• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.757-764
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• 2021

This study analyzes the signification structure and mythical meaning of Hirokazu Koreeda's documentary . In other words, by approaching the signification structure of the semiotic elements that constitute storytelling, the mythical meaning implied by is widely examined. It is to discuss the essential characteristics of the aesthetic form he is aiming for, and at the same time, to look at the aesthetic type that expands the meaning value of documentary storytelling. In particular, Hirokazu Koreeda uses typical and symbolic elements in harmoniously in the storytelling process. By applying such a dual aesthetic form, it effectively conveys the mythical meaning required in the times to the audience. Therefore, is a signification system that emits mythical meaning, and it reflects the aesthetic intention of Hirokazu Koreeda who has confidence in the imagination of the audience.

• Molecules and Cells
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• v.42 no.2
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• pp.183-188
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• 2019

Osteoarthritis (OA) is a naturally occurring, irreversible disorder and a major health burden. The disease is multifactorial, involving both physiological and mechanical processes, but calcium crystals have been associated intimately with its pathogenesis. This study tested the hypothesis that these crystals have a detrimental effect on the differentiation of osteoclasts and bone homeostasis. This study employed an osteoblastosteoclast coculture system that resembles in vivo osteoblastdependent osteoclast differentiation along with $Ca^{2+}$-phosphate-coated culture dishes. The calcium-containing crystals upregulated the expression of RANKL and increased the differentiation of osteoclasts significantly as a result. On the other hand, osteoblast differentiation was unaffected. MicroRNA profiling showed that dual-specificity phosphatases 1 (DUSP1) was associated with the increased RANKL expression. DUSP1 belongs to a family of MAPK phosphatases and is known to inactivate all three groups of MAPKs, p38, JNK, and ERK. Furthermore, knockdown of DUSP1 gene expression suggested that RANKL expression increases significantly in the absence of DUSP1 regulation. Microarray analysis of the DUSP1 mRNA levels in patients with pathological bone diseases also showed that the downregulated DUSP1 expression leads to increased expression of RANKL and consequently to the destruction of the bone observed in these patients. These findings suggest that calcium-containing crystals may play a crucial role in promoting RANKL-induced osteoclastogenesis via DUSP1.

• Asia-Pacific Journal of Business
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• v.10 no.1
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• pp.117-133
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• 2019

This paper examines the most-favored-nation treatment clause on the BITs concluded by China and examines the attitudes of China on the application of the most-favored-nation treatment clause to the ISDs by period as the scope of arbitration increases. Moreover, this study pointed out the problems that would be exposed if the most-favored-nation treatment clause applies to ISDs and then also suggested solutions. The conclusions of this study are as follows; if the Chinese government strictly restricts the applicable expansion of the most-favored-nation treatment clause to the dispute settlement procedure by considering only the position of the capital importing country, it implies a contradiction against the development trend of the arbitration system related to international investment disputes. Of course, in order to protect the rights of Chinese investors investing abroad, expanding the applicability of the most-favored-nation treatment clause to the ISDs procedure unconditionally may have a negative impact under China's dual status of being a capital-importing country and a capital-exporting country. Therefore, China should clearly define the scope of application of the most-favored-nation treatment clause, the completion of the local remedy for the host country in cases of BIT to be concluded in the future or amended, and also clearly define that the most-favored-nation treatment clause should not be retroactively applied into BITs already concluded as an exception of applicability of the most-favored-nation treatment.

• Steel and Composite Structures
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• v.30 no.4
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• pp.365-382
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• 2019

In steel frame-tube structures (SFTSs) the application of flexural beam is not suitable for the beam with span-to-depth ratio lower than five because the plastic hinges at beam-ends can not be developed properly. This can lead to lower ductility and energy dissipation capacity of the SFTS. To address this problem, a replaceable shear link, acting as a ductile fuse at the mid length of deep beams, is proposed. SFTS with replaceable shear links (SFTS-RSLs) dissipate seismic energy through shear deformation of the link. In order to evaluate this proposal, buildings were designed to compare the seismic performance of SFTS-RSLs and SFTSs. Several sub-structures were selected from the design buildings and finite element models (FEMs) were established to study their hysteretic behavior. Static pushover and dynamic analyses were undertaken in comparing seismic performance of the FEMs for each building. The results indicated that the SFTS-RSL and SFTS had similar initial lateral stiffness. Compared with SFTS, SFTS-RSL had lower yield strength and maximum strength, but higher ductility and energy dissipation capacity. During earthquakes, SFTS-RSL had lower interstory drift, maximum base shear force and story shear force compared with the SFTS. Placing a shear link at the beam mid-span did not increase shear lag effects for the structure. The SFTS-RSL concentrates plasticity on the shear link. Other structural components remain elastic during seismic loading. It is expected that the SFTS-RSL will be a reliable dual resistant system. It offers the benefit of being able to repair the structure by replacing damaged shear links after earthquakes.

• Journal of the Korean neurological association
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• v.35 no.4
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• pp.211-214
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• 2017

Acute disseminated encephalomyelitis (ADEM) and Guillain-$Barr{\acute{e}}$ syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.

• Investigative Magnetic Resonance Imaging
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• v.22 no.4
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• pp.218-228
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• 2018

Purpose: The objective of this study is to determine the effect of physical changes on MR temperature imaging at 7.0T and to examine proton-resonance-frequency related changes of MR phase images and T1 related changes of MR magnitude images, which are obtained for MR thermometry at various magnetic field strengths. Materials and Methods: An MR-compatible capacitive-coupled radio-frequency hyperthermia system was implemented for heating a phantom and swine muscle tissue, which can be used for both 7.0T and 3.0T MRI. To determine the effect of flip angle correction on T1-based MR thermometry, proton resonance frequency, apparent T1, actual flip angle, and T1 images were obtained. For this purpose, three types of imaging sequences are used, namely, T1-weighted fast field echo with variable flip angle method, dual repetition time method, and variable flip angle method with radio-frequency field nonuniformity correction. Results: Signal-to-noise ratio of the proton resonance frequency shift-based temperature images obtained at 7.0T was five-fold higher than that at 3.0T. The T1 value increases with increasing temperature at both 3.0T and 7.0T. However, temperature measurement using apparent T1-based MR thermometry results in bias and error because B1 varies with temperature. After correcting for the effect of B1 changes, our experimental results confirmed that the calculated T1 increases with increasing temperature both at 3.0T and 7.0T. Conclusion: This study suggests that the temperature-induced flip angle variations need to be considered for accurate temperature measurements in T1-based MR thermometry.

• Journal of Gastric Cancer
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• v.19 no.2
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• pp.157-164
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• 2019

Purpose: Although standard radical gastrectomy is recommended after noncurative resection of endoscopic submucosal dissection (ESD) for early gastric cancer in most cases, residual tumor and lymph node metastasis have not been identified after surgery. The aim of this study is to evaluate the feasibility of sentinel node navigation surgery after noncurative ESD. Materials and Methods: This trial is an investigator-initiated, multicenter prospective phase II trial. Patients who underwent ESD for clinical stage T1N0M0 gastric cancer with noncurative resections were eligible. Qualified investigators who completed the prior phase III trial (SENORITA 1) are exclusively allowed to participate. In this study, 2 detection methods will be used: 1) intraoperative endoscopic submucosal injection of dual tracer, including radioisotope and indocyanine green (ICG) with sentinel basins detected using gamma-probe; 2) endoscopic injection of ICG, with sentinel basins detected using a fluorescence imaging system. Standard laparoscopic gastrectomy with lymphadenectomy will be performed. Sample size is calculated based on the inferior confidence interval of the detection rate of 95%, and the calculated accrual is 237 patients. The primary endpoint is detection rate, and the secondary endpoints are sensitivity and postoperative complications. Conclusions: This study is expected to clarify the feasibility of laparoscopic sentinel basin dissection after noncurative ESD. If the feasibility is demonstrated, a multicenter phase III trial will be initiated to compare laparoscopic sentinel node navigation surgery versus laparoscopic standard gastrectomy in early gastric cancer after endoscopic resection.

• Journal of Positioning, Navigation, and Timing
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• v.8 no.3
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• pp.95-105
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• 2019

A method that applies space-time adaptive signal processing (STAP) algorithm based on an array antenna consisting of multiple antenna elements has been known to be effective to remove wide-band jamming signals in GPS receivers. However, the occurrence of phase distortion in navigation signals has been a problem when navigation signals, from which jamming signals are removed using STAP, are supplied to global positioning system (GPS) receivers. This paper verified the navigation performance degradation as a result of phase distortion. To mitigate this phenomenon, this paper proposes a mode switching scheme, in which a bypass mode is adopted to make the best use of the tracking performance of receivers without performing signal processing when jamming signals are not present or weak, and a STAP mode is employed when jamming signals exceed the threshold value. In this paper, the mode switching scheme is proposed for two environments: when receivers are stationary, and when receivers are moving. This paper confirmed that the performance of position error improved because phase distortion could be excluded due to STAP if the bypass mode was adopted under a condition where the jamming signal power level was below the threshold value in an environment where receivers were stationary. However, this paper also observed that the navigation failed due to the instability of tracking performance of receivers due to phase distortion that occurred at the switching time, although the number of switching could be reduced dramatically by proposing a dual threshold scheme of on- and off-thresholds that switched a mode due to the array antenna characteristics of varying gains according to the jamming signal incident direction in an environment where receivers were moving. The analysis results verified that running the STAP algorithm at all times is more efficient than the mode switching, in terms of maintaining stable navigation and ensuring position error performance, to remove jamming signals in an environment where receivers were moving.

• Journal of Advanced Navigation Technology
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• v.23 no.5
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• pp.430-436
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• 2019

It is needed to develop an antenna with features of subminiature, light weight and multi-band operation for the variaty services in maritime and industrial fields. The PCB pattern antenna is one of the appropreiate antennas solving these requirements. In this research, the design and fabrication of the PCB pattern antenna operating on the single band of 920 MHz are investigated. The final goal is that the development of the dual band PCB pattern antenna operating on 260 MHz and 920 MHz, which is based on the proposed antenna. It is evident that the performance in the frequencies of 902 MHz, 915 MHz and 928 MHz among of 920 MHz ISM band is better than that in other frequencies. It is also confirmed that the differences of the voltage standing wave ratio, return loss, gain and efficiency between three frequencies are less than 5%. It is expected that the development of communication link of 5-10 km is possible when the induced results are applied into the low power wide area (LPWA) network desinged by the rule of -30 dB sensitivity.

• The Transactions of the Korean Institute of Power Electronics
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• v.26 no.3
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• pp.192-198
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• 2021

The battery's State of Health (SOH) is a critical parameter in the process of battery use, as it represents the Remaining Useful Life (RUL) of the battery. Electrochemical Impedance Spectroscopy (EIS) is a widely used technique in observing the state of the battery. The measured impedance at certain frequencies can be used to evaluate the state of the battery, as it is intimately tied to the underlying chemical reactions. In this work, a low-cost portable EIS instrument is developed on the basis of the ARM Cortex-M4 Microcontroller Unit (MCU) for measuring the impedance spectrum of Li-ion battery packs. The MCU uses a built-in DAC module to generate the sinusoidal sweep perturbation signal. Moreover, it performs the dual-channel acquisition of voltage and current signals, calculates impedance using a Digital Lock-in Amplifier (DLA), and transmits the result to a PC. By using LabVIEW, an interface was developed with the real-time display of the EIS information. The developed instrument was suitable for measuring the impedance spectrum of the battery pack up to 1000 V. The measurement frequency range of the instrument was from 1 hz to 1 Khz. Then, to prove the performance of the developed system, the impedance of a Samsung SM3 battery pack and a Bexel pouch module were measured and compared with those obtained by the commercial instrument.