• 대한의용생체공학회:의공학회지
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• 제35권5호
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• pp.151-159
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• 2014

Computed tomography (CT) is one of the most widely used medical imaging modality. However, substantial x-ray dose exposed to the human subject during the CT scan is a great concern. Region-of-interest (ROI) CT is considered to be a possible solution for its potential to reduce the x-ray dose to the human subject. In most of ROI-CT scans, the ROI is set to a circular shape whose diameter is often considerably smaller than the full field-of-view (FOV). However, an arbitrarily shaped ROI is very desirable to reduce the x-ray dose more than the circularly shaped ROI can do. We propose a new method to make a non-circular convex-shaped ROI along with the image reconstruction method. To make a ROI with an arbitrary convex shape, dynamic collimations are necessary to minimize the x-ray dose at each angle of view. In addition to the dynamic collimation, we get the ROI projection data with slightly lower sampling rate in the view direction to further reduce the x-ray dose. We reconstruct images from the ROI projection data in the compressed sensing (CS) framework assisted by the exterior projection data acquired from the pilot scan to set the ROI. To validate the proposed method, we used the experimental micro-CT projection data after truncating them to simulate the dynamic collimation. The reconstructed ROI images showed little errors as compared to the images reconstructed from the full-FOV scan data as well as little artifacts inside the ROI. We expect the proposed method can significantly reduce the x-ray dose in CT scans if the dynamic collimation is realized in real CT machines.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.305-308
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• 2002

More complex radiotherapy techniques using multi leaf collimation(MLC) such as intensity-modulated radiation therapy(IMRT) has been increasing the significance of verification of leaf position and motion. Due to the reliability and robustness, quality assurance(QA) of MLC is usually performed with portal films. However, the advantage of ease of use and capability of providing digital data of electronic portal imaging devices(EPIDs) have attracted many attentions as alternatives of films for routine quality assurance in spite of the concerns about their clinical feasibility, efficacy, and the cost to benefit ratio. In our work, the method of routine QA of MLC using electronic portal imaging(EPI) was developed. The verification of availability of EPI images for routine QA was performed by comparison with those of the portal films which were simultaneously obtained when radiation was delivered and known prescription input to MLC controller. Specially designed test patterns of dynamic MLC were applied to image acquisition. Quantitative off-line analysis using edge detection algorithm enhanced the verification procedure in addition to on-line qualitative visual assessment. In conclusion, the EPI is available enough for routine QA with the accuracy of portal films.

• International Journal of Precision Engineering and Manufacturing
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• 제8권2호
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• pp.14-19
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• 2007

Angle sensors based on the principle of autocollimation, which are usually called autocollimators, can accurately measure small tilt angles of a light-reflecting flat surface. This paper describes a prototype micro-angle sensor that is based on the laser autocollimation technique. The new angle sensor is compact and consists of a laser diode as the light source and a quadrant photodiode as a position-sensing device. Because of its concise design, the microangle sensor facilitates dynamic measurements of the angular error motions of a precision stage without influencing the original dynamic properties of the stage. This is because the sensor only requires a small extra target mirror to be mounted on the stage. The sensitivity of the angle detection is independent of the focal length of the objective lens; therefore, an objective lens with a relatively short focal length is employed to reduce the size of the device. The micro-angle sensor uses a single lens for the both the laser collimation and focusing, which distinguishes it from the conventional laser autocollimation method that has separate collimate and objective lenses. The new micro-angle sensor has dimensions of $15.1\times22.0\times14.0mm$ and its resolution is better than 0.1 arc-second The optical design and performance of this micro-angle sensor were verified by experimental results.

• 한국의학물리학회지:의학물리
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• 제14권3호
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• pp.151-160
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• 2003

삼차원 입체조형방사선치료나 세기조절방사선치료와 같은 다엽시준기(Multileaf Collmator, MLC)를 이용하는 보다 복잡한 방사선 치료 기술은 다엽시준기의 위치 및 운동의 검증의 중요성을 증가시키고 있다. 이러한 다엽시준기의 검증은 신뢰성과 그동안 축척된 경험적 검증능력으로 인하여 주로 필름을 가지고 수행되어왔다. 그러나 전자포탈영상장치(Electornic Portal Imaging Device, EPID)의 사용의 편이성과 디지털 영상 제공 능력은 낮은 임상편이성, 효율성, 비용대 수익률에도 불구하고 정기적인 정도확립(Quality Assurance, QA)에 현실적인 필름의 대체재로 관심을 모아왔다. 본 연구에서는 EPI를 활용한 다엽시준기의 정기적인, 특히 일간 정도확립법을 개발하였다. 정기적 정도확립을 위한 전자포탈영상(Electronic Portal Imaing, EPI)의 적용가능성에 대한 검증은 방사선 조사시 동시에 획득된 필름과 다엽시준기의 제어장치에 입력한 다엽시준기의 처방과의 비교를 통해 수행되었다. 특별히 설계된 두가지 형태의 시험형(test pattern)이 영상 획득 및 비교에 적용되었다. 정성적인 온라인 육안 검증과 함께 윤곽 검출 알고리듬을 이용한 정량적인 오프라인 분석이 검증 절차에 이용되었다. 결론적으로, 본 연구에서 개발된 EPI를 이용한 다엽시준기의 일간 정도확립법은 필름의 정확도를 가지고 편리하게 수행될 수 있었다.

• 한국의학물리학회지:의학물리
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• 제11권2호
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• pp.147-155
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• 2000

Patient dose verification is one of the most important parts in quality assurance of the treatment delivery for radiation therapy. The dose distributions may be meaningfully improved by modulating two dimensional intensity profile of the individual high energy radiation beams In this study, a new method is presented for the pre-treatment dosimetric verification of these two dimensional distributions of beam intensity by means of a charge coupled device video camera-based fluoroscopic device (henceforth called as CCD-VCFD) as a radiation detecter with a custom-made software for dose calculation from fluorescence signals. This system of dosimeter (CCD-VCFD) could reproduce three dimensional (3D) relative dose distribution from the digitized fluoroscopic signals for small (1.0$\times$1.0 cm$^2$ square, ø 1.0 cm circular ) and large (30$\times$30cm$^2$) field sizes used in intensity modulated radiation therapy (IMRT). For the small beam sizes of photon and electron, the calculations are performed In absolute beam fluence profiles which are usually used for calculation of the patient dose distribution. The good linearity with respect to the absorbed dose, independence of dose rate, and three dimensional profiles of small beams using the CCD-VCFD were demonstrated by relative measurements in high energy Photon (15 MV) and electron (9 MeV) beams. These measurements of beam profiles with CCD-VCFD show good agreement with those with other dosimeters such as utramicro-cylindrical (UC) ionization chamber and radiographic film. The study of the radiation dosimetric technique using CCD-VCFD may provide a fast and accurate pre-treatment verification tool for the small beam used in stereotactic radiosurgery (SRS) and can be used for verification of dose distribution from dynamic multi-leaf collimation system (DMLC).

• Radiation Oncology Journal
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• 제20권1호
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• pp.68-72
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• 2002

최근 들어 새로운 방사선치료법인 강도변조방사선치료가 많은 종류의 종양치료에 적용되어 치료에 따른 부작용을 줄이고 치료율을 향상시키려는 노력들이 이루어지고 있다. 특히 전립선암에서 강도변조방사선치료법을 적용하여 삼차원입체조형치료에 비해 향상된 선량분포와 이로 인한 주위 정상조직의 방사선량을 줄임으로써 더욱 많은 양의 방사선을 전립선에 투여할 수 있고 이로 인하여 치료율의 상승을 기대할 수 있게 되었다. 저자들은 강도변조방사선치료를 전립선암에 적용하였기에 이에 대한 문헌고찰과 함께 치료과정을 보고하고자 한다.

• Macromolecular Research
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• 제10권1호
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• pp.2-12
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• 2002

The small-angle X-ray scattering (SAXS) beamline BL4C1 at the 2.5 GeV storage ring of the Pohang Accelerator Laboratory (PAL) has been in its first you of operation since August 2000. During this first stage it could meet the basic requirements of the rapidly growing domestic SAXS user community, which has been carrying out measurements mainly on various polymer systems. The X-ray source is a bending magnet which produces white radiation with a critical energy of 5.5 keV. A synthetic double multilayer monochromator selects quasi-monochromatic radiation with a bandwidth of ca. 1.5%. This relatively low degree of monochromatization is sufficient for most SAXS measurements and allows a considerably higher flux at the sample as compared to monochromators using single crystals. Higher harmonics from the monochromator are rejected by reflection from a flat mirror, and a slit system is installed for collimation. A charge-coupled device (CCD) system, two one-dimensional photodiode arrays (PDA) and imaging plates (IP) are available its detectors. The overall performance of the beamline optics and of the detector systems has been checked using various standard samples. While the CCD and PDA detectors are well-suited for diffraction measurements, they give unsatisfactory data from weakly scattering samples, due to their high intrinsic noise. By using the IP system smooth scattering curves could be obtained in a wide dynamic range. In the second stage, stating from August 2001, the beamline will be upgraded with additional slits, focusing optics and gas-filled proportional detectors.