• BMB Reports
• /
• v.52 no.2
• /
• pp.113-118
• /
• 2019

The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.

• Molecules and Cells
• /
• v.45 no.3
• /
• pp.101-108
• /
• 2022

Drosophila melanogaster lymph gland, the primary site of hematopoiesis, contains myeloid-like progenitor cells that differentiate into functional hemocytes in the circulation of pupae and adults. Fly hemocytes are dynamic and plastic, and they play diverse roles in the innate immune response and wound healing. Various hematopoietic regulators in the lymph gland ensure the developmental and functional balance between progenitors and mature blood cells. In addition, systemic factors, such as nutrient availability and sensory inputs, integrate environmental variabilities to synchronize the blood development in the lymph gland with larval growth, physiology, and immunity. This review examines the intrinsic and extrinsic factors determining the progenitor states during hemocyte development in the lymph gland and provides new insights for further studies that may extend the frontier of our collective knowledge on hematopoiesis and innate immunity.

• Journal of Institute of Control, Robotics and Systems
• /
• v.11 no.10
• /
• pp.823-829
• /
• 2005

We have newly constructed an in silico model of fermentative metabolism for Lactococcus lactis in order to analyze the characteristics of metabolite flux for dynamic network. A rigorous mathematical model for metabolic flux has been developed and simulation researches have been performed by using GEPASI program. In this simulation task, we were able to predict the whole flux distribution trend for lactate metabolism and analyze the flux ratio on the pyruvate branch point by using metabolic flux analysis(MFA). And we have studied flux control coefficients of key reaction steps in the model by using metabolic control analysis(MCA). The role of pyruvate branch seems to be essential for the secretion of lactate and other organic byproducts. Then we have made an effort to elucidate its metabolic regulation characteristics and key reaction steps, and find an optimal condition for the production of lactate.

• Information Systems Review
• /
• v.19 no.1
• /
• pp.123-145
• /
• 2017

This study empirically examines the effects of regulation on online gaming. Going beyond ad hoc heuristic approaches on individual behavior, we investigate the effects of regulation on dynamic changes of games or service providers. In particular, we propose three theoretical perspectives: social influence to investigate the regulation effect, the role of prior experience to determine the difference in the regulation effect size through users' prior experience, and network externalities to discover the difference in the regulation effect size according to the number of users on an online gaming platform. We use the vector autoregression methodology to model patterns of the co-movement of online games and to forecast game usage. We find that online gamers are heterogeneous. Therefore, policy makers should make suitable regulations for each heterogeneous group to effectively avoid generating gaming addicts without interrupting the economic growth of the online gaming industry.

• Journal of Power Electronics
• /
• v.16 no.5
• /
• pp.1821-1832
• /
• 2016

This study presents a strategy using the synchronized output regulation method (SOR) for controlling inverters operating in stand-alone and grid-connected modes. From the view point of networked dynamic systems, SOR involves nodes with outputs that are synchronized but also display a desirable wave shape. Under the SOR strategy, the inverter and grid are treated as two nodes that comprise a simple network. These two nodes work independently under the stand-alone mode. An intermediate mode, here is named the synchronization mode, is emphasized because the transition from the stand-alone mode to the grid-connected mode can be dealt as a standard SOR problem. In the grid-connected mode, the inverter operates in an independent way, in which the voltage reference changes for generalized synchronization where its output current satisfies the required power injection. Such a relatively independent design leads to a seamless transfer between operation modes. The closed-loop system is analyzed in the state space on the basis of the output regulation theory, which improves the robustness of the design. Simulations and experiments are performed to verify the proposed control strategy.

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.11
• /
• pp.637-645
• /
• 2020

A free-market economic system supported by the progress of the Industrial Revolution 4.0 has given birth to a sharing economy with a disruptive business model. In many ways, this business model is more effective, efficient, and makes it easy for businesses and consumers. However, because disruptive innovation is not asymmetrical with the conventional business that sustains innovation, several regulatory issues arise because it is fundamentally very different and cannot be regulated by standard law. Disruptive innovation may create chaos if it is regulated by norms that are used to regulate conventional business. This research was conducted with a normative method, which examines various theories, principles, laws and regulations to get justification for how the law should govern. The findings of this study are: competition law must be designed pragmatically so that it can keep pace with changes in business models that are rapidly changing. For this reason, it is necessary to shift regulatory authority from the Government to business people to make self-regulation, as a rule, that was born from the agreement of the business actors themselves. Self-regulation is considered more effective in maintaining fair competition, so that the market will be more dynamic, and consumers will be more prosperous.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.9 no.10
• /
• pp.3810-3830
• /
• 2015

In this paper, we investigate the differential game theoretic approach for distributed dynamic cooperative power control in cognitive radio ad hoc networks (CRANETs). First, a payoff function is defined by taking into consideration the tradeoff between the stock of accumulated power interference to the primary networks and the dynamic regulation of the transmit power of secondary users (SUs). Specifically, the payoff function not only reflects the tradeoff between the requirement for quickly finding the stable available spectrum opportunities and the need for better channel conditions, but also reveals the impact of the differentiated types of data traffic on the demand of transmission quality. Then the dynamic power control problem is modeled as a differential game model. Moreover, we convert the differential game model into a dynamic programming problem to obtain a set of optimal strategies of SUs under the condition of the grand coalition. A distributed dynamic cooperative power control algorithm is developed to dynamically adjust the transmit power of SUs under grand coalition. Finally, numerical results are presented to demonstrate the effectiveness of the proposed algorithm for efficient power control in CRANETs.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.44 no.3
• /
• pp.192-206
• /
• 2021

The pharmaceutical industry is an industry that provides medicines related to the health and life of the people. The pharmaceutical industry is a traditional regulation industry with the characteristics of R&D(Research and Development), purchasing, manufacturing, distribution and consumption under strict government management. Until now, pharmaceutical companies have continued to make efforts to maintain competitiveness through patent management, new product development, and marketing. However, industries are rapidly changing, including rising costs for developing new products and expanding generic markets. As these changes and uncertainties in the management environment increase, efforts are required to improve the competitiveness of the pharmaceutical industry from a new perspective. In this study, we intend to examine the impact of SCM(Supply Chain Management) dynamic capability of pharmaceutical companies on corporate performance through partnerships to respond to market changes and uncertainties. It was determined that the agility, visibility and flexibility that constitutes the SCM dynamic capabilities would affect the performance of pharmaceutical companies. In this study, the importance of SCM dynamic capabilities and cooperative relationships was identified through surveys by SCM managers of pharmaceutical companies. Consequently, in the pharmaceutical industry, which is a regulatory industry, we have identified that SCM dynamic capabilities and cooperative relationships with partner companies have a significant impact on corporate performance.

• Journal of Power Electronics
• /
• v.7 no.2
• /
• pp.146-158
• /
• 2007

A multi-pulse GTO based voltage source converter (VSC) topology together with a fundamental frequency switching mode of gate control is a mature technology being widely used in static synchronous compensators (STATCOMs). The present practice in utility/industry is to employ a high number of pulses in the STATCOM, preferably a 48-pulse along with matching components of magnetics for dynamic reactive power compensation, voltage regulation, etc. in electrical networks. With an increase in the pulse order, need of power electronic devices and inter-facing magnetic apparatus increases multi-fold to achieve a desired operating performance. In this paper, a competitive topology with a fewer number of devices and reduced magnetics is evolved to develop an 18-pulse, 2-level $\pm$ 100MVAR STATCOM in which a GTO-VSC device is operated at fundamental frequency switching gate control. The inter-facing magnetics topology is conceptualized in two stages and with this harmonics distortion in the network is minimized to permissible IEEE-519 standard limits. This compensator is modeled, designed and simulated by a SimPowerSystems tool box in MATLAB platform and is tested for voltage regulation and power factor correction in power systems. The operating characteristics corresponding to steady state and dynamic operating conditions show an acceptable performance.

• Journal of Electrical Engineering and Technology
• /
• v.13 no.2
• /
• pp.677-687
• /
• 2018

This paper presents a novel power decoupling control scheme with the bidirectional buck-boost converter for primary-side regulation photovoltaic (PV) micro-inverter. With the proposed power decoupling control scheme, small-capacitance film capacitors are used to overcome the life-span and reliability limitations of the large-capacitance electrolytic capacitors. Then, an improved flyback PV inverter is employed in continuous conduction mode with primary-side regulation for the PV power conditioning. The proposed power-decoupling controller shares the reference for primary side current regulation of the flyback PV inverter. The decoupling controller shapes the input current of the bidirectional buck-boost converter. The shared reference eliminates the phase-delay between the input current to the bidirectional buck-boost converter and the double frequency current at the PV primary current. The elimination of the phase-delay in dynamic response enhances the ripple rejection capability of the power decoupling buck-boost converter even with small film capacitor. With proposed power decoupling control scheme, the additional advantage of the primary-side regulation of flyback PV inverter is that there is no need to have an extra current sensor for obtaining the ripplecurrent reference of the decoupling current-controller of the power-decoupling buck-boost converter. Therefore, the proposed power decoupling control scheme is cost-effective as well as the size benefit. A new transient analysis is carried out which includes the source voltage dynamics instead of considering the source voltage as a pure voltage source. For verification of the proposed control scheme, simulation and experimental results are presented.