• The Korean Journal of Physiology and Pharmacology
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• 제20권4호
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• pp.367-378
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• 2016

Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments to measure the concentration changes of critical molecules associated with mitochondrial apoptosis in both human mesothelioma H2052 and their ${\rho}^0$ cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range of experiments. From parametric perturbation analysis, we further found that apoptosis will reach its saturation level beyond a certain critical cisplatin concentration.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제6권1호
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• pp.446-467
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• 2012

In this paper, the analysis and design of a motion simulator (based on the approach taken by interactive virtual reality (VR) entertainment systems) is conducted. The main components of the system include a bilateral control interface, simulation and a motion simulator control scheme. The space entertainment system uses a virtual environment that enables operators to feel the actual feedback sensing and distorted motion from the virtual environment, just as they would in the real environment. The space entertainment system integrates the dynamics of the motion simulator and the virtual environment and the operator maneuvers a steering wheel to interact with the system. The multiple bilateral control schemes employ a dynamical controller, which is designed by considering the velocity and acceleration that the operator imposes on the joystick, the environmental changes imposed on the motion simulator. In addition, we develop a calculated method to evaluate the Ratio of the simulation results. It is shown that the proposed control scheme can improve the performance of the visual entertainment system. Experiments are conducted on the virtual reality entertainment system to validate the theoretical developments.

• Coupled systems mechanics
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• 제12권1호
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• pp.1-20
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• 2023

On the basis of the explicit time-domain method, an investigation is performed on the influence of the rotational stiffness and rotational damping of the vehicle body and front-rear bogies on the dynamic responses of the vehicle-bridge coupled systems. The equation of motion for the vehicle subsystem is derived employing rigid dynamical theories without considering the rotational stiffness and rotational damping of the vehicle body, as well as the front-rear bogies. The explicit expressions for the dynamic responses of the vehicle and bridge subsystems to contact forces are generated utilizing the explicit time-domain method. Due to the compact wheel-rail model, which reflects the compatibility requirement of the two subsystems, the explicit expression of the evolutionary statistical moment for the contact forces may be performed with relative ease. Then, the evolutionary statistical moments for the respective responses of the two subsystems can be determined. The numerical results indicate that the simplification of vehicle model has little effect on the responses of the bridge subsystem and the vehicle body, except for the responses of the rotational degrees of freedom for the vehicle subsystem, regardless of whether deterministic or random analyses are performed.

• 한국전자통신학회논문지
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• 제12권5호
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• pp.747-754
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• 2017

카오스 기반 보안 통신시스템은 표준 대역확산 시스템의 대안으로서, 이것은 정보신호의 대역을 확산시키며 단순하고 작은 비용으로 카오스회로를 사용하여 정보신호를 암호화할 수 있다. 보안 통신 분야에서는 Lorenz, Chua, Rossler, Duffing등과 같은 전통적인 시스템들이 널리 사용되고 있다. Malasoma 카오스 시스템은 위상학적으로는 단순하지만 불규칙한 신호 생성과 비선형성의 시스템으로서 동기화와 보안 통신을 적용한 시스템은 관련 논문도 거의 없다. 본 논문은 기존의 카오스 시스템의 대안으로서 보안 통신 분야에서 사용될 수 있는 새로운 카오스 시스템을 소개한다. 또한 이 새로운 모델은 시뮬레이션을 통하여 카오스 신호로 보안성을 확인하고 P-C(Pecora-Carroll)방식을 사용하는 동기화 통신시스템을 모델화 한다. Malasoma 시스템의 모델링, 동기화 및 보안 통신 응용은 각각 MATLAB - Simulink 환경에서 구현된다. 이를 통해 도출된 결과는 이 새로운 카오스 시스템이 보안 통신 분야에서 사용될 수 있음을 확인할 수 있다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제29권12호
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• pp.926-939
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• 2002

시스템이 실행 중 다양한 환경 요인에 의해 발생할 수 있는 불확실성을 명세하기 위해 확률의 개념을 적용한 명세 방범이 요구되고 있다. 본 논문에서는 실행에 영향을 주는 많은 환경 요인들을 고려하여, 변화하는 실행 환경에서 시스템의 행위를 예측, 분석하기 위한 확률 정형 기법인 확률 추상 시간 기계(PATM:Probabilistic Abstract Timed Machine)를 제안한다. PATM에서는 확률에 영향을 주는 환경요인을 실행 도중 변경이 가능한 가변 확률 요인과 변경이 불가능한 고정 확률 요인으로 분류하고 있다. 시스템의 행위에 대한 분석은 PATM의 동적 실행모델인 확률 도달성 그래프를 통해서 이루어진다. 분석결과를 토대로 시스템의 동작 실패 가능성을 예측하고, 이에 영향을 미치는 가변 환경 요인을 변경하여 궁극적으로 시스템의 신뢰도를 향상할 수 있도록 한다.

• Smart Structures and Systems
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• 제21권3호
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• pp.287-303
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• 2018

Applications of energy harvesting from mechanical vibrations is becoming popular but the full potential of such applications is yet to be explored. This paper addresses this issue by considering an application of energy harvesting for the dual objective of serving as an indicator of structural health monitoring (SHM) and extent of control. Variation of harvested energy from an undamaged baseline is employed for this purpose and the concept is illustrated by implementing it for active vibrations of a pipe structure. Theoretical and experimental analyses are carried out to determine the energy harvesting potential from undamaged and damaged conditions. The use of energy harvesting as indicator for control is subsequently investigated, considering the effect of the introduction of a tuned mass damper (TMD). It is found that energy harvesting can be used for the detection and monitoring of the location and magnitude of damage occurring within a pipe structure. Additionally, the harvested energy acts as an indicator of the extent of reduction of vibration of pipes when a TMD is attached. This paper extends the range of applications of energy harvesting devices for the monitoring of built infrastructure and illustrates the vast potential of energy harvesters as smart sensors.

• Wind and Structures
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• 제27권6호
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• pp.399-416
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• 2018

In order to reveal the independent relationship between track irregularity and wind loads, the stochastic characteristics of train-bridge coupling systems subjected to wind loads were investigated by the multi-sample calculation. The vehicle was selected as 23 degrees of freedom dynamical model, and the bridge was described by three-dimensional finite element model. It was assumed that the wind loads were random processes with strong spatial correlation, while the track irregularities were stationary random ones. As a case study, a high-speed train running on a cable-stayed bridge subjected to wind loads was studied. The effect of rail irregularities was deemed to be independent of the effect of wind excitations on the coupling system in the same wind circumstance for the same project, leading to the conclusion that the effect of wind loads and moving vehicle could be calculated separately. The variance results of the stochastic responses of vehicle-bridge coupling system under the action of wind loads and rail irregularities together were equivalent to the sum of the variance of the responses induced by each excitation. Therefore, when one of the input excitations is different, only the effect of changed loads needs to be assessed. Moreover, the new calculated results were combined with the effect of unchanged loads to present the stochastic response of coupling system subjected to the different excitations, reducing the cost of computations. The stochastic characteristics, the CFD (cumulative distribution function) of the coupling system with different wind velocities, vehicle speed, and vehicle marshalling were studied likewise.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제3권6호
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• pp.575-596
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• 2009

Facing limited network resources such as bandwidth and processing capability, the Internet will have congestion from time to time. In this paper, we propose a scheme to maximize the total utility offered by the network to the end user during congested times. We believe the only way to achieve our goal is to make the scheme application-aware, that is, to take advantage of the characteristics of the application. To make our scheme scalable, it is designed to be class-based. Traffic from applications with similar characteristics is classified into the same class. We adopted the RED queue management mechanism to adaptively control the traffic belonging to the same class. To achieve the optimal utility, the traffic belonging to different classes should be controlled differently. By adjusting link bandwidth assignments of different classes, the scheme can achieve the goal and adapt to the changes of dynamical incoming traffic. We use the control theoretical approach to analyze our scheme. In this paper, we focus on optimizing the control on two types of traffic flows: TCP and Simple UDP (SUDP, modeling audio or video applications based on UDP). We derive the differential equations to model the dynamics of SUDP traffic flows and drive stability conditions for the system with both SUDP and TCP traffic flows. In our study, we also find analytical results on the TCP traffic stable point are not accurate, so we derived new formulas on the TCP traffic stable point. We verified the proposed scheme with extensive NS2 simulations.

• 복식
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• 제62권5호
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• pp.1-15
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• 2012

In a fast changing postmodern society, contemporary fashion is becoming more complicated and ambiguous along with other genres of art than ever before. This phenomenon reigning as a sociocultural paradigm can be defined as 'indeterminacy' and it means 'undecidability'. The purpose of this study is to clarify and analyze the indeterminate characteristics of contemporary fashion reviewing the theoretical background and the architectural formativeness as a comparative research. The core idea of deconstructivism dismantles a causal relationship between function and form in fashion and the conventional notion about clothes. Complexity theory, which is the study of chaotic dynamical systems, suggests the creative idea and concept of infinite possibilities on a formative method. Meanwhile, catastrophe theory of discontinuous change can be used as interpretative strategies for the process of deconstruction and reconstruction. As a result of this study, the indeterminacy of fashion can be analyzed into five semantic categories: irregularity, immateriality, randomness, complexity and changeability. The intrinsic value of the indeterminacy in contemporary fashion is the interaction with a sociocultural ideology and a technological environment as well as an expansion of formative expression. To conclude, it can be said that the indeterminacy in fashion is a new interpretation of the relationship among body and space, clothes and society.

• 전자공학회논문지SC
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• 제40권3호
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• pp.117-126
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• 2003

본 연구에서는 월쉬함수를 이용하여 샘플링 구간내에서 데이터를 처리할 수 있는 온라인 월쉬변환과 샘플링 구간내에서 미분 방정식을 계산할 수 있는 새로운 온라인 월쉬함수 미분연산법을 제안하였다. 스케일링 인자의 도입과 다음구간에서의 초기조건을 계산하여 줌으로써 임의의 샘플링 시간을 취할 수 있게 하였으며 제안된 월쉬함수 온라인 알고리즘을 이용하여 기존의 직교함수가 가지는 최종시간까지의 신호를 모두 알고 있어야 그 적용이 가능하다는 단점을 제거하였다. 유사변환법을 이용하여 유도된 동적 시스템에 대한 Luenberger관측기를 월쉬함수를 이용하여 새롭게 변환함으로써 관측기에 포함된 출력의 미분항을 없애기 위한 불필요한 관측기 방정식의 분할을 피하였으며 대수적으로 상태 및 미지입력을 추정하였다. 제안된 방법을 이용하면 실시간 처리를 요하는 시스템에 유용하게 적용될 것으로 기대된다.