• Journal of Biomedical Engineering Research
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• v.39 no.5
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• pp.183-187
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• 2018

In this paper, we investigated the efficiency according to the output transmission method of the round window driving type AMEIs (active middle ear implants) through the cadaveric experiment. For the experiment, we fabricated DRT (direct rod transducer) and FMT (floating mass transducer) type vibrational transducers based on our previous studies and conducted their output characteristics were measured. TCBT (tri-coil bellows transducer) and DFMT (differential floating mass transducer) were implemented with the same driving force and electrical characteristics as one of DRT and FMT, respectively. In the experiment using three human temporal bone, normal stapes vibration was measured with 1 Pa in front of tympanic membrane, and then was compared with each output of transducers. From the comparison, the DRT type vibration transducer was superior in overall energy transfer efficiency, especially in the low frequency range. There was no difference in implantation difficulty between the two transducers. The results of this study suggest that the DRT type vibrational transducer is more efficient and needs further study to overcome the low frequency degradation in round window approaching with FMT.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.196-201
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• 2006

Electroacupuncture(EA) is commonly used in various diseases. In the present study, the effect of EA in the allergic mouse model was examined. Allergy is generated via immunological mechanism and non-immunological mechanism. Mast cells activated dy those mechanisms get to release various substances such as histamine, leukotrienes, prostaglandin, TNF-$\alpha$, IL-4, IL-6, etc. which induce allergic reactions and the following inflammatory responses. To evaluate the anti-allergic effects of EA, mortality, ear swelling response, vascular permeability and cytokine secretion were investigated in EA group and non-EA group of which mice were compound 48/80-induced allergy model or PCA model. Compound 48/80 induces allergic reaction via non-immunological mechanism and PCA model is generated through the same mechanism with immediate-type(Type1) allergic reaction, one of immunological allergic reactions. EA inhibited compound 48/80-induced ear swelling response but did not inhibit the systemic anaphylaxis. EA also inhibited passive cutaneous anaphylaxis(PCA) activated dy anti-dinitrophenol IgE. In addition, EA inhibited IL-6 and TNF-$\alpha$ secretion from 48 h PCA in mice. These results indicate that EA may be used for the treatment of mast cell-mediated allergic diseases, especially immediate-type(Type 1) allergy and non-immunologically mediated allergy.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.15.1-15
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• 1982

Clinical findings for 95 patients (159 ears) of MEE (middle ear effusion) treated at Wallace Memorial Baptist Hospital (Busan) from July 1979 to August 1981 were observed. A group who was treated with myringotomy and ventilation tube isertion was compared with another group of children treated with adenotonsillectomy at the same time. The following are the results: 1) The sex distribution showed 48 male and 47 female, and the age distribution was most common in the ages from six to ten (34 cases, 35%). 2) MEE of children treated with adenotonsillectomy in the same duration was 18 cases (14%), and it was 19% of all MEE patients. 3) Bilateral effusion (67%) was as twice as unilateral cases (33%). In children, bilateral effusion (42 cases, 88%) was predominant, and MEE in adenotonsillectomized children was bilateral in all cases. 4) The nature of middle ear fluid was 49% serous exudate, 33% mucoid exudate, 5% purulent and 3% bloody fluid. Serous exudate was 59% in adult group, but serous (41%) and mucoid exudate (43%) was similar incidence in children. 5) In the preoperative tympanogram, there were 6% with type A, 91% with type B, and 3% with type C. The incidence of abnormal tympanogram (type B or C) was same in MEE patients of adenotonsillectomized children (95%) and the other children group (95%), and it was 93% in adult group. 6) Treatment by myringotomy and ventilation tube insertion resulted in postoperative improvement in air conduction hearing acuity especially in adenotonsillectomized children.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.34 no.4
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• pp.364-369
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• 1989

Leaf characteristics of main stem and tiller of IK type maize (IK/ /IRI/B68) were compared with those of Jinjoo Ok hybrid which are not usually tillered. A total of nine leaves from flag leaf to the third or the fourth leaf below ear-bearing node were sampled from each stem or tiller. There was no significant difference in mean leaf length between IK/ /IRI/B68 and Jinjoo Ok. But the mean leaf width of IK/ /IRI/ B68 was about 2 cm narrower than that of Jinjoo Ok. The mean leaf area of the IK/ /IRI/B68 was also smaller than that of Jinjoo Ok due to the narrower leaf width. There were not significant differences in mean leaf characteristics between main stem and tillers of IK/IRI/B68. The longest leaf was the leaf below the ear-bearing node and the widest leaf was the leaf just above the ear-bearing node. Mean length. width and area of leaf on main stem and tillers were similar. Coefficients of variation calculated for individual leaf indicated that the leaves near the ear-bearing node were more uniform than others. The leaf area measured was significantly greater than that estimated by formular, length x width x 0.75. New constant to estimate leaf area of tillering maize was derived as 0.8.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1977.06a
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• pp.5.1-5
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• 1977

Since Metz first introduced the conceps of Impedance Audiometry in 1946. Many pioneers studied for the development of the acoustic Impedance bridge. It is now widely used in clinical audiology and it plays an important role in otology. Recently there was the literature stated on normal value of various test c Impedance. This paper is dealing with the clinical evaluation of type c in comparison with following subjects as; 1. Comparison with the otoscopic finding. 2. Correlation with the pure tone audiometry. 3. Correlation with the stapedial reflex. 4. Correlation between pathologic negative pressure range and middle ear fluid.

• Journal of Biomedical Engineering Research
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• v.23 no.3
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• pp.217-225
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• 2002

The implantable middle ear(IME) system, which has good sound quality. superior sound intelligibility and wide frequency characteristics. can resolve the sound distortion and ringing effect by sound feedback at high gain operation those are the major problems of conventional hearing aid. In this paper, we have manufactured the IME system using differential electromagnetic transducer(DET) and verified the performance of the system by carrying out vibration and animal implanting experiment. The DET was manufactured using micro-machining technology and vibration experiment of the transducer was performed to inspect whether the transducer could vibrate in accordance with the applied sound signal or not. And the result of the loaded experiment using temporal bone sampled from cadaver showed that the transducer can drive the middle ear bone and transmit the signal to inner ear After the internal unit of IME system was implanted in a dog. the auditory brainstem response (ABR) test was carried out. The result of the test indicated the Proper behavior of the IME system in the living body From the results of the experiments, it is verified that the manufactured system ewll work well when it is applied to human and a basis of clinical experiment of IME system to real human hearing impaired was be arranged.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.13 no.2
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• pp.211-220
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• 2000

Shini-San has been used for treatment of allergic disease in Korea. However, its effect in experimental models remains unknown. The mast cell plays a pivotal role in initiating al1ergic response by secreting intracytoplasmic granular mediators such as histamine. The present report describes an inhibitory effect of Shini-San on mast cell-mediated immediate-type al1ergic reactions. Topical application of compound 48/80 can induce an ear swelling response in normal ($WBB6F_1-+/+$) mice but not in congenic mast cell-deficient $WBB6F_1-W/W^v$ mice. Shini-San inhibited concentration dependent mast cell-dependent ear swelling response induced by compound 48/80 in normal mice. Shini-San inhibited concentration-dependent passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) immunoglobulin E (IgE) in rats by topical application. Shini-San also inhibited in concentration-dependent fashion the histamine release from the rat peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, Shini-San had a significant inhibitory effect on compound 48/80-induced systemic anaphylactic reaction. These results indicate that Shini-San inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.19-19
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• 1982

Pathogenesis of otitis media was studied in an animal model of rats from a histopathological and biochemical point of view. Basic anatomical outline, and distribution and type of normal epithelial cells of the rat bulla were described as a background study. Pseudomonas otitis media was developed in rats by inoculating $10^{9}$ bacteria into the tympanic bulla. Histopathologic change of the mucoperiosteal layer showed acute stage of infection from 3 days to 3 weeks, and it became chronic after 4 weeks animals through 12 weeks. Enzyme profile in the extracts of the inflammatory middle ear tissue was studied. The levels of three enzymes, PZ-peptidase, LDH, and lysozyme were much higher in the middle ear tissue than in the corresponding sera as might be expected. Tissue/serum ratios of the enzyme activities were 13-38 for PZ-peptidase, 63-177 for LDH, and 18-94 for lysozyme. Possible role of the PZ-peptidase and possible origins of the three enzymes detected in the tissue were discussed.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.31 no.2
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• pp.156-161
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• 1986

Silage productivity and resistance to rice black streaked dwarf virus (RSDV) of six Korean-improved and six US introduced corn genotypes were tested in the southern part of Korea. There was a negative correlation between culm length retarded by RBSDV and coefficients of variance of culm length. Frequency distribution of culm length could be classified as three genotypic groups according to the type of distribution and percentage of RBSDV diseased plants. There were negative correlations between percent RBSDV diseased plants at harvest and culm length, percent ear bearing plants, silage yield, or ear yield, but percent RBSDV diseased plants did not related to the ear/silage ratio and stover yield. Silage yield of Pioneer XCF38 was highest, but that of Suweon 89 and NC 6131 was lowest. However, there was not signi-ficant difference in silage yield among the remaining genotypes. Pioneer XCF38, Suweon 89, and Jinjuok were quite resistant to RBSDV, but Suweon 19, Kwangok, Hoengseongok, Jecheonok, and Pioneer 3424 were susceptible and NC 6131 was most susceptible to RBSDV. Although Jinjuok and Suweon 89 were resistant to RBSDV, silage yield was not high because of early senescence of leaves after silkillg.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.3
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• pp.77-86
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• 2019

Objectives : By analyzing symptoms of tinnitus, we tried to find out the relationship between deficiency and excess(虛實) and visceral pattern identification(臟腑辨證). By testing Tinnitus Handicap Inventory(THI), we evaluated the quality of life of people suffering from various aspects of tinnitus, as well as comparing treatment efficiency. Methods : 52 patients were recruited in this study who was ill with tinnitus. They wrote out the questionnaire about tinnitus and the THI. Results : The vast majority of high-grade tiny noise patients are deficiency type(虛症). The vast majority of low-grade roar patients are excess type(實症). Tinnitus persistence and feeling of ear occlusion were prominent in low-grade roar patients. low-grade roar patients suggest that overall quality of life is lower than high-grade tiny noise patients. In terms of treatment efficiency, spleen-stomach weakness(脾胃虛弱)-type, stomach heat(胃熱)-type and phlegm-fire(痰火)-type was higher than kidney essence depletion(腎精虧損)-type and liver qi depression(肝氣鬱結)-type regardless of the aspect of tinnitus. Conclusions : The present study suggests that tinnitus pattern may be helpful in differentiating patients with tinnitus, and the effectiveness of treatment can be predicted through differentiation.