• 한국심리학회지:학교
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• 제18권1호
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• pp.71-97
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• 2021

본 연구는 애착외상과 초기 성인기 대인관계문제의 관계에서 자비두려움과 정서조절곤란이 미치는 영향을 탐색하기 위해 수행하였다. 이를 위해 경북 소재 대학의 대학생 296명을 대상으로 아동기외상, 자비불안, 정서조절곤란, 대인관계문제를 측정하는 질문지를 실시하였다. 애착외상이 높은 집단(상위 25%)과 낮은 집단(하위 25%)으로 분류하여 주요 변인 간 차이검증을 실시하였으며, 애착외상이 대인관계문제에 미치는 영향에서 자비두려움과 정서조절곤란의 이중매개 효과를 구조방정식모형으로 분석하였다. 연구결과는 다음과 같다. 첫째, 애착외상이 높은 집단은 애착외상이 낮은 집단에 비해 타인으로부터 받는 자비두려움, 자기자비두려움, 정서조절곤란, 대인관계문제에서 유의미하게 높았다. 둘째, 애착외상과 대인관계문제에서 자비두려움과 정서조절곤란이 각각 완전매개하는 것으로 나타나 애착외상이 자비두려움과 정서조절곤란을 통해 대인관계문제에 영향을 미치는 것으로 밝혀졌다. 셋째, 애착외상과 대인관계문제에서 자비두려움과 정서조절곤란이 완전이중매개하는 것으로 나타났다. 이는 애착외상이 자비두려움에 영향을 미치고 이것이 정서조절곤란으로 이어져 대인관계문제에 영향을 줄 수 있음을 시사한다. 마지막으로 본 연구가 상담 개입 장면에서 갖는 의의를 논의하고 한계와 후속연구를 제언하였다.

• 대한의용생체공학회:의공학회지
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• 제14권1호
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• pp.41-50
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• 1993

This paper proposes an adaptive technique for the cardiac output regulation of a pendulum type electromechanical TAH. This techinque, which consists of two RLSE's and two PASTC' 5, performs Its controllability over the TAIB so that the m(RAP) and m(LAP) values re- main close to their desired values under she assumption that the variation of m(RAP) and m (LAP) are dominated by the variation of C.0. and the difference between the left and right ventricular output, respectively. To evaluate the performance of the proposed control system, a simulation is performed by using a human model which contains physiologic, drug and treatment, artificial heart and noise models. As a result, dual adaptive controller showed that abnormal m(LAP) and m(RAP) could be recovered to the normal range within 10minute and maintained desired value in steady state. The operation of this controller prored to be robust in spite of the rapid variation of human status.

• International Journal of Stem Cells
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• 제16권2호
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• pp.156-167
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• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• 전력전자학회논문지
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• 제21권2호
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• pp.102-110
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• 2016

In this paper, a high-frequency dual mode control LLC resonant converter with wide input voltage range is proposed through zero voltage switching (ZVS) under the universal line input voltage and every load conditions. Conventional small power adapter driving should be satisfied with universal line input voltage because it has no power factor correction circuit regulation. The conventional LLC resonant converter for an adapter can reduce the size of transformer in terms of high-frequency driving and ZVS. However, this converter has a disadvantage in terms of design of resonant tank under various input voltages because the frequency modulation range is very wide to satisfy voltage conversion gain. Compared with the conventional one, the proposed LLC converter can be adapted to universal line input voltage and high-frequency driving because it is controlled by pulse width modulation and pulse frequency modulation with control voltage. The validity of the proposed LLC converter is proved through the 60 W prototype.

• 전력전자학회논문지
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• 제22권2호
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• pp.102-108
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• 2017

Proper design guides are proposed for a practical dual-active bridge (DAB) converter based on the mathematical model on the steady state. The DAB converter is popular in bidirectional application due to its zero-voltage capability and easy bidirectional operation for seamless control, high efficiency, and performance. Some design considerations are taken to overcome the limitation of the DAB converter. The practical design methodology of power stage is discussed to minimize the conduction and switching losses of the DAB converter. Small-signal model and frequency response are derived and analyzed based on the generalized average method, which considers equivalent series resistance, to improve the dynamics, stability, and reliability with voltage regulation of the practical DAB converter. The design of closed-loop control is discussed by the derived small-signal model to obtain the pertinent gain and phase margin in steady-state operation. Experimental results of a 3.3 kW prototype of DAB converter demonstrate the validity and effectiveness of the proposed methods.

• Journal of Radiation Protection and Research
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• 제46권3호
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• pp.112-119
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• 2021

Background: This work aims to develop a new imaging system based on a pulse shape discrimination-capable Cs₂LiYCl₆:Ce (CLYC) scintillation detector combined with the rotational modulation collimator (RMC) technique for dual-particle imaging. Materials and Methods: In this study, a CLYC-based RMC system was designed based on Monte Carlo simulations, and a prototype was fabricated. Therein, a rotation control system was developed to rotate the RMC unit precisely, and a graphical user interface-based software was also developed to operate the data acquisition with RMC rotation. The RMC system was developed to allow combining various types of collimator masks and detectors interchangeably, making the imaging system more versatile for various applications and conditions. Results and Discussion: Operational performance of the fabricated system was studied by checking the accuracy and precision of the collimator rotation and obtaining modulation patterns from a gamma-ray source repeatedly. Conclusion: The prototype RMC system showed reliability in its mechanical properties and reproducibility in the acquisition of modulation patterns, and it will be further investigated for its dual-particle imaging capability with various complex radioactive source conditions.

• Current Optics and Photonics
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• 제6권3호
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• pp.252-259
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• 2022

In this paper, a dual-function dynamically tunable metamaterial absorber is proposed. At frequency points of 1.545 THz and 3.21 THz, two resonance peaks with absorption amplitude of 93.8% (peak I) and 99.4% (peak II) can be achieved. By regulating the conductivity of photosensitive silicon with a pump laser, the resonance frequency of peak I switches to 1.525 THz, and that of peak II switches to 2.79 THz. By adjusting the incident polarization angle by rotating the device, absorption amplitude tuning is obtained. By introducing two degrees of regulation freedom, the absorption amplitude modulation and resonant frequency switching are simultaneously realized. More importantly, dynamic and continuous adjustment of the absorption amplitude is obtained at a fixed resonant frequency, and the modulation depth reaches 100% for both peaks. In addition, the sensing property of the proposed MMA was studied while it was used as a refractive index sensor. Compared with other results reported, our device not only has a dual-function tunable characteristic and the highest modulation depth, but also simultaneously possesses fine sensing performance.

• 생명과학회지
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• 제21권1호
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• pp.31-35
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• 2011

Dual-specificity protein phosphatase (DUSP)들은 인산화된 티로신 잔기와 인산화된 세린 또는 트레오닌 잔기를 탈인산화시키는 단백질 탈인산화효소 군을 이루고 있으며, 대부분의 DUSP들은 세포의 생존이나 분화에 관여하고 있다. 본 연구에서는 잘 알려지지 않은 인간 유래의 dual-specificity protein phosphatase인 DUSP28을 인간신장 cDNA에서 분리하였다. 대장균에서 생산된 재조합단백질은 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP)에 대하여 좋은 활성을 보였다. 다양한 저해제와 2가 금속이온들이 DUSP28의 활성에 미치는 영향을 조사하였다. 다른 DUSP들에서와는 다르게, $Zn^{2+}$은 DUSP28의 탈인산화활성을 강하게 억제하였다. 이러한 결과로부터 DUSP28이 Zn과 연관된 신호전달경로에 관여할 것으로 추정된다. 더욱이, DUSP28은 인산화된 티로신잔기를 더욱 선호하는 경향이 있는 것으로 나타났고, 이는 세포 내에서도 비슷한 작용을 할 것으로 예상된다.

• Journal of Power Electronics
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• 제4권3호
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• pp.138-151
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• 2004

In this paper, a constant frequency phase shifting PWM-controlled voltage source full bridge-type series load resonant high-frequency inverter using the $4^{th}$ generation IGBT power modules is presented for innovative consumer electromagnetic induction heating applications, such as a hot water producer, steamer and super heated steamer. The bridge arm side link passive capacitive snubbers in parallel with each power semiconductor device and AC load side linked active edge inductive snubber-assisted series load resonant tank soft switching inverter with a constant frequency phase shifted PWM control scheme is evaluated and discussed on the basis of the simulation and experimental results. It is proved from a practical point of view that the series load resonant and edge resonant hybrid high-frequency inverter topology, what is called, DE class type, including the variable-power variable-frequency regulation function can expand zero voltage soft switching commutation area even under low output power setting ranges, which is more suitable and acceptable for newly developed induction heated dual pack fluid heaters. Furthermore, even the lower output power regulation mode of this high-frequency load resonant tank inverter circuit is verified so that this inverter can achieve ZVS with the aid of the single auxiliary inductor snubber.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2005년도 전력전자학술대회 논문집
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• pp.774-777
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• 2005

In this paper, a constant frequency phase shifting PWM controlled voltage source full bridge-type series load resonant high-frequency inverter using the IGBT power modules is presented for innovative consumer electromagnetic induction heating applications such as a hot water producer, steamer and super heated steamer. The full bridge arm side link passive quasi-resonant capacitor snubbers in parallel with the each power semiconductor device and high frequency AC load side linked active edge inductive snubber-assisted series load resonant tank soft switching inverter with a constant frequency phase shifted PWM control scheme is discussed and evaluated on the basis of the simulation and experimental results. It is proved from a practical point of view that the series load resonant and edge resonant hybrid high-frequency soft switching PWM inverter topology, what is called class DE type. including the variable-power variable-frequency(VPVF) regulation function can expand zero voltage soft switching commutation range even under low output power setting ranges, which is more suitable and acceptable for induction heated dual packs fluid heater developed newly for consumer power utilizations. Furthermore, even in the lower output power regulation mode of this high-frequency load resonant tank high frequency inverter circuit it is verified that this inverter can achieve ZVS with the aid of the single auxiliary inductor snubber.