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Study on Anti-allergic Effects of Electroacupuncture in Allergic Mouse Model  

Yoon Ji-Won (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University)
Jeong Kyoung-Ah (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University)
Cho Zang-Hee (Neuroscience Research Institute, Gachon Medical School)
Sung Kang-Keyng (Department of Neuroscience and Oriental Internal Medicine, Gwang-Ju Oriental Medical Hospital, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.1, 2006 , pp. 196-201 More about this Journal
Abstract
Electroacupuncture(EA) is commonly used in various diseases. In the present study, the effect of EA in the allergic mouse model was examined. Allergy is generated via immunological mechanism and non-immunological mechanism. Mast cells activated dy those mechanisms get to release various substances such as histamine, leukotrienes, prostaglandin, TNF-$\alpha$, IL-4, IL-6, etc. which induce allergic reactions and the following inflammatory responses. To evaluate the anti-allergic effects of EA, mortality, ear swelling response, vascular permeability and cytokine secretion were investigated in EA group and non-EA group of which mice were compound 48/80-induced allergy model or PCA model. Compound 48/80 induces allergic reaction via non-immunological mechanism and PCA model is generated through the same mechanism with immediate-type(Type1) allergic reaction, one of immunological allergic reactions. EA inhibited compound 48/80-induced ear swelling response but did not inhibit the systemic anaphylaxis. EA also inhibited passive cutaneous anaphylaxis(PCA) activated dy anti-dinitrophenol IgE. In addition, EA inhibited IL-6 and TNF-$\alpha$ secretion from 48 h PCA in mice. These results indicate that EA may be used for the treatment of mast cell-mediated allergic diseases, especially immediate-type(Type 1) allergy and non-immunologically mediated allergy.
Keywords
allergy; electroacupuncture(EA); compound 48/80; passive anaphylaxis(PCA);
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1 Allansmith, M.R., Baird, R.S., Ross, R.N., Barney, N.P., Bloch, K.J. Ocular anaphylaxis induced in the rat bytopical application of compound 48/80. Dose response and time course study. Acta Ophthalmologica Supplement 192, pp 145-153, 1989
2 Kim, H.M., Yi, J.M., Lim, K.S. Magnoliae flos inhibits mast celldependent immediate-type allergic reactions. Pharmacological Research 39, pp 107-111, 1999   DOI   ScienceOn
3 Fortier, C., Barbeau, J., Deslauriers, N. Mast cells in the murine oral mucosa are of the connective tissue-type. Regional Immunology 3, pp 35-41, 1990
4 Mousli, M.C., Bronner, C., Landry, Y., Bockaert, J., Rouot, B. Direct activation of GTP-binding regulatory proteins(G proteins) by substance P and compound 48/80. FEBS Letters 25, pp 260-262, 1990
5 Mousli, M.C., Bronner, C., Bockaert, J., Rouot, B., Landry, Y. Interaction of substance P, compound 48/80 and mastoparan with $\alpha$-subunit C-terminal of G protein. Immunology Letters 25, pp 355-358, 1990   DOI   ScienceOn
6 Alber, G., Miller, L., Jelsema, C., Varin-Blank, N., Metzger, H. Structure-function relationships in the mast cell high affinity receptor for IgE. Role of the cytoplasmic domains and of the beta subunit. Journal of Biological Chemistry 266, pp 22613-22620, 1991
7 Royer, B., Varadaradjalou, S., Saas, P., Gabiot, A.C., Kantelip, B., Feger, F., Guillosson, J.J., Kantelip, J.P., Arock, M. Autocrine regulation of cord blood-derived human mast cell activation by IL-10. Journal of Allergy and Clinical Immunology 108, pp 80-86, 2001   DOI   ScienceOn
8 Conti, P., Kempuraj, D., Di Gioacchino, M., Boucher, W., Letourneau, R., Kandere, K., Barbacane, R.C., Reale, M., Felaco, M., Frydas, S., Theoharides, T.C. Interleukin-6 and mast cells. Allergy and Asthma Proceedings 23, pp 331-335, 2002
9 Kikuchi, T., Ishida, S., Kinoshita, T., Sakuma, S., Sugawara, N., Yamashita, T., Koike, K. IL-6 enhances IgE-dependent histaminrelease from human peripheral blood-derived cultured mast cells. Cytokine 20, pp 200-209, 2002   DOI   ScienceOn
10 Tracy, K.J. The inflammatory reflex. Nature, 853-859
11 Petti, F.B., Liguori, A., Ippoliti, F. Study on cytokines IL-2, IL-6, IL-10 in patients of chronic allergic rhinitis treated with acupuncture. Journal of Traditional Chinese Medicine 22, pp 104-111, 2002
12 Katayama, S., Shionoya, H., Ohtake, S. A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous allergy in guinea pigs and rats. Microbiology and Immunology 22, pp 89-101, 1978   DOI
13 Wu, B., Zhou, R.X., Zhou, M.S. Effect of acupuncture on interleukin-2 level and NK cell immunoactivity of peripheral blood of malignant tumor patients. Zhongguo Zhong Xi Yi Jie He Za Zhi 14, pp 537-539, 1994
14 Kim, H.M. Antiallergy drugs from Oriental medicines. International Journal of Oriental Medicine 1, pp 1-7, 2000
15 Kasahara, T., Wu, Y., Sakurai, Y., Oguchi, K. Suppressive effect of acupuncture on delayed-type hypersensitivity to trinitrochlorobenzene and involvement of opiate receptors. International Journal of Immunopharmacology 14, pp 661-665, 1992   DOI   ScienceOn
16 Van Houwelingen, A.H., Kool, M., de Jager, S.C., Redegeld, F,A., van Heuven-Nolsen, D., Kraneveld, A.D., Nijkamp, F.P. Mast cell-derived TNF-alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction. Journal of Immunology 168, pp 5297-5302, 2002   DOI
17 Kasahara, T., Amemiya, M., Wu, Y., Oguchi, K. Involvement of central opioidergic and nonopiodergic neuroendocrine systems in the suppressive effect of acupuncture on delayed type allergy in mice. International Journal of Immunopharmachology 15, pp 501-508, 1993   DOI   ScienceOn
18 Song, J.J., Park, G.Y., Kim, K.J. The effect of acupuncture on $\beta$-endorphin, ACTH and Cortisol level in serum of chronic LBP patient. The Journal of Korean Acupuncture & Moxibustion 20, pp 117-1303, 2003
19 Kim, S.H., Choi, Y.K., Jeong, H.J., Kang, H.U., Moon, G., Shin, T.Y., Kim, H.M. Suppression of immunoglobulin E-mediated anaphylactic reaction by Alpinia oxyphylla in rats Immunopharmacology and Immunotoxicology 22, pp 267-277, 2000   DOI   ScienceOn
20 Baumgartner, R.A., Yamada, K., Deramo, V.A., Beaven, M.A. Secretion of TNF-a from a rat mast cell line is a brefeldin A-sensitive and a calcium/protein kinase C-regulated process. Journal of Immunology 153, pp 2609-2617, 1994
21 Zhu, Z., Homer, R.J., Wang, Z., Chen, Q., Geba, G.P., Wang, J., Zhang, Y., Elias, J.A. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. Journal of Clinical Investigation 103, pp 779-788, 1999   DOI   ScienceOn
22 Iwasaki, M., Saito, K., Takemura, M., Sekikawa, K., Fujii, H., Yamada, Y., Wada, H., Mizuta, K., Seishima, M., Ito, Y. TNF-alpha contributes to the development of allergic rhinitis in mice. Journal of Allergy and Clinical Immunology 112, pp 134-140, 2003   DOI   ScienceOn
23 Bielory, L., Heimall, J. Review of complementary and alternative medicine in treatment of ocular allergies. Current Opinion Allergy Clinical Immunology 3, pp 395-399, 2003   DOI   ScienceOn
24 Ohshima, S., Saeki, Y., Mima, T., Sasai, M., Nishioka, K., Nomura, S., Kopf, M., Katada, Y., Tanaka, T., Suemura, M., and Kishimoto, T. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proceedings of The National Academy of Sciences of The United States of America 95, p 8222, 1998
25 Kim, H.M. and Cho, S.H. Lavender oil inhibits immediate-type allergic reaction in mice and rats. The Journal of Pharmacy and Pharmacology 51, pp 221-226, 1999   DOI   ScienceOn
26 Vasilenko, A.M., Kirilina, E.A., Sarybaeva, D.V. Prevention and correction of stress-induced immunodeficiency by atrial electroacupuncture. Patol Fiziol Eksp Ter 3, pp 21-24, 1989
27 Metzger, H., Alcaraz, G., Gogman, R., Kinet, J.P., Pribluda, V., Quarto, R. The receptor with high affinity for immunoglobulin E. Annual Review of Immunology 4, pp 419-470, 1986   DOI   ScienceOn
28 Kim, H.M. and Lee, Y.M. Role of TGF-$\beta$1 on the IgE-dependent anaphylaxis reaction. Journal of Immunology 162, pp 4960-4965, 1994
29 Cho et al.. Neural Substrates and Functional Hypothesis of Acupuncture Mechanisms. The journal of Korean Acupuncture & Moxibustion 20, pp 172-186, 2003
30 Na, H.J., Jeong, H.J., Bae, H., Kim, Y.B., Park, S.T., Yun, Y.G., Kim, H.M. Tongkyutang inhibits mast cell-dependent allergic reactions and inflammatory cytokine secretion. Clinica Chimica Acta 319, pp 35-41, 2002   DOI   ScienceOn
31 Rogers, P.A., Schoen, A.M., Limehouse, J. Acupuncture for immune-mediated disorders. Literature review and clinical applications. Probl Vet Med 4, pp 162-193, 1992
32 Zhang, S.P., Zhang, J.S., Yung, K.K., Zhang, H.Q. Non-opioid-dependent anti-inflammatory effects of low frequency electroacupuncture. Brain Reseach Bulletin 15, pp 327-334, 2004
33 Alfonso, A., Cabado, A.G., Vieytes, M.R., Botana, L.M. Functional compartments in rat mast cells for cAMP and calcium on histamin release. Cellular Signalling 12, pp 343-350, 2000   DOI   ScienceOn
34 Stassen, M., Muller, C., Arnold, M., Hultner, L., Klein-Hessling, S., Neudorfl, C., Reineke, T., Serfling, E., Schmitt, E. IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9. Journal of Immunology 166, pp 4391-4398, 2001   DOI
35 Royer, B., Varadaradjalou, S., Saas, P., Guillosson, J.J., Kantelip, J.P., Arock, M. Inhibition of IgE-induced activation of human mast cells by IL-10. Clinical and Experimental Allergy 31, pp 694-704, 2001   DOI
36 Scuderi, P., Sterling, R.E., Lam, K.S., Finley, P.R., Ryan, K.J., Ray, C.G., Slymen, D.J., Salmon, S.E. Raised serum levels of tumor necrosis factor in parasitic infections. Lancet 2, 99 1364-1365, 1986
37 Shin, B.K., Lee, E.H., Kim, H.M. Suppression of L-histidine decarboxylase mRNA expression by methyleugenol. Biochemical and Biophysical Research Communications 232, pp 188-191, 1989   DOI   ScienceOn
38 Samoilova, E.B., Horton, J.L., Hilliard, B., Liu, T.S., and Chen, Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. Journal of Immunology 161:6480, 1998
39 Swieter, M., Midura, R.J., Nishikata, H., Oliver, C., Berenstein, E.H., Mergenhagen, S.E. et al. Mouse 3T3 fibroblasts induce rat basophilic leukemia(RBL-2H3) cells to acquire responsiveness to compound 48/80. Journal of Immunology 150, pp 617-624, 1993