• The Korean Journal of Pain
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• v.29 no.3
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• pp.153-157
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• 2016

Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the ${\mu}$-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys. The most common adverse reactions are nausea, dizziness, vomiting, and somnolence. Constipation is more common in use of the ER formulation. Precautions against concomitant use of central nervous system depressants, including sedatives, hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and alcohol, or use of tapentadol within 14 days of the cessation of monoamine oxidase inhibitors, are advised. The safety and efficacy have not been established for use during pregnancy, labor, and delivery, or for nursing mothers, pediatric patients less than 18 years of age, and cases of severe renal impairment and severe hepatic impairment. The major concerns for tapentadol are abuse, addiction, seeking behavior, withdrawal, and physical dependence. The presumed problem for use of tapentadol is to control the ratio of MOR agonist and NRI. In conclusion, tapentadol produces both nociceptive and neuropathic pain relief, but with worries about abuse and dependence.

• Journal of Biomedical Engineering Research
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• v.24 no.1
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• pp.31-36
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• 2003

Impact characteristics of six DM(Diabetes Mellitus) shoe insole materials (Podian, Plastazote black, Plastazote white, Flexible PU foam, Podialene 200 blue and Podia flex) and three multi-density insoles (AP, OS and PW insoles) were determined in the present study, using a self-designed impact measurement system. The coefficient of restitution, the median frequency and the attenuation index were calculated for each material, based on impact forces and linear accelerations. Podian revealed the superiority in the coefficient of restitution and the attenuation index. The median frequency of the Flexible PU foam was the smallest. Results also showed that the heel region was the most impact-attenuated among other areas in the insole. OS insole showed the better characteristics in the coefficient of restitution and the median frequency. but there was no significant difference in the attenuation index. Similar impact characteristics were found in all areas in PW insole. since it was basically of the same dual-density polyurethane.

• Asian Journal of Atmospheric Environment
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• v.11 no.4
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• pp.283-299
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• 2017

An analytical method using high-performance liquid chromatography (HPLC) with fluorescence (FL) detection was developed for simultaneously analyzing 10 polycyclic aromatic hydrocarbons (PAHs) and 18 nitro-derivatives of PAHs (NPAHs). The two-dimensional HPLC system consists of an on-line clean-up and reduction for NPAHs in the 1st dimension, and separation of the PAHs and the reduced NPAHs and their FL detection in the 2nd dimension after column-switching. To identify an ideal clean-up column for removing sample matrix that may interfere with detection of the analytes, the characteristics of 8 reversed-phase columns were evaluated. The nitrophenylethyl (NPE)-bonded silica column was selected because of its shorter elution band and larger retention factors of the analytes due to strong dipole-dipole interactions. The amino-substituted PAHs (reduced NPAHs), PAHs and deuterated internal standards were separated on polymeric octadecyl-bonded silica (ODS) columns and by dual-channel detection within 120 min including clean-up and reduction steps. The limits of detection were 0.1-9.2 pg per injection for PAHs and 0.1-140 pg per injection for NPAHs. For validation, the method was applied to analyze crude extracts of fine particulate matter ($PM_{2.5}$) samples and achieved good analytical precision and accuracy. Moreover, the standard reference material (SRM1649b, urban dust) was analyzed by this method and the observed concentrations of PAHs and NPAHs were similar to those in previous reports. Thus, the method developed here-in has the potential to become a standard HPLC-based method, especially for NPAHs.

• The Journal of the Korea Contents Association
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• v.7 no.4
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• pp.20-29
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• 2007

Although E-mail system is considered as a most important communication media, 'Spam' is flooding the Internet with many copies of the same message, in an attempt to force the message on people who would not otherwise choose to receive it. Most spam is commercial advertising, often for dubious products, get-rich-quick schemes, or quasi-legal services. Therefore advanced anti-spam techniques are required to basically reduce its transmission volume on sender mail server or MTA, etc. In this study, we propose a new sender authentication model with encryption function based on modified DomainKey with SMS for Spam mail protection. From the SMS message, we can get secret information used for verification of its real sender on e-mail message. And by distributing this secret information with SMS like out-of-band channel, we can also combine proposed modules with existing PGP scheme for secure e-mail generation and authentication steps. Proposed scheme provide enhanced authentication function and security on Spam mail protection function because it is a 'dual mode' authentication mechanism.

• Journal of KIISE:Computing Practices and Letters
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• v.14 no.7
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• pp.636-645
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• 2008

OneNAND flash is a high-performance hybrid flash memory that combines the advantages of both NAND flash and NOR flash. OneNAND flash has not only all virtues of NAND flash but also greatly enhanced read performance which is considered as a downside of NAND flash. As a result, it is widely used in mobile applications such as mobile phones, digital cameras, PMP, and portable game players. However, most of the general purpose operating systems, such as Linux, can not exploit the read performance of OneNAND flash because of the restrictions imposed by their virtual memory system and block I/O architecture. In order to solve that problem, we suggest a new approach called virtual I/O segment. By using virtual I/O segment, the superior read performance of OneNAND flash can be exploited without modifying the existing block I/O architecture and MTD subsystem. Experiments by implementations show that this approach can reduce read latency of OneNAND flash as much as 54%.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.05a
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• pp.347-350
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• 2006

The rocket grade hydrogen peroxide has been widely used as a monopropellant in propulsion systems. In the present paper, we described an experimental study of a catalytic reactor that employs two stage catalyst beds to enhance the low temperature performance of the reactor. $K_2MnO_4$ was chosen as the catalyst for the initial stage of the reactor bed for its superior behavior in the low temperature regime. LSC was used for the catalyst of the second stage of the reactor. The gas generator with combined catalyst beds was built and tested to exhibit high decomposition efficiency over 90% and successful cold-start characteristics.

• Earthquakes and Structures
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• v.12 no.1
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• pp.13-21
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• 2017

Recent seismic events occurred in Italy (Emilia-Romagna 2012, Abruzzo 2009) and worldwide (New Zealand 2010 and 2011) highlighted some of the weaknesses of precast concrete industrial buildings, especially those related to the connecting systems traditionally employed to fasten the cladding panels to the internal framing. In fact, one of the most commons fails it is possible to observe in such structural typologies is related to the out-of-plane collapse of the external walls due to the unsatisfactory behaviour of the connectors used to join the panels to the perimeter beams. In this work, the strengthening of a traditional industrial building, assumed as a case study, made by precast reinforced concrete is proposed by the adoption of a dual system allowing the reinforcement of the structure by acting both internally; by pendular columns and, externally, on the walls. In particular, traditional connections at the top of the walls are substituted by devices able to work as a slider with vertical axis while, the bottom of the walls is equipped with two or more hysteretic dampers working on the uplift of the cladding panels occurring under seismic actions. By means of this approach, the structure is stiffened; obtaining a reduction of the lateral drifts under serviceability limit states. In addition, its seismic behaviour is improved due to the additional source of energy dissipation represented by the dampers located at the base of the walls. The effectiveness of the suggested retrofitting approach has been checked by comparing the performance of the retrofitted structure with those of the structure unreinforced by means of both pushover and Incremental Dynamic Analyses (IDA) in terms of behaviour factor, assumed as a measure of the ductility capacity of the structure.

• Journal of Computing Science and Engineering
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• v.5 no.3
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• pp.210-222
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• 2011

In this work, we study the problem of privacy-preservation data publishing in moving objects databases. In particular, the trajectory of a mobile user in a plane is no longer a polyline in a two-dimensional space, instead it is a two-dimensional surface of fixed width $2A_{min}$, where $A_{min}$ defines the semi-diameter of the minimum spatial circular extent that must replace the real location of the mobile user on the XY-plane, in the anonymized (kNN) request. The desired anonymity is not achieved and the entire system becomes vulnerable to attackers, since a malicious attacker can observe that during the time, many of the neighbors' ids change, except for a small number of users. Thus, we reinforce the privacy model by clustering the mobile users according to their motion patterns in (u, ${\theta}$) plane, where u and ${\theta}$ define the velocity measure and the motion direction (angle) respectively. In this case, the anonymized (kNN) request looks up neighbors, who belong to the same cluster with the mobile requester in (u, ${\theta}$) space: Thus, we know that the trajectory of the k-anonymous mobile user is within this surface, but we do not know exactly where. We transform the surface's boundary poly-lines to dual points and we focus on the information distortion introduced by this space translation. We develop a set of efficient spatiotemporal access methods and we experimentally measure the impact of information distortion by comparing the performance results of the same spatiotemporal range queries executed on the original database and on the anonymized one.

• Journal of Intelligence and Information Systems
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• v.15 no.3
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• pp.119-136
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• 2009

According to the increase of container flows and the appearance of large-sized container vessels, the container handling equipment in ports is evolving continuously. This research introduces the simulation model for evaluating in detail the mechanical productivity of container cranes. The model considers a single trolley and dual trolleys as the mechanism of a container crane and a single lift, a twin lift, and a tandem lift as the spreader type of it. Additionally, the detail specifications such as the dimension and the speed of a container crane are inputted and the kinematic characteristics of it are simulated. The model also considers the size of a vessel, the storage position of containers in the vessel, and the weight of containers as external physical constraints. Experimental conditions can be configured conveniently because various parameters in the model are separated. Moreover, the model can accommodate flexibly new equipment types and the changes of the existing equipment because it is designed and developed in object-oriented concept.

• Journal of information and communication convergence engineering
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• v.10 no.1
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• pp.61-65
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• 2012

Many public organizations have been adopting and operating various servers. These servers run on Windows, Unix, and Linux operating systems that generally use less than 10% of their capacity. For migrating a public organization to cloud computing, we must first virtualize the server environment. This article proposes a strategy for server virtualization that the National IT Industry Promotion Agency (NIPA) has done and describes the effects of a public organization migrating to cloud computing. The NIPA Computer Center planned an effective virtualization migration on various servers. This project of virtualization migration was conducted with the existing policy of separate x86 servers and Unix servers. There are three popular approaches to server virtualization: a virtual machine model, a paravirtual machine model, and virtualization at the operating system layer. We selected a VMware solution that uses the virtual machine model. We selected servers for virtualization in the following manner. Servers were chosen that had the highest rate of service usage and CPU usage and had been operating for five years or more. However, we excluded servers that require 80% or greater rates of CPU usage. After adopting the server virtualization technique, we consolidated 32 servers into 3 servers. Virtualization is a technology that can provide benefits in these areas: server consolidation and optimization, infrastructure cost reduction and improved operational flexibility, and implementation of a dual computing environment.