• BMB Reports
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• 제50권10호
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• pp.485-486
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• 2017

Many intrinsically unstructured/unfolded proteins (IUPs) contain transient local secondary structures even though they are "unstructured" in a tertiary sense. These local secondary structures are named "pre-structured motifs (PreSMos)" and in fact are the specificity determinants for IUP-target binding, i.e., the active sites in IUPs. Using high-resolution NMR we have delineated a PreSMo active site in the intrinsically unfolded mid-domain (residues 201-300) of SUMO-specific protease 4 (SUSP4). This 29-residue motif which we termed a p53 rescue motif can protect p53 from mdm2 quenching by binding to the p53-helix binding pocket in mdm2(3-109). Our work demonstrates that the PreSMo approach is quite effective in providing a structural rationale for interactions of p53-mdm2-SUSP4 and opens a novel avenue for designing mdm2-inhibiting anticancer compounds.

• 대한한방부인과학회지
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• 제28권4호
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• pp.57-64
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• 2015

Objectives : To study correlation between Digital Infrared Thermal Imaging, Kupperman’s Index (KI) and Menopause Rating Scale (MRS) of Postmenopausal Women Methods : We analyzed 114 patients visiting Pohang Oriental Hospital from 1 ^st January 2014 to 30 ^th September 2015. The evaluating indexed of this trial were Age, DITI, KI, MRS. Temperature and different of temperature, such as In-dang (HN3), dan-Jung (CV17), gwan-won (CV4), hyup-back (LU4), no-gung (PC8), bock-to (ST31), and tae-chung (LR3). Results : Age was no correlation with DITI, KI, and MRS. There were positive correlation with KI and MRS significantly. DITI was not correlated with Age, KI and MRS, while ⊿T1 (LU4-PC8) was correlated with ⊿T2 (ST31-LR3) and ⊿T3 (CV17-CV4). Conclusions : There were non-significant correlation between DITI and Menopausal scale, but significant correlation in DITI themselves, Menopausal themselves. The More studies ar needed for the more accurate oriental medical diagnosis

• 척추신경추나의학회지
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• 제9권1호
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• pp.77-87
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• 2014

Objectives: The Purpose of this study is to report the effects of Korean medical treatment on patient of peroneal neuropathy caused by sitting cross-legged. Methods: The patient diagnosed as peroneal neuropathy was treated by Acupuncture, Bee Venom therapy, Herbal medicine. To evaluate the effects of Korean treatment, we used Range of Motion(ROM) of Ankle, Visual Analog Scale(VAS), Numeric Rating Scale(NRS), Ankle-Hind-foot Scale(AHS), Digital Infrared Thermal Imaging(DITI). Results: After treatment, ROM of Ankle, VAS, NRS, AHS were improved. Temperature Difference(${\Delta}T$) was decreased on DITI. Conclusions: This study suggests that Korean medical treatment might be effective on sitting cross-legged patient diagnosed as Peroneal Neuropathy.

• 사상체질의학회지
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• 제28권2호
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• pp.83-102
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• 2016

Objectives This study aimed to provide a basis for treatment of taeeum person by analysing published case reports and case series in Journal of Sasang Constitutional Medicine.Methods We reviewed case reports and case series of taeeum person in the Journal of Sasang Constitutional Medicine from 2006 to 2015.Results Of the forty papers, reporting 182 cases of taeeum person. Thirty-five papers reported 6 types of Sasang Constitutional Medicine pattern. A total of 10 types of interventions were described, of which herbal medicine (100%) was most frequently used. A total of 30 types of outcome measeure were used in papers, for which symptom change (79.2%) was most frequently used. A total of 8 types of diagnosis criteria were used in 38 papers.Conclusions A sufficient number of clinical studies are warranted to provide a clinical evidence for treatment of taeeum person.

• 대한한방부인과학회지
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• 제27권4호
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• pp.25-42
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• 2014

Objectives: To observe the effects of Herb medication on Polycystic Ovary (PCO) in rats. Methods: Riss (Research Information Sharing Service) was searched for Oriental medicine about PCO on 2000~2014. So, Experimental studies using PCO model induced by Estradiol Valerate (EV) was selected to analyze how effects they were. Consequently, 10 studies published on 2000~2014 were selected to analyze about weight of model and both ovaries, the number aries, the number of follicle and corpus of follicle and corpus luteum, the level of serum Androstenedione (ADD) and total estrogen, the level of Nerve Growth Factor (NGF) and Corticotropin Releasing Factor (CRF), the crossover rate and the number of implantation. Results: Among them, there was significantly difference between treatment group and control group in weight of both ovaries, the number of follicle and corpora lutea, the crossover rate and the number of implantation. Conclusions: The effects of Herb medication was observed on making weight of ovaries with PCO to promote. The study about effect of Herb medication on NGF and CRF with PCOS had to be conducted. The further research have to focus on treatment of subfertility and infertility, that is field showing the advantage of Oriental medicine.

• 품질경영학회지
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• 제46권4호
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• pp.923-938
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• 2018

Purpose: O2O service are becoming popular in various industries such as food delivery and taxi. This research explores how users' motivation of O2O service influence customer loyalty through expectation-confirmation and satisfaction. this study attempts to explore the motivation factor (i.e. pricing, enjoyment, immediately, social influence) and to empirically examine the relationships between those and users' loyalty to O2O service. Methods: To test the proposed research model, a survey research methodology was used. Paper survey was distributed to O2O service users in Korea. A total of 198 data were used for the analysis. Structural equation modeling was used to test hypotheses. Results: According to our findings, this study found that satisfaction was positively influenced by users' motivation factors. all hypotheses about the effect of motivation on expectation-confirmation were statistically not significant. Conclusion: O2O service providers should consider the results of this study to satisfy users' expectations and satisfaction for building a better O2O market.

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.17-28
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• 2011

Objectives : Burn is the important adverse effect of the moxibustion treatment. This research does with the purpose to utilize as basic data which the results of histological observation of the burn tissue which generates when operating various commercial indirect moxa (CIM) on the skin, evaluate the burn because of the surgical operation. Methods : It operated 6 kinds of CIM on the depilated abdomen of the rat. By using the H-E staining and TUNEL assay, the image was observed and analyzed. Results : It could be the moxibustion medical treatment using the CIM generated in the first degree burn until the third degree. And in some case, burn has not generated. By using the H-E stain, the second-degree burn and third degree was observed, and it was observed the first degree burn by using TUNEL assay. In the first degree burn, TUNEL reaction in the epidermal layer was confirmed. The damage to the dermal layer was observed in more than 2 degree burn. In the third degree, the tissue degeneration to the subcutaneous fat was observed but the thickness of the skin tissue was not observed. Conclusions : Basic data classifying the burn generated by the CIM treatment through the histological observation of the burn tissue caused by the CIM treatment were built according to this research result.

• 한국지구과학회지
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• 제45권2호
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• pp.136-146
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• 2024

본 논문은 서해 군산분지 퇴적층 내에서 발견되는 다양한 화성암들을 탄성파 반사상에 따라 분류하고 그 공간적 분포 양상을 도시하는 과정에 대해 상술한다. 연구지역인 서해 대륙붕 군산분지의 북동소분지, 남서소분지, 남동소분지 내에서 총 6종류의 분출 화성암 반사상과 3종류의 관입 화성암 반사상이 중생대 후기 백악기, 신생대 에오세 및 전기 마이오세, 신생대 제4기 층에서 발견되었다. 분출 화성암은 그 크기, 외형, 내부 층리구조에 따라 (1) 높이 200 m 이하의 고깔형 화산체들로 1회성 단성화산 분화를 통해 형성된 것으로 추정되는 단성화산체(E.mono), (2) 단성화산체들이 모여 높이 500 m 이내의 하나의 화산체를 형성하는 단성화산복합체(E.comp), (3) 높이 1 km 이상 직경 15 km 이상으로 내부에 복수의 층이 인지되는 성층화산체(E.strato), (4) 기반암 저지대의 정단층 주변에서 고반사 특성을 보이는 열극 분출암(E.fissure), (5) 저각 사면부와 내부에 직경 약 2 km 화도 구조를 보여주는 마르-다이아트림(E.maar), (6) 퇴적층을 교란하는 직경 1 km 이내 파이프형 구조를 갖는 열수분출공(E.vent)으로 구성된다. 관입 화성암은 상부 퇴적층의 변형구조를 통해 인지되며, (1) 수평형, 계단형, 종지형 등 다양한 수직/수평 관입 기하를 나타내는 암맥 및 암상(I.dike/sill), (2) 직경 1-3 km의 뿔 또는 기둥 모양 관입암체인 화성암주(I.stock), (3) 상부 퇴적층을 광범위하게 변형시키는 폭 10 km 이상의 관입암체인 저반/병반(I.batho/lac)으로 구성된다. 분출 화성암은 주로 군산분지 남서소분지 내 백악기 및 신생대 고제3기 에오세 층 내에서 인지되며, 관입암체는 주로 남동 및 남서 소분지 내에서 발견된다. 열수분출공은 군산분지 전역에서 발견되며 활동시기는 전반적으로 중기 마이오세 이후로 일부는 현재까지 활동중인 것으로 보인다.

• 감성과학
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• 제14권3호
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• pp.361-370
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• 2011

본 연구에서는 구매 의사결정에서 소비자가 심미성과 사용성 중 어느 제품 속성에 우선적인 가치를 부여하고 제품을 선택하는지 알아본다. 최근 독일에서 진행된 연구에 의하면, 사람들은 외관 디자인이 뛰어난 제품을 선호하지만 실제로 제품을 선택할 때는 심미성을 상대적으로 중시하지 않았다(Diefenbach & Hassenzahl, 2009). 개인적 가치를 중시하는 개인주의 문화(예, 독일)에 비하여 집단주의 문화(예, 한국)에서는 타인으로부터 인정받는 것을 매우 중시한다. 한국에서는 사람들이 인지하기 쉬운 제품 속성(심미성)이 그렇지 않은 제품 속성(사용성)보다 우선될 것이다. 독일에서 실시된 연구를 한국에서 동일한 절차로 재연한 결과, 예상한대로 참가자들은 심미성에 우선적인 가치를 두고 제품을 선택하였다. 참가자들은 심미성에 있어서는 가격이 비싸더라도 심미성이 높은 제품을 더 많이 선택한 반면, 사용성에 있어서는 사용성이 높지 않더라도 가격이 싼 제품을 더 많이 선택하였다(연구 1). 심미성과 사용성이 상충하는 경우에는 사용성이 낮더라도 심미성이 높은 제품을 더 많이 선택하였다(연구 2). 개인의 사회인정 욕구를 살펴본 결과, 심미성이 높은 제품을 선택한 참가자는 심미성이 낮은 제품을 선택한 참가자보다 사회인정 욕구가 높았으나 사용성에 있어서는 그러한 차이가 나타나지 않았다.

• 한국식품영양학회지
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• 제30권3호
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• pp.591-598
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• 2017

To prolong the shelf-life of strawberry, samples were treated with gel packs containing slow-released chlorine dioxide($ClO_2$) gas at 3~7 ppm for 6 days at room temperature. The weight loss and decay ratio as well as changes in pH, color and texture properties of the treated samples were investigated. The weight of the control and $ClO_2$ gas treated samples decreased slightly, but the weight of the control changed faster than those of the $ClO_2$ gas treated samples during the storage period. The decay ratio of control was higher than those of the $ClO_2$ gas treatments since 4 days of storage. The pH and acidity in the control and in the $ClO_2$ gas treated samples were no differences during storage period. The lightness of strawberry decreased during storage, but there was no difference in lightness among the treatments even when storage time was extended. The redness and yellowness of the control showed higher change than those of the $ClO_2$ gas treatments during 6 days. The firmness of the control changed more rapidly than those of the $ClO_2$ gas treatments during 6 days. Especially, the samples treated 3 and 5 ppm $ClO_2$ gas were the least changed. And the scores for appearance, firmness and overall acceptance control and 7 ppm $ClO_2$ gas treatment decreased more rapidly than those of 3 and 5 ppm treatment.