• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6477-6483
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• 2014

Background: Shammah is a traditional form of chewing tobacco [smokeless tobacco, (ST)] that is commonly used in the Middle East especially in Saudi Arabia (KSA), Yemen and Sudan. The Substance Abuse Research Centre (SARC) at Jazan University noted that no adequate research and information on the prevalence of shammah use in the province of Jazan, and KSA as well, has been provided in the scientific literature. Materials and Methods: An intensive systematic review of online databases was performed, including AMED (The Allied and Complementary Medicine Database), Biological Abstracts, Cochrane Collection Plus, Dentistry and Oral Sciences Source, E-Journals Database, EBSCO Discovery Service, MEDLINE, PEMSoft, PEP Archive, PsycARTICLES, scopus, Sciencedirect and Google Scholar. Results: Shammah is a mixture of powdered tobacco, lime, ash, black pepper, oils and flavorings. ST in KSA is placed in the buccal or lower labial vestibule of the mouth. The user (or dipper) spits out insoluble debris. The importation of ST products is prohibited in KSA. Accessible information on legislative action to control the use of ST in KSA appeared in 1990. The actual percentage use may be higher, than reported since shammah is illegal in KSA and there may be some reluctance to admit to its use. Conclusions: This review paper is an initial step in a funded research project by SARC to understand the pattern of use of shammah and provide adequate epidemiological data. One goal of this review is to generate further data for public health education.

• 한국도서관정보학회지
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• 제46권4호
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• pp.325-354
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• 2015

정보거버넌스는 정보 컴플라이언스 요건을 충족시키고, 정보 가치를 극대화하는 한편 정보 위험을 통제하기 위한 통합적 접근법이다. 기업정보관리에서는 정보가 가진 활용가치뿐 아니라 보유에 따른 위험을 함께 고려해야 한다. 특히 해외 시장에 진출한 기업들이 소송과 전자증거개시에 대비하려면 건실한 기록정보관리에 토대를 둔 정보거버넌스의 도입이 시급하다. 이 연구는 미국 법조계에 영향력을 가진 세도나 컨퍼런스의 정보거버넌스 원칙을 실천적 관점에서 분석하여 기업의 정보거버넌스 구축방안을 제시하기 위한 것이다. 이 원칙을 실무에 적용할 수 있는 통제 기준으로 재구성한 후 이러한 통제 기준을 정보거버넌스의 업무 영역별로 배치하고 이를 해석함으로써 정보거버넌스의 구축과 운영상의 시사점을 제시하였다.

• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3219-3222
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• 2011

Three types of ${\beta}$-ketoacyl acyl carrier protein synthase (KAS) are important for overcoming the bacterial resistance problem. Recently, we reported the discovery of a antimicrobial flavonoid, YKAF01 (3,6-dihydroxyflavone), which exhibits antibacterial activity against Gram-positive bacteria through inhibition of ${\beta}$-ketoacyl acyl carrier protein synthase III (KAS III). In this report, we suggested that YKAF01 can be an inhibitor ${\beta}$-ketoacyl acyl carrier protein synthase I (KAS I) with dual inhibitory activity for KAS I as well as KAS III. KAS I is related to the elongation of unsaturated fatty acids in bacterial fatty acid synthesis and can be a good therapeutic target of designing novel antibiotics. We performed docking study of Escherichia coli KAS I (ecKAS I) and YKAF01, and determined their binding model. YKAF01 binds to KAS I with high binding affinity ($2.12{\times}10^6$) and exhibited an antimicrobial activity against the multidrug-resistant E. coli with minimal inhibitory concentration (MIC) value of 512 ${\mu}g$/mL. Further optimization of this compound will be carried out to improve its antimicrobial activity and membrane permeability against bacterial cell membrane.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 춘계학술대회
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• pp.126-129
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• 2015

최근 단말간 직접 통신이 가능한 단말대단말 통신 기술이 많은 관심을 받고 있다. 따라서 단말대단말 기술이 셀룰러 통신 시스템 및 차량 통신 시스템에 접목되고 있다. 본 논문에서는 Evolved Packet Core Network 기반 단말 탐색 시뮬레이터 개발에 대해서 살펴보고, Proximity기반 서비스의 차량간 애드혹 네트워크로의 적용 가능성에 대해서 살펴보았다. 개발된 시뮬레이터를 활용한 성능 분석을 통해서 유저들이 비슷한 위치에 모여 있는 환경, 즉대중교통과 비슷한 환경에서 LTE 네트워크의 트래픽이 Wi-Fi통해 단말대단말 통신으로 효율적으로 오프로딩될 수 있고 교통 관련 정보 멀티캐스팅에 효율적으로 활용될 수 있음을 보였다.

• BMB Reports
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• 제51권10호
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• pp.484-485
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• 2018

Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is a serine-threonine kinase largely essential for necroptotic cell death; it also plays a role in some inflammatory diseases. High levels of RIP3 are likely sufficient to activate necroptotic and inflammatory pathways downstream of RIP3 in the absence of an upstream stimulus. For example, we have previously detected high levels or RIP3 in the skin of Toxic Epidermal Necrolysis patients; this correlates with increased phosphorylation of MLKL found in these patients. We have long surmised that there are molecular mechanisms to prevent anomalous activity of the RIP3 protein, and so prevent undesirable cell death and inflammatory effects when inappropriately activated. Recent discovery that Carboxyl terminus of Hsp 70-Interacting Protein (CHIP) could mediate ubiquitylation- and lysosome-dependent RIP3 degradation provides a potential protein that has this capacity. However, while screening for RIP3-binding proteins, we discovered that pellino E3 ubiquitin protein ligase 1 (PELI1) also interacts directly with RIP3 protein; further investigation in this study revealed that PELI1 also targets RIP3 for proteasome-dependent degradation. Interestingly, unlike CHIP, which targets RIP3 more generally, PELI1 preferentially targets kinase active RIP3 that has been phosphorylated on T182, subsequently leading to RIP3 degradation.

• 감성과학
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• 제23권1호
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• pp.57-68
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• 2020

This research investigates how digital design agencies and client companies incorporate design thinking-a human-centered approach to solving difficult problems-into their website development processes. Based on a literature review on the design-thinking-driven web development process, multiple case studies of award-winning website projects were performed by in-depth interviews with key practitioners. Through analyses of these cases, their user-centered approaches for website innovation were identified according to the following four phases: web planning (discovery and defining phases) and web design and development (development and delivery phases). Moreover, distinct approaches of design thinking practices were identified according to two website types: a brand promotion website with a killer brand storytelling approach; and a service channel website with a strategic UI/UX-driven approach. Next, the key success drivers of these website projects were suggested in light of the typical themes of design thinking (i.e., human centeredness, research based, context awareness, and collaboration). Some practical limitations were also found in adopting the design-thinking-driven web development process, such as limited research methods and tools, and insufficient prototyping and experimentation. Along with these limitations, it was also discovered that current digital design agencies still face the following challenges in adopting the design-thinking-driven web development process: building a long-term, playful partnership with clients; leveraging decision-makers' design thinking awareness; and coping with limited resources (design thinking practitioners, budgets, and schedules).

• 한국사회복지학
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• 제46권
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• pp.236-262
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• 2001

This discovery-oriented study explored 31 social workers' perceptions of discrepancies between explicit and implicit rules in their work places that are supposed to affect the quality of social work services, and identified eight categories of dilemmas: (a) confused accountability or purpose, (b) ambiguous principle, (c) improper authority, (d) confused role of social workers, (e) conflict between ideal and reality, (f) confused work ethics, (g) confused boundary of workers' rights, and (h) binds. These eight categories revealed the real philosophy and purposes of social work agencies, work ethics and values prevalent among social work agencies, agencies' orientation toward clients, and the conditions of social support from the society in large. Instead of searching for discrete variables as separately responsible for inefficient social work services, this approach probed malfunctioning implicit rules in a holistic context to see if inefficient or ineffective provision of social work services is a logical response to a much larger and deeper nexus. Insight into discrepant rules does not solely ensure the improvement of social work practice in the field, particularly if their identification is simply used as another opportunity to blame and avoid self-responsibility. However, such discrepancies between implicit and explicit rules are real enough to the staff workers and agency administrators that they may want to begin the dialogue of contradictory rules as a way of sanctioning discussion of previously forbidden topics. This study provided the ground-work for the dialogue.

• 기본간호학회지
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• 제20권4호
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• pp.381-388
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• 2013

Purpose: This study was done to investigate nurses' awareness of death and the meaning of life and identify factors influencing the meaning of life. Methods: Participants were 198 women nurses who had experienced the death of patients. They answered a self-administered questionnaire including demographics, awareness of death scale and meaning in life II scale. Data were analyzed using descriptive statistics, t-test, ANOVA, Scheff$\acute{e}$ test, and multiple regression (enter method). Results: The average score for awareness of death was $127.3{\pm}10.14$. This score is moderate not biased toward positive or negative. The average score for meaning of life was $130.3{\pm}9.42$ with 51% for loss steps, 45.5% for pursuit steps and 3.5% for discovery steps to the meaning of life. Factors affecting the meaning of life were religion, Buddhism (${\beta}=6.25$, p=.015) or Atheist (${\beta}=5.91$, p=.017), educational level, Master's or higher (${\beta}=16.22$, p=.003), work department, special department (${\beta}=3.49$, p=.017). Conclusions: Results of the study indicate a need to provide nursing programs that will promote nurses' spiritual and inner maturity.

• 한국화재조사학회논문지
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• 제11권1호
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• pp.41-58
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• 2008

등불의 발견은 인간 생활에 커다란 변화를 가져 왔으며, 그 역사는 매우 오래되었다. 그러나 비약적으로 발전한 것은 1879년 에디슨이 탄소 필라멘트 진공 전구를 발명하여 조명에 사용하면서 시작되었다고 할 수 있다. 조명은 피로를 덜어주고 안전도를 높이며 사람의 활동 능률을 올리고 즐거운 분위기를 만들어 준다. 그러나 부주의나 관리소홀로 인해 소중한 재산과 인명을 앗아가는 화재의 원인이 되기도 한다. 본 연구에서는 조명등의 구조와 원리를 이해하고 일반가정에서 가장 많이 사용되고 있는 백열전구과 형광등을 중심으로 출화가능성과 조사확인사항에 대하여 발화사례를 중심으로 하여 배선과 가연물 접촉에 의한 사례 및 재현실험을 통하여 논문의 신뢰성을 확보하고자 하였다.

• 생명과학회지
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• 제9권1호
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• pp.99-105
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• 1999

Bacillus sp. RH-5로 배양한 배양액을 silica gel column (8.0cmX100cm)chromatography를 행하여 chloroform : methanol = 90 : 10인 항산화 분획층을 얻어 TLC 법에 의해 활성이 있는 물질을 분리하여 thiocyanate method로 활성을 측정하여 본 결과 Vit. E($10^{-2}$ mol)보다 좋았으며 BHA, BHT와는 비슷한 결과를 나타내었다. 한편 $5_\muM$ $CuSO_4$ 촉매 사람 Low Density Lipoprotein(LDL)의 산화에 항산화 활성이 알려진 Fraction 3의 band 4를 각각 100 및 200$\mu$g/$m\ell$ 농도로 $37^{\circ}C$에서 18시간 배양한 결과 LDL의 산화에 대한 억제효과가 좋았다. Fraction 3의 band 4를 HPLC로 정제한 후 IR. NMR 및 GC/MASS.로 확인한 결과 5-hydroxyndole로 확인되었다.