• 생명과학회지
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• 제34권6호
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• pp.408-417
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• 2024

원화(Daphne genkwa (Siebold & Zucc))의 50% 에탄올 추출물인 PB-81이 소 로타바이러스 설사병 환축에서 설사병의 치료효과와 바이러스 증식 억제 효과가 나타나는가를 확인하였다. PB-81에 의해 상피세포주인 A549 세포와 혈액세포주인 NK92 세포에서 각각 IFN-β와 IFN-γ가 유도되는 것을 확인하였다. PB-81의 바이러스의 증식억제 효과를 확인하기 위해 PB-81을 MBDK 세포에 바이러스의 감염 전, 동시, 감염 후에 투여하는 세 가지 경우에서 바이러스 억제효과를 확인한 결과 PB-81을 투여한 모든 경우에서 바이러스가 억제되었으며, 바이러스 감염 전에서 투여하는 경우에서 가장 좋은 바이러스 억제효과가 나타났다. 마우스에서의 독성검사에서는 투여최대용량인 20 mg/mL에서도 독성에 따른 부작용이 나타나지 않았다. 소 로타바이러스 설사병 환축 16두와 대조군 4두를 대상으로 한 치료효과 검증에는 20 mg/5 mL 용량의 PB-81을 투여한 결과, PB-81을 투여한 모든 소 로타바이러스 설사병 환축이 완치되었으며 PB-81의 투여 후에 완치까지 소요된 기간은 PB-81투여군이 평균 2.25일이었고, PB-81을 투여하지 않은 대조군이 6.5일로 PB-81의 투여에 의한 소 로타바이러스 설사병의 치료효과가 나타나는 것을 확인하였으며 PB-81을 투여한 모든 환축에서 부작용이 검출되지 않았다.

• The Korean Journal of Pain
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• 제10권2호
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• pp.241-245
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• 1997

Persistent hiccup is defined as duration lasting longer than 48 hours. Reflex arc of hiccup is divided into three parts : afferent, central, efferent. Afferent portion of the neural pathway of hiccup formation is composed of vagus nerve, phrenic nerve, and sympathetic chain arising from T6 to T12. Efferent limb is phrenic nerve. Hiccup center is located in brain stem, midbrain, reticular system and hypothalamus. Persistent hiccup is very difficult to treat by conventional methods. We performed cervical epidural block of the phrenic nerve root for three patients suffering from persistent hiccup. The therapeutic effect was perfect. The mechanism of the cervical epidural block is not yet defined however it is thought to block the efferent nerve fibers and suppress the reflex arc of hiccup. We conclude cervical epidural block is relatively safe and very effective for treating persistent hiccup.

• Journal of Korean Biological Nursing Science
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• 제26권2호
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• pp.71-82
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• 2024

Purpose: This study systematically analyzed the impact of aromatherapy on pain in individuals with diabetes. Methods: A search was performed in seven electronic databases based on the PICO-SD (Population, Intervention, Comparison, Outcome, Study Design) framework. The population (P) of interest was individuals with diabetes, and the intervention (I) included aromatherapy targeting pain reduction. The comparison (C) consisted of control groups that received no intervention, another intervention, or usual care. The outcome (O) measured was pain. The quality of the selected literature was assessed using the Joanna Briggs Institute checklist. In MIX 2.0 Pro, the pooled overall effect of pain was calculated using Hedge's g and a random-effects model, and heterogeneity was calculated using the Q statistic and Higgin's I2 values. Meta-regression and exclusion sensitivity analyses were performed. Results: Five articles and seven studies were included, showing a significant pooled overall effect of aromatherapy on diabetes-related pain (Hedge's g = -1.83, 95% CI: -2.76 to -0.91). Meta-regression demonstrated that effectiveness in reducing pain was associated with studies conducted in West Asia, those with IRB approval, and those receiving funding. Additionally, interventions involving subjects under 60, lavender oil (vs. turpentine oil or blended oils), massage therapy (vs. topical application), fewer hours per session, and more repeated measurements (vs. pre/post measurements) were associated with pain reduction. Conclusion: Aromatherapy, especially with lavender oil, effectively manages diabetes-related pain. Short-duration massage application is also effective. A personalized selection of oil type and application method could optimize therapeutic outcomes for individuals with diabetes.

• 한국전문물리치료학회지
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• 제20권2호
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• pp.11-19
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• 2013

Delayed onset muscle soreness (DOMS) is a painful condition that arises from exercise-induced muscle damage after unaccustomed physical activities. Various therapeutic interventions have been applied to reduce the intensity and duration of DOMS-related symptoms. Recently, pulsed electromagnetic field (PEMF) intervention has been introduced as an alternative noninvasive treatment for DOMS. This randomized, double-blind, placebo-controlled experiment was conducted to examine the effects of PEMF therapy on DOMS in elbow flexors at 24, 48, and 72 hours after the experimental DOMS induction. Thirty healthy volunteers ($23{\pm}2.4$ yrs, $175{\pm}5.7$ cm, and $74{\pm}7.8$ kg) participated in this study. Each was randomly assigned to a PEMF or placebo group. On the first day, DOMS was induced in the elbow flexors by repeated isokinetic motions at low ($60^{\circ}/s$) and fast ($120^{\circ}/s$) speeds in all subjects. Thereafter, the PEMF group received 15-min daily treatment with a PEMF device. The placebo group received sham treatment of the same duration. Overall, PEMF application was more effective than the sham treatment in reducing the physiological symptoms associated with the DOMS including perceived soreness, median frequency, and electromechanical delay of the surface electromyography. In addition, median frequency and isokinetic peak torque of the PEMF group recovered to the pre-DOMS induction level earlier than the placebo group. In conclusion, this study suggests that PEMF can be applied as a new recovery strategy in reducing DOMS symptoms. Further experiments are required to examine the effect of the PEMF treatment on different types of exercise conditions and to determine the optimal treatment dosage and duration in a real clinical setting.

• 한국가축번식학회지
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• 제7권1호
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• pp.3-14
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• 1983

Estrus was induced and the therapeutic effect was examined with 25mg of PGF2$\alpha$ intramuscular injection and 3mg of PGF2$\alpha$ intraovarian injection to Holstein and Simmental cows which were raised in the large size stockfarms and the dairy farms, and were diagnosed to anestrus. The results obtained were summarized as follows: 1. The estrus inducing effect observed in the cows treated by PGF2$\alpha$ was 83.3% with 25/30 heads in the intramuscular injection group, and 86.7% with 26/30 heads in the intraovarian injection group. 2. Average duration from PGF2$\alpha$ administration to the onest of estrus was 2.7 day in the intramuscular injection group, and 2.6 days in the intraovarian injection group. 3. In status of estrus in the cows treated by PGF2$\alpha$, vigorous estrus was 12.0%, normal estrus 60.0% and silent estrus was 28.0% in the intramuscular injection group, and vigorous estrus was 15.4%, normal estrus 61.5%, and silent estrus 23.1% in the intraovarian injection group. 4. Conception rate in the cows induced to estrus was 64.0% in the intramuscular injection group and 65.4% in the intraovarian injection group.

• 대한두경부종양학회지
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• 제11권1호
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• pp.3-8
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• 1995

Tuberculous cervical lymphadenitis is one of common cause of neck mass in young adult in Korea. Tuberculous cervical lymphadenitis known as scrofula was being treated by the 'Royal Touch' in the 5th century and by surgery in the 17th century, yet the principle of the treatment is still controversal. We report the clinical evaluation and therapeutic result about 121 tuberculous cervical lymphadenitis. The result were as follows: 1) The annual incidence(1985-1994) was 30.5 % (37 cases: 1985-1986), 17.7 % (21 cases: 1990-1992). 19.8%(24 cases: 1994). 2) The age of highest incidence was 20-29 year old age group in 41.3% (50 cases) and female predominated over male by 1.8 : 1. 3) The duration of disease was less than 6 months, in 85.9% (104 cases). 4) The most commonly involved LN group was superficial cervical group in 69.4% (84 cases), and difference between Rt & Lt, was not significant. 5) The most common symptom and local finding(P/E) were, painless swelling of LN in 74.3 % (90 cases) and single mass in 59.5 % (72 cases). 6) In seasonal variation, 85.9% (104 cases) was spring and summer. 7) Procedures except biopsy for evaluation were chest PA, AFB smear & culture(sputum), Mantoux test, USG, CT and, Associated extracervical tuberculous lesions were lung, axilla, breast. 8) In operation method (involving biopsy), Excision was 68.5 % (83 cases), neck dissection was 6.6% (8 cases). 9) The Modality, Duration and side effect of antituberculous medication: INH-Rifampin­Ethambutol was 66.1 % (88 cases), duration was 1 year in 84.3% (102 cases), side effects were severe GI trouble (24.8%), liver function damage (3.3%). 10) 3 cases recurred on the same site after 2 yrs(2 cases) and 4 months(1 case) and its treatment was curretage or I & D, with antituberculous medication.

• 한국잠사곤충학회지
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• 제15권1호
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• pp.15-25
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• 1973

본인은 1972년 춘잠기와 추잠기에 걸쳐서 서울대학교농과대학 잠실에서 FZD의 누에병치료약으로서의 응용가능성을 검토한바 있다. 첫째로 FZD의 누에에의 경구적투약이 가능함을 알아낸 본인은 FZD의 4가지 누에병병원체 (Bacillus thuringiensis, Aspergillus flavus, Aspergillus oryzae, Isaria farinosa)에 대한 시험관내 항균력 측정, B.thuringiensis 로써 일으킨 실험적연화병에 대한 FZD의 발병억제효과 내지는 치료효과 관찰 등 일련의 실험을 거쳐, FZD은 실험적세균성연화병에 대해서 발병 억제효과와 치료효과를 겸해서 발휘한다는 기본적 사실을 밝혔다. 즉, 푸라졸리돈은 시험관내항균력측정에 있어서 세균성 연화병의 병원체인 Bacillus thuringiensis에 대해서는 시험관법으로써는 1$\mu\textrm{g}$/mι의 농도로써 그리고 한천평판법으로써는 $\mu\textrm{g}$/mι의 농도로써 완전한 발육억제효과를 발휘했으며, 한편 B. thuringiensis가 접종된 5령기 누에에 대해서는 잠정적인 용량인 누에 10마리당 150mg. 비율의 용량(누에체액 1ml당 약 2.2mg. 비율의 용량)에 있어서 1일 1회색 2일(2회)투여할 때 거의 완전한발병억제효과와 상당히 좋은 치료효과를 발휘했다. FZD의 임상적 응용에 따르는 용량, 투약시기, 제제형태 등의 여러가지 문제는 앞으로 세밀히 검토되어야 할 것으로 안다.

• Journal of Acupuncture Research
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• 제19권5호
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• pp.149-160
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• 2002

Objetive : To evaluate the effect of treatment for Heel Pain by using Bee-venom Acupuncture that is well known for anti-inflamatory effect and function of activating immunine system. Methods : We investigated 32 cases of patient with Heel Pain. From 1th November 2001 to 30th June 2002, 32 cases of patient with Heel Pain treated at the Department of Acupuncture & Moxibustion of Kyung-won University Oriental Hospital were selected for two group. One group was treated by Bee-venom Acupuncture therapy (Bee-venom Acupuncture Group : BAG), the other group was treated by Common Acupuncture therapy (None Bee-venom Acupuncture Group : NBAG). Both group were composed of 16 patients. After treatment, we evaluated the effects per each group. Results : 1. In the distribution by sex & age : 5 cases were male, 11 cases were female in BAG. 10 cases were male, 6 cases were female in NBGA. Forty aged cases were the most in BAG. Thirty aged cases were the most in NBAG. 2. Assessment of treatment by therapeutic frequency : 14 cases(87.5%) were above "Fair" within 6 times in BAG, 7 cases(43.8%) were above "Fair" beyond 10 times. 3. Assessment of treatment : Excellent were 9 cases, Good 5 cases, Fair 2 cases in BAG, Excellent were 2 cases, Good 7 cases, Fair 2 cases, Poor 5 cases in NBAG. Therapeutic effect above "Fair" were 16 cases(100%) in BAG, 11 cases(68.8%) in NBAG. 4. Comparing BAG with NBAG by therapeutic frequency and assessment in Grade II state : 11 cases(91.7%) were above "Good" within 6 times in BGA, 3 cases (57.1%) above "Fair" beyond 10 times. 5. About average frequency of treatment in the distribution of Grade : Grade III was 5.3 times, Grade II 4.0 times in BGA, whereas Grade III 16.0 times, Grade II 8.4 times in NBGA. Conclusions : In the treatment of Heel Pain, the Bee-venom Acupuncture can be regarded as more useful method in the clinical practice, because it has comparatively shorter duration of treatment and is more effective.

• Radiation Oncology Journal
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• 제11권1호
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• pp.97-102
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• 1993

1983년 4월부터 1991년 9월까지 가톨릭 의과대학 강남성모병원 치료방사선과에서 국한된 폐소세포암으로 확진되어 방사선치료받은 32명의 환자를 대상으로 치료성적을 후향 분석하였다. 이중 5명은 방사선 치료 단독으로 치료받았으며 27명은 화학요법과 방사선치료 병용요법을 하였다. 남녀의 비는 4.3:1 이었으며 연령분포는 24세에서 78세였다(중앙값 : 63세). 6 MV X 선에의한 방사선치료선량은 일일 160-180 cGy씩 치료하여 총 1000-6660 cGy (중앙값 4500 cGy)였다. 치료 후 완전관해율은 $37.5{\%}$ (12/32), 부분관해율은 $34.4{\%}$(11/32)였고, 무반응은 $28.1{\%}$(0/32)였다. 생존기간의 중앙값은 10개월이었고 1년생존율과 2년생존율은 각각 $59.4{\%}$와 $28.1{\%}$였다. 1년생존율을 유의하게 증가시키는 요소로서는 70이상의 Karnofsky수행상태(p<0.04), 화학요법의 병행(CAV, PV, CAV+PV) (p<0.04), 화학요법 6회 이상(p<0.007) , 45 Gy 이상의 방사선량(p<0.03)와 방사선치료에 반응있었던 경우(CR+PR) (p<0.003)등이었다. 나이, 성별, 상대정맥증후군, 예방적 전뇌조사 및 방사선 치료기간은 유의한 영향을 미치지 않았다. 방사선 치료에의한 부작용은 식도염이 $34{\%}$(11명), 전신피로 $28{\%}$(9명)에서 있었으며 오심 구토 같은 위장관 증상은 $15{\%}$(5명) 그리고 백혈구감소증이 $3{\%}$(1명)에서 관찰되었다.

• Journal of Acupuncture Research
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• 제18권2호
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• pp.227-236
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• 2001

Objectives : This study was performed to evaluate the clinical results of the thoracolumbar fracture patients treated with oriental medical methods. Methods : We reviewed 40 patients of thoracolumbar fracture, who were hospitalized at WonKwang University KwangJu Oriental Medical Hospital and treated by oriental medical methods. We classified thoracolumbar fracture according to three column theory and then analyzed the cause of injury, sex-age distribution, treatment, and etc.. Results : 1. The distribution showed female predominance(72.5%) in sex and 70age-bracket predominance in age. 2. In the distribution of causes, the largest group was "lifting heavy objects"(40%) and the next was "slip down"(37.5%). 3. In the duration of symptoms, the largest group was the group of "acutest" (40%). 4. The distribution of injured level was L1 body the most(20%). 5. In classification of fracture, "compression fracture" was the most(57.5%) and the next was "burst fracture", "unstable fracture" in order. 7. Therapeutic effects above "fair" were 37 cases(92.5%). 8. The higher grade of clinical symptoms is, the lower therapeutic effect is. 9. In the distribution of treatment results according to classification of fracture, both the compression fracture and the burst fracture were almost same high and the unstable fracture is relatively lower than them. Conclusions : The result to treating thoracolumbar fracture by oriental medical methods is satisfactory.