• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8019-8026
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• 2014

The promyelocytic leukemia (PML) gene is a gene known to be a tumor suppressor, although recent data suggest that it has a dual function in tumorigenesis. It was initially discovered in acute promyelocytic leukemia (APL) in which a t(15; 17) chromosomal translocation fused it to the retinoic acid receptor alpha ($RAR{\alpha}$). It has been shown to be involved in various types of cancer. It has at least 6 nuclear isoforms and a cytoplasmic type with different characteristics. Its multiple functions in growth inhibition, apoptosis induction, replicative senescence, inhibition of oncogenic transformation, and suppression of migration and angiogenesis have made it a therapeutic target for cancer therapy. However, its dual role in the process of tumorigenesis has made this field challenging. In this review, we discuss PML structure, functions and expression in tumors.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.9
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• pp.671-676
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• 2012

In this paper, TCAD assessment of 30-V class n-channel EDMOS (extended drain metal-oxide-semiconductor) transistors with DWFG (dual work function gate) structure are described. Gate of the DWFG EDMOS transistor is composed of both p- and n-type doped region on source and drain side. Additionally, lengths of p- and n-type doped gate region are varied while keeping physical channel length. Two-dimensional device structures are generated trough TSUPREM-4 and their electrical characteristics are investigated with MEDICI. The DWFG EDMOS transistor shows improved electrical characteristics than conventional device - i.e. higher transconductance ($g_m$), better drain output current ($I_{ON}$), reduced specific on-resistances ($R_{ON}$) and higher breakdown characteristics ($BV_{DSS}$).

• Proceedings of the Korean Vacuum Society Conference
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• 2010.02a
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• pp.127-127
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• 2010

Owing to many advantages on indirect intersubband absorption from the hole miniband to the electron miniband based on the type-II band alignment in InAs/GaSb strained-layer superlattice (SLS), InAs/GaSb SLS infrared photodetector (SLIP) has emerged as a promising system to realize high-detectivity quantum photodetector operating up to room temperature in the spectral range of mid-infrared (MIR) to far-infrared (FIR). In particular, n-barrier-n (n-B-n) structure designed for blocking the majority-carrier dark current makes it possible for MIR/FIR dual-band SLIP whose photoresponse (PR) band can be exclusively selected by the bias polarity. In this study, we present the MIR and FIR photoresponse (PR) mechanism identified by dual-band PR spectra and photoluminescence (PL) profiles taken from InAs/GaSb SLIP. In the MIR/FIR PR spectra measured by changing bias polarity, each spectrum individually shows a series of distinctive peaks related to the transitions from the hole subbands to the conduction one. The PR mechanism at each polarity is discussed in terms of diffusion current, and a superposition of MIR-PR in the FIR-PR spectrum is explained by tunnelling of electrons activated in MIR-SLS. The effective FIR-PR spectrum decomposed into three curves for HH1, LH1, and HH2 has revealed the edge energies of 120, 170, and 220 meV, respectively, and the temperature variation of the MIR-PR edge energies shows that the temperature behavior of the SLS systems can be approximately expressed by the Varshni empirical equation.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.22 no.9
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• pp.904-911
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• 2011

This paper deals with transmission characteristics of a new dual resonant structure for designing waveguide band-pass filter. The structure which has a pass-band between two adjacent stop-bands in a single body consists of circular ridged aperture and four armed conducting patch. The dual resonant behavior of the structure can be represented by a combination of LC series and parallel resonant circuits. Also these resonant properties can be easily controlled by varying the geometry of the aperture and four armed conducting patch. Actually, the structure is fabricated on the microstrip substrate by use of etching technique so that it is formed an iris type resonator which can be easily put into the transverse plane of the waveguide. We use WR-90 standard waveguide, adapters, and VNA(vector network analyzer) to measure the resonant characteristics of the structure. It is very useful to design and to improve the cutoff skirts characteristics in the waveguide band-pass filter design area.

• Proceedings of the KIEE Conference
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• 2000.07c
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• pp.1536-1538
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• 2000

In this paper, designed and fabricated the 1.9GHz band isolator for wire-less communication base-stations. It was investigated that characteristics of insertion loss and return loss. The characteristic results of dual structure design showed values that insertion loss was about -40dB and return loss was about -23dB at 1.93$\sim$1.99GHz.

• Proceedings of the Korean Biophysical Society Conference
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• 1999.06a
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• pp.58-58
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• 1999

The paraventricular nucleus (PVN) is a complex structure comprised of several different populations of cells divided into two main groups, the magnocellular (type I) neurons which secrete vasopressin and oxytocin and the parvocellular (type II) neurons which regulate hormone secretion from the anterior pituitary.(omitted)

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.397-404
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• 2020

Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPARα and PPARγ dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPARα/γ dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.1 s.92
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• pp.1-8
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• 2005

This paper proposes a new type of a dual-band internal antenna for GPS/PCS handsets. The antenna has three monopoles in different lengths, and this structure is referred as a 3-fingers type antenna in this paper. The antenna with low-profile structure is designed to use internal space of handset maximally. The fabrication and the measurement are accomplished by attaching the 3-finger type antenna to the inside of a commercial handset. We obtain gain of 1.97 dBi$\~$0.66 dBi in the GPS band, and -0.92 dBi$\~$1.02 dBi in the PCS band and almost omni-directional patterns at all bands.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.5
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• pp.551-558
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• 2012

This paper presents a dual band loop-type ground antenna using lumped-elements that control the impedance bandwidth and resonant frequency. The dual-band operation of the proposed antenna is realized by inserting an additional resonated loop feed structure into the reference ground antenna. As the proper value of the capacitor and the inductor are chosen, the impedance bandwidth of our antenna with voltage standing wave ratio(VSWR) equal to 3 is 85 MHz and 725 MHz at the 2.45 and 5.5 GHz frequency band, respectively. Its validity is demonstrated via both the computed and measured results. Good antenna patterns and efficiencies are achieved at the dual frequency bands, as well as the physically small antenna element size($10{\times}5mm^2$).

• Coupled systems mechanics
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• v.10 no.6
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• pp.491-507
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• 2021

The aim of this paper is to conduct a hydrodynamic analysis of fluid flow over different weir types using the analytical solution, the physical model taken from another article, and numericalsimulations through the Smoothed particle hydrodynamic method (SPH) using the compiled DualSPHysics source code. The paper covers the field of real fluid dynamics that includes a description of different proposed types of weirs in various flow regimes and the optimal solution for the most efficiency structure shape. A detailed presentation of the method, the structure and it's characteristics are included. Apart from the single stepped weir, two other weir types are proposed: a Divided type and a Downstream slopped type. All of them are modeled using the SPH method.