• 전기의세계
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• v.16 no.2
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• pp.1-8
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• 1967

From the discovery of Alago's disk, a number of trials and efforts have been concentrated on a small-sized and light-weighted induction motor. They have devoted themseleves, however, mainly to a improvement of cooling effect, a proper weight-distribution of copper and iron and desirable number of slots. In consequence, such an effort restricted only to the field of design, has resulted in unsatisfactory developments in the insulating materials consisting of the main parts of an induction motor. The quality of fibre and paper which are used as class-A insulation materials with their "compound" and "varnish" has been increased to some extent. Similarly Class-B insulation materials like asbest mica has been almost a combination of inorganic and binding materials. But nowadays synthesic chemistry is making a remarkable progress. So it comes possible for us to have silicon resin and other good ones of similar charateristics. And even a thin silicon resin insures us to get excellent heat-pro f and insulation, so a better space factor and cost-down in motor design have come possible in most advanced nations of the world, but not in our country. Furthermore, a consideration of productivity and economy in manufacturing process has been neglected by a majority of engineers. This is more unpleasant und more undesirable. I think this rational method of induction motor design using new synthesic resin will devote in making your productivity and economy better. And the nation-wide standard value of electric motor size is sited here. size is sited here.

• Parasites, Hosts and Diseases
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• v.57 no.6
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• pp.595-599
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• 2019

In this study we take a closer look at the diseases that afflicted Japanese police officers who were stationed in a remote mountainous region of Taiwan from 1921 to 1944. Samples were taken from the latrine at the Huabanuo police outpost, and analyzed for the eggs of intestinal parasites, using microscopy and ELISA. The eggs of Eurytrema sp., (possibly E. pancreaticum), whipworm and roundworm were shown to be present. True infection with Eurytrema would indicate that the policemen ate uncooked grasshoppers and crickets infected with the parasite. However, false parasitism might also occur if the policemen ate the uncooked intestines of infected cattle, and the Eurytrema eggs passed through the human intestines. These findings provide an insight into the diet and health of the Japanese colonists in Taiwan nearly a century ago.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.05a
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• pp.281-286
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• 2009

The proposed technique uses cyclic frame structure, where three periods such as beacon period (BP), mesh contention access period (MCAP) and slotted period (SP) are in a data frame. This paper studies on a mechanism to allow communication nodes (6lowpan) in a PAN with different logical channel for global healthcare applications monitoring technology. The proposed super framework structure system has installed 6lowpan sensor nodes to communicate with each other. The basic idea is to time share logical channels to perform 6lowpan sensor node. The concept of 6lowpan sensor node and various biomedical sensors fixed on the patient BAN (Body Area Network) for monitoring health condition. In PAN (hospital area), has fixed gateways that received biomedical data from 6lowpan (patient). Each 6lowpan sensor node (patient) has IP-addresses that would be directly connected to the internet. With the help of IP-address service provider can recognize or analyze patient data from all over the globe by the internet service provider, with specific equipments i.e. cell phone, PDA, note book. The NS-2.33 result shows the performance of data transmission delay and data delivery ratio in the case of hop count in a PAN (Personal Area Networks).

• YAKHAK HOEJI
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• v.48 no.5
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• pp.297-302
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• 2004

The purpose of the present study was to evaluate the bioequivalence of two cimetidine tablets, Tagamet (Yuhan Pharm. Co., Ltd.) and Nex (Bi-nex Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cimetidine release from the two cimetidine tablets in vitro was tested using KP Apparatus I method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solutions and water). The dissolution profiles of two cimetidine tablets were very similar at all dissolution media. Twenty four healthy male volunteers were divided into two groups with a randomized $2{\times}2$ cross-over study. After four tablets (800 mg cimetidine) were orally administrated, blood was taken and the concentrations of cimetidine in serum were determined using HPLC with UV detector. The pharmacokinetic parameters such as $AUC_{t}$, $C_{max}$ and $T_{max}$ were determined. The result showed that the differences in $AUC_{t}$, and $C_{max}$ between two cimetidine tablets based on the Tagamet were -6.82% and -12.98%, respectively. There were no sequence effects between two tablets in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)log(0.97) and log(0.82)log(0.93) for $AUC_{t}$ and $C_{max}$, respectively), indicating that Thrumetin tablet was bioequivalent to Tagamet tablet.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.05a
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• pp.271-272
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• 2014

As E-discovery in criminal investigation is increasing, the importance of Forensic Tools which can legally extract data with high effectiveness is getting higher. Digital products are growing fast. Therefore, Forensic Tools should be implemented readily to suit users and events well. Although forensic industry and governments use expensive forensic tools, some have suggested limitations to its use, such as memory limitations and the limits of post-audit. We need to develop open source forensic tools that can implement a variety of forensic tool fast. This research studies digital forensics technical skills which are commercialized currently and suggests applicable strategies of the open digital forensics to help overcome these limitations.

• Korean Journal of Pharmacognosy
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• v.50 no.3
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• pp.198-204
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• 2019

A facile and convenient method was developed for the mass production of epigallocatechin gallate (EGCG) rich green tea extract (Er-GTE). The Er-GTE was successfully obtained from the crude water extract of green tea by the combination of two step purification, i.e., a simple adsorption process on the cation exchange resins (Trilite SCR-B) followed by the chromatography with Diaion HP-20 resins. The green tea extract produced by water extraction under $45^{\circ}C$ was subjected to adsorb on the strongly acidic cation exchange resin, Trilite SCR-B. The eluate passed through the resin was reabsorbed on Diaion HP-20 resin, which was subjected to elute with a mixture of water and alcohol by conventional chromatographical manner. The EGCG content in Er-GTE was estimated above 97% by HP-LC analysis and the newly developed method was regarded as the most suitable and appropriate process for the mass production of epigallocatechin gallate rich green tea extract (Er-GTE).

• Childhood Kidney Diseases
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• v.23 no.2
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• pp.77-85
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• 2019

Contrast-associated acute kidney injury (CA-AKI) is a major concern when iodinated contrast material is administered, especially in patients at risk. Efforts have been undertaken to understand the detrimental effects of contrast media (CM). With the use of low-osmolar or iso-osmolar CM the incidence of CA-AKI has steadily decreased within the past decade; however, especially in the pediatric population information is scarce. Incidence rates have been reported to range between 0% to 18.75%, particularly depending on indication, selection of population (i.e. preexisting co-morbidities), and definition of AKI. Different biomarkers have been proposed, but confirmatory studies are either lacking or have contributed to their lack of diagnostic power. Proteomic approaches have been employed and may pave the way to such discovery. Prevention strategies have been tested and proposed, but the recently published AMACING and PRESERVE trials have shown that commonly used strategies (such as systematic hydration or administration of N-acetylcysteine) have no role in the prevention of CA-AKI. We propose that thoughtful assessment of one's fluid state is the most appropriate approach and depending on the hydration status diuretics or fluid administration should be provided to achieve an euvolemic state ahead of contrast exposure.

• BMB Reports
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• v.54 no.6
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• pp.305-310
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• 2021

Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and calcium overload in mitochondria, leading to disruption of mitochondrial membrane potential. Notably, long-term CRBN depletion using PROteolysis TArgeting Chimera (PROTAC) induced irreversible mitochondrial dysfunction, resulting in cell death. Our collective findings indicate that CRBN is required for mitochondrial homeostasis in cells.

• Fisheries and Aquatic Sciences
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• v.25 no.5
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• pp.251-263
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• 2022

Sea cucumbers are worm-like, leathery bodied, benthic, marine organisms with a branched gonad. There are over 900 species, and these organisms are capable of changing their mechanical state, regenerating their small appendages, and digestive tract. Additionally, sea cucumbers possess both commercial and therapeutical value. Furthermore, it is thought that the metabolites these organisms possess may give rise to their therapeutical value. The use of sea cucumbers in therapy can be traced back to the Ming dynasty, where they were eaten for their tonic properties against constipation, hypertension, and rheumatism. A plethora of studies have been conducted, whereby different metabolites were extracted from sea cucumbers and tested for different therapeutic properties. Herein, we review and discuss the anti-cancer, anti-microbial, anti-coagulant, anti-diabetic, antioxidant, and anti-inflammatory properties of the sea cucumber by assessing literature on PubMed and Google Scholar. Furthermore, the genome and epigenome of these remarkable species is discussed. With the immense data supporting the therapeutic properties of sea cucumbers, further studies are warranted, in order to develop novel and innovative therapeutic compounds for the benefit of human health from these fascinating marine organisms.

• Genomics & Informatics
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• v.20 no.1
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• pp.5.1-5.10
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• 2022

Non-syndromic hearing loss (NSHL) is a common hereditary disorder. Both clinical and genetic heterogeneity has created many obstacles to understanding the causes of NSHL. The present study has attempted to ravel the genetic aetiology in NSHL progression and to screen out potential target genes using computational approaches. The reported NSHL target genes (2009-2020) have been studied by analyzing different biochemical and signaling pathways, interpretation of their functional association network, and discovery of important regulatory interactions with three previously established miRNAs in the human inner ear as well as in NSHL such as miR-183, miR-182, and miR-96. This study has identified SMAD4 and SNAI2 as the most putative target genes of NSHL. But pathogenic and deleterious non-synonymous single nucleotide polymorphisms discovered within SMAD4 is anticipated to have an impact on NSHL progression. Additionally, the identified deleterious variants in the functional domains of SMAD4 added a supportive clue for further study. Thus, the identified deleterious variant i.e., rs377767367 (G491V) in SMAD4 needs further clinical validation. The present outcomes would provide insights into the genetics of NSHL progression.