at the same time showed the A line body shapes. As for difference of Chest Circumference and Underbust Circumference, American females had the biggest(13.73) followed by Korean(11.1), Japanese(10.9) and Chinese(10.5). Conclusion: The women of the USA, China, Japan and Korea body size is different. Especially the value of the Bust Circumference - the Underbust Circumference is different. Thus, it set the sizing system(Table 8).

• International Journal of Industrial Entomology and Biomaterials
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• v.47 no.2
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• pp.73-78
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• 2023

Currently, Hyphantira cunea Drury, the fall webworms (FWW), is one of the most severe insect pest for various landscaping trees and mulberry trees. In this study, we investigated whether FWW might be managed by Sodium saccharin (SAC) which is a food additive and not toxic to humans and environment. We found that FWW larvae treated with various concentrations of SAC showed dose-dependent delayed development and low survival rates. The lethal-concentration 50% of FWW larvae to SAC was 0.03 M. We also confirmed that SAC can be used to control FWW larvae attacking mulberry trees in the field. Compared to not-treated or tap-water-spraying control groups, SAC-spraying groups showed significantly higher mortality rates of FWW larvae (56.2%). Thus, SAC can be used for control FWW larvae in mulberry trees.